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    TLE3 TLE family member 3, transcriptional corepressor [ Homo sapiens (human) ]

    Gene ID: 7090, updated on 3-Nov-2024

    Summary

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    Official Symbol
    TLE3provided by HGNC
    Official Full Name
    TLE family member 3, transcriptional corepressorprovided by HGNC
    Primary source
    HGNC:HGNC:11839
    See related
    Ensembl:ENSG00000140332 MIM:600190; AllianceGenome:HGNC:11839
    Gene type
    protein coding
    RefSeq status
    REVIEWED
    Organism
    Homo sapiens
    Lineage
    Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Primates; Haplorrhini; Catarrhini; Hominidae; Homo
    Also known as
    ESG; ESG3; GRG3; HsT18976
    Summary
    This gene encodes a transcriptional co-repressor protein that belongs to the transducin-like enhancer family of proteins. The members of this family function in the Notch signaling pathway that regulates determination of cell fate during development. Expression of this gene has been associated with a favorable outcome to chemotherapy with taxanes for ovarian carcinoma. Alternate splicing results in multiple transcript variants. Additional alternatively spliced transcript variants of this gene have been described, but their full-length nature is not known. [provided by RefSeq, Sep 2013]
    Expression
    Ubiquitous expression in bone marrow (RPKM 20.9), prostate (RPKM 8.6) and 25 other tissues See more
    Orthologs
    mouse all
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    Genomic context

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    See TLE3 in Genome Data Viewer
    Location:
    15q23
    Exon count:
    23
    Annotation release Status Assembly Chr Location
    RS_2024_08 current GRCh38.p14 (GCF_000001405.40) 15 NC_000015.10 (70047790..70097917, complement)
    RS_2024_08 current T2T-CHM13v2.0 (GCF_009914755.1) 15 NC_060939.1 (67870017..67920141, complement)
    RS_2024_09 previous assembly GRCh37.p13 (GCF_000001405.25) 15 NC_000015.9 (70340129..70390256, complement)

    Chromosome 15 - NC_000015.10Genomic Context describing neighboring genes Neighboring gene uncharacterized LOC101929129 Neighboring gene ATAC-STARR-seq lymphoblastoid active region 9665 Neighboring gene ATAC-STARR-seq lymphoblastoid active region 9666 Neighboring gene NANOG-H3K4me1 hESC enhancer GRCh37_chr15:70282987-70283875 Neighboring gene H3K4me1 hESC enhancer GRCh37_chr15:70292527-70293028 Neighboring gene H3K27ac-H3K4me1 hESC enhancer GRCh37_chr15:70307241-70307744 Neighboring gene ATAC-STARR-seq lymphoblastoid active region 9667 Neighboring gene Neanderthal introgressed variant-containing enhancer experimental_40838 Neighboring gene uncharacterized LOC124903518 Neighboring gene H3K4me1 hESC enhancer GRCh37_chr15:70324572-70325184 Neighboring gene H3K27ac-H3K4me1 hESC enhancer GRCh37_chr15:70325185-70325795 Neighboring gene ATAC-STARR-seq lymphoblastoid active region 9669 Neighboring gene ATAC-STARR-seq lymphoblastoid active region 9668 Neighboring gene ATAC-STARR-seq lymphoblastoid active region 9670 Neighboring gene H3K4me1 hESC enhancer GRCh37_chr15:70349697-70350197 Neighboring gene H3K4me1 hESC enhancer GRCh37_chr15:70359676-70360176 Neighboring gene H3K4me1 hESC enhancer GRCh37_chr15:70360177-70360677 Neighboring gene H3K4me1 hESC enhancer GRCh37_chr15:70363742-70364242 Neighboring gene H3K27ac-H3K4me1 hESC enhancer GRCh37_chr15:70370658-70371264 Neighboring gene H3K27ac-H3K4me1 hESC enhancer GRCh37_chr15:70371265-70371871 Neighboring gene H3K27ac-H3K4me1 hESC enhancer GRCh37_chr15:70374946-70375494 Neighboring gene H3K4me1 hESC enhancer GRCh37_chr15:70380981-70381568 Neighboring gene ATAC-STARR-seq lymphoblastoid silent region 6602 Neighboring gene ATAC-STARR-seq lymphoblastoid silent region 6603 Neighboring gene ATAC-STARR-seq lymphoblastoid silent region 6604 Neighboring gene NANOG-H3K27ac hESC enhancer GRCh37_chr15:70390514-70391488 Neighboring gene microRNA 629 Neighboring gene VISTA enhancer hs359 Neighboring gene ATAC-STARR-seq lymphoblastoid silent region 6607 Neighboring gene H3K4me1 hESC enhancer GRCh37_chr15:70402651-70403162 Neighboring gene NANOG-H3K4me1 hESC enhancer GRCh37_chr15:70403675-70404186 Neighboring gene H3K4me1 hESC enhancer GRCh37_chr15:70404187-70404696 Neighboring gene Sharpr-MPRA regulatory region 6929 Neighboring gene ATAC-STARR-seq lymphoblastoid active region 9671 Neighboring gene ATAC-STARR-seq lymphoblastoid active region 9672 Neighboring gene uncharacterized LOC107984734 Neighboring gene H3K27ac hESC enhancer GRCh37_chr15:70432131-70432636 Neighboring gene OCT4-NANOG-H3K27ac hESC enhancer GRCh37_chr15:70433141-70433644 Neighboring gene H3K4me1 hESC enhancer GRCh37_chr15:70472929-70473512 Neighboring gene H3K4me1 hESC enhancer GRCh37_chr15:70473513-70474096 Neighboring gene H3K4me1 hESC enhancer GRCh37_chr15:70479256-70479756 Neighboring gene H3K4me1 hESC enhancer GRCh37_chr15:70482961-70483463 Neighboring gene RNA, U6 small nuclear 745, pseudogene

