U.S. flag

An official website of the United States government

Format

Send to:

Choose Destination
    • Showing Current items.

    Ryr2 ryanodine receptor 2 [ Rattus norvegicus (Norway rat) ]

    Gene ID: 689560, updated on 28-Oct-2024

    Summary

    Official Symbol
    Ryr2provided by RGD
    Official Full Name
    ryanodine receptor 2provided by RGD
    Primary source
    RGD:620314
    See related
    EnsemblRapid:ENSRNOG00000017060 AllianceGenome:RGD:620314
    Gene type
    protein coding
    RefSeq status
    VALIDATED
    Organism
    Rattus norvegicus
    Lineage
    Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha; Muroidea; Muridae; Murinae; Rattus
    Also known as
    RyR; RYR-2
    Summary
    Enables ryanodine-sensitive calcium-release channel activity and scaffold protein binding activity. Involved in several processes, including metal ion transport; regulation of cytosolic calcium ion concentration; and response to magnesium ion. Located in several cellular components, including sarcolemma; sarcomere; and sarcoplasmic reticulum membrane. Is extrinsic component of cytoplasmic side of plasma membrane. Part of protein-containing complex. Used to study congestive heart failure. Biomarker of pulmonary hypertension. Human ortholog(s) of this gene implicated in arrhythmogenic right ventricular cardiomyopathy and catecholaminergic polymorphic ventricular tachycardia 1. Orthologous to human RYR2 (ryanodine receptor 2). [provided by Alliance of Genome Resources, Oct 2024]
    Expression
    Restricted expression toward (RPKM 3084.4) See more
    Orthologs
    NEW
    Try the new Gene table
    Try the new Transcript table

    Genomic context

    See Ryr2 in Genome Data Viewer
    Location:
    17q12.1
    Exon count:
    108
    Annotation release Status Assembly Chr Location
    RS_2024_02 current GRCr8 (GCF_036323735.1) 17 NC_086035.1 (63081527..63667141)
    RS_2023_06 previous assembly mRatBN7.2 (GCF_015227675.2) 17 NC_051352.1 (58389925..58975641)
    106 previous assembly Rnor_6.0 (GCF_000001895.5) 17 NC_005116.4 (65533998..65955606, complement)

    Chromosome 17 - NC_086035.1Genomic Context describing neighboring genes Neighboring gene SWI/SNF-related matrix-associated actin-dependent regulator of chromatin subfamily A member 5-like Neighboring gene 5-methyltetrahydrofolate-homocysteine methyltransferase Neighboring gene ribosomal protein S7, pseudogene 15 Neighboring gene small nucleolar RNA U3 Neighboring gene uncharacterized LOC134482861 Neighboring gene uncharacterized LOC134482862 Neighboring gene zona pellucida glycoprotein 4

    Genomic regions, transcripts, and products

    Expression

    • Project title: A rat RNA-Seq transcriptomic BodyMap across 11 organs and 4 developmental stages A rat RNA-Seq transcriptomic BodyMap across 11 organs and 4 developmental stages
    • Description: 320 RNA samples isolated from 11 organs (adrenal gland, brain, heart, kidney, liver, lung, muscle, spleen, thymus, and testes or uterus) from both sexes of Fischer 344 rats across four developmental stages (2-, 6-, 21-, and 104-weeks-old)
    • BioProject: PRJNA238328
    • Publication: PMID 24510058
    • Analysis date: Mon Jun 6 17:44:12 2016

    Bibliography

    GeneRIFs: Gene References Into Functions

    What's a GeneRIF?

