Piwil4 piwi-like RNA-mediated gene silencing 4 [Rattus norvegicus (Norway rat)] - Gene

Summary

Official Symbol: Piwil4provided by RGD
Official Full Name: piwi-like RNA-mediated gene silencing 4provided by RGD
Primary source: RGD:1311015
See related: EnsemblRapid:ENSRNOG00000009043 AllianceGenome:RGD:1311015
Gene type: protein coding
RefSeq status: PROVISIONAL
Organism: Rattus norvegicus
Lineage: Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha; Muroidea; Muridae; Murinae; Rattus
Summary: Predicted to enable RNA endonuclease activity and piRNA binding activity. Involved in regulation of insulin secretion involved in cellular response to glucose stimulus. Predicted to be located in mitochondrion; nucleoplasm; and piP-body. Predicted to be active in P granule and nucleus. Orthologous to human PIWIL4 (piwi like RNA-mediated gene silencing 4). [provided by Alliance of Genome Resources, Oct 2024]
Expression: Biased expression in Spleen (RPKM 146.4), Thymus (RPKM 17.4) and 1 other tissue See more
Orthologs: human mouse all
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Genomic context

Location:: 8q12

Exon count:: 20

Annotation release	Status	Assembly	Chr	Location
RS_2024_02	current	GRCr8 (GCF_036323735.1)	8	NC_086026.1 (19817985..19861327, complement)
RS_2023_06	previous assembly	mRatBN7.2 (GCF_015227675.2)	8	NC_051343.1 (11536520..11579883, complement)
106	previous assembly	Rnor_6.0 (GCF_000001895.5)	8	NC_005107.4 (13208774..13251970, complement)

Chromosome 8 - NC_086026.1 Genomic Context describing neighboring genes

Genomic regions, transcripts, and products

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Genomic Sequence:

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Expression

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See details

Project title: A rat RNA-Seq transcriptomic BodyMap across 11 organs and 4 developmental stages A rat RNA-Seq transcriptomic BodyMap across 11 organs and 4 developmental stages
Description: 320 RNA samples isolated from 11 organs (adrenal gland, brain, heart, kidney, liver, lung, muscle, spleen, thymus, and testes or uterus) from both sexes of Fischer 344 rats across four developmental stages (2-, 6-, 21-, and 104-weeks-old)
BioProject: PRJNA238328
Publication: PMID 24510058
Analysis date: Mon Jun 6 17:44:12 2016

Bibliography

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GeneRIFs: Gene References Into Functions

What's a GeneRIF?

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General gene information

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Gene Ontology Provided by RGD

Function	Evidence Code	Pubs
enables RNA binding	IEA Inferred from Electronic Annotation more info
enables RNA endonuclease activity	IBA Inferred from Biological aspect of Ancestor more info
NOT enables RNA endonuclease activity	ISO Inferred from Sequence Orthology more info
NOT enables RNA endonuclease activity	ISS Inferred from Sequence or Structural Similarity more info
enables piRNA binding	IBA Inferred from Biological aspect of Ancestor more info
enables piRNA binding	IEA Inferred from Electronic Annotation more info
enables piRNA binding	ISO Inferred from Sequence Orthology more info
enables piRNA binding	ISS Inferred from Sequence or Structural Similarity more info

Process	Evidence Code	Pubs
involved_in cell differentiation	IEA Inferred from Electronic Annotation more info
involved_in epithelial structure maintenance	IEA Inferred from Electronic Annotation more info
involved_in epithelial structure maintenance	ISO Inferred from Sequence Orthology more info
involved_in epithelial structure maintenance	ISS Inferred from Sequence or Structural Similarity more info
involved_in meiotic cell cycle	IEA Inferred from Electronic Annotation more info
involved_in piRNA processing	IBA Inferred from Biological aspect of Ancestor more info
involved_in piRNA processing	ISO Inferred from Sequence Orthology more info
involved_in regulation of insulin secretion involved in cellular response to glucose stimulus	IMP Inferred from Mutant Phenotype more info	PubMed
involved_in regulation of translation	IEA Inferred from Electronic Annotation more info
involved_in regulatory ncRNA-mediated gene silencing	IBA Inferred from Biological aspect of Ancestor more info
involved_in regulatory ncRNA-mediated gene silencing	IEA Inferred from Electronic Annotation more info
acts_upstream_of_or_within retrotransposon silencing by heterochromatin formation	ISO Inferred from Sequence Orthology more info
acts_upstream_of_positive_effect retrotransposon silencing by heterochromatin formation	ISO Inferred from Sequence Orthology more info
acts_upstream_of_positive_effect retrotransposon silencing by heterochromatin formation	ISS Inferred from Sequence or Structural Similarity more info
involved_in retrotransposon silencing by mRNA destabilization	ISO Inferred from Sequence Orthology more info
involved_in retrotransposon silencing by piRNA-directed DNA methylation	ISS Inferred from Sequence or Structural Similarity more info
involved_in secondary piRNA processing	ISO Inferred from Sequence Orthology more info
involved_in secondary piRNA processing	ISS Inferred from Sequence or Structural Similarity more info
involved_in siRNA-mediated retrotransposon silencing by heterochromatin formation	ISO Inferred from Sequence Orthology more info
involved_in spermatogenesis	IBA Inferred from Biological aspect of Ancestor more info
acts_upstream_of_or_within spermatogenesis	ISO Inferred from Sequence Orthology more info
involved_in spermatogenesis	ISO Inferred from Sequence Orthology more info
involved_in spermatogenesis	ISS Inferred from Sequence or Structural Similarity more info

