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    TP53 tumor protein p53 [ Macaca mulatta (Rhesus monkey) ]

    Gene ID: 716170, updated on 17-Aug-2024

    Summary

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    Official Symbol
    TP53provided by VGNC
    Official Full Name
    tumor protein p53provided by VGNC
    Primary source
    VGNC:VGNC:78627
    Locus tag
    EGK_08142
    See related
    Ensembl:ENSMMUG00000008639
    Gene type
    protein coding
    RefSeq status
    PROVISIONAL
    Organism
    Macaca mulatta
    Lineage
    Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Primates; Haplorrhini; Catarrhini; Cercopithecidae; Cercopithecinae; Macaca
    Orthologs
    human mouse all
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    Genomic context

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    See TP53 in Genome Data Viewer
    Location:
    chromosome: 16
    Exon count:
    12
    Annotation release Status Assembly Chr Location
    103 current Mmul_10 (GCF_003339765.1) 16 NC_041769.1 (7447315..7466507, complement)
    102 previous assembly Mmul_8.0.1 (GCF_000772875.2) 16 NC_027908.1 (7652077..7670934, complement)

    Chromosome 16 - NC_041769.1Genomic Context describing neighboring genes Neighboring gene sex hormone binding globulin Neighboring gene ATPase Na+/K+ transporting subunit beta 2 Neighboring gene WD repeat containing antisense to TP53 Neighboring gene ephrin B3

    Genomic regions, transcripts, and products

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    Go to nucleotide: Graphics FASTA GenBank

    Bibliography

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    Related articles in PubMed

    1. Sequence of a cDNA encoding the p53 protein in rhesus monkey (Macaca mulatta). Kay HD, et al. Gene, 1994 Jan 28. PMID 8125305
    2. Non-human primate papillomavirus E6-mediated p53 degradation reveals ancient evolutionary adaptation of carcinogenic phenotype to host niche. Long T, et al. PLoS Pathog, 2022 Mar. PMID 35333912, Free PMC Article
    3. Elevated rate of fixation of endogenous retroviral elements in Haplorhini TRIM5 and TRIM22 genomic sequences: impact on transcriptional regulation. Diehl WE, et al. PLoS One, 2013. PMID 23516500, Free PMC Article
    4. Genome sequencing and comparison of two nonhuman primate animal models, the cynomolgus and Chinese rhesus macaques. Yan G, et al. Nat Biotechnol, 2011 Oct 16. PMID 22002653
    5. A new rhesus macaque assembly and annotation for next-generation sequencing analyses. Zimin AV, et al. Biol Direct, 2014 Oct 14. PMID 25319552, Free PMC Article

    See all (7) citations in PubMed

    GeneRIFs: Gene References Into Functions

    What's a GeneRIF?
    1. Non-human primate papillomavirus E6-mediated p53 degradation reveals ancient evolutionary adaptation of carcinogenic phenotype to host niche.
      Title: Non-human primate papillomavirus E6-mediated p53 degradation reveals ancient evolutionary adaptation of carcinogenic phenotype to host niche.
    Submit: New GeneRIF Correction

    General gene information

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    Markers

    Homology

    Gene Ontology Provided by RefSeq

    Function Evidence Code Pubs
    enables DNA-binding transcription factor activity, RNA polymerase II-specific IEA
    Inferred from Electronic Annotation
    more info
    		 PubMed 
    enables RNA polymerase II cis-regulatory region sequence-specific DNA binding IEA
    Inferred from Electronic Annotation
    more info
    		 PubMed 
    enables protein binding IEA
    Inferred from Electronic Annotation
    more info
    		 PubMed 
    Process Evidence Code Pubs
    involved_in apoptotic process IEA
    Inferred from Electronic Annotation
    more info
    		 PubMed 
    involved_in protein tetramerization IEA
    Inferred from Electronic Annotation
    more info
    		 PubMed 
    involved_in regulation of transcription by RNA polymerase II IEA
    Inferred from Electronic Annotation
    more info
    		 PubMed 
    Component Evidence Code Pubs
    located_in nucleus IEA
    Inferred from Electronic Annotation
    more info
    		 PubMed 

    General protein information

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    Preferred Names
    cellular tumor antigen p53
    Names
    P53
    tumor suppressor p53

    NCBI Reference Sequences (RefSeq)

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    RefSeqs maintained independently of Annotated Genomes

    These reference sequences exist independently of genome builds. Explain

    These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

    mRNA and Protein(s)

    1. NM_001047151.2 → NP_001040616.1  cellular tumor antigen p53

      See identical proteins and their annotated locations for NP_001040616.1

      Status: PROVISIONAL

      Source sequence(s)
      L20442
      UniProtKB/Swiss-Prot
      P56424
      UniProtKB/TrEMBL
      A0A1I7Q490, A0A8J8XH32, E3U906, G7NIG9
      Related
      ENSMMUP00000011334.3, ENSMMUT00000012081.4
      Conserved Domains (4) summary
      cd08367
      Location:109 → 289
      P53; P53 DNA-binding domain
      pfam18521
      Location:35 → 59
      TAD2; Transactivation domain 2
      pfam07710
      Location:319 → 355
      P53_tetramer; P53 tetramerisation motif
      pfam08563
      Location:6 → 30
      P53_TAD; P53 transactivation motif

    RefSeqs of Annotated Genomes: Macaca mulatta Annotation Release 103 details...Open this link in a new tab

    The following sections contain reference sequences that belong to a specific genome build. Explain

    Reference Mmul_10 Primary Assembly

    Genomic

    1. NC_041769.1 Reference Mmul_10 Primary Assembly

      Range
      7447315..7466507 complement
      Download
      GenBank, FASTA, Sequence Viewer (Graphics)

    mRNA and Protein(s)

    1. XM_028835713.1 → XP_028691546.1  cellular tumor antigen p53 isoform X1

      UniProtKB/Swiss-Prot
      P56424
      UniProtKB/TrEMBL
      A0A1I7Q490, A0A8J8XH32, E3U906, G7NIG9
      Conserved Domains (4) summary
      cd08367
      Location:109 → 289
      P53; P53 DNA-binding domain
      pfam18521
      Location:35 → 59
      TAD2; Transactivation domain 2
      pfam07710
      Location:319 → 355
      P53_tetramer; P53 tetramerisation motif
      pfam08563
      Location:6 → 30
      P53_TAD; P53 transactivation motif
    Nucleotide Protein
    Heading Accession and Version
    Protein Accession Links
    GenPept Link UniProtKB Link
    P56424.1 GenPept UniProtKB/Swiss-Prot:P56424

    Gene LinkOut

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    Research Materials