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    ZNF202 zinc finger protein 202 [ Homo sapiens (human) ]

    Gene ID: 7753, updated on 28-Oct-2024

    Summary

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    Official Symbol
    ZNF202provided by HGNC
    Official Full Name
    zinc finger protein 202provided by HGNC
    Primary source
    HGNC:HGNC:12994
    See related
    Ensembl:ENSG00000166261 MIM:603430; AllianceGenome:HGNC:12994
    Gene type
    protein coding
    RefSeq status
    VALIDATED
    Organism
    Homo sapiens
    Lineage
    Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Primates; Haplorrhini; Catarrhini; Hominidae; Homo
    Also known as
    ZSCAN42; ZKSCAN10
    Summary
    Enables DNA-binding transcription repressor activity, RNA polymerase II-specific and RNA polymerase II cis-regulatory region sequence-specific DNA binding activity. Involved in negative regulation of transcription by RNA polymerase II. Located in chromosome; nuclear body; and nucleolus. [provided by Alliance of Genome Resources, Oct 2024]
    Expression
    Ubiquitous expression in testis (RPKM 4.3), ovary (RPKM 3.3) and 25 other tissues See more
    Orthologs
    mouse all
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    Genomic context

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    See ZNF202 in Genome Data Viewer
    Location:
    11q24.1
    Exon count:
    11
    Annotation release Status Assembly Chr Location
    RS_2024_08 current GRCh38.p14 (GCF_000001405.40) 11 NC_000011.10 (123723914..123741660, complement)
    RS_2024_08 current T2T-CHM13v2.0 (GCF_009914755.1) 11 NC_060935.1 (123752703..123770446, complement)
    RS_2024_09 previous assembly GRCh37.p13 (GCF_000001405.25) 11 NC_000011.9 (123594622..123612368, complement)

    Chromosome 11 - NC_000011.10Genomic Context describing neighboring genes Neighboring gene uncharacterized LOC124902777 Neighboring gene sodium voltage-gated channel beta subunit 3 Neighboring gene uncharacterized LOC105369543 Neighboring gene ATAC-STARR-seq lymphoblastoid silent region 4020 Neighboring gene ATAC-STARR-seq lymphoblastoid silent region 4021 Neighboring gene H3K4me1 hESC enhancer GRCh37_chr11:123572538-123573038 Neighboring gene H3K4me1 hESC enhancer GRCh37_chr11:123573039-123573539 Neighboring gene CDK7 strongly-dependent group 2 enhancer GRCh37_chr11:123599312-123600511 Neighboring gene ATAC-STARR-seq lymphoblastoid active region 5687 Neighboring gene ATAC-STARR-seq lymphoblastoid silent region 4022 Neighboring gene ATAC-STARR-seq lymphoblastoid silent region 4023 Neighboring gene OCT4-NANOG-H3K27ac hESC enhancer GRCh37_chr11:123612953-123613550 Neighboring gene olfactory receptor family 6 subfamily X member 1 Neighboring gene RNA, U1 small nuclear 21, pseudogene

    Genomic regions, transcripts, and products

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    Go to nucleotide: Graphics FASTA GenBank

    Expression

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    • Project title: HPA RNA-seq normal tissues HPA RNA-seq normal tissues
    • Description: RNA-seq was performed of tissue samples from 95 human individuals representing 27 different tissues in order to determine tissue-specificity of all protein-coding genes
    • BioProject: PRJEB4337
    • Publication: PMID 24309898
    • Analysis date: Wed Apr 4 07:08:55 2018

    Bibliography

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    Related articles in PubMed

    1. Molecular cloning and characterization of ZNF202: a new gene at 11q23.3 encoding testis-specific zinc finger proteins. Monaco C, et al. Genomics, 1998 Sep 15. PMID 9790754
    2. Zinc Finger Protein 202: a new candidate gene for ischemic heart disease: The Copenhagen City Heart Study. Stene MC, et al. Atherosclerosis, 2006 Sep. PMID 16289551
    3. Zinc Finger Protein 202, genetic variation, and HDL cholesterol in the general population. Stene MC, et al. J Lipid Res, 2006 May. PMID 16467280
    4. Functional promoter variant in zinc finger protein 202 predicts severe atherosclerosis and ischemic heart disease. Stene MC, et al. J Am Coll Cardiol, 2008 Jul 29. PMID 18652945
    5. The SCAN domain mediates selective oligomerization. Schumacher C, et al. J Biol Chem, 2000 Jun 2. PMID 10747874

