Mlkl mixed lineage kinase domain like pseudokinase [Rattus norvegicus (Norway rat)] - Gene

Summary

Official Symbol: Mlklprovided by RGD
Official Full Name: mixed lineage kinase domain like pseudokinaseprovided by RGD
Primary source: RGD:1592221
See related: EnsemblRapid:ENSRNOG00000042353 AllianceGenome:RGD:1592221
Gene type: protein coding
RefSeq status: VALIDATED
Organism: Rattus norvegicus
Lineage: Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha; Muroidea; Muridae; Murinae; Rattus
Summary: Predicted to enable several functions, including ATP binding activity; JUN kinase kinase kinase activity; and identical protein binding activity. Predicted to be involved in defense response to virus; necroptotic process; and protein homotrimerization. Predicted to be located in several cellular components, including cell junction; cytosol; and nucleus. Orthologous to human MLKL (mixed lineage kinase domain like pseudokinase). [provided by Alliance of Genome Resources, Apr 2022]
Expression: Biased expression in Lung (RPKM 94.6), Thymus (RPKM 52.4) and 8 other tissues See more
Orthologs: human mouse all
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Genomic context

Location:: 19q12

Exon count:: 15

Annotation release	Status	Assembly	Chr	Location
RS_2024_02	current	GRCr8 (GCF_036323735.1)	19	NC_086037.1 (56186860..56213886, complement)
RS_2023_06	previous assembly	mRatBN7.2 (GCF_015227675.2)	19	NC_051354.1 (39277526..39304555, complement)
106	previous assembly	Rnor_6.0 (GCF_000001895.5)	19	NC_005118.4 (43508416..43535050, complement)

Chromosome 19 - NC_086037.1 Genomic Context describing neighboring genes

Genomic regions, transcripts, and products

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Genomic Sequence:

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Expression

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See details

Project title: A rat RNA-Seq transcriptomic BodyMap across 11 organs and 4 developmental stages A rat RNA-Seq transcriptomic BodyMap across 11 organs and 4 developmental stages
Description: 320 RNA samples isolated from 11 organs (adrenal gland, brain, heart, kidney, liver, lung, muscle, spleen, thymus, and testes or uterus) from both sexes of Fischer 344 rats across four developmental stages (2-, 6-, 21-, and 104-weeks-old)
BioProject: PRJNA238328
Publication: PMID 24510058
Analysis date: Mon Jun 6 17:44:12 2016

Bibliography

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GeneRIFs: Gene References Into Functions

What's a GeneRIF?

Angiotensin II Is Involved in MLKL Activation During the Development of Heart Failure Following Myocardial Infarction in Rats.
Title: Angiotensin II Is Involved in MLKL Activation During the Development of Heart Failure Following Myocardial Infarction in Rats.
MLKL regulates Cx43 ubiquitinational degradation and mediates neuronal necroptosis in ipsilateral thalamus after focal cortical infarction.
Title: MLKL regulates Cx43 ubiquitinational degradation and mediates neuronal necroptosis in ipsilateral thalamus after focal cortical infarction.
Nuclear translocation of MLKL enhances necroptosis by a RIP1/RIP3-independent mechanism in H9c2 cardiomyoblasts.
Title: Nuclear translocation of MLKL enhances necroptosis by a RIP1/RIP3-independent mechanism in H9c2 cardiomyoblasts.
Receptor-interacting protein 3-phosphorylated Ca[2+] /calmodulin-dependent protein kinase II and mixed lineage kinase domain-like protein mediate intracerebral hemorrhage-induced neuronal necroptosis.
Title: Receptor-interacting protein 3-phosphorylated Ca(2+) /calmodulin-dependent protein kinase II and mixed lineage kinase domain-like protein mediate intracerebral hemorrhage-induced neuronal necroptosis.
Protective action of ultrasound-guided intraparenchymal transplantation of BMSCs in adriamycin nephropathy rats through the RIPK3/MLKL and NLRP3 pathways.
Title: Protective action of ultrasound-guided intraparenchymal transplantation of BMSCs in adriamycin nephropathy rats through the RIPK3/MLKL and NLRP3 pathways.
Effects of 17-AAG on the RIP1/RIP3/MLKL pathway during the development of heart failure following myocardial infarction in rats.
Title: Effects of 17-AAG on the RIP1/RIP3/MLKL pathway during the development of heart failure following myocardial infarction in rats.
Inhibition of MLKL-dependent necroptosis via downregulating interleukin-1R1 contributes to neuroprotection of hypoxic preconditioning in transient global cerebral ischemic rats.
Title: Inhibition of MLKL-dependent necroptosis via downregulating interleukin-1R1 contributes to neuroprotection of hypoxic preconditioning in transient global cerebral ischemic rats.
RIP3/MLKL pathway-regulated necroptosis: A new mechanism of paclitaxel-induced peripheral neuropathy.
Title: RIP3/MLKL pathway-regulated necroptosis: A new mechanism of paclitaxel-induced peripheral neuropathy.
Cardioprotection of ischemic preconditioning is associated with inhibition of translocation of MLKL within the plasma membrane.
Title: Cardioprotection of ischaemic preconditioning is associated with inhibition of translocation of MLKL within the plasma membrane.
RIPK1/RIPK3/MLKL-mediated necroptosis may play an important role in nucleus pulposus (NP) cell death induced by continuous mechanical stress. Treatment strategies which aim to regulate necroptosis may prove beneficial, by both reducing NP cells death and slowing IVD degeneration.
Title: RIPK1/RIPK3/MLKL-mediated necroptosis contributes to compression-induced rat nucleus pulposus cells death.

