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    FMR1 Fragile X messenger ribonucleoprotein 1 [ Macaca mulatta (Rhesus monkey) ]

    Gene ID: 700138, updated on 17-Aug-2024

    Summary

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    Official Symbol
    FMR1provided by VGNC
    Official Full Name
    Fragile X messenger ribonucleoprotein 1provided by VGNC
    Primary source
    VGNC:VGNC:72687
    See related
    Ensembl:ENSMMUG00000015814
    Gene type
    protein coding
    RefSeq status
    MODEL
    Organism
    Macaca mulatta
    Lineage
    Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Primates; Haplorrhini; Catarrhini; Cercopithecidae; Cercopithecinae; Macaca
    Orthologs
    human mouse all
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    Genomic context

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    See FMR1 in Genome Data Viewer
    Location:
    chromosome: X
    Exon count:
    18
    Annotation release Status Assembly Chr Location
    103 current Mmul_10 (GCF_003339765.1) X NC_041774.1 (143932009..143970686)
    102 previous assembly Mmul_8.0.1 (GCF_000772875.2) X NC_027913.1 (141614593..141655932)

    Chromosome X - NC_041774.1Genomic Context describing neighboring genes Neighboring gene uncharacterized LOC106995351 Neighboring gene microRNA mir-514a Neighboring gene U6 spliceosomal RNA Neighboring gene FMR1 neighbor Neighboring gene HCLS1-associated protein X-1 pseudogene

    Genomic regions, transcripts, and products

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    Go to nucleotide: Graphics FASTA GenBank

    Bibliography

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    GeneRIFs: Gene References Into Functions

    General gene information

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    Markers

    Homology

    Gene Ontology Provided by RefSeq

    Function Evidence Code Pubs
    enables mRNA 3'-UTR binding IEA
    Inferred from Electronic Annotation
    more info
    		 PubMed 
    enables protein homodimerization activity IEA
    Inferred from Electronic Annotation
    more info
    		 PubMed 
    enables translation regulator activity IEA
    Inferred from Electronic Annotation
    more info
    		 PubMed 
    Process Evidence Code Pubs
    involved_in DNA damage response IEA
    Inferred from Electronic Annotation
    more info
    		 PubMed 
    involved_in anterograde axonal transport IEA
    Inferred from Electronic Annotation
    more info
    		 PubMed 
    involved_in central nervous system development IEA
    Inferred from Electronic Annotation
    more info
    		 PubMed 
    involved_in negative regulation of translation IEA
    Inferred from Electronic Annotation
    more info
    		 PubMed 
    involved_in positive regulation of protein phosphorylation IEA
    Inferred from Electronic Annotation
    more info
    		 PubMed 
    involved_in positive regulation of translation IEA
    Inferred from Electronic Annotation
    more info
    		 PubMed 
    involved_in regulation of alternative mRNA splicing, via spliceosome IEA
    Inferred from Electronic Annotation
    more info
    		 PubMed 
    involved_in regulation of dendrite morphogenesis IEA
    Inferred from Electronic Annotation
    more info
    		 PubMed 
    involved_in regulation of dendritic spine development IEA
    Inferred from Electronic Annotation
    more info
    		 PubMed 
    involved_in regulation of filopodium assembly IEA
    Inferred from Electronic Annotation
    more info
    		 PubMed 
    involved_in regulation of mRNA stability IEA
    Inferred from Electronic Annotation
    more info
    		 PubMed 
    involved_in regulation of modification of synaptic structure IEA
    Inferred from Electronic Annotation
    more info
    		 PubMed 
    involved_in regulation of translation at postsynapse, modulating synaptic transmission IEA
    Inferred from Electronic Annotation
    more info
    		 PubMed 
    Component Evidence Code Pubs
    located_in axon IEA
    Inferred from Electronic Annotation
    more info
    		 PubMed 
    located_in dendritic filopodium IEA
    Inferred from Electronic Annotation
    more info
    		 PubMed 
    located_in dendritic spine IEA
    Inferred from Electronic Annotation
    more info
    		 PubMed 
    located_in dendritic spine neck IEA
    Inferred from Electronic Annotation
    more info
    		 PubMed 
    located_in growth cone IEA
    Inferred from Electronic Annotation
    more info
    		 PubMed 
    located_in membrane IEA
    Inferred from Electronic Annotation
    more info
    		 PubMed 
    located_in neuronal cell body IEA
    Inferred from Electronic Annotation
    more info
    		 PubMed 
    located_in neuronal ribonucleoprotein granule IEA
    Inferred from Electronic Annotation
    more info
    		 PubMed 
    located_in nucleus IEA
    Inferred from Electronic Annotation
    more info
    		 PubMed 
    located_in postsynaptic density IEA
    Inferred from Electronic Annotation
    more info
    		 PubMed 
    located_in presynapse IEA
    Inferred from Electronic Annotation
    more info
    		 PubMed 