    See all (33) citations in PubMed

    GeneRIFs: Gene References Into Functions

    What's a GeneRIF?
    1. Observational study of gene-disease association, gene-environment interaction, and pharmacogenomic / toxicogenomic. (HuGE Navigator)
      Title: Variation at the NFATC2 locus increases the risk of thiazolidinedione-induced edema in the Diabetes REduction Assessment with ramipril and rosiglitazone Medication (DREAM) study.
    2. Observational study and genome-wide association study of gene-disease association. (HuGE Navigator)
      Title: Genomewide association study of movement-related adverse antipsychotic effects.
    3. SOX17-Chromatin immunoprecipitation identified zinc finger protein 202 (Zfp202) as a direct target of SOX17 during endoderm differentiation of F9 embryonal carcinoma cells.
      Title: SOX17 directly activates Zfp202 transcription during in vitro endoderm differentiation.
    4. Homozygosity for a common functional promoter variant in ZNF202 predicts severe atherosclerosis and an increased risk of IHD.
      Title: Functional promoter variant in zinc finger protein 202 predicts severe atherosclerosis and ischemic heart disease.
    5. Observational study of gene-disease association. (HuGE Navigator)
      Title: Gene-centric association signals for lipids and apolipoproteins identified via the HumanCVD BeadChip.
    6. findings show that genetic variation in ZNF202 is common in the general population. However, SNPs in the protein-coding region of ZNF202 do not make a major contribution to HDL cholesterol levels.
      Title: Zinc Finger Protein 202, genetic variation, and HDL cholesterol in the general population.
    7. This is the first study to suggest that ZNF202 could be a new candidate gene for ischemic heart disease and myocardial infarction in the general population.
      Title: Zinc Finger Protein 202: a new candidate gene for ischemic heart disease: The Copenhagen City Heart Study.
    Submit: New GeneRIF Correction

    Phenotypes

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    Find tests for this gene in the NIH Genetic Testing Registry (GTR)

    Review eQTL and phenotype association data in this region using PheGenI

    EBI GWAS Catalog

    Description
    Genomewide association study of movement-related adverse antipsychotic effects.
    EBI GWAS Catalog

    Variation

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    See variants in ClinVar

    See studies and variants in dbVar

    See Variation Viewer (GRCh37.p13)

    See Variation Viewer (GRCh38)

    Genotypes

    HIV-1 interactions

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    Protein interactions

    Protein Gene Interaction Pubs
    retropepsin gag-pol Positional proteomics analysis identifies the cleavage of human zinc finger protein 202 (ZNF202) at amino acid residues 68-69 by the HIV-1 protease PubMed

    Go to the HIV-1, Human Interaction Database

    Interactions

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    Products Interactant Other Gene Complex Source Pubs Description

    General gene information

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    Markers

    Homology

    Gene Ontology Provided by GOA

    Function Evidence Code Pubs
    enables DNA-binding transcription factor activity, RNA polymerase II-specific IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    enables DNA-binding transcription repressor activity, RNA polymerase II-specific IDA
    Inferred from Direct Assay
    more info
    		 PubMed 
    enables RNA polymerase II cis-regulatory region sequence-specific DNA binding IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    enables RNA polymerase II cis-regulatory region sequence-specific DNA binding IDA
    Inferred from Direct Assay
    more info
    		 PubMed 
    enables metal ion binding IEA
    Inferred from Electronic Annotation
    more info
    		  
