Hdac8 histone deacetylase 8 [Mus musculus (house mouse)] - Gene

Summary

Official Symbol: Hdac8provided by MGI
Official Full Name: histone deacetylase 8provided by MGI
Primary source: MGI:MGI:1917565
See related: Ensembl:ENSMUSG00000067567 AllianceGenome:MGI:1917565
Gene type: protein coding
RefSeq status: VALIDATED
Organism: Mus musculus
Lineage: Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha; Muroidea; Muridae; Murinae; Mus; Mus
Also known as: 2610007D20Rik
Summary: Predicted to enable chromatin binding activity; heat shock protein binding activity; and hydrolase activity, acting on carbon-nitrogen (but not peptide) bonds, in linear amides. Predicted to be involved in several processes, including cellular response to forskolin; cellular response to trichostatin A; and regulation of gene expression. Predicted to be located in cytoplasm. Predicted to be part of histone deacetylase complex. Predicted to be active in nucleus. Is expressed in several structures, including 2-cell stage embryo; brain; embryo ectoderm; foregut; and retina. Used to study Cornelia de Lange syndrome 5. Human ortholog(s) of this gene implicated in Cornelia de Lange syndrome 5 and Wilson-Turner syndrome. Orthologous to human HDAC8 (histone deacetylase 8). [provided by Alliance of Genome Resources, Nov 2024]
Expression: Ubiquitous expression in cerebellum adult (RPKM 1.2), bladder adult (RPKM 1.0) and 28 other tissues See more
Orthologs: human all
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Genomic context

Location:: X D; X 45.28 cM

Exon count:: 15

Annotation release	Status	Assembly	Chr	Location
RS_2024_02	current	GRCm39 (GCF_000001635.27)	X	NC_000086.8 (101328244..101549005, complement)
108.20200622	previous assembly	GRCm38.p6 (GCF_000001635.26)	X	NC_000086.7 (102284638..102505381, complement)

Chromosome X - NC_000086.8 Genomic Context describing neighboring genes

Genomic regions, transcripts, and products

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Go to reference sequence details

Genomic Sequence:

Go to nucleotide: Graphics FASTA GenBank

Expression

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See details

Project title: Mouse ENCODE transcriptome data Mouse ENCODE transcriptome data
Description: RNA profiling data sets generated by the Mouse ENCODE project.
BioProject: PRJNA66167
Publication: PMID 25409824
Analysis date: n/a

Bibliography

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GeneRIFs: Gene References Into Functions

What's a GeneRIF?

Inhibition of HDAC8 Reduces the Proliferation of Adult Neural Stem Cells in the Subventricular Zone.
Title: Inhibition of HDAC8 Reduces the Proliferation of Adult Neural Stem Cells in the Subventricular Zone.
Histone deacetylase 8 inhibition prevents the progression of peritoneal fibrosis by counteracting the epithelial-mesenchymal transition and blockade of M2 macrophage polarization.
Title: Histone deacetylase 8 inhibition prevents the progression of peritoneal fibrosis by counteracting the epithelial-mesenchymal transition and blockade of M2 macrophage polarization.
Histone deacetylase 8 regulates NF-kappaB-related inflammation in asthmatic mice through H3K9 acetylation.
Title: Histone deacetylase 8 regulates NF-κB-related inflammation in asthmatic mice through H3K9 acetylation.
Histone-deacetylase 8 drives the immune response and the growth of glioma.
Title: Histone-deacetylase 8 drives the immune response and the growth of glioma.
MiR-451a ameliorates alcoholic hepatitis via repressing HDAC8-mediated proinflammatory response.
Title: MiR-451a ameliorates alcoholic hepatitis via repressing HDAC8-mediated proinflammatory response.
Identification of histone deacetylase 8 as a novel therapeutic target for renal fibrosis.
Title: Identification of histone deacetylase 8 as a novel therapeutic target for renal fibrosis.
The activity of HDAC2 and HDAC8 was elevated 7 days after the ischemia both in neurons and astrocytes of the studied brain structures.
Title: Expression of Class I Histone Deacetylases in Ipsilateral and Contralateral Hemispheres after the Focal Photothrombotic Infarction in the Mouse Brain.
HDAC8 regulates neural differentiation by exerting control of embryoid body formation.
Title: HDAC8 regulates neural differentiation through embryoid body formation in P19 cells.
Results indicate that HDAC8 functions to modulate p53 activity to ensure long-term hematopoietic stem cells (LT-HSCs) maintenance and cell survival under stress.
Title: HDAC8 regulates long-term hematopoietic stem-cell maintenance under stress by modulating p53 activity.
The findings suggest that miR-455-3p plays a critical role during chondrogenesis by directly targeting HDAC2/8 and promoting histone H3 acetylation.
Title: MicroRNA-455-3p modulates cartilage development and degeneration through modification of histone H3 acetylation.