    Pathways from PubChem

    Interactions

    Products Interactant Other Gene Complex Source Pubs Description

    General gene information

    Markers

    Gene Ontology Provided by RGD

    Function Evidence Code Pubs
    enables calcium channel activity ISO
    Inferred from Sequence Orthology
    more info
     
    enables calcium channel activity ISS
    Inferred from Sequence or Structural Similarity
    more info
     
    enables calcium ion binding IEA
    Inferred from Electronic Annotation
    more info
     
    enables calcium-induced calcium release activity IDA
    Inferred from Direct Assay
    more info
    PubMed 
    enables calcium-induced calcium release activity ISO
    Inferred from Sequence Orthology
    more info
     
    enables calmodulin binding IEA
    Inferred from Electronic Annotation
    more info
     
    enables calmodulin binding ISO
    Inferred from Sequence Orthology
    more info
     
    enables calmodulin binding ISS
    Inferred from Sequence or Structural Similarity
    more info
     
    enables enzyme binding ISO
    Inferred from Sequence Orthology
    more info
     
    enables identical protein binding IEA
    Inferred from Electronic Annotation
    more info
     
    enables identical protein binding ISO
    Inferred from Sequence Orthology
    more info
     
    enables intracellularly gated calcium channel activity ISO
    Inferred from Sequence Orthology
    more info
     
    enables intracellularly gated calcium channel activity ISS
    Inferred from Sequence or Structural Similarity
    more info
     
    enables organic cyclic compound binding ISO
    Inferred from Sequence Orthology
    more info
     
    enables protein binding IPI
    Inferred from Physical Interaction
    more info
    PubMed 
    enables protein kinase A catalytic subunit binding IEA
    Inferred from Electronic Annotation
    more info
     
    enables protein kinase A catalytic subunit binding ISO
    Inferred from Sequence Orthology
    more info
     
    enables protein kinase A regulatory subunit binding IEA
    Inferred from Electronic Annotation
    more info
     
    enables protein kinase A regulatory subunit binding ISO
    Inferred from Sequence Orthology
    more info
     
    enables protein kinase binding ISO
    Inferred from Sequence Orthology
    more info
     
    enables ryanodine-sensitive calcium-release channel activity IBA
    Inferred from Biological aspect of Ancestor
    more info
     
    enables ryanodine-sensitive calcium-release channel activity IDA
    Inferred from Direct Assay
    more info
    PubMed 
    enables ryanodine-sensitive calcium-release channel activity IEA
    Inferred from Electronic Annotation
    more info
     
    enables ryanodine-sensitive calcium-release channel activity IMP
    Inferred from Mutant Phenotype
    more info
    PubMed 
    enables ryanodine-sensitive calcium-release channel activity ISO
    Inferred from Sequence Orthology
    more info
     
    enables scaffold protein binding IPI
    Inferred from Physical Interaction
    more info
    PubMed 
    enables suramin binding IEA
    Inferred from Electronic Annotation
    more info
     
    enables suramin binding ISO
    Inferred from Sequence Orthology
    more info
     
    Process Evidence Code Pubs
    involved_in Purkinje myocyte to ventricular cardiac muscle cell signaling IEA
    Inferred from Electronic Annotation
    more info
     
    involved_in Purkinje myocyte to ventricular cardiac muscle cell signaling ISO
    Inferred from Sequence Orthology
    more info
     
    acts_upstream_of_or_within calcium ion transmembrane import into cytosol ISO
    Inferred from Sequence Orthology
    more info
     
    involved_in calcium ion transmembrane transport IEA
    Inferred from Electronic Annotation
    more info
     
    involved_in calcium ion transmembrane transport IMP
    Inferred from Mutant Phenotype
    more info
    PubMed 
    acts_upstream_of_or_within calcium ion transmembrane transport ISO
    Inferred from Sequence Orthology
    more info
     
    acts_upstream_of_or_within calcium ion transport ISO
    Inferred from Sequence Orthology
    more info
     
    involved_in calcium ion transport ISO
    Inferred from Sequence Orthology
    more info
     
    involved_in calcium ion transport ISS
    Inferred from Sequence or Structural Similarity
    more info
     
    involved_in calcium ion transport into cytosol IEA
    Inferred from Electronic Annotation
    more info
     
    involved_in calcium ion transport into cytosol ISO
    Inferred from Sequence Orthology
    more info
     
    involved_in calcium-mediated signaling IEA
    Inferred from Electronic Annotation
    more info
     
    involved_in calcium-mediated signaling ISO
    Inferred from Sequence Orthology
    more info
     
    involved_in calcium-mediated signaling ISS
    Inferred from Sequence or Structural Similarity
    more info
     
    involved_in cardiac muscle contraction ISO
    Inferred from Sequence Orthology
    more info
     
