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    CHRM3 cholinergic receptor muscarinic 3 [ Macaca mulatta (Rhesus monkey) ]

    Gene ID: 708901, updated on 17-Aug-2024

    Summary

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    Official Symbol
    CHRM3provided by VGNC
    Official Full Name
    cholinergic receptor muscarinic 3provided by VGNC
    Primary source
    VGNC:VGNC:71043
    Locus tag
    EGK_02092
    See related
    Ensembl:ENSMMUG00000021442
    Gene type
    protein coding
    RefSeq status
    PROVISIONAL
    Organism
    Macaca mulatta
    Lineage
    Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Primates; Haplorrhini; Catarrhini; Cercopithecidae; Cercopithecinae; Macaca
    Orthologs
    human mouse all
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    Genomic context

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    See CHRM3 in Genome Data Viewer
    Location:
    chromosome: 1
    Exon count:
    12
    Annotation release Status Assembly Chr Location
    103 current Mmul_10 (GCF_003339765.1) 1 NC_041754.1 (9162299..9686319, complement)
    102 previous assembly Mmul_8.0.1 (GCF_000772875.2) 1 NC_027893.1 (215803160..216328635)

    Chromosome 1 - NC_041754.1Genomic Context describing neighboring genes Neighboring gene uncharacterized LOC114677633 Neighboring gene hydroxymethylglutaryl-CoA synthase, cytoplasmic pseudogene Neighboring gene interferon-induced transmembrane protein 1 Neighboring gene uncharacterized LOC114677634

    Genomic regions, transcripts, and products

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    Go to nucleotide: Graphics FASTA GenBank

    Bibliography

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    Related articles in PubMed

    1. Genome sequencing and comparison of two nonhuman primate animal models, the cynomolgus and Chinese rhesus macaques. Yan G, et al. Nat Biotechnol, 2011 Oct 16. PMID 22002653
    2. A new rhesus macaque assembly and annotation for next-generation sequencing analyses. Zimin AV, et al. Biol Direct, 2014 Oct 14. PMID 25319552, Free PMC Article
    3. Manual GO annotation of predictive protein signatures: the InterPro approach to GO curation. Burge S, et al. Database (Oxford), 2012. PMID 22301074, Free PMC Article
    4. TreeGrafter: phylogenetic tree-based annotation of proteins with Gene Ontology terms and other annotations. Tang H, et al. Bioinformatics, 2019 Feb 1. PMID 30032202, Free PMC Article

    GeneRIFs: Gene References Into Functions

    General gene information

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    Markers

    Homology

    Gene Ontology Provided by RefSeq

    Function Evidence Code Pubs
    enables G protein-coupled acetylcholine receptor activity IEA
    Inferred from Electronic Annotation
    more info
    		 PubMed 
    enables G protein-coupled serotonin receptor activity IEA
    Inferred from Electronic Annotation
    more info
    		 PubMed 
    Process Evidence Code Pubs
    involved_in G protein-coupled receptor signaling pathway, coupled to cyclic nucleotide second messenger IEA
    Inferred from Electronic Annotation
    more info
    		 PubMed 
    involved_in adenylate cyclase-inhibiting G protein-coupled acetylcholine receptor signaling pathway IEA
    Inferred from Electronic Annotation
    more info
    		 PubMed 
    involved_in chemical synaptic transmission IEA
    Inferred from Electronic Annotation
    more info
    		 PubMed 
    involved_in positive regulation of smooth muscle contraction IEA
    Inferred from Electronic Annotation
    more info
    		 PubMed 
    involved_in regulation of vascular associated smooth muscle contraction IEA
    Inferred from Electronic Annotation
    more info
    		 PubMed 
    involved_in saliva secretion IEA
    Inferred from Electronic Annotation
    more info
    		 PubMed 
    Component Evidence Code Pubs
    located_in dendrite IEA
    Inferred from Electronic Annotation
    more info
    		 PubMed 
    located_in plasma membrane IEA
    Inferred from Electronic Annotation
    more info
    		 PubMed 
    located_in synapse IEA
    Inferred from Electronic Annotation
    more info
    		 PubMed 

