Ryr2 ryanodine receptor 2 [Rattus norvegicus (Norway rat)] - Gene

Summary

Official Symbol: Ryr2provided by RGD
Official Full Name: ryanodine receptor 2provided by RGD
Primary source: RGD:620314
See related: EnsemblRapid:ENSRNOG00000017060 AllianceGenome:RGD:620314
Gene type: protein coding
RefSeq status: VALIDATED
Organism: Rattus norvegicus
Lineage: Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha; Muroidea; Muridae; Murinae; Rattus
Also known as: RyR; RYR-2
Summary: Enables ryanodine-sensitive calcium-release channel activity and scaffold protein binding activity. Involved in several processes, including metal ion transport; regulation of cytosolic calcium ion concentration; and response to magnesium ion. Located in several cellular components, including sarcolemma; sarcomere; and sarcoplasmic reticulum membrane. Is extrinsic component of cytoplasmic side of plasma membrane. Part of protein-containing complex. Used to study congestive heart failure. Biomarker of pulmonary hypertension. Human ortholog(s) of this gene implicated in arrhythmogenic right ventricular cardiomyopathy and catecholaminergic polymorphic ventricular tachycardia 1. Orthologous to human RYR2 (ryanodine receptor 2). [provided by Alliance of Genome Resources, Nov 2024]
Expression: Restricted expression toward (RPKM 3084.4) See more
Orthologs: human mouse all
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Genomic context

Location:: 17q12.1

Exon count:: 108

Annotation release	Status	Assembly	Chr	Location
RS_2024_02	current	GRCr8 (GCF_036323735.1)	17	NC_086035.1 (63081527..63667141)
RS_2023_06	previous assembly	mRatBN7.2 (GCF_015227675.2)	17	NC_051352.1 (58389925..58975641)
106	previous assembly	Rnor_6.0 (GCF_000001895.5)	17	NC_005116.4 (65533998..65955606, complement)

Chromosome 17 - NC_086035.1 Genomic Context describing neighboring genes

Genomic regions, transcripts, and products

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Go to reference sequence details

Genomic Sequence:

Go to nucleotide: Graphics FASTA GenBank

Expression

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See details

Project title: A rat RNA-Seq transcriptomic BodyMap across 11 organs and 4 developmental stages A rat RNA-Seq transcriptomic BodyMap across 11 organs and 4 developmental stages
Description: 320 RNA samples isolated from 11 organs (adrenal gland, brain, heart, kidney, liver, lung, muscle, spleen, thymus, and testes or uterus) from both sexes of Fischer 344 rats across four developmental stages (2-, 6-, 21-, and 104-weeks-old)
BioProject: PRJNA238328
Publication: PMID 24510058
Analysis date: Mon Jun 6 17:44:12 2016

Bibliography

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GeneRIFs: Gene References Into Functions

What's a GeneRIF?

