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    DGKB diacylglycerol kinase beta [ Macaca mulatta (Rhesus monkey) ]

    Gene ID: 715254, updated on 18-Sep-2024

    Summary

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    Official Symbol
    DGKBprovided by VGNC
    Official Full Name
    diacylglycerol kinase betaprovided by VGNC
    Primary source
    VGNC:VGNC:71782
    See related
    Ensembl:ENSMMUG00000020418
    Gene type
    protein coding
    RefSeq status
    MODEL
    Organism
    Macaca mulatta
    Lineage
    Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Primates; Haplorrhini; Catarrhini; Cercopithecidae; Cercopithecinae; Macaca
    Orthologs
    human mouse all
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    Genomic context

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    See DGKB in Genome Data Viewer
    Location:
    chromosome: 3
    Exon count:
    29
    Annotation release Status Assembly Chr Location
    103 current Mmul_10 (GCF_003339765.1) 3 NC_041756.1 (100092594..100860322)
    102 previous assembly Mmul_8.0.1 (GCF_000772875.2) 3 NC_027895.1 (89982917..90748180, complement)

    Chromosome 3 - NC_041756.1Genomic Context describing neighboring genes Neighboring gene alkylglycerol monooxygenase Neighboring gene transcription factor IIIA pseudogene Neighboring gene uncharacterized LOC106997506 Neighboring gene uncharacterized LOC106997507 Neighboring gene myosin, light chain 6, alkali, smooth muscle and non-muscle-like Neighboring gene 60S ribosomal protein L6 pseudogene Neighboring gene ETS variant transcription factor 1

    Genomic regions, transcripts, and products

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    Go to nucleotide: Graphics FASTA GenBank

    Bibliography

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    Related articles in PubMed

    1. A new rhesus macaque assembly and annotation for next-generation sequencing analyses. Zimin AV, et al. Biol Direct, 2014 Oct 14. PMID 25319552, Free PMC Article
    2. Manual GO annotation of predictive protein signatures: the InterPro approach to GO curation. Burge S, et al. Database (Oxford), 2012. PMID 22301074, Free PMC Article
    3. TreeGrafter: phylogenetic tree-based annotation of proteins with Gene Ontology terms and other annotations. Tang H, et al. Bioinformatics, 2019 Feb 1. PMID 30032202, Free PMC Article

    GeneRIFs: Gene References Into Functions

    General gene information

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    Markers

    Homology

    Gene Ontology Provided by RefSeq

    Function Evidence Code Pubs
    enables ATP-dependent diacylglycerol kinase activity IEA
    Inferred from Electronic Annotation
    more info
    		 PubMed 
    enables calcium ion binding IEA
    Inferred from Electronic Annotation
    more info
    		 PubMed 
    Process Evidence Code Pubs
    involved_in diacylglycerol metabolic process IEA
    Inferred from Electronic Annotation
    more info
    		 PubMed 
    involved_in intracellular signal transduction IEA
    Inferred from Electronic Annotation
    more info
    		 PubMed 
    involved_in lipid phosphorylation IEA
    Inferred from Electronic Annotation
    more info
    		 PubMed 
    Component Evidence Code Pubs
    located_in plasma membrane IEA
    Inferred from Electronic Annotation
    more info
    		 PubMed 

    General protein information

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    Preferred Names
    diacylglycerol kinase beta
    XP_014989402.1
    XP_014989403.1
    XP_014989404.1
    XP_014989405.1
    XP_014989406.1
    XP_014989407.1
    XP_014989408.1
    XP_014989409.1
    XP_014989411.1
    XP_028701829.1
    XP_028701831.1
    XP_028701832.1
    XP_028701833.1
    XP_028701834.1

    NCBI Reference Sequences (RefSeq)

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    RefSeqs of Annotated Genomes: Macaca mulatta Annotation Release 103 details...Open this link in a new tab

    The following sections contain reference sequences that belong to a specific genome build. Explain

