Il23r interleukin 23 receptor [Rattus norvegicus (Norway rat)] - Gene

Summary

Symbol: Il23rprovided by RGD
Full Name: interleukin 23 receptorprovided by RGD
Primary source: RGD:1586368
See related: Ensembl:ENSRNOG00000007544 AllianceGenome:RGD:1586368
Gene type: protein coding
RefSeq status: MODEL
Organism: Rattus norvegicus
Lineage: Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha; Muroidea; Muridae; Murinae; Rattus
Summary: Predicted to enable cytokine binding activity and cytokine receptor activity. Predicted to contribute to interleukin-12 receptor binding activity; interleukin-23 binding activity; and interleukin-23 receptor activity. Predicted to be involved in several processes, including positive regulation of defense response to virus by host; regulation of cytokine production; and response to interferon-gamma. Predicted to be part of interleukin-23 receptor complex. Predicted to be active in external side of plasma membrane. Human ortholog(s) of this gene implicated in several diseases, including autoimmune disease (multiple); inflammatory bowel disease (multiple); pulmonary hypertension; rhinitis; and systemic scleroderma. Orthologous to human IL23R (interleukin 23 receptor). [provided by Alliance of Genome Resources, Apr 2022]
Expression: Biased expression in Adrenal (RPKM 74.5), Spleen (RPKM 6.2) and 1 other tissue See more
Orthologs: human mouse all
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Annotation release	Status	Assembly	Chr	Location
RS_2024_02	current	GRCr8 (GCF_036323735.1)	4	NC_086022.1 (97910230..98003759, complement)
RS_2023_06	previous assembly	mRatBN7.2 (GCF_015227675.2)	4	NC_051339.1 (96580568..96672540, complement)
106	previous assembly	Rnor_6.0 (GCF_000001895.5)	4	NC_005103.4 (98203788..98306729, complement)

Chromosome 4 - NC_086022.1 Genomic Context describing neighboring genes

Genomic Sequence:

Go to nucleotide: Graphics FASTA GenBank

See details

Project title: A rat RNA-Seq transcriptomic BodyMap across 11 organs and 4 developmental stages
Description: 320 RNA samples isolated from 11 organs (adrenal gland, brain, heart, kidney, liver, lung, muscle, spleen, thymus, and testes or uterus) from both sexes of Fischer 344 rats across four developmental stages (2-, 6-, 21-, and 104-weeks-old)
BioProject: PRJNA238328
Publication: PMID 24510058
Analysis date: Mon Jun 6 17:44:12 2016

Mutational analyses of novel rat models with targeted modifications in inflammatory bowel disease susceptibility genes.
Title: Mutational analyses of novel rat models with targeted modifications in inflammatory bowel disease susceptibility genes.
Study provides evidence that IL-23/IL-23R plays a critical role in brain ischemic injury
Title: Damage effect of interleukin (IL)-23 on oxygen-glucose-deprived cells of the neurovascular unit via IL-23 receptor.

Submit: New GeneRIF Correction

Function	Evidence Code	Pubs
enables cytokine binding	IBA Inferred from Biological aspect of Ancestor more info
enables cytokine receptor activity	IBA Inferred from Biological aspect of Ancestor more info
contributes_to interleukin-12 receptor binding	IBA Inferred from Biological aspect of Ancestor more info
contributes_to interleukin-12 receptor binding	ISO Inferred from Sequence Orthology more info
contributes_to interleukin-23 binding	IBA Inferred from Biological aspect of Ancestor more info
contributes_to interleukin-23 binding	ISO Inferred from Sequence Orthology more info
contributes_to interleukin-23 receptor activity	ISO Inferred from Sequence Orthology more info

Process	Evidence Code	Pubs
involved_in biological_process	ND No biological Data available more info
involved_in cytokine-mediated signaling pathway	IBA Inferred from Biological aspect of Ancestor more info
involved_in interleukin-23-mediated signaling pathway	IEA Inferred from Electronic Annotation more info
involved_in negative regulation of interleukin-10 production	ISO Inferred from Sequence Orthology more info
involved_in positive regulation of T-helper 1 type immune response	ISO Inferred from Sequence Orthology more info
involved_in positive regulation of defense response to virus by host	ISO Inferred from Sequence Orthology more info
involved_in positive regulation of interleukin-12 production	ISO Inferred from Sequence Orthology more info
involved_in positive regulation of type II interferon production	ISO Inferred from Sequence Orthology more info
involved_in response to lipopolysaccharide	ISO Inferred from Sequence Orthology more info
involved_in response to type II interferon	ISO Inferred from Sequence Orthology more info

Component	Evidence Code	Pubs
is_active_in external side of plasma membrane	IBA Inferred from Biological aspect of Ancestor more info
part_of interleukin-23 receptor complex	IBA Inferred from Biological aspect of Ancestor more info
part_of interleukin-23 receptor complex	ISO Inferred from Sequence Orthology more info
part_of receptor complex	ISO Inferred from Sequence Orthology more info

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The following sections contain reference sequences that belong to a specific genome build. Explain

XM_039108697.2 → XP_038964625.2 interleukin-23 receptor isoform X1

UniProtKB/TrEMBL

F1LX96
XM_063286966.1 → XP_063143036.1 interleukin-23 receptor isoform X2