    enables protein binding IPI
    Inferred from Physical Interaction
    more info
    		 PubMed 
    Process Evidence Code Pubs
    involved_in lipid metabolic process TAS
    Traceable Author Statement
    more info
    		 PubMed 
    involved_in negative regulation of transcription by RNA polymerase II IDA
    Inferred from Direct Assay
    more info
    		 PubMed 
    involved_in regulation of transcription by RNA polymerase II IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    Component Evidence Code Pubs
    located_in chromosome IDA
    Inferred from Direct Assay
    more info
    		  
    located_in nuclear body IDA
    Inferred from Direct Assay
    more info
    		  
    located_in nucleolus IDA
    Inferred from Direct Assay
    more info
    		  

    General protein information

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    Preferred Names
    zinc finger protein 202
    Names
    zinc finger protein with KRAB and SCAN domains 10

    NCBI Reference Sequences (RefSeq)

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    NEW Try the new Transcript table

    RefSeqs maintained independently of Annotated Genomes

    These reference sequences exist independently of genome builds. Explain

    These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

    mRNA and Protein(s)

    1. NM_001301779.2 → NP_001288708.1  zinc finger protein 202 isoform 1

      See identical proteins and their annotated locations for NP_001288708.1

      Status: VALIDATED

      Description
      Transcript Variant: This variant (2) differs in the 5' UTR compared to variant 1. Variants 1, 2 and 3 encode the same isoform (1).
      Source sequence(s)
      AK226047, AL162031, AP000868, BC013382, DA770117, H89560, H89561
      Consensus CDS
      CCDS8443.1
      UniProtKB/Swiss-Prot
      B0LPH9, O95125, Q4JG21, Q9H1B9, Q9NSM4
      Related
      ENSP00000337724.4, ENST00000336139.8
      Conserved Domains (8) summary
      smart00431
      Location:43 → 153
      SCAN; leucine rich region
      smart00349
      Location:237 → 297
      KRAB; krueppel associated box
      COG5048
      Location:397 → 644
      COG5048; FOG: Zn-finger [General function prediction only]
      sd00017
      Location:567 → 587
      ZF_C2H2; C2H2 Zn finger [structural motif]
      pfam00096
      Location:593 → 615
      zf-C2H2; Zinc finger, C2H2 type
      pfam01352
      Location:237 → 277
      KRAB; KRAB box
      pfam02023
      Location:43 → 130
      SCAN; SCAN domain
      pfam13465
      Location:607 → 632
      zf-H2C2_2; Zinc-finger double domain

    2. NM_001301780.2 → NP_001288709.1  zinc finger protein 202 isoform 1

      See identical proteins and their annotated locations for NP_001288709.1

      Status: VALIDATED

      Description
      Transcript Variant: This variant (3) lacks two consecutive exons in the 5' UTR compared to variant 1. Variants 1, 2 and 3 encode the same isoform (1).
      Source sequence(s)
      AK023751, AL162031, AP000868, BC013382, DA770117, H89560, H89561, HY056142
      Consensus CDS
      CCDS8443.1
      UniProtKB/Swiss-Prot
      B0LPH9, O95125, Q4JG21, Q9H1B9, Q9NSM4
      Related
      ENSP00000433881.1, ENST00000529691.1
      Conserved Domains (8) summary
      smart00431
      Location:43 → 153
      SCAN; leucine rich region
      smart00349
      Location:237 → 297
      KRAB; krueppel associated box
      COG5048
      Location:397 → 644
      COG5048; FOG: Zn-finger [General function prediction only]
      sd00017
      Location:567 → 587
      ZF_C2H2; C2H2 Zn finger [structural motif]
      pfam00096
      Location:593 → 615
      zf-C2H2; Zinc finger, C2H2 type
      pfam01352
      Location:237 → 277
      KRAB; KRAB box
      pfam02023
      Location:43 → 130
      SCAN; SCAN domain
      pfam13465
      Location:607 → 632
      zf-H2C2_2; Zinc-finger double domain