    Reference Mmul_10 Primary Assembly

    Genomic

    1. NC_041756.1 Reference Mmul_10 Primary Assembly

      Range
      100092594..100860322
      Download
      GenBank, FASTA, Sequence Viewer (Graphics)

    mRNA and Protein(s)

    1. XM_015133916.2 → XP_014989402.1  diacylglycerol kinase beta isoform X1

      UniProtKB/TrEMBL
      A0A5F7ZBC6, I2CTX4
      Related
      ENSMMUP00000061925.1, ENSMMUT00000108317.1
      Conserved Domains (8) summary
      smart00045
      Location:582 → 762
      DAGKa; Diacylglycerol kinase accessory domain (presumed)
      smart00046
      Location:440 → 561
      DAGKc; Diacylglycerol kinase catalytic domain (presumed)
      COG1597
      Location:440 → 772
      LCB5; Diacylglycerol kinase family enzyme [Lipid transport and metabolism, General function prediction only]
      cd00029
      Location:245 → 294
      C1; Protein kinase C conserved region 1 (C1) . Cysteine-rich zinc binding domain. Some members of this domain family bind phorbol esters and diacylglycerol, some are reported to bind RasGTP. May occur in tandem arrangement. Diacylglycerol (DAG) is a second ...
      cd00051
      Location:153 → 222
      EFh; EF-hand, calcium binding motif; A diverse superfamily of calcium sensors and calcium signal modulators; most examples in this alignment model have 2 active canonical EF hands. Ca2+ binding induces a conformational change in the EF-hand motif, leading to ...
      pfam00130
      Location:310 → 361
      C1_1; Phorbol esters/diacylglycerol binding domain (C1 domain)
      pfam13499
      Location:154 → 218
      EF-hand_7; EF-hand domain pair
      pfam14513
      Location:6 → 149
      DAG_kinase_N; Diacylglycerol kinase N-terminus

    2. XM_015133918.2 → XP_014989404.1  diacylglycerol kinase beta isoform X2

      UniProtKB/TrEMBL
      A0A5F7ZBC6, F6U0I9, H9FQL9
      Related
      ENSMMUP00000026871.4, ENSMMUT00000028718.4
      Conserved Domains (6) summary
      smart00045
      Location:581 → 761
      DAGKa; Diacylglycerol kinase accessory domain (presumed)
      smart00046
      Location:439 → 560
      DAGKc; Diacylglycerol kinase catalytic domain (presumed)
      cd00051
      Location:153 → 222
      EFh; EF-hand, calcium binding motif; A diverse superfamily of calcium sensors and calcium signal modulators; most examples in this alignment model have 2 active canonical EF hands. Ca2+ binding induces a conformational change in the EF-hand motif, leading to ...
      pfam14513
      Location:6 → 149
      DAG_kinase_N; Diacylglycerol kinase N-terminus
      cd20845
      Location:238 → 303
      C1_DGKbeta_rpt1; first protein kinase C conserved region 1 (C1 domain) found in diacylglycerol kinase beta (DAG kinase beta) and similar proteins
      cd20891
      Location:308 → 366
      C1_DGKbeta_rpt2; second protein kinase C conserved region 1 (C1 domain) found in diacylglycerol kinase beta (DAG kinase beta) and similar proteins