    Genomic regions, transcripts, and products

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    Go to nucleotide: Graphics FASTA GenBank

    Expression

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    • Project title: HPA RNA-seq normal tissues HPA RNA-seq normal tissues
    • Description: RNA-seq was performed of tissue samples from 95 human individuals representing 27 different tissues in order to determine tissue-specificity of all protein-coding genes
    • BioProject: PRJEB4337
    • Publication: PMID 24309898
    • Analysis date: Wed Apr 4 07:08:55 2018

    Bibliography

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    Related articles in PubMed

    1. Angiosarcoma: a study of 98 cases with immunohistochemical evaluation of TLE3, a recently described marker of potential taxane responsiveness. Shon W, et al. J Cutan Pathol, 2011 Dec. PMID 22050093
    2. Identification of predictive markers of the therapeutic effect of eribulin chemotherapy for locally advanced or metastatic breast cancer. Kashiwagi S, et al. BMC Cancer, 2017 Aug 31. PMID 28859615, Free PMC Article
    3. Splice variants of TLE family genes and up-regulation of a TLE3 isoform in prostate tumors. Nakaya HI, et al. Biochem Biophys Res Commun, 2007 Dec 28. PMID 18273443
    4. TLE3 expression is associated with sensitivity to taxane treatment in ovarian carcinoma. Samimi G, et al. Cancer Epidemiol Biomarkers Prev, 2012 Feb. PMID 22194527
    5. Antisense intronic non-coding RNA levels correlate to the degree of tumor differentiation in prostate cancer. Reis EM, et al. Oncogene, 2004 Aug 26. PMID 15221013

