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    Cda cytidine deaminase [ Mus musculus (house mouse) ]

    Gene ID: 72269, updated on 2-Nov-2024

    Summary

    Official Symbol
    Cdaprovided by MGI
    Official Full Name
    cytidine deaminaseprovided by MGI
    Primary source
    MGI:MGI:1919519
    See related
    Ensembl:ENSMUSG00000028755 AllianceGenome:MGI:1919519
    Gene type
    protein coding
    RefSeq status
    PROVISIONAL
    Organism
    Mus musculus
    Lineage
    Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha; Muroidea; Muridae; Murinae; Mus; Mus
    Also known as
    2210401N16Rik
    Summary
    Enables cytidine deaminase activity and identical protein binding activity. Involved in UMP salvage. Is active in cytosol. Is expressed in several structures, including alimentary system; eye; genitourinary system; heart; and nervous system. Human ortholog(s) of this gene implicated in lung non-small cell carcinoma. Orthologous to human CDA (cytidine deaminase). [provided by Alliance of Genome Resources, Nov 2024]
    Expression
    Biased expression in duodenum adult (RPKM 159.2), kidney adult (RPKM 84.5) and 3 other tissues See more
    Orthologs
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    Genomic context

    See Cda in Genome Data Viewer
    Location:
    4 D3; 4 70.17 cM
    Exon count:
    5
    Annotation release Status Assembly Chr Location
    RS_2024_02 current GRCm39 (GCF_000001635.27) 4 NC_000070.7 (138065839..138095623, complement)
    108.20200622 previous assembly GRCm38.p6 (GCF_000001635.26) 4 NC_000070.6 (138338528..138368311, complement)

    Chromosome 4 - NC_000070.7Genomic Context describing neighboring genes Neighboring gene STARR-positive B cell enhancer ABC_E4692 Neighboring gene STARR-seq mESC enhancer starr_11799 Neighboring gene dolichyl-di-phosphooligosaccharide-protein glycotransferase Neighboring gene STARR-positive B cell enhancer ABC_E10270 Neighboring gene microRNA 7019 Neighboring gene PTEN induced putative kinase 1 Neighboring gene hypothetical protein, MNCb-2457 Neighboring gene family with sequence similarity 43, member B Neighboring gene ribosomal protein L38, pseudogene 1

    Genomic regions, transcripts, and products

    Expression

    • Project title: Mouse ENCODE transcriptome data Mouse ENCODE transcriptome data
    • Description: RNA profiling data sets generated by the Mouse ENCODE project.
    • BioProject: PRJNA66167
    • Publication: PMID 25409824
    • Analysis date: n/a

    Bibliography

    GeneRIFs: Gene References Into Functions

    What's a GeneRIF?

    Variation

    Alleles

    Alleles of this type are documented at Mouse Genome Informatics  (MGI)
    • Endonuclease-mediated (1) 
    • Targeted (3)  1 citation

    Pathways from PubChem

    Interactions

    Products Interactant Other Gene Complex Source Pubs Description

    General gene information

    Markers

    Clone Names

    • MGC67370

    Gene Ontology Provided by MGI

    Function Evidence Code Pubs
    enables cytidine deaminase activity IBA
    Inferred from Biological aspect of Ancestor
    more info
     
    enables cytidine deaminase activity IDA
    Inferred from Direct Assay
    more info
    PubMed 
    enables cytidine deaminase activity ISO
    Inferred from Sequence Orthology
    more info
     
    enables cytidine deaminase activity ISS
    Inferred from Sequence or Structural Similarity
    more info
     
    enables deaminase activity ISO
    Inferred from Sequence Orthology
    more info
    PubMed 
    enables identical protein binding IPI
    Inferred from Physical Interaction
    more info
    PubMed 
    enables identical protein binding ISO
    Inferred from Sequence Orthology
    more info
     
    enables nucleoside binding ISO
    Inferred from Sequence Orthology
    more info
     
    enables nucleoside binding ISS
    Inferred from Sequence or Structural Similarity
    more info
     
    enables protein homodimerization activity ISO
    Inferred from Sequence Orthology
    more info
     
    enables protein homodimerization activity ISS
    Inferred from Sequence or Structural Similarity
    more info
     
    enables zinc ion binding IBA
    Inferred from Biological aspect of Ancestor
    more info
     
    enables zinc ion binding ISO
    Inferred from Sequence Orthology
    more info
     
    enables zinc ion binding ISS
    Inferred from Sequence or Structural Similarity
    more info
     