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General gene information

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Gene Ontology Provided by RGD

Function	Evidence Code	Pubs
enables ATP binding	ISO Inferred from Sequence Orthology more info
enables identical protein binding	ISO Inferred from Sequence Orthology more info
enables metal ion binding	IEA Inferred from Electronic Annotation more info
NOT enables protein kinase activity	ISO Inferred from Sequence Orthology more info
enables protein kinase binding	ISO Inferred from Sequence Orthology more info
NOT enables protein serine/threonine kinase activity	IBA Inferred from Biological aspect of Ancestor more info
enables protein-containing complex binding	ISO Inferred from Sequence Orthology more info

Process	Evidence Code	Pubs
involved_in cell surface receptor signaling pathway	IEA Inferred from Electronic Annotation more info
involved_in defense response to virus	ISO Inferred from Sequence Orthology more info
involved_in execution phase of necroptosis	ISO Inferred from Sequence Orthology more info
involved_in necroptotic process	ISO Inferred from Sequence Orthology more info
involved_in necroptotic process	ISS Inferred from Sequence or Structural Similarity more info
involved_in necroptotic signaling pathway	IBA Inferred from Biological aspect of Ancestor more info
involved_in necroptotic signaling pathway	ISO Inferred from Sequence Orthology more info
involved_in protein homotrimerization	ISO Inferred from Sequence Orthology more info
involved_in protein phosphorylation	IEA Inferred from Electronic Annotation more info

Component	Evidence Code	Pubs
located_in cell junction	IEA Inferred from Electronic Annotation more info
located_in cell junction	ISO Inferred from Sequence Orthology more info
is_active_in cytoplasm	IBA Inferred from Biological aspect of Ancestor more info
located_in cytoplasm	ISO Inferred from Sequence Orthology more info
located_in cytosol	IEA Inferred from Electronic Annotation more info
located_in cytosol	ISO Inferred from Sequence Orthology more info
located_in nucleus	ISO Inferred from Sequence Orthology more info
located_in plasma membrane	ISO Inferred from Sequence Orthology more info

General protein information

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Preferred Names: mixed lineage kinase domain-like protein

Names: rCG51567-like

NCBI Reference Sequences (RefSeq)

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RefSeqs maintained independently of Annotated Genomes

These reference sequences exist independently of genome builds. Explain

These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

mRNA and Protein(s)

NM_001401077.1 → NP_001388006.1 mixed lineage kinase domain-like protein

Status: VALIDATED

Source sequence(s)

JAXUCZ010000019

UniProtKB/TrEMBL

A0A8I5ZV82, A6IZ87

Related

ENSRNOP00000081539.1, ENSRNOT00000095360.2

RefSeqs of Annotated Genomes: GCF_036323735.1-RS_2024_02

The following sections contain reference sequences that belong to a specific genome build. Explain

Reference GRCr8

Genomic

NC_086037.1 Reference GRCr8

Range

56186860..56213886 complement

Download

GenBank, FASTA, Sequence Viewer (Graphics)

mRNA and Protein(s)

XM_008772571.4 → XP_008770793.1 mixed lineage kinase domain-like protein isoform X1

See identical proteins and their annotated locations for XP_008770793.1

UniProtKB/TrEMBL

A0A8I5ZV82, A6IZ87, D3ZKP6

Conserved Domains (2) summary

cd21037
Location:5 → 143

MLKL_NTD; N-terminal domain of mixed lineage kinase domain-like protein (MLKL) and similar proteins

cl21453
Location:193 → 453

PKc_like; Protein Kinases, catalytic domain
XM_008772570.4 → XP_008770792.1 mixed lineage kinase domain-like protein isoform X1

See identical proteins and their annotated locations for XP_008770792.1

UniProtKB/TrEMBL

A0A8I5ZV82, A6IZ87, D3ZKP6

Conserved Domains (2) summary

cd21037
Location:5 → 143

MLKL_NTD; N-terminal domain of mixed lineage kinase domain-like protein (MLKL) and similar proteins

cl21453
Location:193 → 453

PKc_like; Protein Kinases, catalytic domain
XM_063278294.1 → XP_063134364.1 mixed lineage kinase domain-like protein isoform X1

UniProtKB/TrEMBL

A0A8I5ZV82, A6IZ87
XM_063278293.1 → XP_063134363.1 mixed lineage kinase domain-like protein isoform X1

UniProtKB/TrEMBL

A0A8I5ZV82, A6IZ87