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    Rhebl1 Ras homolog enriched in brain like 1 [ Mus musculus (house mouse) ]

    Gene ID: 69159, updated on 2-Nov-2024

    Summary

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    Official Symbol
    Rhebl1provided by MGI
    Official Full Name
    Ras homolog enriched in brain like 1provided by MGI
    Primary source
    MGI:MGI:1916409
    See related
    Ensembl:ENSMUSG00000023755 AllianceGenome:MGI:1916409
    Gene type
    protein coding
    RefSeq status
    VALIDATED
    Organism
    Mus musculus
    Lineage
    Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha; Muroidea; Muridae; Murinae; Mus; Mus
    Also known as
    Rheb2; 1810036J22Rik
    Summary
    Predicted to enable GDP binding activity; GTP binding activity; and GTPase activity. Predicted to be involved in TOR signaling; positive regulation of NF-kappaB transcription factor activity; and small GTPase-mediated signal transduction. Predicted to be located in cytoplasm. Predicted to be active in plasma membrane. Is expressed in several structures, including eye; heart; and nervous system. Orthologous to human RHEBL1 (RHEB like 1). [provided by Alliance of Genome Resources, Nov 2024]
    Expression
    Ubiquitous expression in CNS E18 (RPKM 10.2), CNS E14 (RPKM 7.3) and 27 other tissues See more
    Orthologs
    human all
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    Genomic context

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    See Rhebl1 in Genome Data Viewer
    Location:
    15 F1; 15 54.99 cM
    Exon count:
    9
    Annotation release Status Assembly Chr Location
    RS_2024_02 current GRCm39 (GCF_000001635.27) 15 NC_000081.7 (98775659..98779424, complement)
    108.20200622 previous assembly GRCm38.p6 (GCF_000001635.26) 15 NC_000081.6 (98877760..98881497, complement)

    Chromosome 15 - NC_000081.7Genomic Context describing neighboring genes Neighboring gene protein kinase, AMP-activated, gamma 1 non-catalytic subunit Neighboring gene STARR-positive B cell enhancer ABC_E1918 Neighboring gene CapStarr-seq enhancer MGSCv37_chr15:98663163-98663346 Neighboring gene lysine (K)-specific methyltransferase 2D Neighboring gene STARR-seq mESC enhancer starr_39676 Neighboring gene STARR-positive B cell enhancer ABC_E10880 Neighboring gene desert hedgehog Neighboring gene limb region 1 like Neighboring gene predicted gene, 41396

    Genomic regions, transcripts, and products

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    Go to nucleotide: Graphics FASTA GenBank

    Expression

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    • Project title: Mouse ENCODE transcriptome data Mouse ENCODE transcriptome data
    • Description: RNA profiling data sets generated by the Mouse ENCODE project.
    • BioProject: PRJNA66167
    • Publication: PMID 25409824
    • Analysis date: n/a

    Bibliography

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    Related articles in PubMed

    1. Identification of Tmem10 as a novel late-stage oligodendrocytes marker for detecting hypomyelination. Jiang W, et al. Int J Biol Sci, 2013. PMID 24391449, Free PMC Article
    2. The small GTPase Rheb is required for spermatogenesis but not oogenesis. Baker MD, et al. Reproduction, 2014 May. PMID 24713393, Free PMC Article
    3. Rheb1 is required for mTORC1 and myelination in postnatal brain development. Zou J, et al. Dev Cell, 2011 Jan 18. PMID 21238928, Free PMC Article
    4. A novel view of the transcriptome revealed from gene trapping in mouse embryonic stem cells. Roma G, et al. Genome Res, 2007 Jul. PMID 17540781, Free PMC Article
    5. Novel protein interactions with endoglin and activin receptor-like kinase 1: potential role in vascular networks. Xu G, et al. Mol Cell Proteomics, 2014 Feb. PMID 24319055, Free PMC Article

    See all (22) citations in PubMed

    GeneRIFs: Gene References Into Functions

    Variation

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    Alleles

    Alleles of this type are documented at Mouse Genome Informatics  (MGI)
    • Endonuclease-mediated (1) 
    • Targeted (2)  1 citation