    General protein information

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    Preferred Names
    muscarinic acetylcholine receptor M3

    NCBI Reference Sequences (RefSeq)

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    RefSeqs maintained independently of Annotated Genomes

    These reference sequences exist independently of genome builds. Explain

    These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

    mRNA and Protein(s)

    1. NM_001257740.2 → NP_001244669.1  muscarinic acetylcholine receptor M3

      See identical proteins and their annotated locations for NP_001244669.1

      Status: PROVISIONAL

      Source sequence(s)
      JU321096
      UniProtKB/TrEMBL
      A0A1D5Q9F8, A0A8J8XRC4, F7EAQ8, G7MFM3
      Related
      ENSMMUP00000028244.3, ENSMMUT00000030181.3
      Conserved Domains (3) summary
      cd15299
      Location:66 → 270
      7tmA_mAChR_M3; muscarinic acetylcholine receptor subtype M3, member of the class A family of seven-transmembrane G protein-coupled receptors
      cd14964
      Location:487 → 514
      7tm_GPCRs; TM helix 6 [structural motif]
      cl28897
      Location:484 → 564
      7tm_GPCRs; seven-transmembrane G protein-coupled receptor superfamily

    RefSeqs of Annotated Genomes: Macaca mulatta Annotation Release 103 details...Open this link in a new tab

    The following sections contain reference sequences that belong to a specific genome build. Explain

    Reference Mmul_10 Primary Assembly

    Genomic

    1. NC_041754.1 Reference Mmul_10 Primary Assembly

      Range
      9162299..9686319 complement
      Download
      GenBank, FASTA, Sequence Viewer (Graphics)

    mRNA and Protein(s)

    1. XM_028843487.1 → XP_028699320.1  muscarinic acetylcholine receptor M3 isoform X1

      UniProtKB/TrEMBL
      A0A1D5Q9F8, A0A8J8XRC4, F7EAQ8, G7MFM3
      Conserved Domains (3) summary
      cd15299
      Location:66 → 270
      7tmA_mAChR_M3; muscarinic acetylcholine receptor subtype M3, member of the class A family of seven-transmembrane G protein-coupled receptors
      cd14964
      Location:487 → 514
      7tm_GPCRs; TM helix 6 [structural motif]
      cl28897
      Location:484 → 564
      7tm_GPCRs; seven-transmembrane G protein-coupled receptor superfamily

    2. XM_015126482.2 → XP_014981968.1  muscarinic acetylcholine receptor M3 isoform X1

      UniProtKB/TrEMBL
      A0A1D5Q9F8, A0A8J8XRC4, F7EAQ8, G7MFM3
      Conserved Domains (3) summary
      cd15299
      Location:66 → 270
      7tmA_mAChR_M3; muscarinic acetylcholine receptor subtype M3, member of the class A family of seven-transmembrane G protein-coupled receptors
      cd14964
      Location:487 → 514
      7tm_GPCRs; TM helix 6 [structural motif]
      cl28897
      Location:484 → 564
      7tm_GPCRs; seven-transmembrane G protein-coupled receptor superfamily

    3. XM_015126492.2 → XP_014981978.1  muscarinic acetylcholine receptor M3 isoform X1

      UniProtKB/TrEMBL
      A0A1D5Q9F8, A0A8J8XRC4, F7EAQ8, G7MFM3
      Conserved Domains (3) summary
      cd15299
      Location:66 → 270
      7tmA_mAChR_M3; muscarinic acetylcholine receptor subtype M3, member of the class A family of seven-transmembrane G protein-coupled receptors
      cd14964
      Location:487 → 514
      7tm_GPCRs; TM helix 6 [structural motif]
      cl28897
      Location:484 → 564
      7tm_GPCRs; seven-transmembrane G protein-coupled receptor superfamily

