F9 coagulation factor IX [Macaca mulatta (Rhesus monkey)] - Gene

Summary

Official Symbol: F9provided by VGNC
Official Full Name: coagulation factor IXprovided by VGNC
Primary source: VGNC:VGNC:72468
See related: Ensembl:ENSMMUG00000020064
Gene type: protein coding
RefSeq status: PROVISIONAL
Organism: Macaca mulatta
Lineage: Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Primates; Haplorrhini; Catarrhini; Cercopithecidae; Cercopithecinae; Macaca
Orthologs: human mouse all
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Genomic context

Location:: chromosome: X

Exon count:: 9

Annotation release	Status	Assembly	Chr	Location
103	current	Mmul_10 (GCF_003339765.1)	X	NC_041774.1 (135749469..135782394)
102	previous assembly	Mmul_8.0.1 (GCF_000772875.2)	X	NC_027913.1 (133484695..133517201)

Chromosome X - NC_041774.1 Genomic Context describing neighboring genes

Genomic regions, transcripts, and products

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Genomic Sequence:

Go to nucleotide: Graphics FASTA GenBank

Bibliography

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GeneRIFs: Gene References Into Functions

What's a GeneRIF?

The high homology between rhesus monkey and human coagulation factor X ensure the reliability and feasibility of rhesus monkey as a recipient in studies on coagulation disorders in xenotransplantation.
Title: Cloning, sequencing, and analysis of the full-length CDNA of rhesus monkey factor IX.

Submit: New GeneRIF Correction

General gene information

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Markers

GDB:197039 (e-PCR)
- UniSTS:155920

F9 (e-PCR), detects polymorphism
- UniSTS:525911

GDB:177926 (e-PCR)
- UniSTS:154982

G66628 (e-PCR)
- UniSTS:166823

G66629 (e-PCR)
- UniSTS:166824

F9 (e-PCR), detects polymorphism
- UniSTS:266922

GDB:182121 (e-PCR)
- UniSTS:155348

GDB:192503 (e-PCR)
- UniSTS:99325

Gene Ontology Provided by RefSeq

Function	Evidence Code	Pubs
enables calcium ion binding	IEA Inferred from Electronic Annotation more info	PubMed
enables serine-type endopeptidase activity	IEA Inferred from Electronic Annotation more info	PubMed

Process	Evidence Code	Pubs
involved_in blood coagulation	IEA Inferred from Electronic Annotation more info	PubMed
involved_in zymogen activation	IEA Inferred from Electronic Annotation more info	PubMed

Component	Evidence Code	Pubs
located_in extracellular region	IEA Inferred from Electronic Annotation more info	PubMed
located_in extracellular space	IEA Inferred from Electronic Annotation more info	PubMed

General protein information

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Preferred Names: coagulation factor IX

Names: coagulation factor IX protein

NP_001103153.1

EC 3.4.21.22

XP_028697499.1

EC 3.4.21.22

XP_028697500.1

EC 3.4.21.22

NCBI Reference Sequences (RefSeq)

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RefSeqs maintained independently of Annotated Genomes

These reference sequences exist independently of genome builds. Explain

These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

mRNA and Protein(s)

NM_001109683.1 → NP_001103153.1 coagulation factor IX precursor

See identical proteins and their annotated locations for NP_001103153.1

Status: PROVISIONAL

Source sequence(s)

EU128170

UniProtKB/TrEMBL

A8CZ27

Related

ENSMMUP00000026395.3, ENSMMUT00000028211.4

Conserved Domains (5) summary

smart00020
Location:226 → 454

Tryp_SPc; Trypsin-like serine protease

smart00069
Location:28 → 92

GLA; Domain containing Gla (gamma-carboxyglutamate) residues

cd00054
Location:93 → 129

EGF_CA; Calcium-binding EGF-like domain, present in a large number of membrane-bound and extracellular (mostly animal) proteins. Many of these proteins require calcium for their biological function and calcium-binding sites have been found to be located at the ...

cd00190
Location:227 → 457

Tryp_SPc; Trypsin-like serine protease; Many of these are synthesized as inactive precursor zymogens that are cleaved during limited proteolysis to generate their active forms. Alignment contains also inactive enzymes that have substitutions of the catalytic triad ...

pfam14670
Location:134 → 170

FXa_inhibition; Coagulation Factor Xa inhibitory site

RefSeqs of Annotated Genomes: Macaca mulatta Annotation Release 103 details...

The following sections contain reference sequences that belong to a specific genome build. Explain

Reference Mmul_10 Primary Assembly

Genomic

NC_041774.1 Reference Mmul_10 Primary Assembly

Range

135749469..135782394

Download

GenBank, FASTA, Sequence Viewer (Graphics)

mRNA and Protein(s)

XM_028841667.1 → XP_028697500.1 coagulation factor IX isoform X2

Conserved Domains (3) summary

smart00069
Location:28 → 92

GLA; Domain containing Gla (gamma-carboxyglutamate) residues

cd00190
Location:189 → 419

Tryp_SPc; Trypsin-like serine protease; Many of these are synthesized as inactive precursor zymogens that are cleaved during limited proteolysis to generate their active forms. Alignment contains also inactive enzymes that have substitutions of the catalytic triad ...

pfam14670
Location:96 → 132

FXa_inhibition; Coagulation Factor Xa inhibitory site
XM_028841666.1 → XP_028697499.1 coagulation factor IX isoform X1

Conserved Domains (4) summary

smart00069
Location:4 → 66

GLA; Domain containing Gla (gamma-carboxyglutamate) residues

cd00054
Location:67 → 103

EGF_CA; Calcium-binding EGF-like domain, present in a large number of membrane-bound and extracellular (mostly animal) proteins. Many of these proteins require calcium for their biological function and calcium-binding sites have been found to be located at the ...

cd00190
Location:201 → 431

Tryp_SPc; Trypsin-like serine protease; Many of these are synthesized as inactive precursor zymogens that are cleaved during limited proteolysis to generate their active forms. Alignment contains also inactive enzymes that have substitutions of the catalytic triad ...

pfam14670
Location:108 → 144

FXa_inhibition; Coagulation Factor Xa inhibitory site