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    Dcbld2 discoidin, CUB and LCCL domain containing 2 [ Mus musculus (house mouse) ]

    Gene ID: 73379, updated on 2-Nov-2024

    Summary

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    Official Symbol
    Dcbld2provided by MGI
    Official Full Name
    discoidin, CUB and LCCL domain containing 2provided by MGI
    Primary source
    MGI:MGI:1920629
    See related
    Ensembl:ENSMUSG00000035107 AllianceGenome:MGI:1920629
    Gene type
    protein coding
    RefSeq status
    VALIDATED
    Organism
    Mus musculus
    Lineage
    Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha; Muroidea; Muridae; Murinae; Mus; Mus
    Also known as
    Esdn; CLCP1; 1700055P21Rik
    Summary
    Predicted to enable signaling receptor activity. Predicted to be involved in negative regulation of cell growth and wound healing. Predicted to be located in cell surface. Predicted to be active in plasma membrane. Orthologous to human DCBLD2 (discoidin, CUB and LCCL domain containing 2). [provided by Alliance of Genome Resources, Nov 2024]
    Expression
    Ubiquitous expression in bladder adult (RPKM 10.6), CNS E11.5 (RPKM 10.5) and 27 other tissues See more
    Orthologs
    human all
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    Genomic context

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    See Dcbld2 in Genome Data Viewer
    Location:
    16 C1.2; 16 34.52 cM
    Exon count:
    19
    Annotation release Status Assembly Chr Location
    RS_2024_02 current GRCm39 (GCF_000001635.27) 16 NC_000082.7 (58228789..58304013)
    108.20200622 previous assembly GRCm38.p6 (GCF_000001635.26) 16 NC_000082.6 (58408535..58469745)

    Chromosome 16 - NC_000082.7Genomic Context describing neighboring genes Neighboring gene predicted gene, 57639 Neighboring gene STARR-seq mESC enhancer starr_41093 Neighboring gene predicted gene, 41463 Neighboring gene STARR-seq mESC enhancer starr_41094 Neighboring gene STARR-seq mESC enhancer starr_41095 Neighboring gene RIKEN cDNA 4930461C15 gene Neighboring gene STARR-positive B cell enhancer ABC_E1928 Neighboring gene STARR-seq mESC enhancer starr_41096 Neighboring gene STARR-positive B cell enhancer ABC_E3167 Neighboring gene STARR-positive B cell enhancer ABC_E8639 Neighboring gene STARR-positive B cell enhancer ABC_E3168 Neighboring gene ST3 beta-galactoside alpha-2,3-sialyltransferase 6 Neighboring gene STARR-seq mESC enhancer starr_41097 Neighboring gene STARR-seq mESC enhancer starr_41098 Neighboring gene predicted gene, 20942 Neighboring gene ferritin domain containing 1

    Genomic regions, transcripts, and products

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    Go to nucleotide: Graphics FASTA GenBank

    Expression

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    • Project title: Mouse ENCODE transcriptome data Mouse ENCODE transcriptome data
    • Description: RNA profiling data sets generated by the Mouse ENCODE project.
    • BioProject: PRJNA66167
    • Publication: PMID 25409824
    • Analysis date: n/a

    Bibliography

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    Related articles in PubMed

    1. DCBLD2 regulates vascular hyperplasia by modulating the platelet derived growth factor receptor-β endocytosis through Caveolin-1 in vascular smooth muscle cells. Wang S, et al. FASEB J, 2022 Sep. PMID 35929441
    2. The neuropilin-like protein ESDN regulates insulin signaling and sensitivity. Li X, et al. Am J Physiol Heart Circ Physiol, 2016 May 1. PMID 26921437, Free PMC Article
    3. ESDN inhibits melanoma progression by blocking E-selectin expression in endothelial cells via STAT3. Coppo R, et al. Cancer Lett, 2021 Jul 10. PMID 33862151, Free PMC Article
    4. CircDCBLD2 alleviates liver fibrosis by regulating ferroptosis via facilitating STUB1-mediated PARK7 ubiquitination degradation. Wang J, et al. J Gastroenterol, 2024 Mar. PMID 38310161
    5. ESDN, a novel neuropilin-like membrane protein cloned from vascular cells with the longest secretory signal sequence among eukaryotes, is up-regulated after vascular injury. Kobuke K, et al. J Biol Chem, 2001 Sep 7. PMID 11447234

