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    ARHGEF11 Rho guanine nucleotide exchange factor 11 [ Macaca mulatta (Rhesus monkey) ]

    Gene ID: 718727, updated on 17-Aug-2024

    Summary

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    Official Symbol
    ARHGEF11provided by VGNC
    Official Full Name
    Rho guanine nucleotide exchange factor 11provided by VGNC
    Primary source
    VGNC:VGNC:69829
    See related
    Ensembl:ENSMMUG00000012436
    Gene type
    protein coding
    RefSeq status
    MODEL
    Organism
    Macaca mulatta
    Lineage
    Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Primates; Haplorrhini; Catarrhini; Cercopithecidae; Cercopithecinae; Macaca
    Orthologs
    human mouse all
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    Genomic context

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    See ARHGEF11 in Genome Data Viewer
    Location:
    chromosome: 1
    Exon count:
    44
    Annotation release Status Assembly Chr Location
    103 current Mmul_10 (GCF_003339765.1) 1 NC_041754.1 (93919826..94030441)
    102 previous assembly Mmul_8.0.1 (GCF_000772875.2) 1 NC_027893.1 (131578718..131687875, complement)

    Chromosome 1 - NC_041754.1Genomic Context describing neighboring genes Neighboring gene ETS variant transcription factor 3 Neighboring gene ETS variant transcription factor 3 like Neighboring gene microRNA mir-765 Neighboring gene leucine rich repeat containing 71 Neighboring gene platelet endothelial aggregation receptor 1

    Genomic regions, transcripts, and products

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    Go to nucleotide: Graphics FASTA GenBank

    Bibliography

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    Related articles in PubMed

    1. A new rhesus macaque assembly and annotation for next-generation sequencing analyses. Zimin AV, et al. Biol Direct, 2014 Oct 14. PMID 25319552, Free PMC Article
    2. Manual GO annotation of predictive protein signatures: the InterPro approach to GO curation. Burge S, et al. Database (Oxford), 2012. PMID 22301074, Free PMC Article
    3. TreeGrafter: phylogenetic tree-based annotation of proteins with Gene Ontology terms and other annotations. Tang H, et al. Bioinformatics, 2019 Feb 1. PMID 30032202, Free PMC Article

    GeneRIFs: Gene References Into Functions

    General gene information

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    Markers

    Homology

    Gene Ontology Provided by RefSeq

    Function Evidence Code Pubs
    enables G protein-coupled receptor binding IEA
    Inferred from Electronic Annotation
    more info
    		 PubMed 
    enables guanyl-nucleotide exchange factor activity IEA
    Inferred from Electronic Annotation
    more info
    		 PubMed 
    Process Evidence Code Pubs
    involved_in G protein-coupled receptor signaling pathway IEA
    Inferred from Electronic Annotation
    more info
    		 PubMed 
    involved_in Rho protein signal transduction IEA
    Inferred from Electronic Annotation
    more info
    		 PubMed 
    Component Evidence Code Pubs
    located_in cytoplasm IEA
    Inferred from Electronic Annotation
    more info
    		 PubMed 

    General protein information

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    Preferred Names
    rho guanine nucleotide exchange factor 11
    Names
    Rho guanine nucleotide exchange factor (GEF) 11

    NCBI Reference Sequences (RefSeq)

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    NEW Try the new Transcript table

    RefSeqs of Annotated Genomes: Macaca mulatta Annotation Release 103 details...Open this link in a new tab

    The following sections contain reference sequences that belong to a specific genome build. Explain

    Reference Mmul_10 Primary Assembly

    Genomic

    1. NC_041754.1 Reference Mmul_10 Primary Assembly

      Range
      93919826..94030441
      Download
      GenBank, FASTA, Sequence Viewer (Graphics)

    mRNA and Protein(s)