    General protein information

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    Preferred Names
    synaptic functional regulator FMR1
    Names
    FMRP translational regulator 1

    NCBI Reference Sequences (RefSeq)

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    NEW Try the new Transcript table

    RefSeqs of Annotated Genomes: Macaca mulatta Annotation Release 103 details...Open this link in a new tab

    The following sections contain reference sequences that belong to a specific genome build. Explain

    Reference Mmul_10 Primary Assembly

    Genomic

    1. NC_041774.1 Reference Mmul_10 Primary Assembly

      Range
      143932009..143970686
      Download
      GenBank, FASTA, Sequence Viewer (Graphics)

    mRNA and Protein(s)

    1. XM_015128369.2 → XP_014983855.1  synaptic functional regulator FMR1 isoform X9

      UniProtKB/TrEMBL
      H9Z6Y7, I0FIR2
      Conserved Domains (5) summary
      pfam12235
      Location:399 → 469
      FXMRP1_C_core; Fragile X-related 1 protein core C terminal
      pfam16098
      Location:504 → 586
      FXMR_C2; Fragile X-related mental retardation protein C-terminal region 2
      cd20471
      Location:1 → 55
      Tudor_Agenet_FMR1_rpt1; first Tudor-like Agenet domain found in synaptic functional regulator FMR1 and similar proteins
      cd20474
      Location:58 → 120
      Tudor_Agenet_FMR1_rpt2; second Tudor-like Agenet domain found in synaptic functional regulator FMR1 and similar proteins
      cl00098
      Location:123 → 199
      KH-I; K homology (KH) RNA-binding domain, type I

    2. XM_015128359.2 → XP_014983845.1  synaptic functional regulator FMR1 isoform X1

      UniProtKB/TrEMBL
      H9ERS1, H9Z6Y4, I0FIR3
      Related
      ENSMMUP00000058618.1, ENSMMUT00000055789.2
      Conserved Domains (5) summary
      pfam12235
      Location:420 → 524
      FXMRP1_C_core; Fragile X-related 1 protein core C terminal
      pfam16098
      Location:550 → 632
      FXMR_C2; Fragile X-related mental retardation protein C-terminal region 2
      cd20471
      Location:1 → 55
      Tudor_Agenet_FMR1_rpt1; first Tudor-like Agenet domain found in synaptic functional regulator FMR1 and similar proteins
      cd20474
      Location:58 → 120
      Tudor_Agenet_FMR1_rpt2; second Tudor-like Agenet domain found in synaptic functional regulator FMR1 and similar proteins
      cl00098
      Location:123 → 199
      KH-I; K homology (KH) RNA-binding domain, type I