    involved_in cardiac muscle hypertrophy IEA
    Inferred from Electronic Annotation
    more info
     
    acts_upstream_of_or_within cardiac muscle hypertrophy ISO
    Inferred from Sequence Orthology
    more info
     
    involved_in cellular response to caffeine IEA
    Inferred from Electronic Annotation
    more info
     
    acts_upstream_of_or_within cellular response to caffeine ISO
    Inferred from Sequence Orthology
    more info
     
    involved_in cellular response to caffeine ISO
    Inferred from Sequence Orthology
    more info
     
    involved_in cellular response to caffeine ISS
    Inferred from Sequence or Structural Similarity
    more info
     
    involved_in cellular response to epinephrine stimulus IEA
    Inferred from Electronic Annotation
    more info
     
    involved_in cellular response to epinephrine stimulus ISO
    Inferred from Sequence Orthology
    more info
     
    involved_in detection of calcium ion IEA
    Inferred from Electronic Annotation
    more info
     
    involved_in detection of calcium ion ISO
    Inferred from Sequence Orthology
    more info
     
    involved_in embryonic heart tube morphogenesis IEA
    Inferred from Electronic Annotation
    more info
     
    involved_in embryonic heart tube morphogenesis ISO
    Inferred from Sequence Orthology
    more info
     
    involved_in embryonic heart tube morphogenesis ISS
    Inferred from Sequence or Structural Similarity
    more info
     
    involved_in establishment of localization in cell IEA
    Inferred from Electronic Annotation
    more info
     
    acts_upstream_of_or_within establishment of localization in cell ISO
    Inferred from Sequence Orthology
    more info
     
    involved_in establishment of protein localization to endoplasmic reticulum IEA
    Inferred from Electronic Annotation
    more info
     
    involved_in establishment of protein localization to endoplasmic reticulum ISO
    Inferred from Sequence Orthology
    more info
     
    involved_in intracellular calcium ion homeostasis IEA
    Inferred from Electronic Annotation
    more info
     
    involved_in intracellular calcium ion homeostasis ISO
    Inferred from Sequence Orthology
    more info
     
    involved_in intracellular calcium ion homeostasis ISS
    Inferred from Sequence or Structural Similarity
    more info
     
    involved_in left ventricular cardiac muscle tissue morphogenesis IEA
    Inferred from Electronic Annotation
    more info
     
    acts_upstream_of_or_within left ventricular cardiac muscle tissue morphogenesis ISO
    Inferred from Sequence Orthology
    more info
     
    involved_in manganese ion transmembrane transport IMP
    Inferred from Mutant Phenotype
    more info
    PubMed 
    involved_in monoatomic ion transmembrane transport IMP
    Inferred from Mutant Phenotype
    more info
    PubMed 
    involved_in negative regulation of cytosolic calcium ion concentration IDA
    Inferred from Direct Assay
    more info
    PubMed 
    involved_in positive regulation of heart rate IEA
    Inferred from Electronic Annotation
    more info
     
    acts_upstream_of_or_within positive regulation of heart rate ISO
    Inferred from Sequence Orthology
    more info
     
    involved_in positive regulation of sequestering of calcium ion IEA
    Inferred from Electronic Annotation
    more info
     
    involved_in positive regulation of sequestering of calcium ion ISO
    Inferred from Sequence Orthology
    more info
     
    involved_in positive regulation of the force of heart contraction IEA
    Inferred from Electronic Annotation
    more info
     
    involved_in positive regulation of the force of heart contraction ISO
    Inferred from Sequence Orthology
    more info
     
    involved_in regulation of AV node cell action potential IEA
    Inferred from Electronic Annotation
    more info
     
    involved_in regulation of AV node cell action potential ISO
    Inferred from Sequence Orthology
    more info
     
    involved_in regulation of SA node cell action potential IEA
    Inferred from Electronic Annotation
    more info
     
    involved_in regulation of SA node cell action potential ISO
    Inferred from Sequence Orthology
    more info
     
    involved_in regulation of atrial cardiac muscle cell action potential IEA
    Inferred from Electronic Annotation
    more info
     
