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    PKM pyruvate kinase M1/2 [ Macaca mulatta (Rhesus monkey) ]

    Gene ID: 697742, updated on 5-Mar-2024

    Summary

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    Gene symbol
    PKM
    Gene description
    pyruvate kinase M1/2
    See related
    Ensembl:ENSMMUG00000023454
    Gene type
    protein coding
    RefSeq status
    MODEL
    Organism
    Macaca mulatta
    Lineage
    Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Primates; Haplorrhini; Catarrhini; Cercopithecidae; Cercopithecinae; Macaca
    Also known as
    PKM2
    Orthologs
    human mouse all
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    Genomic context

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    See PKM in Genome Data Viewer
    Location:
    chromosome: 7
    Exon count:
    14
    Annotation release Status Assembly Chr Location
    103 current Mmul_10 (GCF_003339765.1) 7 NC_041760.1 (48935313..48968834, complement)
    102 previous assembly Mmul_8.0.1 (GCF_000772875.2) 7 NC_027899.1 (49211766..49245983, complement)

    Chromosome 7 - NC_041760.1Genomic Context describing neighboring genes Neighboring gene myosin IXA Neighboring gene uncharacterized LOC106999233 Neighboring gene SUMO peptidase family member, NEDD8 specific Neighboring gene GRAM domain containing 2A Neighboring gene poly(ADP-ribose) polymerase family member 6 Neighboring gene CUGBP Elav-like family member 6

    Genomic regions, transcripts, and products

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    Go to nucleotide: Graphics FASTA GenBank

    Bibliography

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    Related articles in PubMed

    1. A new rhesus macaque assembly and annotation for next-generation sequencing analyses. Zimin AV, et al. Biol Direct, 2014 Oct 14. PMID 25319552, Free PMC Article
    2. Manual GO annotation of predictive protein signatures: the InterPro approach to GO curation. Burge S, et al. Database (Oxford), 2012. PMID 22301074, Free PMC Article
    3. TreeGrafter: phylogenetic tree-based annotation of proteins with Gene Ontology terms and other annotations. Tang H, et al. Bioinformatics, 2019 Feb 1. PMID 30032202, Free PMC Article

    GeneRIFs: Gene References Into Functions

    General gene information

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    Markers

    Homology

    Gene Ontology Provided by RefSeq

    Function Evidence Code Pubs
    enables magnesium ion binding IEA
    Inferred from Electronic Annotation
    more info
    		 PubMed 
    enables potassium ion binding IEA
    Inferred from Electronic Annotation
    more info
    		 PubMed 
    enables pyruvate kinase activity IEA
    Inferred from Electronic Annotation
    more info
    		 PubMed 
    Process Evidence Code Pubs
    involved_in cellular response to insulin stimulus IEA
    Inferred from Electronic Annotation
    more info
    		 PubMed 
    involved_in glycolytic process IEA
    Inferred from Electronic Annotation
    more info
    		 PubMed 
    Component Evidence Code Pubs
    located_in cytoplasm IEA
    Inferred from Electronic Annotation
    more info
    		 PubMed 

    General protein information

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    Preferred Names
    pyruvate kinase PKM
    Names
    pyruvate kinase isozymes M1/M2
    pyruvate kinase, muscle

    NCBI Reference Sequences (RefSeq)

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    RefSeqs of Annotated Genomes: Macaca mulatta Annotation Release 103 details...Open this link in a new tab

    The following sections contain reference sequences that belong to a specific genome build. Explain

    Reference Mmul_10 Primary Assembly

    Genomic

    1. NC_041760.1 Reference Mmul_10 Primary Assembly

      Range
      48935313..48968834 complement
      Download
      GenBank, FASTA, Sequence Viewer (Graphics)

    mRNA and Protein(s)

    1. XM_015142653.2 → XP_014998139.1  pyruvate kinase PKM isoform X3

      UniProtKB/TrEMBL
      F7F0E2, F7FI45, F7GPY9, G7MY48
      Related
      ENSMMUP00000030465.4, ENSMMUT00000032557.4
      Conserved Domains (1) summary
      cd00288
      Location:42 → 530
      Pyruvate_Kinase; Pyruvate kinase (PK): Large allosteric enzyme that regulates glycolysis through binding of the substrate, phosphoenolpyruvate, and one or more allosteric effectors. Like other allosteric enzymes, PK has a high substrate affinity R state and a low ...