    3. NM_001301819.1 → NP_001288748.1  zinc finger protein 202 isoform 2

      See identical proteins and their annotated locations for NP_001288748.1

      Status: VALIDATED

      Description
      Transcript Variant: This variant (4) differs in the 5' UTR, lacks a portion of the 5' coding region, and uses a downstream start codon compared to variant 1. It encodes isoform 2 which has a shorter N-terminus compared to isoform 1.
      Source sequence(s)
      AF027218, AL162031, BC013382, DA770117, H89560, H89561
      UniProtKB/Swiss-Prot
      O95125
      Conserved Domains (3) summary
      smart00349
      Location:13 → 73
      KRAB; krueppel associated box
      COG5048
      Location:367 → 424
      COG5048; FOG: Zn-finger [General function prediction only]
      sd00017
      Location:343 → 363
      ZF_C2H2; C2H2 Zn finger [structural motif]

    4. NM_003455.4 → NP_003446.2  zinc finger protein 202 isoform 1

      See identical proteins and their annotated locations for NP_003446.2

      Status: VALIDATED

      Description
      Transcript Variant: This variant (1) represents the longest transcript. Variants 1, 2 and 3 encode the same isoform (1).
      Source sequence(s)
      AL162031, AP000868, BC013382, DA770117, H89560, H89561, HY056142
      Consensus CDS
      CCDS8443.1
      UniProtKB/Swiss-Prot
      B0LPH9, O95125, Q4JG21, Q9H1B9, Q9NSM4
      Related
      ENSP00000432504.1, ENST00000530393.6
      Conserved Domains (8) summary
      smart00431
      Location:43 → 153
      SCAN; leucine rich region
      smart00349
      Location:237 → 297
      KRAB; krueppel associated box
      COG5048
      Location:397 → 644
      COG5048; FOG: Zn-finger [General function prediction only]
      sd00017
      Location:567 → 587
      ZF_C2H2; C2H2 Zn finger [structural motif]
      pfam00096
      Location:593 → 615
      zf-C2H2; Zinc finger, C2H2 type
      pfam01352
      Location:237 → 277
      KRAB; KRAB box
      pfam02023
      Location:43 → 130
      SCAN; SCAN domain
      pfam13465
      Location:607 → 632
      zf-H2C2_2; Zinc-finger double domain

    RefSeqs of Annotated Genomes: GCF_000001405.40-RS_2024_08

    The following sections contain reference sequences that belong to a specific genome build. Explain

    Reference GRCh38.p14 Primary Assembly

    Genomic

    1. NC_000011.10 Reference GRCh38.p14 Primary Assembly

      Range
      123723914..123741660 complement
      Download
      GenBank, FASTA, Sequence Viewer (Graphics)

    mRNA and Protein(s)

    1. XM_005271661.2 → XP_005271718.1  zinc finger protein 202 isoform X1

      See identical proteins and their annotated locations for XP_005271718.1

      UniProtKB/Swiss-Prot
      B0LPH9, O95125, Q4JG21, Q9H1B9, Q9NSM4
      Conserved Domains (8) summary
      smart00431
      Location:43 → 153
      SCAN; leucine rich region
      smart00349
      Location:237 → 297
      KRAB; krueppel associated box
      COG5048
      Location:397 → 644
      COG5048; FOG: Zn-finger [General function prediction only]
      sd00017
      Location:567 → 587
      ZF_C2H2; C2H2 Zn finger [structural motif]
      pfam00096
      Location:593 → 615
      zf-C2H2; Zinc finger, C2H2 type
      pfam01352
      Location:237 → 277
      KRAB; KRAB box
      pfam02023
      Location:43 → 130
      SCAN; SCAN domain
      pfam13465
      Location:607 → 632
      zf-H2C2_2; Zinc-finger double domain

    2. XM_005271659.2 → XP_005271716.1  zinc finger protein 202 isoform X1

      See identical proteins and their annotated locations for XP_005271716.1

      UniProtKB/Swiss-Prot
      B0LPH9, O95125, Q4JG21, Q9H1B9, Q9NSM4
      Conserved Domains (8) summary
      smart00431
      Location:43 → 153
      SCAN; leucine rich region
      smart00349
      Location:237 → 297
      KRAB; krueppel associated box
      COG5048
      Location:397 → 644
      COG5048; FOG: Zn-finger [General function prediction only]
      sd00017
      Location:567 → 587
      ZF_C2H2; C2H2 Zn finger [structural motif]
      pfam00096
      Location:593 → 615
      zf-C2H2; Zinc finger, C2H2 type
      pfam01352
      Location:237 → 277
      KRAB; KRAB box
      pfam02023
      Location:43 → 130
      SCAN; SCAN domain
      pfam13465
      Location:607 → 632
      zf-H2C2_2; Zinc-finger double domain