    See all (116) citations in PubMed

    GeneRIFs: Gene References Into Functions

    What's a GeneRIF?
    1. The Wnt-pathway corepressor TLE3 interacts with the histone methyltransferase KMT1A to inhibit differentiation in Rhabdomyosarcoma.
      Title: The Wnt-pathway corepressor TLE3 interacts with the histone methyltransferase KMT1A to inhibit differentiation in Rhabdomyosarcoma.
    2. HHEX suppresses advanced thyroid cancer by interacting with TLE3.
      Title: HHEX suppresses advanced thyroid cancer by interacting with TLE3.
    3. Enhancer recruitment of transcription repressors RUNX1 and TLE3 by mis-expressed FOXC1 blocks differentiation in acute myeloid leukemia.
      Title: Enhancer recruitment of transcription repressors RUNX1 and TLE3 by mis-expressed FOXC1 blocks differentiation in acute myeloid leukemia.
    4. Differential functions of TLE1 and TLE3 depending on a specific phosphorylation site.
      Title: Differential functions of TLE1 and TLE3 depending on a specific phosphorylation site.
    5. vour findings reveal a mechanistic link between TLE3 and GR-mediated resistance to AR inhibitors in human prostate cancer
      Title: TLE3 loss confers AR inhibitor resistance by facilitating GR-mediated human prostate cancer cell growth.
    6. RNF6-mediated ubiquitination and degradation of TLE3 activates the Wnt/beta-catenin pathway in colorectal carcinogenesis
      Title: RNF6 Promotes Colorectal Cancer by Activating the Wnt/β-Catenin Pathway via Ubiquitination of TLE3.
    7. Patients with TLE3-negative tumors displayed poorer outcomes regarding progression-free survival than patients with TLE3-positive tumors when prognosis within the group of patients with triple-negative breast cancer (TNBC) lesions was analyzed. In contrast, no such difference in prognosis was found in a comparison of TLE-3 positive/negative patients in the group of all patients.
      Title: Identification of predictive markers of the therapeutic effect of eribulin chemotherapy for locally advanced or metastatic breast cancer.
    8. Wnt signaling pathway inactivates the TLE3 co-repressor via HECT E3 ubiquitin ligase Hyd/UBR5 ubiquitination.
      Title: Wnt-Dependent Inactivation of the Groucho/TLE Co-repressor by the HECT E3 Ubiquitin Ligase Hyd/UBR5.
    9. Data indicate that microRNA miR-744 activated Wnt/beta-catenin pathway by targeting multiple negative regulators of Wnt/beta-catenin signaling, including SFRP1, GSK3beta, TLE3 and NKD1, and that NKD1 is a major functional target of miR-744.
      Title: MicroRNA-744 promotes prostate cancer progression through aberrantly activating Wnt/β-catenin signaling.
    10. Increased adipose tissue (AT) TLE3 in subjects with type 2 diabetes and in AT from high fat diet and PPARgamma knockout mice suggest that TLE3 may play an adaptive regulatory role that improves AT function under decreased PPARgamma expression
      Title: Transducin-like enhancer of split 3 (TLE3) in adipose tissue is increased in situations characterized by decreased PPARγ gene expression.
    Submit: New GeneRIF Correction See all GeneRIFs (15)

    Phenotypes

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    Find tests for this gene in the NIH Genetic Testing Registry (GTR)

    Review eQTL and phenotype association data in this region using PheGenI

    EBI GWAS Catalog

    Description
    Biological insights from 108 schizophrenia-associated genetic loci.
    EBI GWAS Catalog
    Genome-wide association study of lung function phenotypes in a founder population.
    EBI GWAS Catalog
    Heritability and genetic association analysis of cognition in the Diabetes Heart Study.
    EBI GWAS Catalog
    Hundreds of variants clustered in genomic loci and biological pathways affect human height.
    EBI GWAS Catalog

    Variation

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    See Variation Viewer (GRCh37.p13)

    Pathways from PubChem

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    Interactions

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    Products Interactant Other Gene Complex Source Pubs Description

    General gene information

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    Markers

    Homology

    Clone Names

    • FLJ39460, KIAA1547

    Gene Ontology Provided by GOA

    Function Evidence Code Pubs
    enables protein binding IPI
    Inferred from Physical Interaction
    more info
    		 PubMed 
    enables transcription corepressor activity IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    Process Evidence Code Pubs
    involved_in Wnt signaling pathway IEA
    Inferred from Electronic Annotation
    more info
    		  
    involved_in animal organ morphogenesis TAS
    Traceable Author Statement
    more info
    		 PubMed 
    involved_in negative regulation of DNA-templated transcription IEA
    Inferred from Electronic Annotation
    more info
    		  
    involved_in negative regulation of canonical Wnt signaling pathway IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    involved_in negative regulation of cold-induced thermogenesis ISS
    Inferred from Sequence or Structural Similarity
    more info
    		 PubMed 
    involved_in signal transduction TAS
    Traceable Author Statement
    more info
    		 PubMed 
    Component Evidence Code Pubs
    part_of beta-catenin-TCF complex IDA
    Inferred from Direct Assay
    more info
    		 PubMed 
    located_in nucleoplasm IDA
    Inferred from Direct Assay
    more info
    		  
    located_in nucleoplasm TAS
    Traceable Author Statement
    more info
    		  
    is_active_in nucleus IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    is_active_in nucleus IDA
    Inferred from Direct Assay
    more info
    		 PubMed 
    part_of transcription regulator complex IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  

    General protein information

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    Preferred Names
    transducin-like enhancer protein 3
    Names
    enhancer of split groucho 3
    enhancer of split groucho-like protein 3
    transducin like enhancer of split 3
    transducin-like enhancer of split 3 (E(sp1) homolog, Drosophila)
    transducin-like enhancer of split 3, homolog of Drosophila E(sp1)

    NCBI Reference Sequences (RefSeq)