    2. XM_028851092.1 → XP_028706925.1  pyruvate kinase PKM isoform X3

      UniProtKB/TrEMBL
      F7F0E2, F7FI45, F7GPY9, G7MY48
      Related
      ENSMMUP00000030877.4, ENSMMUT00000032997.4
      Conserved Domains (1) summary
      cd00288
      Location:42 → 530
      Pyruvate_Kinase; Pyruvate kinase (PK): Large allosteric enzyme that regulates glycolysis through binding of the substrate, phosphoenolpyruvate, and one or more allosteric effectors. Like other allosteric enzymes, PK has a high substrate affinity R state and a low ...

    3. XM_028851093.1 → XP_028706926.1  pyruvate kinase PKM isoform X3

      UniProtKB/TrEMBL
      F7F0E2, F7FI45, F7GPY9, G7MY48
      Related
      ENSMMUP00000065027.1, ENSMMUT00000089073.1
      Conserved Domains (1) summary
      cd00288
      Location:42 → 530
      Pyruvate_Kinase; Pyruvate kinase (PK): Large allosteric enzyme that regulates glycolysis through binding of the substrate, phosphoenolpyruvate, and one or more allosteric effectors. Like other allosteric enzymes, PK has a high substrate affinity R state and a low ...

    4. XM_015142654.2 → XP_014998140.1  pyruvate kinase PKM isoform X4

      UniProtKB/TrEMBL
      F7F0E8, H9FVV7, I0FSN6
      Related
      ENSMMUP00000030876.4, ENSMMUT00000032996.4
      Conserved Domains (1) summary
      cd00288
      Location:42 → 530
      Pyruvate_Kinase; Pyruvate kinase (PK): Large allosteric enzyme that regulates glycolysis through binding of the substrate, phosphoenolpyruvate, and one or more allosteric effectors. Like other allosteric enzymes, PK has a high substrate affinity R state and a low ...

    5. XM_015142651.2 → XP_014998137.2  pyruvate kinase PKM isoform X2

      UniProtKB/TrEMBL
      F7F0E8
      Conserved Domains (1) summary
      cd00288
      Location:102 → 590
      Pyruvate_Kinase; Pyruvate kinase (PK): Large allosteric enzyme that regulates glycolysis through binding of the substrate, phosphoenolpyruvate, and one or more allosteric effectors. Like other allosteric enzymes, PK has a high substrate affinity R state and a low ...

    6. XM_015142652.2 → XP_014998138.1  pyruvate kinase PKM isoform X1

      UniProtKB/TrEMBL
      A0A1D5R3F4
      Related
      ENSMMUP00000054840.2, ENSMMUT00000062546.2
      Conserved Domains (2) summary
      cd00288
      Location:102 → 590
      Pyruvate_Kinase; Pyruvate kinase (PK): Large allosteric enzyme that regulates glycolysis through binding of the substrate, phosphoenolpyruvate, and one or more allosteric effectors. Like other allosteric enzymes, PK has a high substrate affinity R state and a low ...
      TIGR01064
      Location:103 → 587
      pyruv_kin; pyruvate kinase

    7. XM_015142655.1 → XP_014998141.1  pyruvate kinase PKM isoform X5

      UniProtKB/TrEMBL
      F7F0E8
      Conserved Domains (1) summary
      cd00288
      Location:68 → 515
      Pyruvate_Kinase; Pyruvate kinase (PK): Large allosteric enzyme that regulates glycolysis through binding of the substrate, phosphoenolpyruvate, and one or more allosteric effectors. Like other allosteric enzymes, PK has a high substrate affinity R state and a low ...
    Nucleotide Protein
    Heading Accession and Version

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