    3. XM_015133921.2 → XP_014989407.1  diacylglycerol kinase beta isoform X5

      UniProtKB/TrEMBL
      A0A5F7ZBC6
      Conserved Domains (6) summary
      smart00045
      Location:570 → 750
      DAGKa; Diacylglycerol kinase accessory domain (presumed)
      smart00046
      Location:428 → 549
      DAGKc; Diacylglycerol kinase catalytic domain (presumed)
      cd00051
      Location:153 → 222
      EFh; EF-hand, calcium binding motif; A diverse superfamily of calcium sensors and calcium signal modulators; most examples in this alignment model have 2 active canonical EF hands. Ca2+ binding induces a conformational change in the EF-hand motif, leading to ...
      pfam14513
      Location:6 → 149
      DAG_kinase_N; Diacylglycerol kinase N-terminus
      cd20845
      Location:238 → 303
      C1_DGKbeta_rpt1; first protein kinase C conserved region 1 (C1 domain) found in diacylglycerol kinase beta (DAG kinase beta) and similar proteins
      cd20891
      Location:308 → 366
      C1_DGKbeta_rpt2; second protein kinase C conserved region 1 (C1 domain) found in diacylglycerol kinase beta (DAG kinase beta) and similar proteins

    4. XM_015133919.2 → XP_014989405.1  diacylglycerol kinase beta isoform X3

      UniProtKB/TrEMBL
      A0A5F7ZBC6
      Conserved Domains (6) summary
      smart00045
      Location:575 → 755
      DAGKa; Diacylglycerol kinase accessory domain (presumed)
      smart00046
      Location:433 → 554
      DAGKc; Diacylglycerol kinase catalytic domain (presumed)
      cd00051
      Location:146 → 215
      EFh; EF-hand, calcium binding motif; A diverse superfamily of calcium sensors and calcium signal modulators; most examples in this alignment model have 2 active canonical EF hands. Ca2+ binding induces a conformational change in the EF-hand motif, leading to ...
      pfam14513
      Location:6 → 142
      DAG_kinase_N; Diacylglycerol kinase N-terminus
      cd20845
      Location:231 → 296
      C1_DGKbeta_rpt1; first protein kinase C conserved region 1 (C1 domain) found in diacylglycerol kinase beta (DAG kinase beta) and similar proteins
      cd20891
      Location:301 → 359
      C1_DGKbeta_rpt2; second protein kinase C conserved region 1 (C1 domain) found in diacylglycerol kinase beta (DAG kinase beta) and similar proteins

    5. XM_015133920.2 → XP_014989406.1  diacylglycerol kinase beta isoform X4

      UniProtKB/TrEMBL
      A0A5F7ZBC6, H9FQL5
      Conserved Domains (6) summary
      smart00045
      Location:574 → 754
      DAGKa; Diacylglycerol kinase accessory domain (presumed)
      smart00046
      Location:432 → 553
      DAGKc; Diacylglycerol kinase catalytic domain (presumed)
      cd00051
      Location:146 → 215
      EFh; EF-hand, calcium binding motif; A diverse superfamily of calcium sensors and calcium signal modulators; most examples in this alignment model have 2 active canonical EF hands. Ca2+ binding induces a conformational change in the EF-hand motif, leading to ...
      pfam14513
      Location:6 → 142
      DAG_kinase_N; Diacylglycerol kinase N-terminus
      cd20845
      Location:231 → 296
      C1_DGKbeta_rpt1; first protein kinase C conserved region 1 (C1 domain) found in diacylglycerol kinase beta (DAG kinase beta) and similar proteins
      cd20891
      Location:301 → 359
      C1_DGKbeta_rpt2; second protein kinase C conserved region 1 (C1 domain) found in diacylglycerol kinase beta (DAG kinase beta) and similar proteins

