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    pla2g6 phospholipase A2 group VI [ Xenopus tropicalis (tropical clawed frog) ]

    Gene ID: 780118, updated on 4-Nov-2024

    Summary

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    Official Symbol
    pla2g6provided by Xenbase
    Official Full Name
    phospholipase A2 group VIprovided by Xenbase
    Primary source
    Xenbase:XB-GENE-920447
    See related
    Ensembl:ENSXETG00000006353 AllianceGenome:Xenbase:XB-GENE-920447
    Gene type
    protein coding
    RefSeq status
    MODEL
    Organism
    Xenopus tropicalis
    Lineage
    Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Amphibia; Batrachia; Anura; Pipoidea; Pipidae; Xenopodinae; Xenopus; Silurana
    Also known as
    gvi; pla2; inad1; ipla2; pnpla9; cai-pla2
    Summary
    Predicted to enable serine-type endopeptidase activity. Predicted to be involved in zymogen activation. Predicted to act upstream of or within lipid catabolic process. Predicted to be active in plasma membrane. Human ortholog(s) of this gene implicated in dystonia 12; neuroaxonal dystrophy; and neurodegenerative disease (multiple). Orthologous to human PLA2G6 (phospholipase A2 group VI). [provided by Alliance of Genome Resources, Nov 2024]
    Orthologs
    human mouse all
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    Genomic context

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    See pla2g6 in Genome Data Viewer
    Location:
    chromosome: 4
    Exon count:
    18
    Annotation release Status Assembly Chr Location
    104 current UCB_Xtro_10.0 (GCF_000004195.4) 4 NC_030680.2 (122244861..122265941, complement)
    103 previous assembly Xenopus_tropicalis_v9.1 (GCF_000004195.3) 4 NC_030680.1 (111850040..111873172, complement)

    Chromosome 4 - NC_030680.2Genomic Context describing neighboring genes Neighboring gene uncharacterized LOC105946980 Neighboring gene BAI1 associated protein 2 like 2 Neighboring gene v-maf avian musculoaponeurotic fibrosarcoma oncogene homolog F Neighboring gene transmembrane protein 184B

    Genomic regions, transcripts, and products

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    Go to nucleotide: Graphics FASTA GenBank

    Bibliography

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    Related articles in PubMed

    1. Genetic and genomic tools for Xenopus research: The NIH Xenopus initiative. Klein SL, et al. Dev Dyn, 2002 Dec. PMID 12454917
    2. Generation and initial analysis of more than 15,000 full-length human and mouse cDNA sequences. Strausberg RL, et al. Proc Natl Acad Sci U S A, 2002 Dec 24. PMID 12477932, Free PMC Article
    3. Phylogenetic-based propagation of functional annotations within the Gene Ontology consortium. Gaudet P, et al. Brief Bioinform, 2011 Sep. PMID 21873635, Free PMC Article

    GeneRIFs: Gene References Into Functions

    General gene information

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    Homology

    Clone Names

    • MGC146383

    Gene Ontology Provided by Xenbase

    Function Evidence Code Pubs
    enables calcium-independent phospholipase A2 activity IEA
    Inferred from Electronic Annotation
    more info
    		  
    enables catalytic activity IEA
    Inferred from Electronic Annotation
    more info
    		  
    enables hydrolase activity IEA
    Inferred from Electronic Annotation
    more info
    		  
    enables serine-type endopeptidase activity IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    Process Evidence Code Pubs
    acts_upstream_of_or_within lipid catabolic process IEA
    Inferred from Electronic Annotation
    more info
    		  
    acts_upstream_of_or_within lipid metabolic process IEA
    Inferred from Electronic Annotation
    more info
    		  
    involved_in zymogen activation IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    Component Evidence Code Pubs
    is_active_in plasma membrane IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  

    General protein information

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    Preferred Names
    85/88 kDa calcium-independent phospholipase A2
    Names
    phospholipase A2, group 6 (cytosolic, calcium-independent)
    XP_012816940.2
    XP_031756947.1
    XP_031756948.1

    NCBI Reference Sequences (RefSeq)

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    RefSeqs of Annotated Genomes: Xenopus tropicalis Annotation Release 104 details...Open this link in a new tab

    The following sections contain reference sequences that belong to a specific genome build. Explain

    Reference UCB_Xtro_10.0 Primary Assembly

    Genomic

    1. NC_030680.2 Reference UCB_Xtro_10.0 Primary Assembly

      Range
      122244861..122265941 complement
      Download
      GenBank, FASTA, Sequence Viewer (Graphics)

    mRNA and Protein(s)

    1. XM_031901088.1 → XP_031756948.1  85/88 kDa calcium-independent phospholipase A2 isoform X2

      UniProtKB/TrEMBL
      A0A6I8QLR3
      Related
      ENSXETP00000073241.2, ENSXETT00000097600.2
      Conserved Domains (4) summary
      cd07212
      Location:430 → 743
      Pat_PNPLA9; Patatin-like phospholipase domain containing protein 9
      COG0666
      Location:286 → 395
      ANKYR; Ankyrin repeat [Signal transduction mechanisms]
      sd00045
      Location:316 → 347
      ANK; ANK repeat [structural motif]
      pfam12796
      Location:156 → 248
      Ank_2; Ankyrin repeats (3 copies)

    2. XM_012961486.2 → XP_012816940.2  85/88 kDa calcium-independent phospholipase A2 isoform X1

      UniProtKB/TrEMBL
      F7AE83
      Conserved Domains (4) summary
      cd07212
      Location:475 → 788
      Pat_PNPLA9; Patatin-like phospholipase domain containing protein 9
      COG0666
      Location:286 → 406
      ANKYR; Ankyrin repeat [Signal transduction mechanisms]
      sd00045
      Location:316 → 347
      ANK; ANK repeat [structural motif]
      pfam12796
      Location:156 → 248
      Ank_2; Ankyrin repeats (3 copies)

    3. XM_031901087.1 → XP_031756947.1  85/88 kDa calcium-independent phospholipase A2 isoform X1

      UniProtKB/TrEMBL
      F7AE83
      Related
      ENSXETP00000013911.5, ENSXETT00000013911.5
      Conserved Domains (4) summary
      cd07212
      Location:475 → 788
      Pat_PNPLA9; Patatin-like phospholipase domain containing protein 9
      COG0666
      Location:286 → 406
      ANKYR; Ankyrin repeat [Signal transduction mechanisms]
      sd00045
      Location:316 → 347
      ANK; ANK repeat [structural motif]
      pfam12796
      Location:156 → 248
      Ank_2; Ankyrin repeats (3 copies)

    Suppressed Reference Sequence(s)

    The following Reference Sequences have been suppressed. Explain

    1. NM_001079193.1: Suppressed sequence

      Description
      NM_001079193.1: This RefSeq was suppressed temporarily based on the calculation that the encoded protein was shorter than proteins from the putative ortholog from human: PLA2G6 (GeneID:8398).
    Nucleotide Protein Strain
    Heading Accession and Version

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