    See all (28) citations in PubMed

    GeneRIFs: Gene References Into Functions

    What's a GeneRIF?
    1. CircDCBLD2 alleviates liver fibrosis by regulating ferroptosis via facilitating STUB1-mediated PARK7 ubiquitination degradation.
      Title: CircDCBLD2 alleviates liver fibrosis by regulating ferroptosis via facilitating STUB1-mediated PARK7 ubiquitination degradation.
    2. DCBLD2 regulates vascular hyperplasia by modulating the platelet derived growth factor receptor-beta endocytosis through Caveolin-1 in vascular smooth muscle cells.
      Title: DCBLD2 regulates vascular hyperplasia by modulating the platelet derived growth factor receptor-β endocytosis through Caveolin-1 in vascular smooth muscle cells.
    3. ESDN regulates insulin signaling and subsequently a wide array of insulin effects in cultured cells and in vivo through modulation of IR interaction with APS and Grb10.
      Title: The neuropilin-like protein ESDN regulates insulin signaling and sensitivity.
    4. Deletion of Esdn in the mouse interfered with adult and developmental angiogenesis.
      Title: Transmembrane protein ESDN promotes endothelial VEGF signaling and regulates angiogenesis.
    Submit: New GeneRIF Correction

    Variation

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    Alleles

    Alleles of this type are documented at Mouse Genome Informatics  (MGI)
    • Endonuclease-mediated (2) 
    • Targeted (3)  1 citation

    Interactions

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    Products Interactant Other Gene Complex Source Pubs Description

    General gene information

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    Markers

    Homology

    Gene Ontology Provided by MGI

    Function Evidence Code Pubs
    enables signaling receptor activity IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    Process Evidence Code Pubs
    involved_in negative regulation of cell growth ISO
    Inferred from Sequence Orthology
    more info
    		  
    involved_in negative regulation of cell growth ISS
    Inferred from Sequence or Structural Similarity
    more info
    		  
    involved_in wound healing IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    involved_in wound healing ISO
    Inferred from Sequence Orthology
    more info
    		  
    involved_in wound healing ISS
    Inferred from Sequence or Structural Similarity
    more info
    		  
    Component Evidence Code Pubs
    located_in cell surface ISO
    Inferred from Sequence Orthology
    more info
    		  
    located_in cell surface ISS
    Inferred from Sequence or Structural Similarity
    more info
    		  
    is_active_in plasma membrane IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    located_in plasma membrane ISO
    Inferred from Sequence Orthology
    more info
    		  
    located_in plasma membrane ISS
    Inferred from Sequence or Structural Similarity
    more info
    		  

    General protein information

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    Preferred Names
    discoidin, CUB and LCCL domain-containing protein 2
    Names
    endothelial and smooth muscle cell-derived neuropilin-like protein

    NCBI Reference Sequences (RefSeq)

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    RefSeqs maintained independently of Annotated Genomes

    These reference sequences exist independently of genome builds. Explain

    These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

    mRNA and Protein(s)

    1. NM_001356484.1 → NP_001343413.1  discoidin, CUB and LCCL domain-containing protein 2 isoform 2 precursor

      Status: VALIDATED

      Source sequence(s)
      CT027564
      Conserved Domains (3) summary
      cd00041
      Location:69 → 183
      CUB; CUB domain; extracellular domain; present in proteins mostly known to be involved in development; not found in prokaryotes, plants and yeast.
      cd00057
      Location:293 → 445
      FA58C; Coagulation factor 5/8 C-terminal domain, discoidin domain; Cell surface-attached carbohydrate-binding domain, present in eukaryotes and assumed to have horizontally transferred to eubacterial genomes.
      cl02694
      Location:190 → 272
      LCCL; LCCL domain

