PRSS1 cationic trypsin [Bos taurus (cattle)] - Gene

Summary

Gene symbol: PRSS1
Gene description: cationic trypsin
See related: BGD:BT29793; Ensembl:ENSBTAG00000067483
Gene type: protein coding
RefSeq status: PROVISIONAL
Organism: Bos taurus
Lineage: Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Laurasiatheria; Artiodactyla; Ruminantia; Pecora; Bovidae; Bovinae; Bos
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Genomic context

Location:: chromosome: 4

Exon count:: 5

Annotation release	Status	Assembly	Chr	Location
RS_2023_09	current	ARS-UCD2.0 (GCF_002263795.3)	4	NC_037331.1 (105521590..105525991, complement)

Chromosome 4 - NC_037331.1 Genomic Context describing neighboring genes

Genomic regions, transcripts, and products

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Go to reference sequence details

Genomic Sequence:: NC_037331.1 Chromosome 4 Reference ARS-UCD2.0 Primary Assembly

Go to nucleotide: Graphics FASTA GenBank

Bibliography

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GeneRIFs: Gene References Into Functions

What's a GeneRIF?

Isothermal titration calorimetry was used to obtain Michaelis-Menten plots for the trypsin-catalyzed hydrolysis of several substrates at different temperatures (278-318K).
Title: Isothermal titration calorimetry determination of individual rate constants of trypsin catalytic activity.
The identification of fluorinated fragments binding to the serine protease trypsin, and the X-ray structures of the complexes are presented.
Title: Combined use of computational chemistry, NMR screening, and X-ray crystallography for identification and characterization of fluorophilic protein environments.
Results describe the functional and structural roles of the Cys14-Cys38 disulfide of bovine pancreatic trypsin inhibitor.
Title: Functional and structural roles of the Cys14-Cys38 disulfide of bovine pancreatic trypsin inhibitor.

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General gene information

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Gene Ontology Provided by RefSeq

Function	Evidence Code	Pubs
enables serine-type endopeptidase activity	IEA Inferred from Electronic Annotation more info	PubMed

Process	Evidence Code	Pubs
involved_in proteolysis	IEA Inferred from Electronic Annotation more info	PubMed

Component	Evidence Code	Pubs
located_in extracellular space	IEA Inferred from Electronic Annotation more info	PubMed

General protein information

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Preferred Names: serine protease 1

Names: anionic trypsin I; beta-trypsin; pretrypsinogen I; trypsin I; trypsin, beta

NP_001107199.1

EC 3.4.21.4

NCBI Reference Sequences (RefSeq)

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RefSeqs maintained independently of Annotated Genomes

These reference sequences exist independently of genome builds. Explain

These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

mRNA and Protein(s)

NM_001113727.2 → NP_001107199.1 serine protease 1 precursor

See identical proteins and their annotated locations for NP_001107199.1

Status: PROVISIONAL

Source sequence(s)

BC134797

UniProtKB/Swiss-Prot

A6H6Y3, P00760

UniProtKB/TrEMBL

A0AAA9S633

Related

ENSBTAP00000004737.4, ENSBTAT00000004737.5

Conserved Domains (1) summary

cd00190
Location:24 → 242

Tryp_SPc; Trypsin-like serine protease; Many of these are synthesized as inactive precursor zymogens that are cleaved during limited proteolysis to generate their active forms. Alignment contains also inactive enzymes that have substitutions of the catalytic triad ...