    1. XM_028827374.1 → XP_028683207.1  rho guanine nucleotide exchange factor 11 isoform X1

      UniProtKB/TrEMBL
      A0A8J8XRX4, G7ME17, H9G2I5
      Conserved Domains (5) summary
      cd08753
      Location:346 → 490
      RGS_PDZRhoGEF; Regulator of G protein signaling (RGS) domain found in the PDZ-Rho guanine nucleotide exchange factor (RhoGEF) protein
      PHA03307
      Location:1256 → 1579
      PHA03307; transcriptional regulator ICP4; Provisional
      cd00160
      Location:792 → 978
      RhoGEF; Guanine nucleotide exchange factor for Rho/Rac/Cdc42-like GTPases; Also called Dbl-homologous (DH) domain. It appears that PH domains invariably occur C-terminal to RhoGEF/DH domains.
      cd00992
      Location:62 → 136
      PDZ_signaling; PDZ domain found in a variety of Eumetazoan signaling molecules, often in tandem arrangements. May be responsible for specific protein-protein interactions, as most PDZ domains bind C-terminal polypeptides, and binding to internal (non-C-terminal) ...
      cd13391
      Location:996 → 1138
      PH_PRG; PDZ Rho guanine nucleotide exchange factor Pleckstrin homology (PH) domain

    2. XM_001116843.4 → XP_001116843.1  rho guanine nucleotide exchange factor 11 isoform X7

      UniProtKB/TrEMBL
      A0A1D5QFZ2, A0A8J8XRX4, G7ME17, H9G2I5
      Related
      ENSMMUP00000046962.2, ENSMMUT00000069935.2
      Conserved Domains (6) summary
      cd08753
      Location:330 → 474
      RGS_PDZRhoGEF; Regulator of G protein signaling (RGS) domain found in the PDZ-Rho guanine nucleotide exchange factor (RhoGEF) protein
      COG0265
      Location:61 → 120
      DegQ; Periplasmic serine protease, S1-C subfamily, contain C-terminal PDZ domain [Posttranslational modification, protein turnover, chaperones]
      cd00992
      Location:46 → 120
      PDZ_signaling; PDZ domain found in a variety of Eumetazoan signaling molecules, often in tandem arrangements. May be responsible for specific protein-protein interactions, as most PDZ domains bind C-terminal polypeptides, and binding to internal (non-C-terminal) ...
      cd13391
      Location:979 → 1121
      PH_PRG; PDZ Rho guanine nucleotide exchange factor Pleckstrin homology (PH) domain
      pfam00169
      Location:1039 → 1119
      PH; PH domain
      pfam00621
      Location:778 → 962
      RhoGEF; RhoGEF domain

    3. XM_001116835.4 → XP_001116835.1  rho guanine nucleotide exchange factor 11 isoform X12

      UniProtKB/TrEMBL
      H9G2I3
      Related
      ENSMMUP00000016333.4, ENSMMUT00000017440.4
      Conserved Domains (6) summary
      cd08753
      Location:290 → 434
      RGS_PDZRhoGEF; Regulator of G protein signaling (RGS) domain found in the PDZ-Rho guanine nucleotide exchange factor (RhoGEF) protein
      COG0265
      Location:61 → 120
      DegQ; Periplasmic serine protease, S1-C subfamily, contain C-terminal PDZ domain [Posttranslational modification, protein turnover, chaperones]
      cd00992
      Location:46 → 120
      PDZ_signaling; PDZ domain found in a variety of Eumetazoan signaling molecules, often in tandem arrangements. May be responsible for specific protein-protein interactions, as most PDZ domains bind C-terminal polypeptides, and binding to internal (non-C-terminal) ...
      cd13391
      Location:939 → 1081
      PH_PRG; PDZ Rho guanine nucleotide exchange factor Pleckstrin homology (PH) domain
      pfam00169
      Location:999 → 1079
      PH; PH domain
      pfam00621
      Location:738 → 922
      RhoGEF; RhoGEF domain

