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    WNT2B Wnt family member 2B [ Homo sapiens (human) ]

    Gene ID: 7482, updated on 28-Oct-2024

    Summary

    Official Symbol
    WNT2Bprovided by HGNC
    Official Full Name
    Wnt family member 2Bprovided by HGNC
    Primary source
    HGNC:HGNC:12781
    See related
    Ensembl:ENSG00000134245 MIM:601968; AllianceGenome:HGNC:12781
    Gene type
    protein coding
    RefSeq status
    REVIEWED
    Organism
    Homo sapiens
    Lineage
    Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Primates; Haplorrhini; Catarrhini; Hominidae; Homo
    Also known as
    WNT13
    Summary
    This gene encodes a member of the wingless-type MMTV integration site (WNT) family of highly conserved, secreted signaling factors. WNT family members function in a variety of developmental processes including regulation of cell growth and differentiation and are characterized by a WNT-core domain. This gene may play a role in human development as well as carcinogenesis. Alternative splicing results in multiple transcript variants. [provided by RefSeq, May 2014]
    Expression
    Broad expression in ovary (RPKM 4.3), skin (RPKM 3.1) and 21 other tissues See more
    Orthologs
    NEW
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    Genomic context

    See WNT2B in Genome Data Viewer
    Location:
    1p13.2
    Exon count:
    7
    Annotation release Status Assembly Chr Location
    RS_2024_08 current GRCh38.p14 (GCF_000001405.40) 1 NC_000001.11 (112466541..112530165)
    RS_2024_08 current T2T-CHM13v2.0 (GCF_009914755.1) 1 NC_060925.1 (112479107..112542734)
    RS_2024_09 previous assembly GRCh37.p13 (GCF_000001405.25) 1 NC_000001.10 (113009163..113072787)

    Chromosome 1 - NC_000001.11Genomic Context describing neighboring genes Neighboring gene ATAC-STARR-seq lymphoblastoid silent region 1195 Neighboring gene CTTNBP2 N-terminal like Neighboring gene NANOG-H3K27ac-H3K4me1 hESC enhancer GRCh37_chr1:112947097-112947622 Neighboring gene ReSE screen-validated silencer GRCh37_chr1:112950375-112950562 Neighboring gene Sharpr-MPRA regulatory region 6417 Neighboring gene ATAC-STARR-seq lymphoblastoid active region 1512 Neighboring gene ATAC-STARR-seq lymphoblastoid active region 1513 Neighboring gene MPRA-validated peak369 silencer Neighboring gene microRNA 4256 Neighboring gene ATAC-STARR-seq lymphoblastoid silent region 1196 Neighboring gene H3K4me1 hESC enhancer GRCh37_chr1:113050855-113051398 Neighboring gene ATAC-STARR-seq lymphoblastoid silent region 1198 Neighboring gene Sharpr-MPRA regulatory region 8072 Neighboring gene ATAC-STARR-seq lymphoblastoid silent region 1200 Neighboring gene ATAC-STARR-seq lymphoblastoid silent region 1199 Neighboring gene H3K4me1 hESC enhancer GRCh37_chr1:113052323-113052822 Neighboring gene suppression of tumorigenicity 7 like Neighboring gene MPRA-validated peak370 silencer Neighboring gene ATAC-STARR-seq lymphoblastoid active region 1514 Neighboring gene MED14-independent group 3 enhancer GRCh37_chr1:113161935-113163134 Neighboring gene mitochondrial ribosomal protein L53 pseudogene 1 Neighboring gene capping actin protein of muscle Z-line subunit alpha 1 Neighboring gene RNA, U7 small nuclear 70 pseudogene

    Genomic regions, transcripts, and products

    Expression

    • Project title: HPA RNA-seq normal tissues HPA RNA-seq normal tissues
    • Description: RNA-seq was performed of tissue samples from 95 human individuals representing 27 different tissues in order to determine tissue-specificity of all protein-coding genes
    • BioProject: PRJEB4337
    • Publication: PMID 24309898
    • Analysis date: Wed Apr 4 07:08:55 2018

    Bibliography

    GeneRIFs: Gene References Into Functions

    What's a GeneRIF?

    Pathways from PubChem

    Interactions

    Products Interactant Other Gene Complex Source Pubs Description

    General gene information

    Markers

    Gene Ontology Provided by GOA

    Function Evidence Code Pubs
    enables cytokine activity IBA
    Inferred from Biological aspect of Ancestor
    more info
     
    enables frizzled binding IBA
    Inferred from Biological aspect of Ancestor
    more info
     