    involved_in regulation of atrial cardiac muscle cell action potential ISO
    Inferred from Sequence Orthology
    more info
     
    involved_in regulation of cardiac muscle contraction ISO
    Inferred from Sequence Orthology
    more info
     
    involved_in regulation of cardiac muscle contraction by calcium ion signaling ISO
    Inferred from Sequence Orthology
    more info
     
    involved_in regulation of cardiac muscle contraction by regulation of the release of sequestered calcium ion IEA
    Inferred from Electronic Annotation
    more info
     
    involved_in regulation of cardiac muscle contraction by regulation of the release of sequestered calcium ion ISO
    Inferred from Sequence Orthology
    more info
     
    involved_in regulation of cytosolic calcium ion concentration IMP
    Inferred from Mutant Phenotype
    more info
    PubMed 
    involved_in regulation of heart rate ISO
    Inferred from Sequence Orthology
    more info
     
    involved_in regulation of ventricular cardiac muscle cell action potential IEA
    Inferred from Electronic Annotation
    more info
     
    involved_in regulation of ventricular cardiac muscle cell action potential ISO
    Inferred from Sequence Orthology
    more info
     
    involved_in release of sequestered calcium ion into cytosol ISO
    Inferred from Sequence Orthology
    more info
     
    involved_in release of sequestered calcium ion into cytosol by sarcoplasmic reticulum IBA
    Inferred from Biological aspect of Ancestor
    more info
     
    involved_in release of sequestered calcium ion into cytosol by sarcoplasmic reticulum IEA
    Inferred from Electronic Annotation
    more info
     
    acts_upstream_of_or_within release of sequestered calcium ion into cytosol by sarcoplasmic reticulum ISO
    Inferred from Sequence Orthology
    more info
     
    involved_in release of sequestered calcium ion into cytosol by sarcoplasmic reticulum ISO
    Inferred from Sequence Orthology
    more info
     
    involved_in release of sequestered calcium ion into cytosol by sarcoplasmic reticulum ISS
    Inferred from Sequence or Structural Similarity
    more info
     
    acts_upstream_of_or_within response to caffeine ISO
    Inferred from Sequence Orthology
    more info
     
    involved_in response to caffeine ISO
    Inferred from Sequence Orthology
    more info
     
    involved_in response to calcium ion IDA
    Inferred from Direct Assay
    more info
    PubMed 
    involved_in response to hypoxia IEA
    Inferred from Electronic Annotation
    more info
     
    involved_in response to hypoxia IEP
    Inferred from Expression Pattern
    more info
    PubMed 
    involved_in response to hypoxia ISO
    Inferred from Sequence Orthology
    more info
     
    involved_in response to magnesium ion IDA
    Inferred from Direct Assay
    more info
    PubMed 
    involved_in response to muscle activity IEA
    Inferred from Electronic Annotation
    more info
     
    involved_in response to muscle activity ISO
    Inferred from Sequence Orthology
    more info
     
    involved_in response to muscle stretch IEA
    Inferred from Electronic Annotation
    more info
     
    involved_in response to muscle stretch ISO
    Inferred from Sequence Orthology
    more info
     
    involved_in response to nutrient IEP
    Inferred from Expression Pattern
    more info
    PubMed 
    involved_in response to redox state IEA
    Inferred from Electronic Annotation
    more info
     
    involved_in response to redox state ISO
    Inferred from Sequence Orthology
    more info
     
    involved_in response to xenobiotic stimulus IEP
    Inferred from Expression Pattern
    more info
    PubMed 
    involved_in sarcoplasmic reticulum calcium ion transport IMP
    Inferred from Mutant Phenotype
    more info
    PubMed 
    involved_in striated muscle contraction IBA
    Inferred from Biological aspect of Ancestor
    more info
     
    involved_in type B pancreatic cell apoptotic process IEA
    Inferred from Electronic Annotation
    more info
     
    involved_in type B pancreatic cell apoptotic process ISO
    Inferred from Sequence Orthology
    more info
     
    involved_in ventricular cardiac muscle cell action potential IEA
    Inferred from Electronic Annotation
    more info
     
    involved_in ventricular cardiac muscle cell action potential ISO
    Inferred from Sequence Orthology
    more info
     
