ICAM5 intercellular adhesion molecule 5 [Homo sapiens (human)] - Gene

Summary

Official Symbol: ICAM5provided by HGNC
Official Full Name: intercellular adhesion molecule 5provided by HGNC
Primary source: HGNC:HGNC:5348
See related: Ensembl:ENSG00000105376 MIM:601852; AllianceGenome:HGNC:5348
Gene type: protein coding
RefSeq status: REVIEWED
Organism: Homo sapiens
Lineage: Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Primates; Haplorrhini; Catarrhini; Hominidae; Homo
Also known as: TLN; TLCN
Summary: The protein encoded by this gene is a member of the intercellular adhesion molecule (ICAM) family. All ICAM proteins are type I transmembrane glycoproteins, contain 2-9 immunoglobulin-like C2-type domains, and bind to the leukocyte adhesion LFA-1 protein. This protein is expressed on the surface of telencephalic neurons and displays two types of adhesion activity, homophilic binding between neurons and heterophilic binding between neurons and leukocytes. It may be a critical component in neuron-microglial cell interactions in the course of normal development or as part of neurodegenerative diseases. [provided by RefSeq, Jul 2008]
Expression: Biased expression in brain (RPKM 11.7), lung (RPKM 3.3) and 1 other tissue See more
Orthologs: mouse all
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Genomic context

Location:: 19p13.2

Exon count:: 11

Annotation release	Status	Assembly	Chr	Location
RS_2024_08	current	GRCh38.p14 (GCF_000001405.40)	19	NC_000019.10 (10289952..10296778)
RS_2024_08	current	T2T-CHM13v2.0 (GCF_009914755.1)	19	NC_060943.1 (10415547..10422890)
RS_2024_09	previous assembly	GRCh37.p13 (GCF_000001405.25)	19	NC_000019.9 (10400628..10407454)

Chromosome 19 - NC_000019.10 Genomic Context describing neighboring genes

Genomic regions, transcripts, and products

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Genomic Sequence:

Go to nucleotide: Graphics FASTA GenBank

Expression

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See details

Project title: HPA RNA-seq normal tissues HPA RNA-seq normal tissues
Description: RNA-seq was performed of tissue samples from 95 human individuals representing 27 different tissues in order to determine tissue-specificity of all protein-coding genes
BioProject: PRJEB4337
Publication: PMID 24309898
Analysis date: Wed Apr 4 07:08:55 2018

Bibliography

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GeneRIFs: Gene References Into Functions

What's a GeneRIF?

Here the authors identify neuron-specific intercellular adhesion molecule 5 (ICAM-5/telencephalin) as a cellular receptor for sialic acid-dependent and -independent entry of enterovirus D68.
Title: ICAM-5/Telencephalin Is a Functional Entry Receptor for Enterovirus D68.
ICAM5 V301I and rs281439 variants may contribute to the susceptibility of breast cancer. [Meta-analysis]
Title: The genetic polymorphisms of intercellular cell adhesion molecules and breast cancer susceptibility: a meta-analysis.
A specific microenvironment facilitating ARF6-mediated mobilization of TLN that contributes to promotion of dendritic spine development.
Title: ARF6-mediated endosomal transport of Telencephalin affects dendritic filopodia-to-spine maturation.
Observational study of gene-disease association, gene-environment interaction, and pharmacogenomic / toxicogenomic. (HuGE Navigator)
Title: A large-scale candidate gene approach identifies SNPs in SOD2 and IL13 as predictive markers of response to preoperative chemoradiation in rectal cancer.
Observational study of gene-disease association and gene-gene interaction. (HuGE Navigator)
Title: Polymorphisms in innate immunity genes and risk of childhood leukemia.
ICAM-5 is involved in immune privilege of the brain and acts as an anti-inflammatory agent.
Title: Shedded neuronal ICAM-5 suppresses T-cell activation.
Observational study of gene-disease association. (HuGE Navigator)
Title: Common single nucleotide polymorphisms in immunoregulatory genes and multiple myeloma risk among women in Connecticut.
Observational study of gene-disease association and gene-environment interaction. (HuGE Navigator)
Title: ICAM gene cluster SNPs and prostate cancer risk in African Americans.
study does not confirm association between ICAM 5 V3001 polymorphism and breast cancer risk
Title: Polymorphisms in the ICAM gene locus are not associated with breast cancer Risk.

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Phenotypes

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Review eQTL and phenotype association data in this region using PheGenI

Variation

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See variants in ClinVar

See studies and variants in dbVar

See Variation Viewer (GRCh37.p13)

See Variation Viewer (GRCh38)

Interactions

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Products	Interactant	Other Gene	Complex	Source	Pubs	Description

General gene information

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Markers

RH78910 (e-PCR)
- UniSTS:70662

RH35820 (e-PCR)
- UniSTS:53309

STS-H18323 (e-PCR)
- UniSTS:72927

STS-U72671 (e-PCR)
- UniSTS:24822

Gene Ontology Provided by GOA

Function	Evidence Code	Pubs
enables integrin binding	IBA Inferred from Biological aspect of Ancestor more info
enables protein binding	IPI Inferred from Physical Interaction more info	PubMed

Process	Evidence Code	Pubs
involved_in cell adhesion	IBA Inferred from Biological aspect of Ancestor more info
involved_in cell-cell adhesion	IEA Inferred from Electronic Annotation more info
involved_in phagocytosis	IEA Inferred from Electronic Annotation more info
involved_in regulation of synapse assembly	IEA Inferred from Electronic Annotation more info

Component	Evidence Code	Pubs
located_in glutamatergic synapse	IEA Inferred from Electronic Annotation more info
is_active_in plasma membrane	IBA Inferred from Biological aspect of Ancestor more info
located_in plasma membrane	TAS Traceable Author Statement more info
located_in postsynapse	IEA Inferred from Electronic Annotation more info

General protein information

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Preferred Names: intercellular adhesion molecule 5

Names: ICAM-5; intercellular adhesion molecule 5, telencephalin; telencephalin

NCBI Reference Sequences (RefSeq)

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RefSeqs maintained independently of Annotated Genomes

These reference sequences exist independently of genome builds. Explain

These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

mRNA and Protein(s)

NM_003259.4 → NP_003250.3 intercellular adhesion molecule 5 precursor

See identical proteins and their annotated locations for NP_003250.3

Status: REVIEWED

Source sequence(s)

AC011511, AI199660, AI568610, BC030132, U72671

Consensus CDS

CCDS12233.1

UniProtKB/Swiss-Prot

Q9UMF0, Q9Y6F3

UniProtKB/TrEMBL

Q8TAM9

Related

ENSP00000221980.3, ENST00000221980.5

Conserved Domains (6) summary

cd05755
Location:120 → 219

Ig2_ICAM-1_like; Second immunoglobulin (Ig)-like domain of intercellular cell adhesion molecule-1 (ICAM-1, CD54) and similar proteins

smart00408
Location:761 → 821

IGc2; Immunoglobulin C-2 Type

smart00410
Location:759 → 831

IG_like; Immunoglobulin like

pfam03921
Location:31 → 103

ICAM_N; Intercellular adhesion molecule (ICAM), N-terminal domain

pfam13895
Location:325 → 404

Ig_2; Immunoglobulin domain

cl11960
Location:512 → 570

Ig; Immunoglobulin domain