Submit: New GeneRIF Correction See all GeneRIFs (17)

Variation

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Alleles

Alleles of this type are documented at Mouse Genome Informatics (MGI)

Endonuclease-mediated (1)
Targeted (6) 1 citation

Interactions

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Products	Interactant	Other Gene	Complex	Source	Pubs	Description

General gene information

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Markers

px-22f3 (e-PCR)
- UniSTS:257417

px-12a4 (e-PCR)
- UniSTS:257263

Gene Ontology Provided by MGI

Function	Evidence Code	Pubs
enables DNA-binding transcription factor binding	TAS Traceable Author Statement more info	PubMed
enables Hsp70 protein binding	IEA Inferred from Electronic Annotation more info
enables Hsp70 protein binding	ISO Inferred from Sequence Orthology more info
enables Hsp90 protein binding	IEA Inferred from Electronic Annotation more info
enables Hsp90 protein binding	ISO Inferred from Sequence Orthology more info
enables chromatin binding	ISO Inferred from Sequence Orthology more info
enables deacetylase activity	ISO Inferred from Sequence Orthology more info
enables histone deacetylase activity	IBA Inferred from Biological aspect of Ancestor more info
enables histone deacetylase activity	ISO Inferred from Sequence Orthology more info
enables histone deacetylase activity	ISS Inferred from Sequence or Structural Similarity more info
enables histone deacetylase activity	TAS Traceable Author Statement more info	PubMed
enables histone decrotonylase activity	ISO Inferred from Sequence Orthology more info
enables histone decrotonylase activity	ISS Inferred from Sequence or Structural Similarity more info
enables metal ion binding	IEA Inferred from Electronic Annotation more info
enables protein lysine deacetylase activity	ISO Inferred from Sequence Orthology more info

Process	Evidence Code	Pubs
involved_in cellular response to forskolin	ISO Inferred from Sequence Orthology more info
involved_in cellular response to trichostatin A	ISO Inferred from Sequence Orthology more info
involved_in chromatin organization	TAS Traceable Author Statement more info	PubMed
involved_in chromatin remodeling	IEA Inferred from Electronic Annotation more info
involved_in epigenetic regulation of gene expression	IBA Inferred from Biological aspect of Ancestor more info
involved_in mitotic sister chromatid cohesion	ISO Inferred from Sequence Orthology more info
involved_in mitotic sister chromatid cohesion	ISS Inferred from Sequence or Structural Similarity more info
involved_in negative regulation of gene expression	ISO Inferred from Sequence Orthology more info
involved_in negative regulation of osteoblast differentiation	ISO Inferred from Sequence Orthology more info
involved_in negative regulation of protein modification process	ISO Inferred from Sequence Orthology more info
involved_in negative regulation of protein ubiquitination	IEA Inferred from Electronic Annotation more info
involved_in negative regulation of protein ubiquitination	ISO Inferred from Sequence Orthology more info
involved_in regulation of protein stability	IEA Inferred from Electronic Annotation more info
involved_in regulation of protein stability	ISO Inferred from Sequence Orthology more info
involved_in regulation of telomere maintenance	IEA Inferred from Electronic Annotation more info
involved_in regulation of telomere maintenance	ISO Inferred from Sequence Orthology more info
involved_in response to 11-deoxycorticosterone	ISO Inferred from Sequence Orthology more info