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    NEW Try the new Transcript table

    RefSeqs maintained independently of Annotated Genomes

    These reference sequences exist independently of genome builds. Explain

    These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

    mRNA and Protein(s)

    1. NM_001105192.3 → NP_001098662.1  transducin-like enhancer protein 3 isoform b

      See identical proteins and their annotated locations for NP_001098662.1

      Status: REVIEWED

      Description
      Transcript Variant: This variant (2) uses an alternate in-frame splice site in the coding region compared to variant 1. The encoded isoform (b) is shorter than isoform a.
      Source sequence(s)
      AB046767, AC026583, AC068327, AK315058, BC043247, BM676381
      Consensus CDS
      CCDS45294.1
      UniProtKB/TrEMBL
      Q6PRX3
      Related
      ENSP00000394717.3, ENST00000451782.7
      Conserved Domains (3) summary
      cd00200
      Location:481 → 766
      WD40; WD40 domain, found in a number of eukaryotic proteins that cover a wide variety of functions including adaptor/regulatory modules in signal transduction, pre-mRNA processing and cytoskeleton assembly; typically contains a GH dipeptide 11-24 residues from ...
      sd00039
      Location:486 → 525
      7WD40; WD40 repeat [structural motif]
      pfam03920
      Location:9 → 133
      TLE_N; Groucho/TLE N-terminal Q-rich domain

    2. NM_001282979.2 → NP_001269908.1  transducin-like enhancer protein 3 isoform e

      See identical proteins and their annotated locations for NP_001269908.1

      Status: REVIEWED

      Description
      Transcript Variant: This variant (5) uses two alternate in-frame splice sites in the 3' coding region compared to variant 1. The encoded isoform (e) is shorter than isoform a.
      Source sequence(s)
      AB046767, AC026583, AC068327, AY583459, BC043247, BM676381, M99438
      Consensus CDS
      CCDS61692.1
      UniProtKB/TrEMBL
      Q6PRX3
      Related
      ENSP00000453083.1, ENST00000557997.5
      Conserved Domains (3) summary
      cd00200
      Location:476 → 761
      WD40; WD40 domain, found in a number of eukaryotic proteins that cover a wide variety of functions including adaptor/regulatory modules in signal transduction, pre-mRNA processing and cytoskeleton assembly; typically contains a GH dipeptide 11-24 residues from ...
      sd00039
      Location:481 → 520
      7WD40; WD40 repeat [structural motif]
      pfam03920
      Location:9 → 133
      TLE_N; Groucho/TLE N-terminal Q-rich domain

    3. NM_001282980.2 → NP_001269909.1  transducin-like enhancer protein 3 isoform d

      See identical proteins and their annotated locations for NP_001269909.1

      Status: REVIEWED

      Description
      Transcript Variant: This variant (4) uses an alternate in-frame splice site in the 3' coding region compared to variant 1. The encoded isoform (d) is shorter than isoform a.
      Source sequence(s)
      AB046767, AC026583, AC068327, BC043247, BM676381
      Consensus CDS
      CCDS61691.1
      UniProtKB/TrEMBL
      Q6PRX2
      Related
      ENSP00000453435.1, ENST00000558379.5
      Conserved Domains (3) summary
      cd00200
      Location:479 → 764
      WD40; WD40 domain, found in a number of eukaryotic proteins that cover a wide variety of functions including adaptor/regulatory modules in signal transduction, pre-mRNA processing and cytoskeleton assembly; typically contains a GH dipeptide 11-24 residues from ...
      sd00039
      Location:484 → 523
      7WD40; WD40 repeat [structural motif]
      pfam03920
      Location:9 → 133
      TLE_N; Groucho/TLE N-terminal Q-rich domain

    4. NM_001282981.2 → NP_001269910.1  transducin-like enhancer protein 3 isoform f

      See identical proteins and their annotated locations for NP_001269910.1

      Status: REVIEWED

      Description
      Transcript Variant: This variant (6) has multiple differences compared to variant 1. These differences result in a novel 5' coding region and 5' UTR compared to variant 1. The encoded isoform (f) is shorter than isoform a.
      Source sequence(s)
      AB046767, AC068327, AK298482, BM676381, BP373048
      Consensus CDS
      CCDS61689.1
      UniProtKB/TrEMBL
      H0YKT5
      Related
      ENSP00000415057.3, ENST00000440567.7
      Conserved Domains (3) summary
      cd00200
      Location:474 → 759
      WD40; WD40 domain, found in a number of eukaryotic proteins that cover a wide variety of functions including adaptor/regulatory modules in signal transduction, pre-mRNA processing and cytoskeleton assembly; typically contains a GH dipeptide 11-24 residues from ...
      sd00039
      Location:479 → 518
      7WD40; WD40 repeat [structural motif]
      pfam03920
      Location:2 → 126
      TLE_N; Groucho/TLE N-terminal Q-rich domain

