Ube2d2b ubiquitin-conjugating enzyme E2D 2B [Rattus norvegicus (Norway rat)] - Gene

Summary

Official Symbol: Ube2d2bprovided by RGD
Official Full Name: ubiquitin-conjugating enzyme E2D 2Bprovided by RGD
Primary source: RGD:69425
See related: EnsemblRapid:ENSRNOG00000082439 AllianceGenome:RGD:69425
Gene type: protein coding
RefSeq status: PROVISIONAL
Organism: Rattus norvegicus
Lineage: Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha; Muroidea; Muridae; Murinae; Rattus
Also known as: Ube2d2; Ube2d4; RGD69425
Summary: Predicted to enable ubiquitin conjugating enzyme activity. Involved in cellular response to arsenite(3-) and cellular response to cadmium ion. Predicted to be active in nucleus. Orthologous to human UBE2D2 (ubiquitin conjugating enzyme E2 D2); UBE2D3 (ubiquitin conjugating enzyme E2 D3); and UBE2D4 (ubiquitin conjugating enzyme E2 D4 (putative)). [provided by Alliance of Genome Resources, Apr 2022]
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Genomic context

Location:: 14p22

Exon count:: 1

Annotation release	Status	Assembly	Chr	Location
RS_2024_02	current	GRCr8 (GCF_036323735.1)	14	NC_086032.1 (2060926..2062400, complement)
RS_2023_06	previous assembly	mRatBN7.2 (GCF_015227675.2)	14	NC_051349.1 (1915999..1917473, complement)
106	previous assembly	Rnor_6.0 (GCF_000001895.5)	14	NC_005113.4 (2933097..2934571, complement)

Chromosome 14 - NC_086032.1 Genomic Context describing neighboring genes

Genomic regions, transcripts, and products

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Genomic Sequence:

Go to nucleotide: Graphics FASTA GenBank

Bibliography

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GeneRIFs: Gene References Into Functions

What's a GeneRIF?

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General gene information

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Gene Ontology Provided by RGD

Function	Evidence Code	Pubs
enables ATP binding	IEA Inferred from Electronic Annotation more info
enables transferase activity	IEA Inferred from Electronic Annotation more info
enables ubiquitin conjugating enzyme activity	IBA Inferred from Biological aspect of Ancestor more info
enables ubiquitin conjugating enzyme activity	ISO Inferred from Sequence Orthology more info
enables ubiquitin-protein transferase activity	ISO Inferred from Sequence Orthology more info

Process	Evidence Code	Pubs
involved_in cellular response to arsenite(3-)	IEP Inferred from Expression Pattern more info	PubMed
involved_in cellular response to cadmium ion	IEP Inferred from Expression Pattern more info	PubMed
involved_in protein K11-linked ubiquitination	IBA Inferred from Biological aspect of Ancestor more info
involved_in protein K11-linked ubiquitination	ISO Inferred from Sequence Orthology more info
involved_in protein K27-linked ubiquitination	ISO Inferred from Sequence Orthology more info
involved_in protein K29-linked ubiquitination	ISO Inferred from Sequence Orthology more info
involved_in protein K48-linked ubiquitination	IBA Inferred from Biological aspect of Ancestor more info
involved_in protein K48-linked ubiquitination	ISO Inferred from Sequence Orthology more info
involved_in protein K6-linked ubiquitination	ISO Inferred from Sequence Orthology more info
involved_in protein K63-linked ubiquitination	ISO Inferred from Sequence Orthology more info
acts_upstream_of_or_within protein ubiquitination	ISO Inferred from Sequence Orthology more info
involved_in ubiquitin-dependent protein catabolic process	IBA Inferred from Biological aspect of Ancestor more info

Component	Evidence Code	Pubs
is_active_in nucleus	IBA Inferred from Biological aspect of Ancestor more info

General protein information

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Preferred Names: ubiquitin-conjugating enzyme E2 D2B

Names: E2 ubiquitin-conjugating enzyme D2B; E2(17)KB 2B; ubiquitin carrier protein D2B; ubiquitin-conjugating enzyme E2(17)KB 2B; ubiquitin-conjugating enzyme E2-17 kDa 2B; ubiquitin-conjugating enzyme E2D 2; ubiquitin-conjugating enzyme E2D 4 (putative); ubiquitin-protein ligase D2B

NP_112263.1

EC 2.3.2.23

NCBI Reference Sequences (RefSeq)

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RefSeqs maintained independently of Annotated Genomes

These reference sequences exist independently of genome builds. Explain

These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

mRNA and Protein(s)

NM_031001.2 → NP_112263.1 ubiquitin-conjugating enzyme E2 D2B

See identical proteins and their annotated locations for NP_112263.1

Status: PROVISIONAL

Source sequence(s)

BC078808

UniProtKB/Swiss-Prot

P70711

UniProtKB/TrEMBL

A0A8I5ZTI3, A6KPH8

Related

ENSRNOP00000101492.1, ENSRNOT00000162982.1

Conserved Domains (1) summary

cl00154
Location:1 → 146

UBCc; Ubiquitin-conjugating enzyme E2, catalytic (UBCc) domain. This is part of the ubiquitin-mediated protein degradation pathway in which a thiol-ester linkage forms between a conserved cysteine and the C-terminus of ubiquitin and complexes with ubiquitin ...