    6. XM_015133922.2 → XP_014989408.1  diacylglycerol kinase beta isoform X6

      UniProtKB/TrEMBL
      A0A5F7ZBC6, A0A5F8A472
      Conserved Domains (8) summary
      smart00045
      Location:563 → 743
      DAGKa; Diacylglycerol kinase accessory domain (presumed)
      smart00046
      Location:421 → 542
      DAGKc; Diacylglycerol kinase catalytic domain (presumed)
      COG1597
      Location:421 → 753
      LCB5; Diacylglycerol kinase family enzyme [Lipid transport and metabolism, General function prediction only]
      cd00029
      Location:238 → 287
      C1; Protein kinase C conserved region 1 (C1) . Cysteine-rich zinc binding domain. Some members of this domain family bind phorbol esters and diacylglycerol, some are reported to bind RasGTP. May occur in tandem arrangement. Diacylglycerol (DAG) is a second ...
      cd00051
      Location:146 → 215
      EFh; EF-hand, calcium binding motif; A diverse superfamily of calcium sensors and calcium signal modulators; most examples in this alignment model have 2 active canonical EF hands. Ca2+ binding induces a conformational change in the EF-hand motif, leading to ...
      pfam00130
      Location:303 → 354
      C1_1; Phorbol esters/diacylglycerol binding domain (C1 domain)
      pfam13499
      Location:147 → 211
      EF-hand_7; EF-hand domain pair
      pfam14513
      Location:6 → 142
      DAG_kinase_N; Diacylglycerol kinase N-terminus

    7. XM_028845996.1 → XP_028701829.1  diacylglycerol kinase beta isoform X2

      UniProtKB/TrEMBL
      A0A5F7ZBC6, F6U0I9, H9FQL9
      Conserved Domains (6) summary
      smart00045
      Location:581 → 761
      DAGKa; Diacylglycerol kinase accessory domain (presumed)
      smart00046
      Location:439 → 560
      DAGKc; Diacylglycerol kinase catalytic domain (presumed)
      cd00051
      Location:153 → 222
      EFh; EF-hand, calcium binding motif; A diverse superfamily of calcium sensors and calcium signal modulators; most examples in this alignment model have 2 active canonical EF hands. Ca2+ binding induces a conformational change in the EF-hand motif, leading to ...
      pfam14513
      Location:6 → 149
      DAG_kinase_N; Diacylglycerol kinase N-terminus
      cd20845
      Location:238 → 303
      C1_DGKbeta_rpt1; first protein kinase C conserved region 1 (C1 domain) found in diacylglycerol kinase beta (DAG kinase beta) and similar proteins
      cd20891
      Location:308 → 366
      C1_DGKbeta_rpt2; second protein kinase C conserved region 1 (C1 domain) found in diacylglycerol kinase beta (DAG kinase beta) and similar proteins

    8. XM_015133917.2 → XP_014989403.1  diacylglycerol kinase beta isoform X1

      UniProtKB/TrEMBL
      A0A5F7ZBC6, I2CTX4
      Conserved Domains (8) summary
      smart00045
      Location:582 → 762
      DAGKa; Diacylglycerol kinase accessory domain (presumed)
      smart00046
      Location:440 → 561
      DAGKc; Diacylglycerol kinase catalytic domain (presumed)
      COG1597
      Location:440 → 772
      LCB5; Diacylglycerol kinase family enzyme [Lipid transport and metabolism, General function prediction only]
      cd00029
      Location:245 → 294
      C1; Protein kinase C conserved region 1 (C1) . Cysteine-rich zinc binding domain. Some members of this domain family bind phorbol esters and diacylglycerol, some are reported to bind RasGTP. May occur in tandem arrangement. Diacylglycerol (DAG) is a second ...
      cd00051
      Location:153 → 222
      EFh; EF-hand, calcium binding motif; A diverse superfamily of calcium sensors and calcium signal modulators; most examples in this alignment model have 2 active canonical EF hands. Ca2+ binding induces a conformational change in the EF-hand motif, leading to ...
      pfam00130
      Location:310 → 361
      C1_1; Phorbol esters/diacylglycerol binding domain (C1 domain)
      pfam13499
      Location:154 → 218
      EF-hand_7; EF-hand domain pair
      pfam14513
      Location:6 → 149
      DAG_kinase_N; Diacylglycerol kinase N-terminus