    5. NM_001282982.2 → NP_001269911.1  transducin-like enhancer protein 3 isoform g

      See identical proteins and their annotated locations for NP_001269911.1

      Status: REVIEWED

      Description
      Transcript Variant: This variant (7) represents the use of an alternate promoter and has multiple differences compared to variant 1. These differences result in a distinct 5' UTR and cause translation initiation at a downstream start codon compared to variant 1. The encoded isoform (g) is shorter than isoform a.
      Source sequence(s)
      AB046767, AC026583, AC068327, AK096779, BM676381
      UniProtKB/TrEMBL
      B3KUA2
      Conserved Domains (3) summary
      cd00200
      Location:411 → 696
      WD40; WD40 domain, found in a number of eukaryotic proteins that cover a wide variety of functions including adaptor/regulatory modules in signal transduction, pre-mRNA processing and cytoskeleton assembly; typically contains a GH dipeptide 11-24 residues from ...
      sd00039
      Location:416 → 455
      7WD40; WD40 repeat [structural motif]
      pfam03920
      Location:1 → 77
      TLE_N; Groucho/TLE N-terminal Q-rich domain

    6. NM_005078.4 → NP_005069.2  transducin-like enhancer protein 3 isoform a

      See identical proteins and their annotated locations for NP_005069.2

      Status: REVIEWED

      Description
      Transcript Variant: This variant (1) represents the longest transcript and encodes the longest isoform (a).
      Source sequence(s)
      AB046767, AC026583, AC068327, BC043247, BM676381, M99438
      Consensus CDS
      CCDS45293.1
      UniProtKB/Swiss-Prot
      B4DPT0, E9PD64, F8W964, Q04726, Q6PI57, Q8IVV6, Q8WVR2, Q9HCM5
      UniProtKB/TrEMBL
      Q6PRX2
      Related
      ENSP00000452871.1, ENST00000558939.5
      Conserved Domains (3) summary
      cd00200
      Location:484 → 769
      WD40; WD40 domain, found in a number of eukaryotic proteins that cover a wide variety of functions including adaptor/regulatory modules in signal transduction, pre-mRNA processing and cytoskeleton assembly; typically contains a GH dipeptide 11-24 residues from ...
      sd00039
      Location:489 → 528
      7WD40; WD40 repeat [structural motif]
      pfam03920
      Location:9 → 133
      TLE_N; Groucho/TLE N-terminal Q-rich domain

    7. NM_020908.3 → NP_065959.1  transducin-like enhancer protein 3 isoform c

      See identical proteins and their annotated locations for NP_065959.1

      Status: REVIEWED

      Description
      Transcript Variant: This variant (3) uses an alternate in-frame splice site in the 3' coding region compared to variant 1. The encoded isoform (c) is shorter than isoform a.
      Source sequence(s)
      AB046767, AC026583, AC068327, BC043247, BM676381
      Consensus CDS
      CCDS58375.1
      UniProtKB/TrEMBL
      Q6PRX2
      Related
      ENSP00000319233.8, ENST00000317509.12
      Conserved Domains (4) summary
      cd00200
      Location:472 → 757
      WD40; WD40 domain, found in a number of eukaryotic proteins that cover a wide variety of functions including adaptor/regulatory modules in signal transduction, pre-mRNA processing and cytoskeleton assembly; typically contains a GH dipeptide 11-24 residues from ...
      pfam05109
      Location:251 → 460
      Herpes_BLLF1; Herpes virus major outer envelope glycoprotein (BLLF1)
      sd00039
      Location:477 → 516
      7WD40; WD40 repeat [structural motif]
      pfam03920
      Location:9 → 133
      TLE_N; Groucho/TLE N-terminal Q-rich domain

    RefSeqs of Annotated Genomes: GCF_000001405.40-RS_2024_08

    The following sections contain reference sequences that belong to a specific genome build. Explain

    Reference GRCh38.p14 Primary Assembly

    Genomic

    1. NC_000015.10 Reference GRCh38.p14 Primary Assembly

      Range
      70047790..70097917 complement
      Download
      GenBank, FASTA, Sequence Viewer (Graphics)

    mRNA and Protein(s)