    4. XM_015112394.2 → XP_014967880.1  rho guanine nucleotide exchange factor 11 isoform X1

      UniProtKB/TrEMBL
      A0A8J8XRX4, G7ME17, H9G2I5
      Conserved Domains (5) summary
      cd08753
      Location:346 → 490
      RGS_PDZRhoGEF; Regulator of G protein signaling (RGS) domain found in the PDZ-Rho guanine nucleotide exchange factor (RhoGEF) protein
      PHA03307
      Location:1256 → 1579
      PHA03307; transcriptional regulator ICP4; Provisional
      cd00160
      Location:792 → 978
      RhoGEF; Guanine nucleotide exchange factor for Rho/Rac/Cdc42-like GTPases; Also called Dbl-homologous (DH) domain. It appears that PH domains invariably occur C-terminal to RhoGEF/DH domains.
      cd00992
      Location:62 → 136
      PDZ_signaling; PDZ domain found in a variety of Eumetazoan signaling molecules, often in tandem arrangements. May be responsible for specific protein-protein interactions, as most PDZ domains bind C-terminal polypeptides, and binding to internal (non-C-terminal) ...
      cd13391
      Location:996 → 1138
      PH_PRG; PDZ Rho guanine nucleotide exchange factor Pleckstrin homology (PH) domain

    5. XM_015112387.2 → XP_014967873.1  rho guanine nucleotide exchange factor 11 isoform X1

      UniProtKB/TrEMBL
      A0A8J8XRX4, G7ME17, H9G2I5
      Conserved Domains (5) summary
      cd08753
      Location:346 → 490
      RGS_PDZRhoGEF; Regulator of G protein signaling (RGS) domain found in the PDZ-Rho guanine nucleotide exchange factor (RhoGEF) protein
      PHA03307
      Location:1256 → 1579
      PHA03307; transcriptional regulator ICP4; Provisional
      cd00160
      Location:792 → 978
      RhoGEF; Guanine nucleotide exchange factor for Rho/Rac/Cdc42-like GTPases; Also called Dbl-homologous (DH) domain. It appears that PH domains invariably occur C-terminal to RhoGEF/DH domains.
      cd00992
      Location:62 → 136
      PDZ_signaling; PDZ domain found in a variety of Eumetazoan signaling molecules, often in tandem arrangements. May be responsible for specific protein-protein interactions, as most PDZ domains bind C-terminal polypeptides, and binding to internal (non-C-terminal) ...
      cd13391
      Location:996 → 1138
      PH_PRG; PDZ Rho guanine nucleotide exchange factor Pleckstrin homology (PH) domain

    6. XM_028827395.1 → XP_028683228.1  rho guanine nucleotide exchange factor 11 isoform X8

      UniProtKB/TrEMBL
      A0A8J8XRX4, G7ME17, H9G2I5
      Conserved Domains (5) summary
      cd08753
      Location:346 → 490
      RGS_PDZRhoGEF; Regulator of G protein signaling (RGS) domain found in the PDZ-Rho guanine nucleotide exchange factor (RhoGEF) protein
      PHA03307
      Location:1256 → 1547
      PHA03307; transcriptional regulator ICP4; Provisional
      cd00160
      Location:792 → 978
      RhoGEF; Guanine nucleotide exchange factor for Rho/Rac/Cdc42-like GTPases; Also called Dbl-homologous (DH) domain. It appears that PH domains invariably occur C-terminal to RhoGEF/DH domains.
      cd00992
      Location:62 → 136
      PDZ_signaling; PDZ domain found in a variety of Eumetazoan signaling molecules, often in tandem arrangements. May be responsible for specific protein-protein interactions, as most PDZ domains bind C-terminal polypeptides, and binding to internal (non-C-terminal) ...
      cd13391
      Location:996 → 1138
      PH_PRG; PDZ Rho guanine nucleotide exchange factor Pleckstrin homology (PH) domain