RyR2 Stabilizer Attenuates Cardiac Hypertrophy by Downregulating TNF-alpha/NF-kappaB/NLRP3 Signaling Pathway through Inhibiting Calcineurin.
Title: RyR2 Stabilizer Attenuates Cardiac Hypertrophy by Downregulating TNF-α/NF-κB/NLRP3 Signaling Pathway through Inhibiting Calcineurin.
Hyperglycemia triggers RyR2-dependent alterations of mitochondrial calcium homeostasis in response to cardiac ischemia-reperfusion: Key role of DRP1 activation.
Title: Hyperglycemia triggers RyR2-dependent alterations of mitochondrial calcium homeostasis in response to cardiac ischemia-reperfusion: Key role of DRP1 activation.
Oxidative stress in early metabolic syndrome impairs cardiac RyR2 and SERCA2a activity and modifies the interplay of these proteins during Ca[2+] waves.
Title: Oxidative stress in early metabolic syndrome impairs cardiac RyR2 and SERCA2a activity and modifies the interplay of these proteins during Ca(2+) waves.
Hippocampal dendritic spines express the RyR3 but not the RyR2 ryanodine receptor isoform.
Title: Hippocampal dendritic spines express the RyR3 but not the RyR2 ryanodine receptor isoform.
Stabilization of RyR2 maintains right ventricular function, reduces the development of ventricular arrhythmias, and improves prognosis in pulmonary hypertension.
Title: Stabilization of RyR2 maintains right ventricular function, reduces the development of ventricular arrhythmias, and improves prognosis in pulmonary hypertension.
RyR2/IRBIT regulates insulin gene transcript, insulin content, and secretion in the insulinoma cell line INS-1.
Title: RyR2/IRBIT regulates insulin gene transcript, insulin content, and secretion in the insulinoma cell line INS-1.
Ryanodine receptor-mediated Ca(2+) release and atlastin-2 GTPase activity contribute to IP3-induced dendritic Ca(2+) signals in primary hippocampal neurons.
Title: Ryanodine receptor-mediated Ca(2+) release and atlastin-2 GTPase activity contribute to IP(3)-induced dendritic Ca(2+) signals in primary hippocampal neurons.
MALAT1 knockdown protects from bronchial/tracheal smooth muscle cell injury via regulation of microRNA-133a/ryanodine receptor 2 axis.
Title: MALAT1 knockdown protects from bronchial/tracheal smooth muscle cell injury via regulation of microRNA-133a/ryanodine receptor 2 axis.
Cardiac ryanodine receptor distribution is dynamic and changed by auxiliary proteins and post-translational modification.
Title: Cardiac ryanodine receptor distribution is dynamic and changed by auxiliary proteins and post-translational modification.
results provide preclinical experimental evidence that the cardiac expression of RyR2 nanobodies with AAV9 vectors is a promising therapeutic strategy for heart failure
Title: Targeting RyR2 with a phosphorylation site-specific nanobody reverses dysfunction of failing cardiomyocytes in rats.

Submit: New GeneRIF Correction See all GeneRIFs (83)

Interactions

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Products	Interactant	Other Gene	Complex	Source	Pubs	Description