    3. XM_017018268.3 → XP_016873757.1  zinc finger protein 202 isoform X1

      UniProtKB/Swiss-Prot
      B0LPH9, O95125, Q4JG21, Q9H1B9, Q9NSM4
      Conserved Domains (8) summary
      smart00431
      Location:43 → 153
      SCAN; leucine rich region
      smart00349
      Location:237 → 297
      KRAB; krueppel associated box
      COG5048
      Location:397 → 644
      COG5048; FOG: Zn-finger [General function prediction only]
      sd00017
      Location:567 → 587
      ZF_C2H2; C2H2 Zn finger [structural motif]
      pfam00096
      Location:593 → 615
      zf-C2H2; Zinc finger, C2H2 type
      pfam01352
      Location:237 → 277
      KRAB; KRAB box
      pfam02023
      Location:43 → 130
      SCAN; SCAN domain
      pfam13465
      Location:607 → 632
      zf-H2C2_2; Zinc-finger double domain

    4. XM_005271660.2 → XP_005271717.1  zinc finger protein 202 isoform X1

      See identical proteins and their annotated locations for XP_005271717.1

      UniProtKB/Swiss-Prot
      B0LPH9, O95125, Q4JG21, Q9H1B9, Q9NSM4
      Conserved Domains (8) summary
      smart00431
      Location:43 → 153
      SCAN; leucine rich region
      smart00349
      Location:237 → 297
      KRAB; krueppel associated box
      COG5048
      Location:397 → 644
      COG5048; FOG: Zn-finger [General function prediction only]
      sd00017
      Location:567 → 587
      ZF_C2H2; C2H2 Zn finger [structural motif]
      pfam00096
      Location:593 → 615
      zf-C2H2; Zinc finger, C2H2 type
      pfam01352
      Location:237 → 277
      KRAB; KRAB box
      pfam02023
      Location:43 → 130
      SCAN; SCAN domain
      pfam13465
      Location:607 → 632
      zf-H2C2_2; Zinc-finger double domain

    5. XM_006718901.3 → XP_006718964.1  zinc finger protein 202 isoform X1

      See identical proteins and their annotated locations for XP_006718964.1

      UniProtKB/Swiss-Prot
      B0LPH9, O95125, Q4JG21, Q9H1B9, Q9NSM4
      Conserved Domains (8) summary
      smart00431
      Location:43 → 153
      SCAN; leucine rich region
      smart00349
      Location:237 → 297
      KRAB; krueppel associated box
      COG5048
      Location:397 → 644
      COG5048; FOG: Zn-finger [General function prediction only]
      sd00017
      Location:567 → 587
      ZF_C2H2; C2H2 Zn finger [structural motif]
      pfam00096
      Location:593 → 615
      zf-C2H2; Zinc finger, C2H2 type
      pfam01352
      Location:237 → 277
      KRAB; KRAB box
      pfam02023
      Location:43 → 130
      SCAN; SCAN domain
      pfam13465
      Location:607 → 632
      zf-H2C2_2; Zinc-finger double domain

    6. XM_011542972.2 → XP_011541274.1  zinc finger protein 202 isoform X1

      See identical proteins and their annotated locations for XP_011541274.1

      UniProtKB/Swiss-Prot
      B0LPH9, O95125, Q4JG21, Q9H1B9, Q9NSM4
      Conserved Domains (8) summary
      smart00431
      Location:43 → 153
      SCAN; leucine rich region
      smart00349
      Location:237 → 297
      KRAB; krueppel associated box
      COG5048
      Location:397 → 644
      COG5048; FOG: Zn-finger [General function prediction only]
      sd00017
      Location:567 → 587
      ZF_C2H2; C2H2 Zn finger [structural motif]
      pfam00096
      Location:593 → 615
      zf-C2H2; Zinc finger, C2H2 type
      pfam01352
      Location:237 → 277
      KRAB; KRAB box
      pfam02023
      Location:43 → 130
      SCAN; SCAN domain
      pfam13465
      Location:607 → 632
      zf-H2C2_2; Zinc-finger double domain