    3. XM_015128362.2 → XP_014983848.1  synaptic functional regulator FMR1 isoform X3

      UniProtKB/TrEMBL
      H9ERS1, H9Z6Y4
      Conserved Domains (7) summary
      pfam12235
      Location:420 → 524
      FXMRP1_C_core; Fragile X-related 1 protein core C terminal
      pfam16098
      Location:550 → 615
      FXMR_C2; Fragile X-related mental retardation protein C-terminal region 2
      cd20471
      Location:1 → 55
      Tudor_Agenet_FMR1_rpt1; first Tudor-like Agenet domain found in synaptic functional regulator FMR1 and similar proteins
      cd20474
      Location:58 → 120
      Tudor_Agenet_FMR1_rpt2; second Tudor-like Agenet domain found in synaptic functional regulator FMR1 and similar proteins
      cd22506
      Location:123 → 199
      KH_I_FMR1_rpt1; first type I K homology (KH) RNA-binding domain found in fragile X mental retardation protein 1 (FMR1) and similar proteins
      cd22509
      Location:218 → 280
      KH_I_FMR1_rpt2; second type I K homology (KH) RNA-binding domain found in fragile X mental retardation protein 1 (FMR1) and similar proteins
      cl00098
      Location:281 → 424
      KH-I; K homology (KH) RNA-binding domain, type I

    4. XM_015128360.2 → XP_014983846.1  synaptic functional regulator FMR1 isoform X2

      UniProtKB/TrEMBL
      H9ERS1, H9Z6Y4
      Conserved Domains (7) summary
      pfam12235
      Location:420 → 512
      FXMRP1_C_core; Fragile X-related 1 protein core C terminal
      pfam16098
      Location:538 → 620
      FXMR_C2; Fragile X-related mental retardation protein C-terminal region 2
      cd20471
      Location:1 → 55
      Tudor_Agenet_FMR1_rpt1; first Tudor-like Agenet domain found in synaptic functional regulator FMR1 and similar proteins
      cd20474
      Location:58 → 120
      Tudor_Agenet_FMR1_rpt2; second Tudor-like Agenet domain found in synaptic functional regulator FMR1 and similar proteins
      cd22506
      Location:123 → 199
      KH_I_FMR1_rpt1; first type I K homology (KH) RNA-binding domain found in fragile X mental retardation protein 1 (FMR1) and similar proteins
      cd22509
      Location:218 → 280
      KH_I_FMR1_rpt2; second type I K homology (KH) RNA-binding domain found in fragile X mental retardation protein 1 (FMR1) and similar proteins
      cl00098
      Location:281 → 424
      KH-I; K homology (KH) RNA-binding domain, type I

    5. XM_015128366.2 → XP_014983852.1  synaptic functional regulator FMR1 isoform X6

      UniProtKB/TrEMBL
      H9ERS1, H9Z6Y4
      Conserved Domains (7) summary
      pfam12235
      Location:420 → 512
      FXMRP1_C_core; Fragile X-related 1 protein core C terminal
      pfam16098
      Location:538 → 603
      FXMR_C2; Fragile X-related mental retardation protein C-terminal region 2
      cd20471
      Location:1 → 55
      Tudor_Agenet_FMR1_rpt1; first Tudor-like Agenet domain found in synaptic functional regulator FMR1 and similar proteins
      cd20474
      Location:58 → 120
      Tudor_Agenet_FMR1_rpt2; second Tudor-like Agenet domain found in synaptic functional regulator FMR1 and similar proteins
      cd22506
      Location:123 → 199
      KH_I_FMR1_rpt1; first type I K homology (KH) RNA-binding domain found in fragile X mental retardation protein 1 (FMR1) and similar proteins
      cd22509
      Location:218 → 280
      KH_I_FMR1_rpt2; second type I K homology (KH) RNA-binding domain found in fragile X mental retardation protein 1 (FMR1) and similar proteins
      cl00098
      Location:281 → 424
      KH-I; K homology (KH) RNA-binding domain, type I