    1. XM_047432993.1 → XP_047288949.1  transducin-like enhancer protein 3 isoform X14

    2. XM_047432992.1 → XP_047288948.1  transducin-like enhancer protein 3 isoform X12

    3. XM_011521983.4 → XP_011520285.1  transducin-like enhancer protein 3 isoform X13

      UniProtKB/TrEMBL
      Q6PRX2
      Conserved Domains (4) summary
      COG2319
      Location:406 → 691
      WD40; WD40 repeat [General function prediction only]
      cd00200
      Location:405 → 690
      WD40; WD40 domain, found in a number of eukaryotic proteins that cover a wide variety of functions including adaptor/regulatory modules in signal transduction, pre-mRNA processing and cytoskeleton assembly; typically contains a GH dipeptide 11-24 residues from ...
      pfam03920
      Location:1 → 124
      TLE_N; Groucho/TLE N-terminal Q-rich domain
      sd00039
      Location:410 → 449
      7WD40; WD40 repeat [structural motif]

    4. XM_011521982.4 → XP_011520284.1  transducin-like enhancer protein 3 isoform X11

      UniProtKB/TrEMBL
      Q6PRX2
      Conserved Domains (4) summary
      COG2319
      Location:411 → 696
      WD40; WD40 repeat [General function prediction only]
      cd00200
      Location:410 → 695
      WD40; WD40 domain, found in a number of eukaryotic proteins that cover a wide variety of functions including adaptor/regulatory modules in signal transduction, pre-mRNA processing and cytoskeleton assembly; typically contains a GH dipeptide 11-24 residues from ...
      pfam03920
      Location:1 → 124
      TLE_N; Groucho/TLE N-terminal Q-rich domain
      sd00039
      Location:415 → 454
      7WD40; WD40 repeat [structural motif]

    5. XM_006720665.5 → XP_006720728.1  transducin-like enhancer protein 3 isoform X16

      UniProtKB/TrEMBL
      Q6PRX3
      Conserved Domains (3) summary
      cd00200
      Location:475 → 760
      WD40; WD40 domain, found in a number of eukaryotic proteins that cover a wide variety of functions including adaptor/regulatory modules in signal transduction, pre-mRNA processing and cytoskeleton assembly; typically contains a GH dipeptide 11-24 residues from ...
      sd00039
      Location:480 → 519
      7WD40; WD40 repeat [structural motif]
      pfam03920
      Location:9 → 132
      TLE_N; Groucho/TLE N-terminal Q-rich domain

    6. XM_011521980.4 → XP_011520282.1  transducin-like enhancer protein 3 isoform X7

      UniProtKB/TrEMBL
      Q6PRX2
      Conserved Domains (3) summary
      cd00200
      Location:483 → 768
      WD40; WD40 domain, found in a number of eukaryotic proteins that cover a wide variety of functions including adaptor/regulatory modules in signal transduction, pre-mRNA processing and cytoskeleton assembly; typically contains a GH dipeptide 11-24 residues from ...
      sd00039
      Location:488 → 527
      7WD40; WD40 repeat [structural motif]
      pfam03920
      Location:9 → 132
      TLE_N; Groucho/TLE N-terminal Q-rich domain

    7. XM_005254633.4 → XP_005254690.1  transducin-like enhancer protein 3 isoform X17

      See identical proteins and their annotated locations for XP_005254690.1

      UniProtKB/TrEMBL
      Q6PRX2
      Conserved Domains (3) summary
      cd00200
      Location:467 → 752
      WD40; WD40 domain, found in a number of eukaryotic proteins that cover a wide variety of functions including adaptor/regulatory modules in signal transduction, pre-mRNA processing and cytoskeleton assembly; typically contains a GH dipeptide 11-24 residues from ...
      sd00039
      Location:472 → 511
      7WD40; WD40 repeat [structural motif]
      pfam03920
      Location:9 → 133
      TLE_N; Groucho/TLE N-terminal Q-rich domain

    8. XM_011521977.4 → XP_011520279.1  transducin-like enhancer protein 3 isoform X2

      UniProtKB/TrEMBL
      Q6PRX2
      Conserved Domains (3) summary
      cd00200
      Location:493 → 778
      WD40; WD40 domain, found in a number of eukaryotic proteins that cover a wide variety of functions including adaptor/regulatory modules in signal transduction, pre-mRNA processing and cytoskeleton assembly; typically contains a GH dipeptide 11-24 residues from ...
      sd00039
      Location:498 → 537
      7WD40; WD40 repeat [structural motif]
      pfam03920
      Location:9 → 142
      TLE_N; Groucho/TLE N-terminal Q-rich domain