Component	Evidence Code	Pubs
is_active_in P granule	IBA Inferred from Biological aspect of Ancestor more info
located_in P granule	ISO Inferred from Sequence Orthology more info
located_in P granule	ISS Inferred from Sequence or Structural Similarity more info
located_in cytoplasm	ISO Inferred from Sequence Orthology more info
located_in cytoplasm	ISS Inferred from Sequence or Structural Similarity more info
located_in mitochondrion	IEA Inferred from Electronic Annotation more info
located_in mitochondrion	ISO Inferred from Sequence Orthology more info
located_in nucleoplasm	IEA Inferred from Electronic Annotation more info
located_in nucleoplasm	ISO Inferred from Sequence Orthology more info
is_active_in nucleus	IBA Inferred from Biological aspect of Ancestor more info
located_in nucleus	ISO Inferred from Sequence Orthology more info
located_in nucleus	ISS Inferred from Sequence or Structural Similarity more info
located_in piP-body	ISO Inferred from Sequence Orthology more info
located_in piP-body	ISS Inferred from Sequence or Structural Similarity more info

General protein information

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Preferred Names: piwi-like protein 4

Names: piwi-like 4

NCBI Reference Sequences (RefSeq)

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RefSeqs maintained independently of Annotated Genomes

These reference sequences exist independently of genome builds. Explain

These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

mRNA and Protein(s)

NM_001271133.1 → NP_001258062.1 piwi-like protein 4

Status: PROVISIONAL

Source sequence(s)

JAXUCZ010000008

UniProtKB/Swiss-Prot

Q4G033

UniProtKB/TrEMBL

F1LQ32

Related

ENSRNOP00000039460.5, ENSRNOT00000049724.7

Conserved Domains (3) summary

cd02845
Location:249 → 365

PAZ_piwi_like; PAZ domain, Piwi_like subfamily. In multi-cellular organisms, the Piwi protein appears to be essential for the maintenance of germline stem cells. In the Drosophila male germline, Piwi was shown to be involved in the silencing of retrotransposons in the ...

cd04658
Location:373 → 815

Piwi_piwi-like_Euk; Piwi_piwi-like_Euk: PIWI domain, Piwi-like subfamily found in eukaryotes. This domain is found in Piwi and closely related proteins, where it is believed to perform a crucial role in germline cells, via RNA silencing. RNA silencing refers to a group of ...

pfam16486
Location:79 → 189

ArgoN; N-terminal domain of argonaute

RefSeqs of Annotated Genomes: GCF_036323735.1-RS_2024_02

The following sections contain reference sequences that belong to a specific genome build. Explain

Reference GRCr8

Genomic

NC_086026.1 Reference GRCr8

Range

19817985..19861327 complement

Download

GenBank, FASTA, Sequence Viewer (Graphics)

mRNA and Protein(s)

XM_008765980.4 → XP_008764202.1 piwi-like protein 4 isoform X1

UniProtKB/Swiss-Prot

Q4G033

Related

ENSRNOP00000109100.1, ENSRNOT00000138878.1

Conserved Domains (3) summary

cd02845
Location:265 → 381

PAZ_piwi_like; PAZ domain, Piwi_like subfamily. In multi-cellular organisms, the Piwi protein appears to be essential for the maintenance of germline stem cells. In the Drosophila male germline, Piwi was shown to be involved in the silencing of retrotransposons in the ...

cd04658
Location:389 → 831

Piwi_piwi-like_Euk; Piwi_piwi-like_Euk: PIWI domain, Piwi-like subfamily found in eukaryotes. This domain is found in Piwi and closely related proteins, where it is believed to perform a crucial role in germline cells, via RNA silencing. RNA silencing refers to a group of ...

pfam16486
Location:95 → 205

ArgoN; N-terminal domain of argonaute