    2. NM_028523.3 → NP_082799.2  discoidin, CUB and LCCL domain-containing protein 2 isoform 1 precursor

      See identical proteins and their annotated locations for NP_082799.2

      Status: VALIDATED

      Source sequence(s)
      AK043915, AK051889, AK052189, BC066097, CAAA01184608
      Consensus CDS
      CCDS28229.1
      UniProtKB/Swiss-Prot
      A6X950, Q8BKI4, Q91ZV3
      Related
      ENSMUSP00000039915.8, ENSMUST00000046663.8
      Conserved Domains (4) summary
      smart00231
      Location:288 → 446
      FA58C; Coagulation factor 5/8 C-terminal domain, discoidin domain
      cd00041
      Location:69 → 183
      CUB; CUB domain; extracellular domain; present in proteins mostly known to be involved in development; not found in prokaryotes, plants and yeast.
      cd00057
      Location:293 → 445
      FA58C; Coagulation factor 5/8 C-terminal domain, discoidin domain; Cell surface-attached carbohydrate-binding domain, present in eukaryotes and assumed to have horizontally transferred to eubacterial genomes.
      cl02694
      Location:190 → 272
      LCCL; LCCL domain

    RefSeqs of Annotated Genomes: GCF_000001635.27-RS_2024_02

    The following sections contain reference sequences that belong to a specific genome build. Explain

    Reference GRCm39 C57BL/6J

    Genomic

    1. NC_000082.7 Reference GRCm39 C57BL/6J

      Range
      58228789..58304013
      Download
      GenBank, FASTA, Sequence Viewer (Graphics)

    mRNA and Protein(s)

    1. XM_036160148.1 → XP_036016041.1  discoidin, CUB and LCCL domain-containing protein 2 isoform X1

      Conserved Domains (3) summary
      cd00041
      Location:69 → 183
      CUB; CUB domain; extracellular domain; present in proteins mostly known to be involved in development; not found in prokaryotes, plants and yeast.
      cl25480
      Location:293 → 400
      FA58C; Coagulation factor 5/8 C-terminal domain, discoidin domain; Cell surface-attached carbohydrate-binding domain, present in eukaryotes and assumed to have horizontally transferred to eubacterial genomes.
      cl02694
      Location:190 → 272
      LCCL; LCCL domain

    2. XM_036160149.1 → XP_036016042.1  discoidin, CUB and LCCL domain-containing protein 2 isoform X2

      Conserved Domains (3) summary
      cd00041
      Location:69 → 183
      CUB; CUB domain; extracellular domain; present in proteins mostly known to be involved in development; not found in prokaryotes, plants and yeast.
      cl25480
      Location:293 → 400
      FA58C; Coagulation factor 5/8 C-terminal domain, discoidin domain; Cell surface-attached carbohydrate-binding domain, present in eukaryotes and assumed to have horizontally transferred to eubacterial genomes.
      cl02694
      Location:190 → 272
      LCCL; LCCL domain

    3. XM_011246022.3 → XP_011244324.1  discoidin, CUB and LCCL domain-containing protein 2 isoform X3

      Conserved Domains (3) summary
      cd00057
      Location:217 → 369
      FA58C; Coagulation factor 5/8 C-terminal domain, discoidin domain; Cell surface-attached carbohydrate-binding domain, present in eukaryotes and assumed to have horizontally transferred to eubacterial genomes.
      cl00049
      Location:66 → 107
      CUB; CUB domain; extracellular domain; present in proteins mostly known to be involved in development; not found in prokaryotes, plants and yeast.
      cl02694
      Location:114 → 196
      LCCL; LCCL domain

    RNA

    1. XR_004939243.1 RNA Sequence

    2. XR_004939244.1 RNA Sequence

    3. XR_004939245.1 RNA Sequence

    4. XR_004939246.1 RNA Sequence

    5. XR_004939247.1 RNA Sequence

    6. XR_004939248.1 RNA Sequence

    Nucleotide Protein Strain
    Heading Accession and Version
    Protein Accession Links
    GenPept Link UniProtKB Link
    Q91ZV3.1 GenPept UniProtKB/Swiss-Prot:Q91ZV3

    Gene LinkOut

    The following LinkOut resources are supplied by external providers. These providers are responsible for maintaining the links.

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