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    TLL2 tolloid like 2 [ Macaca mulatta (Rhesus monkey) ]

    Gene ID: 705290, updated on 17-Aug-2024

    Summary

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    Official Symbol
    TLL2provided by VGNC
    Official Full Name
    tolloid like 2provided by VGNC
    Primary source
    VGNC:VGNC:78370
    See related
    Ensembl:ENSMMUG00000015826
    Gene type
    protein coding
    RefSeq status
    MODEL
    Organism
    Macaca mulatta
    Lineage
    Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Primates; Haplorrhini; Catarrhini; Cercopithecidae; Cercopithecinae; Macaca
    Orthologs
    human mouse all
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    Genomic context

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    See TLL2 in Genome Data Viewer
    Location:
    chromosome: 9
    Exon count:
    22
    Annotation release Status Assembly Chr Location
    103 current Mmul_10 (GCF_003339765.1) 9 NC_041762.1 (96785739..96934384, complement)
    102 previous assembly Mmul_8.0.1 (GCF_000772875.2) 9 NC_027901.1 (91829719..91977117, complement)

    Chromosome 9 - NC_041762.1Genomic Context describing neighboring genes Neighboring gene uncharacterized LOC107000242 Neighboring gene DNA nucleotidylexotransferase Neighboring gene uncharacterized LOC107000243 Neighboring gene oligodendrocytic myelin paranodal and inner loop protein Neighboring gene transmembrane 9 superfamily member 3 Neighboring gene nucleophosmin pseudogene Neighboring gene phosphoinositide-3-kinase adaptor protein 1

    Genomic regions, transcripts, and products

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    Go to nucleotide: Graphics FASTA GenBank

    Bibliography

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    Related articles in PubMed

    1. A new rhesus macaque assembly and annotation for next-generation sequencing analyses. Zimin AV, et al. Biol Direct, 2014 Oct 14. PMID 25319552, Free PMC Article
    2. Manual GO annotation of predictive protein signatures: the InterPro approach to GO curation. Burge S, et al. Database (Oxford), 2012. PMID 22301074, Free PMC Article

    GeneRIFs: Gene References Into Functions

    General gene information

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    Homology

    Gene Ontology Provided by RefSeq

    Function Evidence Code Pubs
    enables calcium ion binding IEA
    Inferred from Electronic Annotation
    more info
    		 PubMed 
    enables metalloendopeptidase activity IEA
    Inferred from Electronic Annotation
    more info
    		 PubMed 
    enables zinc ion binding IEA
    Inferred from Electronic Annotation
    more info
    		 PubMed 
    Process Evidence Code Pubs
    involved_in proteolysis IEA
    Inferred from Electronic Annotation
    more info
    		 PubMed 

    General protein information

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    Preferred Names
    tolloid-like protein 2
    XP_015003325.1
    XP_015003326.1
    XP_028682547.1

    NCBI Reference Sequences (RefSeq)

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    RefSeqs of Annotated Genomes: Macaca mulatta Annotation Release 103 details...Open this link in a new tab

    The following sections contain reference sequences that belong to a specific genome build. Explain

    Reference Mmul_10 Primary Assembly

    Genomic

    1. NC_041762.1 Reference Mmul_10 Primary Assembly

      Range
      96785739..96934384 complement
      Download
      GenBank, FASTA, Sequence Viewer (Graphics)

    mRNA and Protein(s)

    1. XM_015147839.2 → XP_015003325.1  tolloid-like protein 2 isoform X1

      UniProtKB/TrEMBL
      F7CEL9, G7N2N2
      Related
      ENSMMUP00000020803.4, ENSMMUT00000022234.4
      Conserved Domains (4) summary
      cd04281
      Location:150 → 349
      ZnMc_BMP1_TLD; Zinc-dependent metalloprotease; BMP1/TLD-like subfamily. BMP1 (Bone morphogenetic protein 1) and TLD (tolloid)-like metalloproteases play vital roles in extracellular matrix formation, by cleaving precursor proteins such as enzymes, structural proteins, ...
      pfam00431
      Location:464 → 573
      CUB; CUB domain
      pfam01400
      Location:157 → 350
      Astacin; Astacin (Peptidase family M12A)
      pfam14670
      Location:736 → 771
      FXa_inhibition; Coagulation Factor Xa inhibitory site

    2. XM_028826714.1 → XP_028682547.1  tolloid-like protein 2 isoform X2

      UniProtKB/TrEMBL
      G7N2N2
      Conserved Domains (3) summary
      cd04281
      Location:124 → 323
      ZnMc_BMP1_TLD; Zinc-dependent metalloprotease; BMP1/TLD-like subfamily. BMP1 (Bone morphogenetic protein 1) and TLD (tolloid)-like metalloproteases play vital roles in extracellular matrix formation, by cleaving precursor proteins such as enzymes, structural proteins, ...
      pfam00431
      Location:438 → 547
      CUB; CUB domain
      pfam14670
      Location:710 → 745
      FXa_inhibition; Coagulation Factor Xa inhibitory site

    3. XM_015147840.2 → XP_015003326.1  tolloid-like protein 2 isoform X3

      UniProtKB/TrEMBL
      G7N2N2
      Conserved Domains (4) summary
      pfam00431
      Location:281 → 390
      CUB; CUB domain
      pfam01400
      Location:1 → 167
      Astacin; Astacin (Peptidase family M12A)
      pfam14670
      Location:553 → 588
      FXa_inhibition; Coagulation Factor Xa inhibitory site
      cl00064
      Location:1 → 166
      ZnMc; Zinc-dependent metalloprotease. This super-family of metalloproteases contains two major branches, the astacin-like proteases and the adamalysin/reprolysin-like proteases. Both branches have wide phylogenetic distribution, and contain sub-families, which ...
    Nucleotide Protein
    Heading Accession and Version

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