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    STAT1 signal transducer and activator of transcription 1 [ Macaca mulatta (Rhesus monkey) ]

    Gene ID: 693650, updated on 17-Aug-2024

    Summary

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    Official Symbol
    STAT1provided by VGNC
    Official Full Name
    signal transducer and activator of transcription 1provided by VGNC
    Primary source
    VGNC:VGNC:77904
    See related
    Ensembl:ENSMMUG00000005613
    Gene type
    protein coding
    RefSeq status
    PROVISIONAL
    Organism
    Macaca mulatta
    Lineage
    Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Primates; Haplorrhini; Catarrhini; Cercopithecidae; Cercopithecinae; Macaca
    Orthologs
    human mouse all
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    Genomic context

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    See STAT1 in Genome Data Viewer
    Location:
    chromosome: 12
    Exon count:
    25
    Annotation release Status Assembly Chr Location
    103 current Mmul_10 (GCF_003339765.1) 12 NC_041765.1 (78191086..78235621, complement)
    102 previous assembly Mmul_8.0.1 (GCF_000772875.2) 12 NC_027904.1 (78588311..78632387, complement)

    Chromosome 12 - NC_041765.1Genomic Context describing neighboring genes Neighboring gene heterogeneous nuclear ribonucleoprotein A3 pseudogene Neighboring gene glutaminase Neighboring gene ras-related protein Rab-1A-like Neighboring gene uncharacterized LOC106992672 Neighboring gene signal transducer and activator of transcription 4 Neighboring gene U6 spliceosomal RNA

    Genomic regions, transcripts, and products

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    Go to nucleotide: Graphics FASTA GenBank

    Bibliography

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    Related articles in PubMed

    1. A recombinant measles virus unable to antagonize STAT1 function cannot control inflammation and is attenuated in rhesus monkeys. Devaux P, et al. J Virol, 2011 Jan. PMID 20980517, Free PMC Article
    2. A new rhesus macaque assembly and annotation for next-generation sequencing analyses. Zimin AV, et al. Biol Direct, 2014 Oct 14. PMID 25319552, Free PMC Article
    3. TreeGrafter: phylogenetic tree-based annotation of proteins with Gene Ontology terms and other annotations. Tang H, et al. Bioinformatics, 2019 Feb 1. PMID 30032202, Free PMC Article

    GeneRIFs: Gene References Into Functions

    General gene information

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    Markers

    Homology

    Gene Ontology Provided by RefSeq

    Function Evidence Code Pubs
    enables DNA-binding transcription factor activity, RNA polymerase II-specific IEA
    Inferred from Electronic Annotation
    more info
    		 PubMed 
    enables RNA polymerase II cis-regulatory region sequence-specific DNA binding IEA
    Inferred from Electronic Annotation
    more info
    		 PubMed 
    Process Evidence Code Pubs
    involved_in cell surface receptor signaling pathway via JAK-STAT IEA
    Inferred from Electronic Annotation
    more info
    		 PubMed 
    involved_in defense response IEA
    Inferred from Electronic Annotation
    more info
    		 PubMed 
    involved_in regulation of cell population proliferation IEA
    Inferred from Electronic Annotation
    more info
    		 PubMed 
    involved_in regulation of transcription by RNA polymerase II IEA
    Inferred from Electronic Annotation
    more info
    		 PubMed 
    involved_in response to peptide hormone IEA
    Inferred from Electronic Annotation
    more info
    		 PubMed 
    involved_in type I interferon-mediated signaling pathway IEA
    Inferred from Electronic Annotation
    more info
    		 PubMed 

    General protein information

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    Preferred Names
    signal transducer and activator of transcription 1-alpha/beta
    Names
    signal transducer and activator of transcription 1, 91kDa

    NCBI Reference Sequences (RefSeq)

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    RefSeqs maintained independently of Annotated Genomes

    These reference sequences exist independently of genome builds. Explain

    These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

    mRNA and Protein(s)

    1. NM_001261614.1 → NP_001248543.1  signal transducer and activator of transcription 1-alpha/beta

      See identical proteins and their annotated locations for NP_001248543.1

      Status: PROVISIONAL

      Source sequence(s)
      JV048043
      UniProtKB/TrEMBL
      A0A1D5QW10, A0A1D5R5F0, F6WE02
      Related
      ENSMMUP00000052240.2, ENSMMUT00000079170.2
      Conserved Domains (5) summary
      cd10372
      Location:557 → 707
      SH2_STAT1; Src homology 2 (SH2) domain found in signal transducer and activator of transcription (STAT) 1 proteins
      smart00964
      Location:2 → 121
      STAT_int; STAT protein, protein interaction domain
      cd16851
      Location:138 → 313
      STAT1_CCD; Coiled-coil domain of Signal Transducer and Activator of Transcription 1 (STAT1)
      cd16845
      Location:317 → 477
      STAT1_DBD; DNA-binding domain of Signal Transducer and Activator of Transcription 1 (STAT1)
      pfam12162
      Location:715 → 739
      STAT1_TAZ2bind; STAT1 TAZ2 binding domain

    RefSeqs of Annotated Genomes: Macaca mulatta Annotation Release 103 details...Open this link in a new tab

    The following sections contain reference sequences that belong to a specific genome build. Explain

    Reference Mmul_10 Primary Assembly

    Genomic

    1. NC_041765.1 Reference Mmul_10 Primary Assembly

      Range
      78191086..78235621 complement
      Download
      GenBank, FASTA, Sequence Viewer (Graphics)

    mRNA and Protein(s)

    1. XM_028830374.1 → XP_028686207.1  signal transducer and activator of transcription 1-alpha/beta isoform X1

      UniProtKB/TrEMBL
      A0A1D5QW10, A0A1D5R5F0, F6WE02
      Conserved Domains (5) summary
      cd10372
      Location:557 → 707
      SH2_STAT1; Src homology 2 (SH2) domain found in signal transducer and activator of transcription (STAT) 1 proteins
      smart00964
      Location:2 → 121
      STAT_int; STAT protein, protein interaction domain
      cd16851
      Location:138 → 313
      STAT1_CCD; Coiled-coil domain of Signal Transducer and Activator of Transcription 1 (STAT1)
      cd16845
      Location:317 → 477
      STAT1_DBD; DNA-binding domain of Signal Transducer and Activator of Transcription 1 (STAT1)
      pfam12162
      Location:715 → 739
      STAT1_TAZ2bind; STAT1 TAZ2 binding domain
    Nucleotide Protein
    Heading Accession and Version

    Gene LinkOut

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