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    Pbld1 phenazine biosynthesis-like protein domain containing 1 [ Mus musculus (house mouse) ]

    Gene ID: 68371, updated on 2-Nov-2024

    Summary

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    Official Symbol
    Pbld1provided by MGI
    Official Full Name
    phenazine biosynthesis-like protein domain containing 1provided by MGI
    Primary source
    MGI:MGI:1915621
    See related
    Ensembl:ENSMUSG00000112129 AllianceGenome:MGI:1915621
    Gene type
    protein coding
    RefSeq status
    VALIDATED
    Organism
    Mus musculus
    Lineage
    Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha; Muroidea; Muridae; Murinae; Mus; Mus
    Also known as
    Pbld; Mawbp; 0610038K03Rik
    Summary
    Predicted to enable identical protein binding activity and isomerase activity. Predicted to be involved in maintenance of gastrointestinal epithelium. Predicted to act upstream of or within with a positive effect on negative regulation of transforming growth factor beta receptor signaling pathway. Predicted to be active in cytoplasm. Is expressed in eye; heart; liver; metanephros; and retina. Orthologous to human PBLD (phenazine biosynthesis like protein domain containing). [provided by Alliance of Genome Resources, Nov 2024]
    Expression
    Biased expression in liver adult (RPKM 53.4), kidney adult (RPKM 47.4) and 3 other tissues See more
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    Genomic context

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    See Pbld1 in Genome Data Viewer
    Location:
    10 B4; 10 32.53 cM
    Exon count:
    12
    Annotation release Status Assembly Chr Location
    RS_2024_02 current GRCm39 (GCF_000001635.27) 10 NC_000076.7 (62896404..62913743)
    108.20200622 previous assembly GRCm38.p6 (GCF_000001635.26) 10 NC_000076.6 (63060625..63077964)

    Chromosome 10 - NC_000076.7Genomic Context describing neighboring genes Neighboring gene RUN and FYVE domain-containing 2 Neighboring gene STARR-seq mESC enhancer starr_26916 Neighboring gene heterogeneous nuclear ribonucleoprotein H3 Neighboring gene phenazine biosynthesis-like protein domain containing 2 Neighboring gene predicted gene 16143 Neighboring gene STARR-seq mESC enhancer starr_26919 Neighboring gene atonal bHLH transcription factor 7 Neighboring gene myopalladin Neighboring gene STARR-seq mESC enhancer starr_26921 Neighboring gene STARR-seq mESC enhancer starr_26922 Neighboring gene STARR-seq mESC enhancer starr_26924

    Genomic regions, transcripts, and products

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    Go to nucleotide: Graphics FASTA GenBank

    Expression

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    • Project title: Mouse ENCODE transcriptome data Mouse ENCODE transcriptome data
    • Description: RNA profiling data sets generated by the Mouse ENCODE project.
    • BioProject: PRJNA66167
    • Publication: PMID 25409824
    • Analysis date: n/a

    Bibliography

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    Related articles in PubMed

    1. Deletion of a remote enhancer near ATOH7 disrupts retinal neurogenesis, causing NCRNA disease. Ghiasvand NM, et al. Nat Neurosci, 2011 May. PMID 21441919, Free PMC Article
    2. Chd8 Mutation Leads to Autistic-like Behaviors and Impaired Striatal Circuits. Platt RJ, et al. Cell Rep, 2017 Apr 11. PMID 28402856, Free PMC Article
    3. Database resources of the National Center for Biotechnology Information. Wheeler DL, et al. Nucleic Acids Res, 2001 Jan 1. PMID 11125038, Free PMC Article
    4. BraInMap Elucidates the Macromolecular Connectivity Landscape of Mammalian Brain. Pourhaghighi R, et al. Cell Syst, 2020 Apr 22. PMID 32325033, Free PMC Article
    5. Genetic determinants of micronucleus formation in vivo. Adams DJ, et al. Nature, 2024 Mar. PMID 38355793, Free PMC Article

    See all (16) citations in PubMed

    GeneRIFs: Gene References Into Functions

    Variation

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    Alleles

    Alleles of this type are documented at Mouse Genome Informatics  (MGI)
    • Endonuclease-mediated (4) 

    Interactions

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    Products Interactant Other Gene Complex Source Pubs Description

    General gene information

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    Markers

    Homology

    Gene Ontology Provided by MGI

    Function Evidence Code Pubs
    enables identical protein binding ISO
    Inferred from Sequence Orthology
    more info
    		  
    enables isomerase activity IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    enables isomerase activity IEA
    Inferred from Electronic Annotation
    more info
    		  