    6. XM_015128364.2 → XP_014983850.1  synaptic functional regulator FMR1 isoform X5

      UniProtKB/TrEMBL
      H9Z6Y7
      Conserved Domains (7) summary
      pfam12235
      Location:420 → 490
      FXMRP1_C_core; Fragile X-related 1 protein core C terminal
      pfam16098
      Location:525 → 607
      FXMR_C2; Fragile X-related mental retardation protein C-terminal region 2
      cd20471
      Location:1 → 55
      Tudor_Agenet_FMR1_rpt1; first Tudor-like Agenet domain found in synaptic functional regulator FMR1 and similar proteins
      cd20474
      Location:58 → 120
      Tudor_Agenet_FMR1_rpt2; second Tudor-like Agenet domain found in synaptic functional regulator FMR1 and similar proteins
      cd22506
      Location:123 → 199
      KH_I_FMR1_rpt1; first type I K homology (KH) RNA-binding domain found in fragile X mental retardation protein 1 (FMR1) and similar proteins
      cd22509
      Location:218 → 280
      KH_I_FMR1_rpt2; second type I K homology (KH) RNA-binding domain found in fragile X mental retardation protein 1 (FMR1) and similar proteins
      cl00098
      Location:281 → 424
      KH-I; K homology (KH) RNA-binding domain, type I

    7. XM_015128368.2 → XP_014983854.1  synaptic functional regulator FMR1 isoform X8

      UniProtKB/TrEMBL
      H9Z6Y7
      Conserved Domains (7) summary
      pfam12235
      Location:420 → 490
      FXMRP1_C_core; Fragile X-related 1 protein core C terminal
      pfam16098
      Location:525 → 590
      FXMR_C2; Fragile X-related mental retardation protein C-terminal region 2
      cd20471
      Location:1 → 55
      Tudor_Agenet_FMR1_rpt1; first Tudor-like Agenet domain found in synaptic functional regulator FMR1 and similar proteins
      cd20474
      Location:58 → 120
      Tudor_Agenet_FMR1_rpt2; second Tudor-like Agenet domain found in synaptic functional regulator FMR1 and similar proteins
      cd22506
      Location:123 → 199
      KH_I_FMR1_rpt1; first type I K homology (KH) RNA-binding domain found in fragile X mental retardation protein 1 (FMR1) and similar proteins
      cd22509
      Location:218 → 280
      KH_I_FMR1_rpt2; second type I K homology (KH) RNA-binding domain found in fragile X mental retardation protein 1 (FMR1) and similar proteins
      cl00098
      Location:281 → 424
      KH-I; K homology (KH) RNA-binding domain, type I

    8. XM_028842440.1 → XP_028698273.1  synaptic functional regulator FMR1 isoform X11

      Conserved Domains (3) summary
      smart00322
      Location:221 → 280
      KH; K homology RNA-binding domain
      pfam00013
      Location:285 → 332
      KH_1; KH domain
      pfam05641
      Location:63 → 117
      Agenet; Agenet domain

    9. XM_028842441.1 → XP_028698274.1  synaptic functional regulator FMR1 isoform X12

      Conserved Domains (3) summary
      smart00322
      Location:221 → 280
      KH; K homology RNA-binding domain
      pfam00013
      Location:285 → 332
      KH_1; KH domain
      pfam05641
      Location:63 → 117
      Agenet; Agenet domain

    10. XM_015128363.2 → XP_014983849.1  synaptic functional regulator FMR1 isoform X4

      UniProtKB/TrEMBL
      H9ERN3, H9Z6Y6, I0FIR4
      Related
      ENSMMUP00000050476.1, ENSMMUT00000061414.2
      Conserved Domains (7) summary
      pfam12235
      Location:399 → 503
      FXMRP1_C_core; Fragile X-related 1 protein core C terminal
      pfam16098
      Location:529 → 611
      FXMR_C2; Fragile X-related mental retardation protein C-terminal region 2
      cd20471
      Location:1 → 55
      Tudor_Agenet_FMR1_rpt1; first Tudor-like Agenet domain found in synaptic functional regulator FMR1 and similar proteins
      cd20474
      Location:58 → 120
      Tudor_Agenet_FMR1_rpt2; second Tudor-like Agenet domain found in synaptic functional regulator FMR1 and similar proteins
      cd22506
      Location:123 → 199
      KH_I_FMR1_rpt1; first type I K homology (KH) RNA-binding domain found in fragile X mental retardation protein 1 (FMR1) and similar proteins
      cd22509
      Location:218 → 280
      KH_I_FMR1_rpt2; second type I K homology (KH) RNA-binding domain found in fragile X mental retardation protein 1 (FMR1) and similar proteins
      cd22512
      Location:281 → 403
      KH_I_FMR1_rpt3; third type I K homology (KH) RNA-binding domain found in fragile X mental retardation protein 1 (FMR1) and similar proteins

