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    UBA2 ubiquitin like modifier activating enzyme 2 [ Macaca mulatta (Rhesus monkey) ]

    Gene ID: 705808, updated on 17-Aug-2024

    Summary

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    Official Symbol
    UBA2provided by VGNC
    Official Full Name
    ubiquitin like modifier activating enzyme 2provided by VGNC
    Primary source
    VGNC:VGNC:97838
    Locus tag
    EGK_10449
    See related
    Ensembl:ENSMMUG00000005884
    Gene type
    protein coding
    RefSeq status
    MODEL
    Organism
    Macaca mulatta
    Lineage
    Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Primates; Haplorrhini; Catarrhini; Cercopithecidae; Cercopithecinae; Macaca
    Orthologs
    human mouse all
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    Genomic context

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    See UBA2 in Genome Data Viewer
    Location:
    chromosome: 19
    Exon count:
    17
    Annotation release Status Assembly Chr Location
    103 current Mmul_10 (GCF_003339765.1) 19 NC_041772.1 (33937356..33979916)
    102 previous assembly Mmul_8.0.1 (GCF_000772875.2) 19 NC_027911.1 (30422563..30466112)

    Chromosome 19 - NC_041772.1Genomic Context describing neighboring genes Neighboring gene glucose-6-phosphate isomerase Neighboring gene programmed cell death 2 like Neighboring gene uncharacterized LOC114674101 Neighboring gene WT1 interacting protein Neighboring gene endogenous retrovirus group K member 19 Env polyprotein-like

    Genomic regions, transcripts, and products

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    Go to nucleotide: Graphics FASTA GenBank

    Bibliography

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    Related articles in PubMed

    1. A new rhesus macaque assembly and annotation for next-generation sequencing analyses. Zimin AV, et al. Biol Direct, 2014 Oct 14. PMID 25319552, Free PMC Article
    2. Manual GO annotation of predictive protein signatures: the InterPro approach to GO curation. Burge S, et al. Database (Oxford), 2012. PMID 22301074, Free PMC Article
    3. TreeGrafter: phylogenetic tree-based annotation of proteins with Gene Ontology terms and other annotations. Tang H, et al. Bioinformatics, 2019 Feb 1. PMID 30032202, Free PMC Article

    GeneRIFs: Gene References Into Functions

    General gene information

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    Markers

    Homology

    Gene Ontology Provided by RefSeq

    Function Evidence Code Pubs
    enables SUMO activating enzyme activity IEA
    Inferred from Electronic Annotation
    more info
    		 PubMed 
    Process Evidence Code Pubs
    involved_in protein sumoylation IEA
    Inferred from Electronic Annotation
    more info
    		 PubMed 
    Component Evidence Code Pubs
    part_of SUMO activating enzyme complex IEA
    Inferred from Electronic Annotation
    more info
    		 PubMed 
    located_in cytoplasm IEA
    Inferred from Electronic Annotation
    more info
    		 PubMed 

    General protein information

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    Preferred Names
    SUMO-activating enzyme subunit 2
    Names
    SUMO-1 activating enzyme subunit 2
    XP_001091974.2
    XP_028695382.1

    NCBI Reference Sequences (RefSeq)

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    RefSeqs of Annotated Genomes: Macaca mulatta Annotation Release 103 details...Open this link in a new tab

    The following sections contain reference sequences that belong to a specific genome build. Explain

    Reference Mmul_10 Primary Assembly

    Genomic

    1. NC_041772.1 Reference Mmul_10 Primary Assembly

      Range
      33937356..33979916
      Download
      GenBank, FASTA, Sequence Viewer (Graphics)

    mRNA and Protein(s)

    1. XM_001091974.4 → XP_001091974.2  SUMO-activating enzyme subunit 2 isoform X1

      UniProtKB/TrEMBL
      A0A663DGH8, A0A8J8XEP8, F6TLE0, G7NM30, H9ETZ4
      Related
      ENSMMUP00000007742.3, ENSMMUT00000008236.4
      Conserved Domains (5) summary
      cd01489
      Location:19 → 444
      Uba2_SUMO; Ubiquitin activating enzyme (E1) subunit UBA2. UBA2 is part of the heterodimeric activating enzyme (E1), specific for the SUMO family of ubiquitin-like proteins (Ubls). E1 enzymes are part of a conjugation cascade to attach Ub or Ubls, covalently to ...
      pfam00899
      Location:9 → 175
      ThiF; ThiF family
      pfam10585
      Location:179 → 362
      UBA_e1_thiolCys; Ubiquitin-activating enzyme active site
      pfam14732
      Location:452 → 538
      UAE_UbL; Ubiquitin/SUMO-activating enzyme ubiquitin-like domain
      pfam16195
      Location:549 → 635
      UBA2_C; SUMO-activating enzyme subunit 2 C-terminus

    2. XM_028839549.1 → XP_028695382.1  SUMO-activating enzyme subunit 2 isoform X2

      UniProtKB/TrEMBL
      H9ETZ4
      Conserved Domains (4) summary
      cl22428
      Location:19 → 375
      E1_enzyme_family; Superfamily of activating enzymes (E1) of the ubiquitin-like proteins. This family includes classical ubiquitin-activating enzymes E1, ubiquitin-like (ubl) activating enzymes and other mechanistic homologes, like MoeB, Thif1 and others. The common ...
      pfam16195
      Location:480 → 566
      UBA2_C; SUMO-activating enzyme subunit 2 C-terminus
      pfam10585
      Location:179 → 284
      UBA_e1_thiolCys; Ubiquitin-activating enzyme active site
      pfam14732
      Location:383 → 469
      UAE_UbL; Ubiquitin/SUMO-activating enzyme ubiquitin-like domain
    Nucleotide Protein
    Heading Accession and Version

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