    7. XM_015112439.2 → XP_014967925.1  rho guanine nucleotide exchange factor 11 isoform X10

      UniProtKB/TrEMBL
      A0A8J8XRX4, G7ME17, H9G2I5
      Conserved Domains (6) summary
      cd08753
      Location:346 → 490
      RGS_PDZRhoGEF; Regulator of G protein signaling (RGS) domain found in the PDZ-Rho guanine nucleotide exchange factor (RhoGEF) protein
      COG0265
      Location:77 → 136
      DegQ; Periplasmic serine protease, S1-C subfamily, contain C-terminal PDZ domain [Posttranslational modification, protein turnover, chaperones]
      cd00992
      Location:62 → 136
      PDZ_signaling; PDZ domain found in a variety of Eumetazoan signaling molecules, often in tandem arrangements. May be responsible for specific protein-protein interactions, as most PDZ domains bind C-terminal polypeptides, and binding to internal (non-C-terminal) ...
      cd13391
      Location:996 → 1138
      PH_PRG; PDZ Rho guanine nucleotide exchange factor Pleckstrin homology (PH) domain
      pfam00169
      Location:1056 → 1136
      PH; PH domain
      pfam00621
      Location:795 → 979
      RhoGEF; RhoGEF domain

    8. XM_015112411.2 → XP_014967897.1  rho guanine nucleotide exchange factor 11 isoform X4

      UniProtKB/TrEMBL
      H9G2I4
      Conserved Domains (6) summary
      cd08753
      Location:346 → 490
      RGS_PDZRhoGEF; Regulator of G protein signaling (RGS) domain found in the PDZ-Rho guanine nucleotide exchange factor (RhoGEF) protein
      COG0265
      Location:77 → 136
      DegQ; Periplasmic serine protease, S1-C subfamily, contain C-terminal PDZ domain [Posttranslational modification, protein turnover, chaperones]
      cd00992
      Location:62 → 136
      PDZ_signaling; PDZ domain found in a variety of Eumetazoan signaling molecules, often in tandem arrangements. May be responsible for specific protein-protein interactions, as most PDZ domains bind C-terminal polypeptides, and binding to internal (non-C-terminal) ...
      cd13391
      Location:986 → 1128
      PH_PRG; PDZ Rho guanine nucleotide exchange factor Pleckstrin homology (PH) domain
      pfam00169
      Location:1046 → 1126
      PH; PH domain
      pfam00621
      Location:785 → 969
      RhoGEF; RhoGEF domain

    9. XM_015112403.2 → XP_014967889.1  rho guanine nucleotide exchange factor 11 isoform X2

      UniProtKB/TrEMBL
      A0A8J8XRX4, G7ME17, H9G2I5
      Conserved Domains (6) summary
      cd08753
      Location:346 → 490
      RGS_PDZRhoGEF; Regulator of G protein signaling (RGS) domain found in the PDZ-Rho guanine nucleotide exchange factor (RhoGEF) protein
      COG0265
      Location:77 → 136
      DegQ; Periplasmic serine protease, S1-C subfamily, contain C-terminal PDZ domain [Posttranslational modification, protein turnover, chaperones]
      cd00992
      Location:62 → 136
      PDZ_signaling; PDZ domain found in a variety of Eumetazoan signaling molecules, often in tandem arrangements. May be responsible for specific protein-protein interactions, as most PDZ domains bind C-terminal polypeptides, and binding to internal (non-C-terminal) ...
      cd13391
      Location:995 → 1137
      PH_PRG; PDZ Rho guanine nucleotide exchange factor Pleckstrin homology (PH) domain
      pfam00169
      Location:1055 → 1135
      PH; PH domain
      pfam00621
      Location:794 → 978
      RhoGEF; RhoGEF domain

    10. XM_015112419.2 → XP_014967905.1  rho guanine nucleotide exchange factor 11 isoform X5

      UniProtKB/TrEMBL
      H9G2I4
      Conserved Domains (6) summary
      cd08753
      Location:346 → 490
      RGS_PDZRhoGEF; Regulator of G protein signaling (RGS) domain found in the PDZ-Rho guanine nucleotide exchange factor (RhoGEF) protein
      COG0265
      Location:77 → 136
      DegQ; Periplasmic serine protease, S1-C subfamily, contain C-terminal PDZ domain [Posttranslational modification, protein turnover, chaperones]
      cd00992
      Location:62 → 136
      PDZ_signaling; PDZ domain found in a variety of Eumetazoan signaling molecules, often in tandem arrangements. May be responsible for specific protein-protein interactions, as most PDZ domains bind C-terminal polypeptides, and binding to internal (non-C-terminal) ...
      cd13391
      Location:985 → 1127
      PH_PRG; PDZ Rho guanine nucleotide exchange factor Pleckstrin homology (PH) domain
      pfam00169
      Location:1045 → 1125
      PH; PH domain
      pfam00621
      Location:784 → 968
      RhoGEF; RhoGEF domain