General gene information

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Markers

D17Rat123 (e-PCR), detects polymorphism
- UniSTS:226834

D17Got77 (e-PCR)
- UniSTS:112415

AU049552 (e-PCR)
- UniSTS:145999

d17arb5 (e-PCR)
- UniSTS:121185

AU049096 (e-PCR)
- UniSTS:145544

D17Got79 (e-PCR)
- UniSTS:114088

PMC21940P1 (e-PCR)
- UniSTS:272079

Ryr2 (e-PCR), detects polymorphism
- UniSTS:507352

RH131486 (e-PCR)
- UniSTS:214769

D17Rat68 (e-PCR), detects polymorphism
- UniSTS:240376

Gene Ontology Provided by RGD

Function	Evidence Code	Pubs
enables calcium channel activity	ISO Inferred from Sequence Orthology more info
enables calcium channel activity	ISS Inferred from Sequence or Structural Similarity more info
enables calcium ion binding	IEA Inferred from Electronic Annotation more info
enables calcium-induced calcium release activity	IDA Inferred from Direct Assay more info	PubMed
enables calcium-induced calcium release activity	ISO Inferred from Sequence Orthology more info
enables calmodulin binding	IEA Inferred from Electronic Annotation more info
enables calmodulin binding	ISO Inferred from Sequence Orthology more info
enables calmodulin binding	ISS Inferred from Sequence or Structural Similarity more info
enables enzyme binding	ISO Inferred from Sequence Orthology more info
enables identical protein binding	IEA Inferred from Electronic Annotation more info
enables identical protein binding	ISO Inferred from Sequence Orthology more info
enables intracellularly gated calcium channel activity	ISO Inferred from Sequence Orthology more info
enables intracellularly gated calcium channel activity	ISS Inferred from Sequence or Structural Similarity more info
enables organic cyclic compound binding	ISO Inferred from Sequence Orthology more info
enables protein binding	IPI Inferred from Physical Interaction more info	PubMed
enables protein kinase A catalytic subunit binding	IEA Inferred from Electronic Annotation more info
enables protein kinase A catalytic subunit binding	ISO Inferred from Sequence Orthology more info
enables protein kinase A regulatory subunit binding	IEA Inferred from Electronic Annotation more info
enables protein kinase A regulatory subunit binding	ISO Inferred from Sequence Orthology more info
enables protein kinase binding	ISO Inferred from Sequence Orthology more info
enables ryanodine-sensitive calcium-release channel activity	IBA Inferred from Biological aspect of Ancestor more info
enables ryanodine-sensitive calcium-release channel activity	IDA Inferred from Direct Assay more info	PubMed
enables ryanodine-sensitive calcium-release channel activity	IEA Inferred from Electronic Annotation more info
enables ryanodine-sensitive calcium-release channel activity	IMP Inferred from Mutant Phenotype more info	PubMed
enables ryanodine-sensitive calcium-release channel activity	ISO Inferred from Sequence Orthology more info
enables scaffold protein binding	IPI Inferred from Physical Interaction more info	PubMed
enables suramin binding	IEA Inferred from Electronic Annotation more info
enables suramin binding	ISO Inferred from Sequence Orthology more info