Component	Evidence Code	Pubs
located_in chromosome	IEA Inferred from Electronic Annotation more info
located_in cytoplasm	TAS Traceable Author Statement more info	PubMed
part_of histone deacetylase complex	TAS Traceable Author Statement more info	PubMed
is_active_in nucleus	IBA Inferred from Biological aspect of Ancestor more info
located_in nucleus	TAS Traceable Author Statement more info	PubMed

General protein information

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Preferred Names: histone deacetylase 8

Names: HD8; protein deacetylase HDAC8; protein decrotonylase HDAC8

NP_001300671.1

EC 3.5.1.98

NP_081658.1

EC 3.5.1.98

XP_006528338.1

EC 3.5.1.98

XP_006528339.1

EC 3.5.1.98

XP_011245973.1

EC 3.5.1.98

XP_011245975.1

EC 3.5.1.98

NCBI Reference Sequences (RefSeq)

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RefSeqs maintained independently of Annotated Genomes

These reference sequences exist independently of genome builds. Explain

These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

mRNA and Protein(s)

NM_001313742.1 → NP_001300671.1 histone deacetylase 8 isoform 2

Status: VALIDATED

Description

Transcript Variant: This variant (2) lacks several exons and includes an alternate 3' terminal exon compared to variant 1. The resulting isoform (2) has a shorter and distinct C-terminus compared to isoform 1.

Source sequence(s)

AK034511, AK131998

UniProtKB/Swiss-Prot

Q8VH37

Related

ENSMUST00000148481.8

Conserved Domains (1) summary

cl17011
Location:16 → 246

Arginase_HDAC; Arginase-like and histone-like hydrolases
NM_027382.4 → NP_081658.1 histone deacetylase 8 isoform 1

See identical proteins and their annotated locations for NP_081658.1

Status: VALIDATED

Description

Transcript Variant: This variant (1) encodes the longer isoform (1).

Source sequence(s)

AK131998, AL954850

Consensus CDS

CCDS41084.1

UniProtKB/Swiss-Prot

Q3V270, Q8VH37, Q9D0K6

Related

ENSMUSP00000085226.5, ENSMUST00000087916.11

Conserved Domains (1) summary

cd10000
Location:16 → 377

HDAC8; Histone deacetylase 8 (HDAC8)

RefSeqs of Annotated Genomes: GCF_000001635.27-RS_2024_02

The following sections contain reference sequences that belong to a specific genome build. Explain

Reference GRCm39 C57BL/6J

Genomic

NC_000086.8 Reference GRCm39 C57BL/6J

Range

101328244..101549005 complement

Download

GenBank, FASTA, Sequence Viewer (Graphics)

mRNA and Protein(s)

XM_006528276.5 → XP_006528339.1 histone deacetylase 8 isoform X2

Conserved Domains (1) summary

cd10000
Location:16 → 335

HDAC8; Histone deacetylase 8 (HDAC8)
XM_006528275.5 → XP_006528338.1 histone deacetylase 8 isoform X1

Conserved Domains (1) summary

cd10000
Location:16 → 370

HDAC8; Histone deacetylase 8 (HDAC8)
XM_011247671.4 → XP_011245973.1 histone deacetylase 8 isoform X3

Conserved Domains (1) summary

cd10000
Location:16 → 335

HDAC8; Histone deacetylase 8 (HDAC8)
XM_011247673.4 → XP_011245975.1 histone deacetylase 8 isoform X4

Conserved Domains (1) summary

cl17011
Location:16 → 153

Arginase_HDAC; Arginase-like and histone-like hydrolases