    Component Evidence Code Pubs
    located_in A band IDA
    Inferred from Direct Assay
    more info
    PubMed 
    is_active_in Z disc IBA
    Inferred from Biological aspect of Ancestor
    more info
     
    located_in Z disc IDA
    Inferred from Direct Assay
    more info
    PubMed 
    located_in Z disc IEA
    Inferred from Electronic Annotation
    more info
     
    located_in Z disc ISO
    Inferred from Sequence Orthology
    more info
     
    part_of calcium channel complex IBA
    Inferred from Biological aspect of Ancestor
    more info
     
    part_of calcium channel complex IEA
    Inferred from Electronic Annotation
    more info
     
    part_of calcium channel complex ISO
    Inferred from Sequence Orthology
    more info
     
    located_in extrinsic component of cytoplasmic side of plasma membrane IDA
    Inferred from Direct Assay
    more info
    PubMed 
    located_in membrane ISO
    Inferred from Sequence Orthology
    more info
     
    located_in nuclear envelope IDA
    Inferred from Direct Assay
    more info
    PubMed 
    part_of protein-containing complex IDA
    Inferred from Direct Assay
    more info
    PubMed 
    part_of protein-containing complex IEA
    Inferred from Electronic Annotation
    more info
     
    part_of protein-containing complex ISO
    Inferred from Sequence Orthology
    more info
     
    is_active_in sarcolemma IBA
    Inferred from Biological aspect of Ancestor
    more info
     
    located_in sarcolemma IDA
    Inferred from Direct Assay
    more info
    PubMed 
    located_in sarcomere ISO
    Inferred from Sequence Orthology
    more info
     
    located_in sarcoplasmic reticulum IDA
    Inferred from Direct Assay
    more info
    PubMed 
    located_in sarcoplasmic reticulum ISO
    Inferred from Sequence Orthology
    more info
     
    is_active_in sarcoplasmic reticulum membrane IBA
    Inferred from Biological aspect of Ancestor
    more info
     
    located_in sarcoplasmic reticulum membrane IDA
    Inferred from Direct Assay
    more info
    PubMed 
    located_in sarcoplasmic reticulum membrane IEA
    Inferred from Electronic Annotation
    more info
     
    located_in sarcoplasmic reticulum membrane ISO
    Inferred from Sequence Orthology
    more info
     
    is_active_in sarcoplasmic reticulum membrane ISS
    Inferred from Sequence or Structural Similarity
    more info
     
    is_active_in smooth endoplasmic reticulum IBA
    Inferred from Biological aspect of Ancestor
    more info
     
    located_in smooth endoplasmic reticulum IEA
    Inferred from Electronic Annotation
    more info
     
    located_in smooth endoplasmic reticulum ISO
    Inferred from Sequence Orthology
    more info
     

    General protein information

    Preferred Names
    ryanodine receptor 2
    Names
    cardiac muscle ryanodine receptor
    cardiac muscle ryanodine receptor-calcium release channel
    cardiac-type ryaodine receptor
    ryanodine receptor 2, cardiac
    ryanodine receptor type II
    type 2 ryanodine receptor

    NCBI Reference Sequences (RefSeq)

    NEW Try the new Transcript table

    RefSeqs maintained independently of Annotated Genomes

    These reference sequences exist independently of genome builds. Explain

    These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

    mRNA and Protein(s)