    9. XM_028846000.1 → XP_028701833.1  diacylglycerol kinase beta isoform X5

      UniProtKB/TrEMBL
      A0A5F7ZBC6
      Conserved Domains (6) summary
      smart00045
      Location:570 → 750
      DAGKa; Diacylglycerol kinase accessory domain (presumed)
      smart00046
      Location:428 → 549
      DAGKc; Diacylglycerol kinase catalytic domain (presumed)
      cd00051
      Location:153 → 222
      EFh; EF-hand, calcium binding motif; A diverse superfamily of calcium sensors and calcium signal modulators; most examples in this alignment model have 2 active canonical EF hands. Ca2+ binding induces a conformational change in the EF-hand motif, leading to ...
      pfam14513
      Location:6 → 149
      DAG_kinase_N; Diacylglycerol kinase N-terminus
      cd20845
      Location:238 → 303
      C1_DGKbeta_rpt1; first protein kinase C conserved region 1 (C1 domain) found in diacylglycerol kinase beta (DAG kinase beta) and similar proteins
      cd20891
      Location:308 → 366
      C1_DGKbeta_rpt2; second protein kinase C conserved region 1 (C1 domain) found in diacylglycerol kinase beta (DAG kinase beta) and similar proteins

    10. XM_028845998.1 → XP_028701831.1  diacylglycerol kinase beta isoform X3

      UniProtKB/TrEMBL
      A0A5F7ZBC6
      Conserved Domains (6) summary
      smart00045
      Location:575 → 755
      DAGKa; Diacylglycerol kinase accessory domain (presumed)
      smart00046
      Location:433 → 554
      DAGKc; Diacylglycerol kinase catalytic domain (presumed)
      cd00051
      Location:146 → 215
      EFh; EF-hand, calcium binding motif; A diverse superfamily of calcium sensors and calcium signal modulators; most examples in this alignment model have 2 active canonical EF hands. Ca2+ binding induces a conformational change in the EF-hand motif, leading to ...
      pfam14513
      Location:6 → 142
      DAG_kinase_N; Diacylglycerol kinase N-terminus
      cd20845
      Location:231 → 296
      C1_DGKbeta_rpt1; first protein kinase C conserved region 1 (C1 domain) found in diacylglycerol kinase beta (DAG kinase beta) and similar proteins
      cd20891
      Location:301 → 359
      C1_DGKbeta_rpt2; second protein kinase C conserved region 1 (C1 domain) found in diacylglycerol kinase beta (DAG kinase beta) and similar proteins

    11. XM_015133923.2 → XP_014989409.1  diacylglycerol kinase beta isoform X6

      UniProtKB/TrEMBL
      A0A5F7ZBC6, A0A5F8A472
      Related
      ENSMMUP00000071702.1, ENSMMUT00000100885.1
      Conserved Domains (8) summary
      smart00045
      Location:563 → 743
      DAGKa; Diacylglycerol kinase accessory domain (presumed)
      smart00046
      Location:421 → 542
      DAGKc; Diacylglycerol kinase catalytic domain (presumed)
      COG1597
      Location:421 → 753
      LCB5; Diacylglycerol kinase family enzyme [Lipid transport and metabolism, General function prediction only]
      cd00029
      Location:238 → 287
      C1; Protein kinase C conserved region 1 (C1) . Cysteine-rich zinc binding domain. Some members of this domain family bind phorbol esters and diacylglycerol, some are reported to bind RasGTP. May occur in tandem arrangement. Diacylglycerol (DAG) is a second ...
      cd00051
      Location:146 → 215
      EFh; EF-hand, calcium binding motif; A diverse superfamily of calcium sensors and calcium signal modulators; most examples in this alignment model have 2 active canonical EF hands. Ca2+ binding induces a conformational change in the EF-hand motif, leading to ...
      pfam00130
      Location:303 → 354
      C1_1; Phorbol esters/diacylglycerol binding domain (C1 domain)
      pfam13499
      Location:147 → 211
      EF-hand_7; EF-hand domain pair
      pfam14513
      Location:6 → 142
      DAG_kinase_N; Diacylglycerol kinase N-terminus