    11. XM_015128367.2 → XP_014983853.1  synaptic functional regulator FMR1 isoform X7

      UniProtKB/TrEMBL
      H9ERN3, H9Z6Y6
      Conserved Domains (5) summary
      pfam12235
      Location:399 → 503
      FXMRP1_C_core; Fragile X-related 1 protein core C terminal
      pfam16098
      Location:529 → 594
      FXMR_C2; Fragile X-related mental retardation protein C-terminal region 2
      cd20471
      Location:1 → 55
      Tudor_Agenet_FMR1_rpt1; first Tudor-like Agenet domain found in synaptic functional regulator FMR1 and similar proteins
      cd20474
      Location:58 → 120
      Tudor_Agenet_FMR1_rpt2; second Tudor-like Agenet domain found in synaptic functional regulator FMR1 and similar proteins
      cl00098
      Location:123 → 199
      KH-I; K homology (KH) RNA-binding domain, type I

    12. XM_015128370.2 → XP_014983856.1  synaptic functional regulator FMR1 isoform X10

      UniProtKB/TrEMBL
      H9Z6Y5
      Conserved Domains (5) summary
      pfam12235
      Location:399 → 491
      FXMRP1_C_core; Fragile X-related 1 protein core C terminal
      pfam16098
      Location:517 → 582
      FXMR_C2; Fragile X-related mental retardation protein C-terminal region 2
      cd20471
      Location:1 → 55
      Tudor_Agenet_FMR1_rpt1; first Tudor-like Agenet domain found in synaptic functional regulator FMR1 and similar proteins
      cd20474
      Location:58 → 120
      Tudor_Agenet_FMR1_rpt2; second Tudor-like Agenet domain found in synaptic functional regulator FMR1 and similar proteins
      cl00098
      Location:123 → 199
      KH-I; K homology (KH) RNA-binding domain, type I

    13. XM_028842442.1 → XP_028698275.1  synaptic functional regulator FMR1 isoform X13

      Conserved Domains (3) summary
      smart00322
      Location:221 → 280
      KH; K homology RNA-binding domain
      pfam00013
      Location:285 → 332
      KH_1; KH domain
      pfam05641
      Location:63 → 117
      Agenet; Agenet domain

    14. XM_028842443.1 → XP_028698276.1  synaptic functional regulator FMR1 isoform X14

      UniProtKB/TrEMBL
      H9Z6Y7
      Conserved Domains (6) summary
      pfam12235
      Location:420 → 490
      FXMRP1_C_core; Fragile X-related 1 protein core C terminal
      cd20471
      Location:1 → 55
      Tudor_Agenet_FMR1_rpt1; first Tudor-like Agenet domain found in synaptic functional regulator FMR1 and similar proteins
      cd20474
      Location:58 → 120
      Tudor_Agenet_FMR1_rpt2; second Tudor-like Agenet domain found in synaptic functional regulator FMR1 and similar proteins
      cd22506
      Location:123 → 199
      KH_I_FMR1_rpt1; first type I K homology (KH) RNA-binding domain found in fragile X mental retardation protein 1 (FMR1) and similar proteins
      cd22509
      Location:218 → 280
      KH_I_FMR1_rpt2; second type I K homology (KH) RNA-binding domain found in fragile X mental retardation protein 1 (FMR1) and similar proteins
      cl00098
      Location:281 → 424
      KH-I; K homology (KH) RNA-binding domain, type I
    Nucleotide Protein
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