    9. XM_005254628.5 → XP_005254685.1  transducin-like enhancer protein 3 isoform X10

      UniProtKB/TrEMBL
      Q6PRX2
      Conserved Domains (3) summary
      cd00200
      Location:477 → 762
      WD40; WD40 domain, found in a number of eukaryotic proteins that cover a wide variety of functions including adaptor/regulatory modules in signal transduction, pre-mRNA processing and cytoskeleton assembly; typically contains a GH dipeptide 11-24 residues from ...
      sd00039
      Location:482 → 521
      7WD40; WD40 repeat [structural motif]
      pfam03920
      Location:9 → 143
      TLE_N; Groucho/TLE N-terminal Q-rich domain

    10. XM_005254625.5 → XP_005254682.1  transducin-like enhancer protein 3 isoform X8

      UniProtKB/TrEMBL
      Q6PRX2
      Conserved Domains (4) summary
      cd00200
      Location:482 → 767
      WD40; WD40 domain, found in a number of eukaryotic proteins that cover a wide variety of functions including adaptor/regulatory modules in signal transduction, pre-mRNA processing and cytoskeleton assembly; typically contains a GH dipeptide 11-24 residues from ...
      pfam05109
      Location:261 → 470
      Herpes_BLLF1; Herpes virus major outer envelope glycoprotein (BLLF1)
      sd00039
      Location:487 → 526
      7WD40; WD40 repeat [structural motif]
      pfam03920
      Location:9 → 143
      TLE_N; Groucho/TLE N-terminal Q-rich domain

    11. XM_005254623.5 → XP_005254680.1  transducin-like enhancer protein 3 isoform X5

      UniProtKB/TrEMBL
      Q6PRX3
      Conserved Domains (3) summary
      cd00200
      Location:486 → 771
      WD40; WD40 domain, found in a number of eukaryotic proteins that cover a wide variety of functions including adaptor/regulatory modules in signal transduction, pre-mRNA processing and cytoskeleton assembly; typically contains a GH dipeptide 11-24 residues from ...
      sd00039
      Location:491 → 530
      7WD40; WD40 repeat [structural motif]
      pfam03920
      Location:9 → 143
      TLE_N; Groucho/TLE N-terminal Q-rich domain

    12. XM_005254622.6 → XP_005254679.1  transducin-like enhancer protein 3 isoform X3

      UniProtKB/TrEMBL
      Q6PRX3
      Conserved Domains (3) summary
      cd00200
      Location:491 → 776
      WD40; WD40 domain, found in a number of eukaryotic proteins that cover a wide variety of functions including adaptor/regulatory modules in signal transduction, pre-mRNA processing and cytoskeleton assembly; typically contains a GH dipeptide 11-24 residues from ...
      sd00039
      Location:496 → 535
      7WD40; WD40 repeat [structural motif]
      pfam03920
      Location:9 → 143
      TLE_N; Groucho/TLE N-terminal Q-rich domain

    13. XM_011521978.4 → XP_011520280.1  transducin-like enhancer protein 3 isoform X4

      UniProtKB/TrEMBL
      Q6PRX2
      Conserved Domains (3) summary
      cd00200
      Location:489 → 774
      WD40; WD40 domain, found in a number of eukaryotic proteins that cover a wide variety of functions including adaptor/regulatory modules in signal transduction, pre-mRNA processing and cytoskeleton assembly; typically contains a GH dipeptide 11-24 residues from ...
      sd00039
      Location:494 → 533
      7WD40; WD40 repeat [structural motif]
      pfam03920
      Location:9 → 143
      TLE_N; Groucho/TLE N-terminal Q-rich domain

    14. XM_011521976.4 → XP_011520278.1  transducin-like enhancer protein 3 isoform X1

      See identical proteins and their annotated locations for XP_011520278.1

      UniProtKB/TrEMBL
      H0YL70, Q6PRX2
      Related
      ENSP00000453081.1, ENST00000559929.5
      Conserved Domains (3) summary
      cd00200
      Location:494 → 779
      WD40; WD40 domain, found in a number of eukaryotic proteins that cover a wide variety of functions including adaptor/regulatory modules in signal transduction, pre-mRNA processing and cytoskeleton assembly; typically contains a GH dipeptide 11-24 residues from ...
      sd00039
      Location:499 → 538
      7WD40; WD40 repeat [structural motif]
      pfam03920
      Location:9 → 143
      TLE_N; Groucho/TLE N-terminal Q-rich domain