    11. XM_015112434.2 → XP_014967920.1  rho guanine nucleotide exchange factor 11 isoform X9

      UniProtKB/TrEMBL
      H9G2I3
      Conserved Domains (6) summary
      cd08753
      Location:306 → 450
      RGS_PDZRhoGEF; Regulator of G protein signaling (RGS) domain found in the PDZ-Rho guanine nucleotide exchange factor (RhoGEF) protein
      COG0265
      Location:77 → 136
      DegQ; Periplasmic serine protease, S1-C subfamily, contain C-terminal PDZ domain [Posttranslational modification, protein turnover, chaperones]
      cd00992
      Location:62 → 136
      PDZ_signaling; PDZ domain found in a variety of Eumetazoan signaling molecules, often in tandem arrangements. May be responsible for specific protein-protein interactions, as most PDZ domains bind C-terminal polypeptides, and binding to internal (non-C-terminal) ...
      cd13391
      Location:956 → 1098
      PH_PRG; PDZ Rho guanine nucleotide exchange factor Pleckstrin homology (PH) domain
      pfam00169
      Location:1016 → 1096
      PH; PH domain
      pfam00621
      Location:755 → 939
      RhoGEF; RhoGEF domain

    12. XM_015112446.2 → XP_014967932.1  rho guanine nucleotide exchange factor 11 isoform X11

      UniProtKB/TrEMBL
      H9G2I3
      Conserved Domains (6) summary
      cd08753
      Location:306 → 450
      RGS_PDZRhoGEF; Regulator of G protein signaling (RGS) domain found in the PDZ-Rho guanine nucleotide exchange factor (RhoGEF) protein
      COG0265
      Location:77 → 136
      DegQ; Periplasmic serine protease, S1-C subfamily, contain C-terminal PDZ domain [Posttranslational modification, protein turnover, chaperones]
      cd00992
      Location:62 → 136
      PDZ_signaling; PDZ domain found in a variety of Eumetazoan signaling molecules, often in tandem arrangements. May be responsible for specific protein-protein interactions, as most PDZ domains bind C-terminal polypeptides, and binding to internal (non-C-terminal) ...
      cd13391
      Location:955 → 1097
      PH_PRG; PDZ Rho guanine nucleotide exchange factor Pleckstrin homology (PH) domain
      pfam00169
      Location:1015 → 1095
      PH; PH domain
      pfam00621
      Location:754 → 938
      RhoGEF; RhoGEF domain

    13. XM_015112408.2 → XP_014967894.1  rho guanine nucleotide exchange factor 11 isoform X3

      UniProtKB/TrEMBL
      A0A8J8XRX4, G7ME17, H9G2I5
      Conserved Domains (6) summary
      cd08753
      Location:341 → 485
      RGS_PDZRhoGEF; Regulator of G protein signaling (RGS) domain found in the PDZ-Rho guanine nucleotide exchange factor (RhoGEF) protein
      COG0265
      Location:72 → 131
      DegQ; Periplasmic serine protease, S1-C subfamily, contain C-terminal PDZ domain [Posttranslational modification, protein turnover, chaperones]
      cd00992
      Location:57 → 131
      PDZ_signaling; PDZ domain found in a variety of Eumetazoan signaling molecules, often in tandem arrangements. May be responsible for specific protein-protein interactions, as most PDZ domains bind C-terminal polypeptides, and binding to internal (non-C-terminal) ...
      cd13391
      Location:991 → 1133
      PH_PRG; PDZ Rho guanine nucleotide exchange factor Pleckstrin homology (PH) domain
      pfam00169
      Location:1051 → 1131
      PH; PH domain
      pfam00621
      Location:790 → 974
      RhoGEF; RhoGEF domain