Process	Evidence Code	Pubs
involved_in Purkinje myocyte to ventricular cardiac muscle cell signaling	IEA Inferred from Electronic Annotation more info
involved_in Purkinje myocyte to ventricular cardiac muscle cell signaling	ISO Inferred from Sequence Orthology more info
acts_upstream_of_or_within calcium ion transmembrane import into cytosol	ISO Inferred from Sequence Orthology more info
involved_in calcium ion transmembrane transport	IEA Inferred from Electronic Annotation more info
involved_in calcium ion transmembrane transport	IMP Inferred from Mutant Phenotype more info	PubMed
acts_upstream_of_or_within calcium ion transmembrane transport	ISO Inferred from Sequence Orthology more info
acts_upstream_of_or_within calcium ion transport	ISO Inferred from Sequence Orthology more info
involved_in calcium ion transport	ISO Inferred from Sequence Orthology more info
involved_in calcium ion transport	ISS Inferred from Sequence or Structural Similarity more info
involved_in calcium ion transport into cytosol	IEA Inferred from Electronic Annotation more info
involved_in calcium ion transport into cytosol	ISO Inferred from Sequence Orthology more info
involved_in calcium-mediated signaling	IEA Inferred from Electronic Annotation more info
involved_in calcium-mediated signaling	ISO Inferred from Sequence Orthology more info
involved_in calcium-mediated signaling	ISS Inferred from Sequence or Structural Similarity more info
involved_in cardiac muscle contraction	ISO Inferred from Sequence Orthology more info
involved_in cardiac muscle hypertrophy	IEA Inferred from Electronic Annotation more info
acts_upstream_of_or_within cardiac muscle hypertrophy	ISO Inferred from Sequence Orthology more info
involved_in cellular response to caffeine	IEA Inferred from Electronic Annotation more info
acts_upstream_of_or_within cellular response to caffeine	ISO Inferred from Sequence Orthology more info
involved_in cellular response to caffeine	ISO Inferred from Sequence Orthology more info
involved_in cellular response to caffeine	ISS Inferred from Sequence or Structural Similarity more info
involved_in cellular response to epinephrine stimulus	IEA Inferred from Electronic Annotation more info
involved_in cellular response to epinephrine stimulus	ISO Inferred from Sequence Orthology more info
involved_in detection of calcium ion	IEA Inferred from Electronic Annotation more info
involved_in detection of calcium ion	ISO Inferred from Sequence Orthology more info
involved_in embryonic heart tube morphogenesis	IEA Inferred from Electronic Annotation more info
involved_in embryonic heart tube morphogenesis	ISO Inferred from Sequence Orthology more info
involved_in embryonic heart tube morphogenesis	ISS Inferred from Sequence or Structural Similarity more info
involved_in establishment of localization in cell	IEA Inferred from Electronic Annotation more info
acts_upstream_of_or_within establishment of localization in cell	ISO Inferred from Sequence Orthology more info
involved_in establishment of protein localization to endoplasmic reticulum	IEA Inferred from Electronic Annotation more info
involved_in establishment of protein localization to endoplasmic reticulum	ISO Inferred from Sequence Orthology more info
involved_in intracellular calcium ion homeostasis	IEA Inferred from Electronic Annotation more info
involved_in intracellular calcium ion homeostasis	ISO Inferred from Sequence Orthology more info
involved_in intracellular calcium ion homeostasis	ISS Inferred from Sequence or Structural Similarity more info
involved_in left ventricular cardiac muscle tissue morphogenesis	IEA Inferred from Electronic Annotation more info
acts_upstream_of_or_within left ventricular cardiac muscle tissue morphogenesis	ISO Inferred from Sequence Orthology more info
involved_in manganese ion transmembrane transport	IMP Inferred from Mutant Phenotype more info	PubMed
involved_in monoatomic ion transmembrane transport	IMP Inferred from Mutant Phenotype more info	PubMed
involved_in negative regulation of cytosolic calcium ion concentration	IDA Inferred from Direct Assay more info	PubMed
involved_in positive regulation of heart rate	IEA Inferred from Electronic Annotation more info
acts_upstream_of_or_within positive regulation of heart rate	ISO Inferred from Sequence Orthology more info
involved_in positive regulation of sequestering of calcium ion	IEA Inferred from Electronic Annotation more info
involved_in positive regulation of sequestering of calcium ion	ISO Inferred from Sequence Orthology more info
involved_in positive regulation of the force of heart contraction	IEA Inferred from Electronic Annotation more info
involved_in positive regulation of the force of heart contraction	ISO Inferred from Sequence Orthology more info
involved_in regulation of AV node cell action potential	IEA Inferred from Electronic Annotation more info
involved_in regulation of AV node cell action potential	ISO Inferred from Sequence Orthology more info
involved_in regulation of SA node cell action potential	IEA Inferred from Electronic Annotation more info
involved_in regulation of SA node cell action potential	ISO Inferred from Sequence Orthology more info
involved_in regulation of atrial cardiac muscle cell action potential	IEA Inferred from Electronic Annotation more info
involved_in regulation of atrial cardiac muscle cell action potential	ISO Inferred from Sequence Orthology more info
involved_in regulation of cardiac muscle contraction	ISO Inferred from Sequence Orthology more info
involved_in regulation of cardiac muscle contraction by calcium ion signaling	ISO Inferred from Sequence Orthology more info
involved_in regulation of cardiac muscle contraction by regulation of the release of sequestered calcium ion	IEA Inferred from Electronic Annotation more info
involved_in regulation of cardiac muscle contraction by regulation of the release of sequestered calcium ion	ISO Inferred from Sequence Orthology more info
involved_in regulation of cytosolic calcium ion concentration	IMP Inferred from Mutant Phenotype more info	PubMed
involved_in regulation of heart rate	ISO Inferred from Sequence Orthology more info
involved_in regulation of ventricular cardiac muscle cell action potential	IEA Inferred from Electronic Annotation more info
involved_in regulation of ventricular cardiac muscle cell action potential	ISO Inferred from Sequence Orthology more info
involved_in release of sequestered calcium ion into cytosol	ISO Inferred from Sequence Orthology more info
involved_in release of sequestered calcium ion into cytosol by sarcoplasmic reticulum	IBA Inferred from Biological aspect of Ancestor more info
involved_in release of sequestered calcium ion into cytosol by sarcoplasmic reticulum	IEA Inferred from Electronic Annotation more info
acts_upstream_of_or_within release of sequestered calcium ion into cytosol by sarcoplasmic reticulum	ISO Inferred from Sequence Orthology more info
involved_in release of sequestered calcium ion into cytosol by sarcoplasmic reticulum	ISO Inferred from Sequence Orthology more info
involved_in release of sequestered calcium ion into cytosol by sarcoplasmic reticulum	ISS Inferred from Sequence or Structural Similarity more info
acts_upstream_of_or_within response to caffeine	ISO Inferred from Sequence Orthology more info
involved_in response to caffeine	ISO Inferred from Sequence Orthology more info
involved_in response to calcium ion	IDA Inferred from Direct Assay more info	PubMed
involved_in response to hypoxia	IEA Inferred from Electronic Annotation more info
involved_in response to hypoxia	IEP Inferred from Expression Pattern more info	PubMed
involved_in response to hypoxia	ISO Inferred from Sequence Orthology more info
involved_in response to magnesium ion	IDA Inferred from Direct Assay more info	PubMed
involved_in response to muscle activity	IEA Inferred from Electronic Annotation more info
involved_in response to muscle activity	ISO Inferred from Sequence Orthology more info
involved_in response to muscle stretch	IEA Inferred from Electronic Annotation more info
involved_in response to muscle stretch	ISO Inferred from Sequence Orthology more info
involved_in response to nutrient	IEP Inferred from Expression Pattern more info	PubMed
involved_in response to redox state	IEA Inferred from Electronic Annotation more info
involved_in response to redox state	ISO Inferred from Sequence Orthology more info
involved_in response to xenobiotic stimulus	IEP Inferred from Expression Pattern more info	PubMed
involved_in sarcoplasmic reticulum calcium ion transport	IMP Inferred from Mutant Phenotype more info	PubMed
involved_in striated muscle contraction	IBA Inferred from Biological aspect of Ancestor more info
involved_in type B pancreatic cell apoptotic process	IEA Inferred from Electronic Annotation more info
involved_in type B pancreatic cell apoptotic process	ISO Inferred from Sequence Orthology more info
involved_in ventricular cardiac muscle cell action potential	IEA Inferred from Electronic Annotation more info
involved_in ventricular cardiac muscle cell action potential	ISO Inferred from Sequence Orthology more info