    Process Evidence Code Pubs
    involved_in biosynthetic process IEA
    Inferred from Electronic Annotation
    more info
    		  
    involved_in maintenance of gastrointestinal epithelium ISO
    Inferred from Sequence Orthology
    more info
    		  
    acts_upstream_of_or_within_positive_effect negative regulation of transforming growth factor beta receptor signaling pathway ISO
    Inferred from Sequence Orthology
    more info
    		  
    Component Evidence Code Pubs
    is_active_in cytoplasm IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    located_in cytoplasm ISO
    Inferred from Sequence Orthology
    more info
    		  

    General protein information

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    Preferred Names
    phenazine biosynthesis-like domain-containing protein 1
    Names
    MAWD binding protein homolog 1

    NCBI Reference Sequences (RefSeq)

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    RefSeqs maintained independently of Annotated Genomes

    These reference sequences exist independently of genome builds. Explain

    These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

    mRNA and Protein(s)

    1. NM_001359529.1 → NP_001346458.1  phenazine biosynthesis-like domain-containing protein 1 isoform 1

      Status: VALIDATED

      Source sequence(s)
      AC113107, AK143947
      Consensus CDS
      CCDS23895.1
      UniProtKB/Swiss-Prot
      Q8VCF3, Q9DCG6
      UniProtKB/TrEMBL
      K3W4L7
      Conserved Domains (1) summary
      cl27516
      Location:9 → 284
      PhzC-PhzF; Phenazine biosynthesis-like protein

    2. NM_026701.3 → NP_080977.2  phenazine biosynthesis-like domain-containing protein 1 isoform 1

      See identical proteins and their annotated locations for NP_080977.2

      Status: VALIDATED

      Source sequence(s)
      AC113107, AK143947
      Consensus CDS
      CCDS23895.1
      UniProtKB/Swiss-Prot
      Q8VCF3, Q9DCG6
      UniProtKB/TrEMBL
      K3W4L7
      Related
      ENSMUSP00000136589.2, ENSMUST00000178684.3
      Conserved Domains (1) summary
      cl27516
      Location:9 → 284
      PhzC-PhzF; Phenazine biosynthesis-like protein

    RNA

    1. NR_153192.1 RNA Sequence

      Status: VALIDATED

      Source sequence(s)
      AC113107, BC028493, BE628967
      Related
      ENSMUST00000219687.2

    2. NR_153193.1 RNA Sequence

      Status: VALIDATED

      Source sequence(s)
      AC113107, BC028493
      Related
      ENSMUST00000219045.2

    RefSeqs of Annotated Genomes: GCF_000001635.27-RS_2024_02

    The following sections contain reference sequences that belong to a specific genome build. Explain

    Reference GRCm39 C57BL/6J

    Genomic

    1. NC_000076.7 Reference GRCm39 C57BL/6J

      Range
      62896404..62913743
      Download
      GenBank, FASTA, Sequence Viewer (Graphics)

    mRNA and Protein(s)

    1. XM_006514030.4 → XP_006514093.1  phenazine biosynthesis-like domain-containing protein 1 isoform X2

      Conserved Domains (1) summary
      cl29427
      Location:74 → 285
      PhzC-PhzF; Phenazine biosynthesis-like protein

    2. XM_006514029.4 → XP_006514092.1  phenazine biosynthesis-like domain-containing protein 1 isoform X1

      UniProtKB/TrEMBL
      K3W4L7
      Conserved Domains (1) summary
      cl29427
      Location:74 → 349
      PhzC-PhzF; Phenazine biosynthesis-like protein

    3. XM_006514031.1 → XP_006514094.1  phenazine biosynthesis-like domain-containing protein 1 isoform X3

      UniProtKB/TrEMBL
      K3W4L7
      Conserved Domains (1) summary
      cl29427
      Location:41 → 316
      PhzC-PhzF; Phenazine biosynthesis-like protein
    Nucleotide Protein Strain
    Heading Accession and Version
    Protein Accession Links
    GenPept Link UniProtKB Link
    Q9DCG6.2 GenPept UniProtKB/Swiss-Prot:Q9DCG6

    Gene LinkOut

    The following LinkOut resources are supplied by external providers. These providers are responsible for maintaining the links.

    Other Literature Sources
    Chemical Information
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