    Process Evidence Code Pubs
    involved_in canonical Wnt signaling pathway IBA
    Inferred from Biological aspect of Ancestor
    more info
     
    involved_in canonical Wnt signaling pathway IDA
    Inferred from Direct Assay
    more info
    PubMed 
    involved_in canonical Wnt signaling pathway IMP
    Inferred from Mutant Phenotype
    more info
    PubMed 
    involved_in cell fate commitment IBA
    Inferred from Biological aspect of Ancestor
    more info
     
    involved_in cellular response to starvation IEA
    Inferred from Electronic Annotation
    more info
     
    involved_in chondrocyte differentiation IEP
    Inferred from Expression Pattern
    more info
    PubMed 
    involved_in cornea development in camera-type eye ISS
    Inferred from Sequence or Structural Similarity
    more info
    PubMed 
    involved_in forebrain regionalization IEP
    Inferred from Expression Pattern
    more info
    PubMed 
    involved_in hematopoietic stem cell proliferation IDA
    Inferred from Direct Assay
    more info
    PubMed 
    involved_in iris morphogenesis ISS
    Inferred from Sequence or Structural Similarity
    more info
    PubMed 
    involved_in lens development in camera-type eye ISS
    Inferred from Sequence or Structural Similarity
    more info
    PubMed 
    involved_in lung induction IEA
    Inferred from Electronic Annotation
    more info
     
    involved_in male gonad development IEP
    Inferred from Expression Pattern
    more info
    PubMed 
    involved_in mesenchymal-epithelial cell signaling IEA
    Inferred from Electronic Annotation
    more info
     
    involved_in neuron differentiation IBA
    Inferred from Biological aspect of Ancestor
    more info
     
    involved_in neuron differentiation ISS
    Inferred from Sequence or Structural Similarity
    more info
     
    involved_in positive regulation of branching involved in ureteric bud morphogenesis IEA
    Inferred from Electronic Annotation
    more info
     

    General protein information

    Preferred Names
    protein Wnt-2b
    Names
    XWNT2, Xenopus, homolog of
    wingless-type MMTV integration site family, member 13
    wingless-type MMTV integration site family, member 2B

    NCBI Reference Sequences (RefSeq)

    NEW Try the new Transcript table

    RefSeqs maintained independently of Annotated Genomes

    These reference sequences exist independently of genome builds. Explain

    These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

    Genomic

    1. NG_052953.2 RefSeqGene

      Range
      47426..68626
      Download
      GenBank, FASTA, Sequence Viewer (Graphics)

    mRNA and Protein(s)

    1. NM_001291880.1NP_001278809.1  protein Wnt-2b isoform 3

      See identical proteins and their annotated locations for NP_001278809.1

      Status: REVIEWED

      Description
      Transcript Variant: This variant (3) differs in the 5' UTR and uses a downstream start codon, compared to variant WNT-2B2. The encoded isoform (3) has a shorter N-terminus, compared to isoform WNT-2B2.
      Source sequence(s)
      AK127449, BC141825
      Consensus CDS
      CCDS76188.1
      UniProtKB/TrEMBL
      Q5TEH8
      Related
      ENSP00000256640.5, ENST00000256640.9
      Conserved Domains (1) summary
      cl38924
      Location:1288
      Wnt; Wnt domain found in the WNT signaling gene family, also called Wingless-type mouse mammary tumor virus (MMTV) integration site family
    2. NM_004185.4NP_004176.2  protein Wnt-2b isoform WNT-2B1

      See identical proteins and their annotated locations for NP_004176.2

      Status: REVIEWED

      Description
      Transcript Variant: This variant (WNT-2B1) differs in the 5' UTR and 5' coding region, compared to variant WNT-2B2. The encoded isoform (WNT-2B1) has a shorter and distinct N-terminus, compared to isoform WNT-2B2.
      Source sequence(s)
      AB045116, AK127449, BC141825
      Consensus CDS
      CCDS846.1
      UniProtKB/Swiss-Prot
      Q93097
      Related
      ENSP00000358700.4, ENST00000369686.9
      Conserved Domains (1) summary
      pfam00110
      Location:55361
      wnt; wnt family
    3. NM_024494.3NP_078613.1  protein Wnt-2b isoform WNT-2B2

      See identical proteins and their annotated locations for NP_078613.1

      Status: REVIEWED

      Description
      Transcript Variant: This variant (WNT-2B2) represents the shortest transcript and encodes the longest isoform (WNT-2B2).
      Source sequence(s)
      AL109932, BC141825
      Consensus CDS
      CCDS847.1
      UniProtKB/Swiss-Prot
      O14903, Q5TEH9, Q5TEI2, Q93097, Q9HDC1, Q9HDC2
      Related
      ENSP00000358698.4, ENST00000369684.5
      Conserved Domains (1) summary
      pfam00110
      Location:74380
      wnt; wnt family

    RefSeqs of Annotated Genomes: GCF_000001405.40-RS_2024_08

    The following sections contain reference sequences that belong to a specific genome build. Explain

    Reference GRCh38.p14 Primary Assembly

    Genomic

    1. NC_000001.11 Reference GRCh38.p14 Primary Assembly

      Range
      112466541..112530165
      Download
      GenBank, FASTA, Sequence Viewer (Graphics)

    Alternate T2T-CHM13v2.0

    Genomic

    1. NC_060925.1 Alternate T2T-CHM13v2.0

      Range
      112479107..112542734
      Download
      GenBank, FASTA, Sequence Viewer (Graphics)