Component	Evidence Code	Pubs
located_in A band	IDA Inferred from Direct Assay more info	PubMed
is_active_in Z disc	IBA Inferred from Biological aspect of Ancestor more info
located_in Z disc	IDA Inferred from Direct Assay more info	PubMed
located_in Z disc	IEA Inferred from Electronic Annotation more info
located_in Z disc	ISO Inferred from Sequence Orthology more info
part_of calcium channel complex	IBA Inferred from Biological aspect of Ancestor more info
part_of calcium channel complex	IEA Inferred from Electronic Annotation more info
part_of calcium channel complex	ISO Inferred from Sequence Orthology more info
located_in extrinsic component of cytoplasmic side of plasma membrane	IDA Inferred from Direct Assay more info	PubMed
located_in membrane	ISO Inferred from Sequence Orthology more info
located_in nuclear envelope	IDA Inferred from Direct Assay more info	PubMed
part_of protein-containing complex	IDA Inferred from Direct Assay more info	PubMed
part_of protein-containing complex	IEA Inferred from Electronic Annotation more info
part_of protein-containing complex	ISO Inferred from Sequence Orthology more info
is_active_in sarcolemma	IBA Inferred from Biological aspect of Ancestor more info
located_in sarcolemma	IDA Inferred from Direct Assay more info	PubMed
located_in sarcomere	ISO Inferred from Sequence Orthology more info
located_in sarcoplasmic reticulum	IDA Inferred from Direct Assay more info	PubMed
located_in sarcoplasmic reticulum	ISO Inferred from Sequence Orthology more info
is_active_in sarcoplasmic reticulum membrane	IBA Inferred from Biological aspect of Ancestor more info
located_in sarcoplasmic reticulum membrane	IDA Inferred from Direct Assay more info	PubMed
located_in sarcoplasmic reticulum membrane	IEA Inferred from Electronic Annotation more info
located_in sarcoplasmic reticulum membrane	ISO Inferred from Sequence Orthology more info
is_active_in sarcoplasmic reticulum membrane	ISS Inferred from Sequence or Structural Similarity more info
is_active_in smooth endoplasmic reticulum	IBA Inferred from Biological aspect of Ancestor more info
located_in smooth endoplasmic reticulum	IEA Inferred from Electronic Annotation more info
located_in smooth endoplasmic reticulum	ISO Inferred from Sequence Orthology more info