    7. XM_011542975.2 → XP_011541277.1  zinc finger protein 202 isoform X1

      See identical proteins and their annotated locations for XP_011541277.1

      UniProtKB/Swiss-Prot
      B0LPH9, O95125, Q4JG21, Q9H1B9, Q9NSM4
      Conserved Domains (8) summary
      smart00431
      Location:43 → 153
      SCAN; leucine rich region
      smart00349
      Location:237 → 297
      KRAB; krueppel associated box
      COG5048
      Location:397 → 644
      COG5048; FOG: Zn-finger [General function prediction only]
      sd00017
      Location:567 → 587
      ZF_C2H2; C2H2 Zn finger [structural motif]
      pfam00096
      Location:593 → 615
      zf-C2H2; Zinc finger, C2H2 type
      pfam01352
      Location:237 → 277
      KRAB; KRAB box
      pfam02023
      Location:43 → 130
      SCAN; SCAN domain
      pfam13465
      Location:607 → 632
      zf-H2C2_2; Zinc-finger double domain

    8. XM_011542973.2 → XP_011541275.1  zinc finger protein 202 isoform X1

      See identical proteins and their annotated locations for XP_011541275.1

      UniProtKB/Swiss-Prot
      B0LPH9, O95125, Q4JG21, Q9H1B9, Q9NSM4
      Conserved Domains (8) summary
      smart00431
      Location:43 → 153
      SCAN; leucine rich region
      smart00349
      Location:237 → 297
      KRAB; krueppel associated box
      COG5048
      Location:397 → 644
      COG5048; FOG: Zn-finger [General function prediction only]
      sd00017
      Location:567 → 587
      ZF_C2H2; C2H2 Zn finger [structural motif]
      pfam00096
      Location:593 → 615
      zf-C2H2; Zinc finger, C2H2 type
      pfam01352
      Location:237 → 277
      KRAB; KRAB box
      pfam02023
      Location:43 → 130
      SCAN; SCAN domain
      pfam13465
      Location:607 → 632
      zf-H2C2_2; Zinc-finger double domain

    9. XM_047427564.1 → XP_047283520.1  zinc finger protein 202 isoform X1

      UniProtKB/Swiss-Prot
      B0LPH9, O95125, Q4JG21, Q9H1B9, Q9NSM4

    Alternate T2T-CHM13v2.0

    Genomic

    1. NC_060935.1 Alternate T2T-CHM13v2.0

      Range
      123752703..123770446 complement
      Download
      GenBank, FASTA, Sequence Viewer (Graphics)

    mRNA and Protein(s)

    1. XM_054369893.1 → XP_054225868.1  zinc finger protein 202 isoform X1

    2. XM_054369892.1 → XP_054225867.1  zinc finger protein 202 isoform X1

    3. XM_054369895.1 → XP_054225870.1  zinc finger protein 202 isoform X1

    4. XM_054369896.1 → XP_054225871.1  zinc finger protein 202 isoform X1

    5. XM_054369898.1 → XP_054225873.1  zinc finger protein 202 isoform X1

    6. XM_054369891.1 → XP_054225866.1  zinc finger protein 202 isoform X1

    7. XM_054369897.1 → XP_054225872.1  zinc finger protein 202 isoform X1

    8. XM_054369894.1 → XP_054225869.1  zinc finger protein 202 isoform X1

    Nucleotide Protein
    Heading Accession and Version
    Protein Accession Links
    GenPept Link UniProtKB Link
    O95125.4 GenPept UniProtKB/Swiss-Prot:O95125

    Gene LinkOut

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