    Process Evidence Code Pubs
    involved_in CMP catabolic process ISO
    Inferred from Sequence Orthology
    more info
     
    involved_in UMP salvage IDA
    Inferred from Direct Assay
    more info
    PubMed 
    involved_in cellular response to external biotic stimulus IEA
    Inferred from Electronic Annotation
    more info
     
    involved_in cytidine deamination IBA
    Inferred from Biological aspect of Ancestor
    more info
     
    involved_in cytidine deamination ISO
    Inferred from Sequence Orthology
    more info
     
    involved_in cytidine deamination ISS
    Inferred from Sequence or Structural Similarity
    more info
     
    involved_in dCMP catabolic process ISO
    Inferred from Sequence Orthology
    more info
     
    involved_in negative regulation of cell growth ISO
    Inferred from Sequence Orthology
    more info
     
    involved_in negative regulation of cell growth ISS
    Inferred from Sequence or Structural Similarity
    more info
     
    involved_in negative regulation of nucleotide metabolic process ISO
    Inferred from Sequence Orthology
    more info
     
    involved_in negative regulation of nucleotide metabolic process ISS
    Inferred from Sequence or Structural Similarity
    more info
     
    involved_in response to cycloheximide IEA
    Inferred from Electronic Annotation
    more info
     
    Component Evidence Code Pubs
    is_active_in cytosol IBA
    Inferred from Biological aspect of Ancestor
    more info
     
    is_active_in cytosol IDA
    Inferred from Direct Assay
    more info
    PubMed 
    is_active_in cytosol ISO
    Inferred from Sequence Orthology
    more info
     
    located_in cytosol ISO
    Inferred from Sequence Orthology
    more info
     

    General protein information

    Preferred Names
    cytidine deaminase
    Names
    cytidine aminohydrolase
    NP_082452.1
    XP_006539259.1

    NCBI Reference Sequences (RefSeq)

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    RefSeqs maintained independently of Annotated Genomes

    These reference sequences exist independently of genome builds. Explain

    These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

    mRNA and Protein(s)

    1. NM_028176.1NP_082452.1  cytidine deaminase

      See identical proteins and their annotated locations for NP_082452.1

      Status: PROVISIONAL

      Source sequence(s)
      BC050114
      Consensus CDS
      CCDS18826.1
      UniProtKB/Swiss-Prot
      P56389, Q9D7V3
      Related
      ENSMUSP00000030535.4, ENSMUST00000030535.4
      Conserved Domains (1) summary
      TIGR01354
      Location:16142
      cyt_deam_tetra; cytidine deaminase, homotetrameric

    RefSeqs of Annotated Genomes: GCF_000001635.27-RS_2024_02

    The following sections contain reference sequences that belong to a specific genome build. Explain

    Reference GRCm39 C57BL/6J

    Genomic

    1. NC_000070.7 Reference GRCm39 C57BL/6J

      Range
      138065839..138095623 complement
      Download
      GenBank, FASTA, Sequence Viewer (Graphics)

    mRNA and Protein(s)

    1. XM_006539196.4XP_006539259.1  cytidine deaminase isoform X1

      Conserved Domains (1) summary
      cl00269
      Location:2351
      cytidine_deaminase-like; Cytidine and deoxycytidylate deaminase zinc-binding region. The family contains cytidine deaminases, nucleoside deaminases, deoxycytidylate deaminases and riboflavin deaminases. Also included are the apoBec family of mRNA editing enzymes. All members ...