    1. NM_001191043.3NP_001177972.2  ryanodine receptor 2 isoform 2

      Status: VALIDATED

      Source sequence(s)
      JAXUCZ010000017
      UniProtKB/Swiss-Prot
      B0LPN4, D7UNT3
      Conserved Domains (11) summary
      cd12877
      Location:647798
      SPRY1_RyR; SPRY domain 1 (SPRY1) of ryanodine receptor (RyR)
      cd12878
      Location:10791211
      SPRY2_RyR; SPRY domain 2 (SPRY2) of ryanodine receptor (RyR)
      cd12879
      Location:14051552
      SPRY3_RyR; SPRY domain 3 (SPRY3) of ryanodine receptor (RyR)
      pfam00520
      Location:46984858
      Ion_trans; Ion transport protein
      pfam01365
      Location:448641
      RYDR_ITPR; RIH domain
      pfam02026
      Location:26932783
      RyR; RyR domain
      pfam02815
      Location:219399
      MIR; MIR domain
      pfam06459
      Location:43144579
      RR_TM4-6; Ryanodine Receptor TM 4-6
      pfam08454
      Location:38113928
      RIH_assoc; RyR and IP3R Homology associated
      pfam13499
      Location:40124067
      EF-hand_7; EF-hand domain pair
      cl19745
      Location:9215
      Ins145_P3_rec; Inositol 1,4,5-trisphosphate/ryanodine receptor
    2. NM_032078.3NP_114467.2  ryanodine receptor 2 isoform 1

      Status: VALIDATED

      Source sequence(s)
      JAXUCZ010000017
      UniProtKB/Swiss-Prot
      B0LPN4, D7UNT3
      UniProtKB/TrEMBL
      F1LS89
      Related
      ENSRNOP00000108473.1, ENSRNOT00000158171.1
      Conserved Domains (5) summary
      smart00472
      Location:279369
      MIR; Domain in ryanodine and inositol trisphosphate receptors and protein O-mannosyltransferases
      cd12877
      Location:647798
      SPRY1_RyR; SPRY domain 1 (SPRY1) of ryanodine receptor (RyR)
      cd12878
      Location:10791211
      SPRY2_RyR; SPRY domain 2 (SPRY2) of ryanodine receptor (RyR)
      cd12879
      Location:14051552
      SPRY3_RyR; SPRY domain 3 (SPRY3) of ryanodine receptor (RyR)
      cl08302
      Location:40184073
      EFh; EF-hand, calcium binding motif; A diverse superfamily of calcium sensors and calcium signal modulators; most examples in this alignment model have 2 active canonical EF hands. Ca2+ binding induces a conformational change in the EF-hand motif, leading to ...

    RefSeqs of Annotated Genomes: GCF_036323735.1-RS_2024_02

    The following sections contain reference sequences that belong to a specific genome build. Explain

    Reference GRCr8

    Genomic

    1. NC_086035.1 Reference GRCr8

      Range
      63081527..63667141
      Download
      GenBank, FASTA, Sequence Viewer (Graphics)

    mRNA and Protein(s)

    1. XM_063276749.1XP_063132819.1  ryanodine receptor 2 isoform X1

    2. XM_063276751.1XP_063132821.1  ryanodine receptor 2 isoform X3

    3. XM_063276756.1XP_063132826.1  ryanodine receptor 2 isoform X8

    4. XM_063276752.1XP_063132822.1  ryanodine receptor 2 isoform X4

    5. XM_063276757.1XP_063132827.1  ryanodine receptor 2 isoform X9

    6. XM_063276754.1XP_063132824.1  ryanodine receptor 2 isoform X6

    7. XM_063276758.1XP_063132828.1  ryanodine receptor 2 isoform X10

    8. XM_063276753.1XP_063132823.1  ryanodine receptor 2 isoform X5

    9. XM_063276762.1XP_063132832.1  ryanodine receptor 2 isoform X14

    10. XM_063276763.1XP_063132833.1  ryanodine receptor 2 isoform X15

    11. XM_063276759.1XP_063132829.1  ryanodine receptor 2 isoform X11

      UniProtKB/TrEMBL
      F1LRZ1
      Related
      ENSRNOP00000023601.7, ENSRNOT00000023601.9
    12. XM_063276760.1XP_063132830.1  ryanodine receptor 2 isoform X12

    13. XM_063276750.1XP_063132820.1  ryanodine receptor 2 isoform X2

    14. XM_063276755.1XP_063132825.1  ryanodine receptor 2 isoform X7

    15. XM_063276764.1XP_063132834.1  ryanodine receptor 2 isoform X16

      Related
      ENSRNOP00000087428.1, ENSRNOT00000111439.2
    16. XM_063276761.1XP_063132831.1  ryanodine receptor 2 isoform X13

    RNA

    1. XR_005495333.2 RNA Sequence

    2. XR_010058952.1 RNA Sequence