General protein information

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Preferred Names: ryanodine receptor 2

Names: cardiac muscle ryanodine receptor; cardiac muscle ryanodine receptor-calcium release channel; cardiac-type ryaodine receptor; ryanodine receptor 2, cardiac; ryanodine receptor type II; type 2 ryanodine receptor

NCBI Reference Sequences (RefSeq)

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RefSeqs maintained independently of Annotated Genomes

These reference sequences exist independently of genome builds. Explain

These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

mRNA and Protein(s)

NM_001191043.3 → NP_001177972.2 ryanodine receptor 2 isoform 2

Status: VALIDATED

Source sequence(s)

JAXUCZ010000017

UniProtKB/Swiss-Prot

B0LPN4, D7UNT3

Conserved Domains (11) summary

cd12877
Location:647 → 798

SPRY1_RyR; SPRY domain 1 (SPRY1) of ryanodine receptor (RyR)

cd12878
Location:1079 → 1211

SPRY2_RyR; SPRY domain 2 (SPRY2) of ryanodine receptor (RyR)

cd12879
Location:1405 → 1552

SPRY3_RyR; SPRY domain 3 (SPRY3) of ryanodine receptor (RyR)

pfam00520
Location:4698 → 4858

Ion_trans; Ion transport protein

pfam01365
Location:448 → 641

RYDR_ITPR; RIH domain

pfam02026
Location:2693 → 2783

RyR; RyR domain

pfam02815
Location:219 → 399

MIR; MIR domain

pfam06459
Location:4314 → 4579

RR_TM4-6; Ryanodine Receptor TM 4-6

pfam08454
Location:3811 → 3928

RIH_assoc; RyR and IP3R Homology associated

pfam13499
Location:4012 → 4067

EF-hand_7; EF-hand domain pair

cl19745
Location:9 → 215

Ins145_P3_rec; Inositol 1,4,5-trisphosphate/ryanodine receptor
NM_032078.3 → NP_114467.2 ryanodine receptor 2 isoform 1

Status: VALIDATED

Source sequence(s)

JAXUCZ010000017

UniProtKB/Swiss-Prot

B0LPN4, D7UNT3

UniProtKB/TrEMBL

F1LS89

Related

ENSRNOP00000108473.1, ENSRNOT00000158171.1

Conserved Domains (5) summary

smart00472
Location:279 → 369

MIR; Domain in ryanodine and inositol trisphosphate receptors and protein O-mannosyltransferases

cd12877
Location:647 → 798

SPRY1_RyR; SPRY domain 1 (SPRY1) of ryanodine receptor (RyR)

cd12878
Location:1079 → 1211

SPRY2_RyR; SPRY domain 2 (SPRY2) of ryanodine receptor (RyR)

cd12879
Location:1405 → 1552

SPRY3_RyR; SPRY domain 3 (SPRY3) of ryanodine receptor (RyR)

cl08302
Location:4018 → 4073

EFh; EF-hand, calcium binding motif; A diverse superfamily of calcium sensors and calcium signal modulators; most examples in this alignment model have 2 active canonical EF hands. Ca2+ binding induces a conformational change in the EF-hand motif, leading to ...