    14. XM_015112426.2 → XP_014967912.1  rho guanine nucleotide exchange factor 11 isoform X6

      UniProtKB/TrEMBL
      A0A8J8XRX4, G7ME17, H9G2I5
      Conserved Domains (6) summary
      cd08753
      Location:330 → 474
      RGS_PDZRhoGEF; Regulator of G protein signaling (RGS) domain found in the PDZ-Rho guanine nucleotide exchange factor (RhoGEF) protein
      COG0265
      Location:61 → 120
      DegQ; Periplasmic serine protease, S1-C subfamily, contain C-terminal PDZ domain [Posttranslational modification, protein turnover, chaperones]
      cd00992
      Location:46 → 120
      PDZ_signaling; PDZ domain found in a variety of Eumetazoan signaling molecules, often in tandem arrangements. May be responsible for specific protein-protein interactions, as most PDZ domains bind C-terminal polypeptides, and binding to internal (non-C-terminal) ...
      cd13391
      Location:980 → 1122
      PH_PRG; PDZ Rho guanine nucleotide exchange factor Pleckstrin homology (PH) domain
      pfam00169
      Location:1040 → 1120
      PH; PH domain
      pfam00621
      Location:779 → 963
      RhoGEF; RhoGEF domain

    15. XM_015112457.2 → XP_014967943.1  rho guanine nucleotide exchange factor 11 isoform X13

      UniProtKB/TrEMBL
      F7FKU2
      Conserved Domains (4) summary
      cd08753
      Location:278 → 422
      RGS_PDZRhoGEF; Regulator of G protein signaling (RGS) domain found in the PDZ-Rho guanine nucleotide exchange factor (RhoGEF) protein
      PHA03307
      Location:1188 → 1511
      PHA03307; transcriptional regulator ICP4; Provisional
      cd00160
      Location:724 → 910
      RhoGEF; Guanine nucleotide exchange factor for Rho/Rac/Cdc42-like GTPases; Also called Dbl-homologous (DH) domain. It appears that PH domains invariably occur C-terminal to RhoGEF/DH domains.
      cd13391
      Location:928 → 1070
      PH_PRG; PDZ Rho guanine nucleotide exchange factor Pleckstrin homology (PH) domain

    16. XM_015112464.2 → XP_014967950.1  rho guanine nucleotide exchange factor 11 isoform X14

      UniProtKB/TrEMBL
      F7FKT2
      Conserved Domains (4) summary
      cd08753
      Location:238 → 382
      RGS_PDZRhoGEF; Regulator of G protein signaling (RGS) domain found in the PDZ-Rho guanine nucleotide exchange factor (RhoGEF) protein
      cd13391
      Location:888 → 1030
      PH_PRG; PDZ Rho guanine nucleotide exchange factor Pleckstrin homology (PH) domain
      pfam00169
      Location:948 → 1028
      PH; PH domain
      pfam00621
      Location:687 → 871
      RhoGEF; RhoGEF domain

    17. XM_028827418.1 → XP_028683251.1  rho guanine nucleotide exchange factor 11 isoform X13

      UniProtKB/TrEMBL
      F7FKU2
      Related
      ENSMMUP00000047671.2, ENSMMUT00000069454.2
      Conserved Domains (4) summary
      cd08753
      Location:278 → 422
      RGS_PDZRhoGEF; Regulator of G protein signaling (RGS) domain found in the PDZ-Rho guanine nucleotide exchange factor (RhoGEF) protein
      PHA03307
      Location:1188 → 1511
      PHA03307; transcriptional regulator ICP4; Provisional
      cd00160
      Location:724 → 910
      RhoGEF; Guanine nucleotide exchange factor for Rho/Rac/Cdc42-like GTPases; Also called Dbl-homologous (DH) domain. It appears that PH domains invariably occur C-terminal to RhoGEF/DH domains.
      cd13391
      Location:928 → 1070
      PH_PRG; PDZ Rho guanine nucleotide exchange factor Pleckstrin homology (PH) domain
    Nucleotide Protein
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