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    CD1C CD1c molecule [ Macaca mulatta (Rhesus monkey) ]

    Gene ID: 717148, updated on 17-Aug-2024

    Summary

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    Official Symbol
    CD1Cprovided by VGNC
    Official Full Name
    CD1c moleculeprovided by VGNC
    Primary source
    VGNC:VGNC:70756
    See related
    Ensembl:ENSMMUG00000010626
    Gene type
    protein coding
    RefSeq status
    PROVISIONAL
    Organism
    Macaca mulatta
    Lineage
    Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Primates; Haplorrhini; Catarrhini; Cercopithecidae; Cercopithecinae; Macaca
    Orthologs
    human all
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    Genomic context

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    See CD1C in Genome Data Viewer
    Location:
    chromosome: 1
    Exon count:
    6
    Annotation release Status Assembly Chr Location
    103 current Mmul_10 (GCF_003339765.1) 1 NC_041754.1 (92718975..92724009, complement)
    102 previous assembly Mmul_8.0.1 (GCF_000772875.2) Unplaced Scaffold NW_014860438.1 (31888..37084)

    Chromosome 1 - NC_041754.1Genomic Context describing neighboring genes Neighboring gene CD1b molecule Neighboring gene T-cell surface glycoprotein CD1a Neighboring gene CD1a molecule Neighboring gene 40S ribosomal protein S10 pseudogene

    Genomic regions, transcripts, and products

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    Go to nucleotide: Graphics FASTA GenBank

    Bibliography

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    Related articles in PubMed

    1. Major T cell response to a mycolyl glycolipid is mediated by CD1c molecules in rhesus macaques. Morita D, et al. Infect Immun, 2013 Jan. PMID 23132493, Free PMC Article
    2. Elevated frequency of CD1c+ myeloid dendritic cells in the peripheral blood mononuclear cells of simian/human immunodeficiency virus (SHIV) and simian immunodeficiency virus (SIV) repeatedly infected Chinese rhesus macaques. Yang GB, et al. Cell Immunol, 2011. PMID 21714961
    3. Trans-species activation of human T cells by rhesus macaque CD1b molecules. Morita D, et al. Biochem Biophys Res Commun, 2008 Dec 19. PMID 18951873
    4. A new rhesus macaque assembly and annotation for next-generation sequencing analyses. Zimin AV, et al. Biol Direct, 2014 Oct 14. PMID 25319552, Free PMC Article
    5. TreeGrafter: phylogenetic tree-based annotation of proteins with Gene Ontology terms and other annotations. Tang H, et al. Bioinformatics, 2019 Feb 1. PMID 30032202, Free PMC Article

    GeneRIFs: Gene References Into Functions

    What's a GeneRIF?
    1. GMM-specific, CD1c-restricted T cells were detected in the circulation of all 4 rhesus macaque monkeys tested after but not before vaccination with BCG.
      Title: Major T cell response to a mycolyl glycolipid is mediated by CD1c molecules in rhesus macaques.
    2. Data show that the CD1c+ cells were found to be mononuclear leukocytes rather than granulocytes, and most of them expressed CD20.
      Title: Elevated frequency of CD1c+ myeloid dendritic cells in the peripheral blood mononuclear cells of simian/human immunodeficiency virus (SHIV) and simian immunodeficiency virus (SIV) repeatedly infected Chinese rhesus macaques.
    Submit: New GeneRIF Correction

    General gene information

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    Markers

    Homology

    Gene Ontology Provided by RefSeq

    Function Evidence Code Pubs
    enables endogenous lipid antigen binding IEA
    Inferred from Electronic Annotation
    more info
    		 PubMed 
    enables exogenous lipid antigen binding IEA
    Inferred from Electronic Annotation
    more info
    		 PubMed 
    enables lipopeptide binding IEA
    Inferred from Electronic Annotation
    more info
    		 PubMed 
    Process Evidence Code Pubs
    involved_in antigen processing and presentation, endogenous lipid antigen via MHC class Ib IEA
    Inferred from Electronic Annotation
    more info
    		 PubMed 
    involved_in antigen processing and presentation, exogenous lipid antigen via MHC class Ib IEA
    Inferred from Electronic Annotation
    more info
    		 PubMed 
    involved_in immune response IEA
    Inferred from Electronic Annotation
    more info
    		 PubMed 
    involved_in positive regulation of T cell mediated cytotoxicity IEA
    Inferred from Electronic Annotation
    more info
    		 PubMed 
    Component Evidence Code Pubs
    located_in external side of plasma membrane IEA
    Inferred from Electronic Annotation
    more info
    		 PubMed 
    located_in extracellular space IEA
    Inferred from Electronic Annotation
    more info
    		 PubMed 

    General protein information

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    Preferred Names
    T-cell surface glycoprotein CD1c
    Names
    CD1C antigen, c polypeptide

    NCBI Reference Sequences (RefSeq)

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    RefSeqs maintained independently of Annotated Genomes

    These reference sequences exist independently of genome builds. Explain

    These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

    mRNA and Protein(s)

    1. NM_001145533.1 → NP_001139005.1  T-cell surface glycoprotein CD1c precursor

      See identical proteins and their annotated locations for NP_001139005.1

      Status: PROVISIONAL

      Source sequence(s)
      AB458513
      UniProtKB/TrEMBL
      B9X0T6, H9ZF51
      Related
      ENSMMUP00000062457.1, ENSMMUT00000107780.1
      Conserved Domains (2) summary
      cd21029
      Location:202 → 294
      IgC1_CD1; Immunoglobulin domain of Cluster of Differentiation (CD) 1; member of the C1-set of Ig superfamily (IgSF) domains
      cl08246
      Location:19 → 195
      MHC_I; Class I Histocompatibility antigen, domains alpha 1 and 2

    RefSeqs of Annotated Genomes: Macaca mulatta Annotation Release 103 details...Open this link in a new tab

    The following sections contain reference sequences that belong to a specific genome build. Explain

    Reference Mmul_10 Primary Assembly

    Genomic

    1. NC_041754.1 Reference Mmul_10 Primary Assembly

      Range
      92718975..92724009 complement
      Download
      GenBank, FASTA, Sequence Viewer (Graphics)

    mRNA and Protein(s)

    1. XM_028845778.1 → XP_028701611.1  T-cell surface glycoprotein CD1c isoform X1

      UniProtKB/TrEMBL
      A0A5F7ZJL4, H9H3E8
      Related
      ENSMMUP00000064822.1, ENSMMUT00000082780.1
      Conserved Domains (2) summary
      cd07698
      Location:203 → 295
      IgC_MHC_I_alpha3; Class I major histocompatibility complex (MHC) alpha chain immunoglobulin domain
      cl08246
      Location:19 → 196
      MHC_I; Class I Histocompatibility antigen, domains alpha 1 and 2
    Nucleotide Protein
    Heading Accession and Version

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