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    GALC galactosylceramidase [ Macaca mulatta (Rhesus monkey) ]

    Gene ID: 693322, updated on 17-Aug-2024

    Summary

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    Official Symbol
    GALCprovided by VGNC
    Official Full Name
    galactosylceramidaseprovided by VGNC
    Primary source
    VGNC:VGNC:72867
    See related
    Ensembl:ENSMMUG00000017261
    Gene type
    protein coding
    RefSeq status
    PROVISIONAL
    Organism
    Macaca mulatta
    Lineage
    Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Primates; Haplorrhini; Catarrhini; Cercopithecidae; Cercopithecinae; Macaca
    Orthologs
    human mouse all
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    Genomic context

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    See GALC in Genome Data Viewer
    Location:
    chromosome: 7
    Exon count:
    19
    Annotation release Status Assembly Chr Location
    103 current Mmul_10 (GCF_003339765.1) 7 NC_041760.1 (150047244..150104678, complement)
    102 previous assembly Mmul_8.0.1 (GCF_000772875.2) 7 NC_027899.1 (150047101..150106069, complement)

    Chromosome 7 - NC_041760.1Genomic Context describing neighboring genes Neighboring gene uncharacterized LOC114679617 Neighboring gene uncharacterized LOC114679616 Neighboring gene uncharacterized LOC106999532 Neighboring gene G protein-coupled receptor 65 Neighboring gene potassium two pore domain channel subfamily K member 10

    Genomic regions, transcripts, and products

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    Go to nucleotide: Graphics FASTA GenBank

    Bibliography

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    Related articles in PubMed

    1. Characterization of the rhesus monkey galactocerebrosidase (GALC) cDNA and gene and identification of the mutation causing globoid cell leukodystrophy (Krabbe disease) in this primate. Luzi P, et al. Genomics, 1997 Jun 1. PMID 9192853
    2. A new rhesus macaque assembly and annotation for next-generation sequencing analyses. Zimin AV, et al. Biol Direct, 2014 Oct 14. PMID 25319552, Free PMC Article
    3. Manual GO annotation of predictive protein signatures: the InterPro approach to GO curation. Burge S, et al. Database (Oxford), 2012. PMID 22301074, Free PMC Article
    4. TreeGrafter: phylogenetic tree-based annotation of proteins with Gene Ontology terms and other annotations. Tang H, et al. Bioinformatics, 2019 Feb 1. PMID 30032202, Free PMC Article

    GeneRIFs: Gene References Into Functions

    General gene information

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    Markers

    Homology

    Gene Ontology Provided by RefSeq

    Function Evidence Code Pubs
    enables galactosylceramidase activity IEA
    Inferred from Electronic Annotation
    more info
    		 PubMed 
    Process Evidence Code Pubs
    involved_in galactosylceramide catabolic process IEA
    Inferred from Electronic Annotation
    more info
    		 PubMed 
    Component Evidence Code Pubs
    located_in lysosome IEA
    Inferred from Electronic Annotation
    more info
    		 PubMed 

    General protein information

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    Preferred Names
    galactocerebrosidase
    Names
    GALCERase
    galactocerebroside beta-galactosidase
    galactosylceramide beta-galactosidase
    NP_001037727.1
    XP_014999771.1
    XP_014999772.1
    XP_014999773.1

    NCBI Reference Sequences (RefSeq)

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    RefSeqs maintained independently of Annotated Genomes

    These reference sequences exist independently of genome builds. Explain

    These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

    mRNA and Protein(s)

    1. NM_001044262.2 → NP_001037727.1  galactocerebrosidase precursor

      See identical proteins and their annotated locations for NP_001037727.1

      Status: PROVISIONAL

      Source sequence(s)
      U87628
      UniProtKB/TrEMBL
      H9F4H7
      Related
      ENSMMUP00000051400.1, ENSMMUT00000060256.2
      Conserved Domains (2) summary
      pfam02057
      Location:1 → 669
      Glyco_hydro_59; Glycosyl hydrolase family 59
      cl23815
      Location:15 → 342
      Glyco_hydro_30; O-Glycosyl hydrolase family 30

    RefSeqs of Annotated Genomes: Macaca mulatta Annotation Release 103 details...Open this link in a new tab

    The following sections contain reference sequences that belong to a specific genome build. Explain

    Reference Mmul_10 Primary Assembly

    Genomic

    1. NC_041760.1 Reference Mmul_10 Primary Assembly

      Range
      150047244..150104678 complement
      Download
      GenBank, FASTA, Sequence Viewer (Graphics)

    mRNA and Protein(s)

    1. XM_015144287.2 → XP_014999773.1  galactocerebrosidase isoform X2

      UniProtKB/TrEMBL
      H9F4H7
      Conserved Domains (1) summary
      pfam02057
      Location:1 → 569
      Glyco_hydro_59; Glycosyl hydrolase family 59

    2. XM_015144285.2 → XP_014999771.1  galactocerebrosidase isoform X1

      UniProtKB/TrEMBL
      H9F4H7
      Conserved Domains (2) summary
      pfam02057
      Location:7 → 626
      Glyco_hydro_59; Glycosyl hydrolase family 59
      cl23815
      Location:79 → 299
      Glyco_hydro_30; O-Glycosyl hydrolase family 30

    3. XM_015144286.2 → XP_014999772.1  galactocerebrosidase isoform X2

      UniProtKB/TrEMBL
      H9F4H7
      Conserved Domains (1) summary
      pfam02057
      Location:1 → 569
      Glyco_hydro_59; Glycosyl hydrolase family 59
    Nucleotide Protein
    Heading Accession and Version
    Protein Accession Links
    GenPept Link UniProtKB Link
    O02791.2 GenPept UniProtKB/Swiss-Prot:O02791

    Gene LinkOut

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