    12. XM_028845999.1 → XP_028701832.1  diacylglycerol kinase beta isoform X4

      UniProtKB/TrEMBL
      A0A5F7ZBC6, H9FQL5
      Conserved Domains (6) summary
      smart00045
      Location:574 → 754
      DAGKa; Diacylglycerol kinase accessory domain (presumed)
      smart00046
      Location:432 → 553
      DAGKc; Diacylglycerol kinase catalytic domain (presumed)
      cd00051
      Location:146 → 215
      EFh; EF-hand, calcium binding motif; A diverse superfamily of calcium sensors and calcium signal modulators; most examples in this alignment model have 2 active canonical EF hands. Ca2+ binding induces a conformational change in the EF-hand motif, leading to ...
      pfam14513
      Location:6 → 142
      DAG_kinase_N; Diacylglycerol kinase N-terminus
      cd20845
      Location:231 → 296
      C1_DGKbeta_rpt1; first protein kinase C conserved region 1 (C1 domain) found in diacylglycerol kinase beta (DAG kinase beta) and similar proteins
      cd20891
      Location:301 → 359
      C1_DGKbeta_rpt2; second protein kinase C conserved region 1 (C1 domain) found in diacylglycerol kinase beta (DAG kinase beta) and similar proteins

    13. XM_028846001.1 → XP_028701834.1  diacylglycerol kinase beta isoform X7

      UniProtKB/TrEMBL
      A0A5F7ZBC6
      Conserved Domains (6) summary
      smart00046
      Location:440 → 561
      DAGKc; Diacylglycerol kinase catalytic domain (presumed)
      cd00051
      Location:153 → 222
      EFh; EF-hand, calcium binding motif; A diverse superfamily of calcium sensors and calcium signal modulators; most examples in this alignment model have 2 active canonical EF hands. Ca2+ binding induces a conformational change in the EF-hand motif, leading to ...
      pfam14513
      Location:6 → 149
      DAG_kinase_N; Diacylglycerol kinase N-terminus
      cd20845
      Location:238 → 303
      C1_DGKbeta_rpt1; first protein kinase C conserved region 1 (C1 domain) found in diacylglycerol kinase beta (DAG kinase beta) and similar proteins
      cd20891
      Location:308 → 366
      C1_DGKbeta_rpt2; second protein kinase C conserved region 1 (C1 domain) found in diacylglycerol kinase beta (DAG kinase beta) and similar proteins
      cl02440
      Location:582 → 679
      DAGK_acc; Diacylglycerol kinase accessory domain

    14. XM_015133925.2 → XP_014989411.1  diacylglycerol kinase beta isoform X8

      UniProtKB/TrEMBL
      G7MLS2
      Conserved Domains (8) summary
      smart00045
      Location:472 → 652
      DAGKa; Diacylglycerol kinase accessory domain (presumed)
      smart00046
      Location:330 → 451
      DAGKc; Diacylglycerol kinase catalytic domain (presumed)
      COG1597
      Location:330 → 662
      LCB5; Diacylglycerol kinase family enzyme [Lipid transport and metabolism, General function prediction only]
      cd00029
      Location:135 → 184
      C1; Protein kinase C conserved region 1 (C1) . Cysteine-rich zinc binding domain. Some members of this domain family bind phorbol esters and diacylglycerol, some are reported to bind RasGTP. May occur in tandem arrangement. Diacylglycerol (DAG) is a second ...
      cd00051
      Location:43 → 112
      EFh; EF-hand, calcium binding motif; A diverse superfamily of calcium sensors and calcium signal modulators; most examples in this alignment model have 2 active canonical EF hands. Ca2+ binding induces a conformational change in the EF-hand motif, leading to ...
      pfam00130
      Location:200 → 251
      C1_1; Phorbol esters/diacylglycerol binding domain (C1 domain)
      pfam13499
      Location:44 → 108
      EF-hand_7; EF-hand domain pair
      pfam14513
      Location:3 → 39
      DAG_kinase_N; Diacylglycerol kinase N-terminus
    Nucleotide Protein
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