    Interactions

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    Products Interactant Other Gene Complex Source Pubs Description

    General gene information

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    Markers

    Homology

    Gene Ontology Provided by MGI

    Function Evidence Code Pubs
    enables GDP binding IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    enables GTP binding IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    enables GTP binding IEA
    Inferred from Electronic Annotation
    more info
    		  
    enables GTP binding ISO
    Inferred from Sequence Orthology
    more info
    		  
    enables GTPase activity IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    enables GTPase activity IEA
    Inferred from Electronic Annotation
    more info
    		  
    enables metal ion binding IEA
    Inferred from Electronic Annotation
    more info
    		  
    Process Evidence Code Pubs
    involved_in TOR signaling ISO
    Inferred from Sequence Orthology
    more info
    		  
    involved_in positive regulation of NF-kappaB transcription factor activity ISO
    Inferred from Sequence Orthology
    more info
    		  
    involved_in signal transduction IEA
    Inferred from Electronic Annotation
    more info
    		  
    involved_in small GTPase-mediated signal transduction IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    Component Evidence Code Pubs
    located_in cytoplasm IEA
    Inferred from Electronic Annotation
    more info
    		  
    located_in cytoplasm ISO
    Inferred from Sequence Orthology
    more info
    		  
    located_in endomembrane system IEA
    Inferred from Electronic Annotation
    more info
    		  
    located_in membrane IEA
    Inferred from Electronic Annotation
    more info
    		  
    is_active_in plasma membrane IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  

    General protein information

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    Preferred Names
    GTPase RhebL1
    Names
    ras homolog enriched in brain-like protein 1
    rheb-like protein 1

    NCBI Reference Sequences (RefSeq)

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    RefSeqs maintained independently of Annotated Genomes

    These reference sequences exist independently of genome builds. Explain

    These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

    mRNA and Protein(s)

    1. NM_026967.5 → NP_081243.1  GTPase RhebL1

      See identical proteins and their annotated locations for NP_081243.1

      Status: VALIDATED

      Source sequence(s)
      AC161165
      Consensus CDS
      CCDS27809.1
      UniProtKB/Swiss-Prot
      Q9D8T3
      UniProtKB/TrEMBL
      A0A2R8VHI8
      Related
      ENSMUSP00000024518.10, ENSMUST00000024518.11
      Conserved Domains (1) summary
      cd04137
      Location:6 → 184
      RheB; Ras Homolog Enriched in Brain (RheB) is a small GTPase

    RefSeqs of Annotated Genomes: GCF_000001635.27-RS_2024_02

    The following sections contain reference sequences that belong to a specific genome build. Explain

    Reference GRCm39 C57BL/6J

    Genomic

    1. NC_000081.7 Reference GRCm39 C57BL/6J

      Range
      98775659..98779424 complement
      Download
      GenBank, FASTA, Sequence Viewer (Graphics)

    mRNA and Protein(s)

    1. XM_030248739.2 → XP_030104599.1  GTPase RhebL1 isoform X2

      UniProtKB/Swiss-Prot
      Q9D8T3
      UniProtKB/TrEMBL
      A0A2R8VHI8
      Conserved Domains (1) summary
      cd04137
      Location:6 → 184
      RheB; Ras Homolog Enriched in Brain (RheB) is a small GTPase

    2. XM_006521345.3 → XP_006521408.1  GTPase RhebL1 isoform X1

      UniProtKB/TrEMBL
      A0A2R8VHI8, A0A2R8VHL6
      Related
      ENSMUSP00000155216.2, ENSMUST00000229348.2
      Conserved Domains (1) summary
      cl38936
      Location:6 → 188
      P-loop_NTPase; P-loop containing Nucleoside Triphosphate Hydrolases
    Nucleotide Protein Strain
    Heading Accession and Version
    Protein Accession Links
    GenPept Link UniProtKB Link
    Q9D8T3.1 GenPept UniProtKB/Swiss-Prot:Q9D8T3

    Gene LinkOut

    The following LinkOut resources are supplied by external providers. These providers are responsible for maintaining the links.

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