    15. XM_011521979.4 → XP_011520281.1  transducin-like enhancer protein 3 isoform X6

      See identical proteins and their annotated locations for XP_011520281.1

      UniProtKB/TrEMBL
      H0YNT2
      Related
      ENSP00000453760.1, ENST00000559048.5
      Conserved Domains (3) summary
      cd00200
      Location:422 → 707
      WD40; WD40 domain, found in a number of eukaryotic proteins that cover a wide variety of functions including adaptor/regulatory modules in signal transduction, pre-mRNA processing and cytoskeleton assembly; typically contains a GH dipeptide 11-24 residues from ...
      sd00039
      Location:427 → 466
      7WD40; WD40 repeat [structural motif]
      pfam03920
      Location:1 → 76
      TLE_N; Groucho/TLE N-terminal Q-rich domain

    16. XM_011521981.3 → XP_011520283.1  transducin-like enhancer protein 3 isoform X9

      UniProtKB/TrEMBL
      Q6PRX2
      Conserved Domains (4) summary
      COG2319
      Location:488 → 747
      WD40; WD40 repeat [General function prediction only]
      cd00200
      Location:494 → 738
      WD40; WD40 domain, found in a number of eukaryotic proteins that cover a wide variety of functions including adaptor/regulatory modules in signal transduction, pre-mRNA processing and cytoskeleton assembly; typically contains a GH dipeptide 11-24 residues from ...
      pfam03920
      Location:1 → 143
      TLE_N; Groucho/TLE N-terminal Q-rich domain
      sd00039
      Location:499 → 538
      7WD40; WD40 repeat [structural motif]

    17. XM_017022532.3 → XP_016878021.1  transducin-like enhancer protein 3 isoform X15

      UniProtKB/TrEMBL
      H0YLI3
      Related
      ENSP00000453373.1, ENST00000561453.5

    Alternate T2T-CHM13v2.0

    Genomic

    1. NC_060939.1 Alternate T2T-CHM13v2.0

      Range
      67870017..67920141 complement
      Download
      GenBank, FASTA, Sequence Viewer (Graphics)

    mRNA and Protein(s)

    1. XM_054378731.1 → XP_054234706.1  transducin-like enhancer protein 3 isoform X14

    2. XM_054378729.1 → XP_054234704.1  transducin-like enhancer protein 3 isoform X12

    3. XM_054378730.1 → XP_054234705.1  transducin-like enhancer protein 3 isoform X13

    4. XM_054378728.1 → XP_054234703.1  transducin-like enhancer protein 3 isoform X11

    5. XM_054378733.1 → XP_054234708.1  transducin-like enhancer protein 3 isoform X16

    6. XM_054378724.1 → XP_054234699.1  transducin-like enhancer protein 3 isoform X7

    7. XM_054378734.1 → XP_054234709.1  transducin-like enhancer protein 3 isoform X17

    8. XM_054378719.1 → XP_054234694.1  transducin-like enhancer protein 3 isoform X2

    9. XM_054378727.1 → XP_054234702.1  transducin-like enhancer protein 3 isoform X10

    10. XM_054378725.1 → XP_054234700.1  transducin-like enhancer protein 3 isoform X8

    11. XM_054378722.1 → XP_054234697.1  transducin-like enhancer protein 3 isoform X5

    12. XM_054378720.1 → XP_054234695.1  transducin-like enhancer protein 3 isoform X3

    13. XM_054378721.1 → XP_054234696.1  transducin-like enhancer protein 3 isoform X4

    14. XM_054378718.1 → XP_054234693.1  transducin-like enhancer protein 3 isoform X1

      UniProtKB/TrEMBL
      H0YL70

    15. XM_054378723.1 → XP_054234698.1  transducin-like enhancer protein 3 isoform X6

    16. XM_054378726.1 → XP_054234701.1  transducin-like enhancer protein 3 isoform X9

    17. XM_054378732.1 → XP_054234707.1  transducin-like enhancer protein 3 isoform X15

    Nucleotide Protein
    Heading Accession and Version
    Protein Accession Links
    GenPept Link UniProtKB Link
    Q04726.2 GenPept UniProtKB/Swiss-Prot:Q04726

    Gene LinkOut

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