    4. XM_028843478.1 → XP_028699311.1  muscarinic acetylcholine receptor M3 isoform X1

      UniProtKB/TrEMBL
      A0A1D5Q9F8, A0A8J8XRC4, F7EAQ8, G7MFM3
      Conserved Domains (3) summary
      cd15299
      Location:66 → 270
      7tmA_mAChR_M3; muscarinic acetylcholine receptor subtype M3, member of the class A family of seven-transmembrane G protein-coupled receptors
      cd14964
      Location:487 → 514
      7tm_GPCRs; TM helix 6 [structural motif]
      cl28897
      Location:484 → 564
      7tm_GPCRs; seven-transmembrane G protein-coupled receptor superfamily

    5. XM_028843477.1 → XP_028699310.1  muscarinic acetylcholine receptor M3 isoform X1

      UniProtKB/TrEMBL
      A0A1D5Q9F8, A0A8J8XRC4, F7EAQ8, G7MFM3
      Conserved Domains (3) summary
      cd15299
      Location:66 → 270
      7tmA_mAChR_M3; muscarinic acetylcholine receptor subtype M3, member of the class A family of seven-transmembrane G protein-coupled receptors
      cd14964
      Location:487 → 514
      7tm_GPCRs; TM helix 6 [structural motif]
      cl28897
      Location:484 → 564
      7tm_GPCRs; seven-transmembrane G protein-coupled receptor superfamily

    6. XM_015126487.2 → XP_014981973.1  muscarinic acetylcholine receptor M3 isoform X1

      UniProtKB/TrEMBL
      A0A1D5Q9F8, A0A8J8XRC4, F7EAQ8, G7MFM3
      Conserved Domains (3) summary
      cd15299
      Location:66 → 270
      7tmA_mAChR_M3; muscarinic acetylcholine receptor subtype M3, member of the class A family of seven-transmembrane G protein-coupled receptors
      cd14964
      Location:487 → 514
      7tm_GPCRs; TM helix 6 [structural motif]
      cl28897
      Location:484 → 564
      7tm_GPCRs; seven-transmembrane G protein-coupled receptor superfamily

    7. XM_028843485.1 → XP_028699318.1  muscarinic acetylcholine receptor M3 isoform X1

      UniProtKB/TrEMBL
      A0A1D5Q9F8, A0A8J8XRC4, F7EAQ8, G7MFM3
      Conserved Domains (3) summary
      cd15299
      Location:66 → 270
      7tmA_mAChR_M3; muscarinic acetylcholine receptor subtype M3, member of the class A family of seven-transmembrane G protein-coupled receptors
      cd14964
      Location:487 → 514
      7tm_GPCRs; TM helix 6 [structural motif]
      cl28897
      Location:484 → 564
      7tm_GPCRs; seven-transmembrane G protein-coupled receptor superfamily

    8. XM_028843481.1 → XP_028699314.1  muscarinic acetylcholine receptor M3 isoform X1

      UniProtKB/TrEMBL
      A0A1D5Q9F8, A0A8J8XRC4, F7EAQ8, G7MFM3
      Conserved Domains (3) summary
      cd15299
      Location:66 → 270
      7tmA_mAChR_M3; muscarinic acetylcholine receptor subtype M3, member of the class A family of seven-transmembrane G protein-coupled receptors
      cd14964
      Location:487 → 514
      7tm_GPCRs; TM helix 6 [structural motif]
      cl28897
      Location:484 → 564
      7tm_GPCRs; seven-transmembrane G protein-coupled receptor superfamily

    9. XM_028843492.1 → XP_028699325.1  muscarinic acetylcholine receptor M3 isoform X1

      UniProtKB/TrEMBL
      A0A1D5Q9F8, A0A8J8XRC4, F7EAQ8, G7MFM3
      Conserved Domains (3) summary
      cd15299
      Location:66 → 270
      7tmA_mAChR_M3; muscarinic acetylcholine receptor subtype M3, member of the class A family of seven-transmembrane G protein-coupled receptors
      cd14964
      Location:487 → 514
      7tm_GPCRs; TM helix 6 [structural motif]
      cl28897
      Location:484 → 564
      7tm_GPCRs; seven-transmembrane G protein-coupled receptor superfamily
    Nucleotide Protein
    Heading Accession and Version

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