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    SULT1A3 sulfotransferase family 1A member 3 [ Homo sapiens (human) ]

    Gene ID: 6818, updated on 14-Nov-2024

    Summary

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    Official Symbol
    SULT1A3provided by HGNC
    Official Full Name
    sulfotransferase family 1A member 3provided by HGNC
    Primary source
    HGNC:HGNC:11455
    See related
    Ensembl:ENSG00000261052 MIM:600641; AllianceGenome:HGNC:11455
    Gene type
    protein coding
    RefSeq status
    REVIEWED
    Organism
    Homo sapiens
    Lineage
    Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Primates; Haplorrhini; Catarrhini; Hominidae; Homo
    Also known as
    STM; HAST; HAST3; M-PST; ST1A3; ST1A4; ST1A5; TL-PST; ST1A3/ST1A4
    Summary
    Sulfotransferase enzymes catalyze the sulfate conjugation of many hormones, neurotransmitters, drugs, and xenobiotic compounds. These cytosolic enzymes are different in their tissue distributions and substrate specificities. The gene structure (number and length of exons) is similar among family members. This gene encodes a phenol sulfotransferase with thermolabile enzyme activity. Four sulfotransferase genes are located on the p arm of chromosome 16; this gene and SULT1A4 arose from a segmental duplication. This gene is the most centromeric of the four sulfotransferase genes. Read-through transcription exists between this gene and the upstream SLX1A (SLX1 structure-specific endonuclease subunit homolog A) gene that encodes a protein containing GIY-YIG domains. [provided by RefSeq, Nov 2010]
    Expression
    Broad expression in duodenum (RPKM 134.6), small intestine (RPKM 93.8) and 23 other tissues See more
    Orthologs
    all
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    Genomic context

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    See SULT1A3 in Genome Data Viewer
    Location:
    16p11.2
    Exon count:
    8
    Annotation release Status Assembly Chr Location
    RS_2024_08 current GRCh38.p14 (GCF_000001405.40) 16 NC_000016.10 (30199255..30204310)
    RS_2024_08 current T2T-CHM13v2.0 (GCF_009914755.1) 16 NC_060940.1 (30483809..30488863)
    RS_2024_09 previous assembly GRCh37.p13 (GCF_000001405.25) 16 NC_000016.9 (30210576..30215631)

    Chromosome 16 - NC_000016.10Genomic Context describing neighboring genes Neighboring gene OCT4-NANOG-H3K27ac hESC enhancer GRCh37_chr16:30204716-30205440 Neighboring gene SLX1A-SULT1A3 readthrough (NMD candidate) Neighboring gene H3K27ac-H3K4me1 hESC enhancer GRCh37_chr16:30206166-30206889 Neighboring gene bolA family member 2B Neighboring gene SLX1 homolog A, structure-specific endonuclease subunit Neighboring gene SAGA complex associated factor 29 pseudogene Neighboring gene H3K4me1 hESC enhancer GRCh37_chr16:30218380-30219378 Neighboring gene uncharacterized LOC101929894 Neighboring gene phospholipase A2 group XJ, pseudogene

    Genomic regions, transcripts, and products

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    Go to nucleotide: Graphics FASTA GenBank

    Expression

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    • Project title: HPA RNA-seq normal tissues HPA RNA-seq normal tissues
    • Description: RNA-seq was performed of tissue samples from 95 human individuals representing 27 different tissues in order to determine tissue-specificity of all protein-coding genes
    • BioProject: PRJEB4337
    • Publication: PMID 24309898
    • Analysis date: Wed Apr 4 07:08:55 2018

    Bibliography

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    Related articles in PubMed

    1. Cigarette smoke toxicants as substrates and inhibitors for human cytosolic SULTs. Yasuda S, et al. Toxicol Appl Pharmacol, 2007 May 15. PMID 17433394
    2. SULT1A3-mediated regiospecific 7-O-sulfation of flavonoids in Caco-2 cells can be explained by the relevant molecular docking studies. Meng S, et al. Mol Pharm, 2012 Apr 2. PMID 22352375, Free PMC Article
    3. Sulfation of chlorotyrosine and nitrotyrosine by human lung endothelial and epithelial cells: role of the human SULT1A3. Yasuda S, et al. Toxicol Appl Pharmacol, 2011 Mar 1. PMID 21168432
    4. Quantitative evaluation of the expression and activity of five major sulfotransferases (SULTs) in human tissues: the SULT "pie". Riches Z, et al. Drug Metab Dispos, 2009 Nov. PMID 19679676, Free PMC Article
    5. Expression and functional activities of selected sulfotransferase isoforms in BeWo cells and primary cytotrophoblast cells. Mitra P, et al. Biochem Pharmacol, 2009 Dec 15. PMID 19646966, Free PMC Article

    See all (78) citations in PubMed

    GeneRIFs: Gene References Into Functions

    What's a GeneRIF?
    1. Role of Conformational Dynamics of Sulfotransferases SULT1A1 and SULT1A3 in Substrate Specificity.
      Title: Role of Conformational Dynamics of Sulfotransferases SULT1A1 and SULT1A3 in Substrate Specificity.
    2. Farnesoid X receptor represses human sulfotransferase 1A3 expression through direct binding to the promoter.
      Title: Farnesoid X receptor represses human sulfotransferase 1A3 expression through direct binding to the promoter.
    3. Interaction of the Brain-Selective Sulfotransferase SULT4A1 with Other Cytosolic Sulfotransferases: Effects on Protein Expression and Function.
      Title: Interaction of the Brain-Selective Sulfotransferase SULT4A1 with Other Cytosolic Sulfotransferases: Effects on Protein Expression and Function.
    4. The results obtained showed clearly the differential enzymatic characteristics of SULT1A3 allozymes in mediating the sulfation of phenylephrine and salbutamol. This information may contribute toward a better understanding of the pharmacokinetics of these two drugs in individuals with distinct SULT1A3 and/or SULT1A4 genotypes.
      Title: Impact of SULT1A3/SULT1A4 genetic polymorphisms on the sulfation of phenylephrine and salbutamol by human SULT1A3 allozymes.
    5. In Alzheimer's disease patients, there was a significantly lower copy number in SULT1A3 genes compared to controls.
      Title: Sulfotransferase 1A3/4 copy number variation is associated with neurodegenerative disease.
    6. Effects of human SULT1A3/SULT1A4 genetic polymorphisms on the sulfation of acetaminophen and opioid drugs by the cytosolic sulfotransferase SULT1A3
      Title: Effects of human SULT1A3/SULT1A4 genetic polymorphisms on the sulfation of acetaminophen and opioid drugs by the cytosolic sulfotransferase SULT1A3.
    7. analysis of the catechin-binding site of SULT1A3
      Title: Tetrahydrobiopterin regulates monoamine neurotransmitter sulfonation.
    8. Our results implied that SULT1A3/4 exhibited bidirectional effect on tumor and normal hepatocytes and may thus provide a novel strategy for hepatocellular carcinoma clinical targeting. In addition, SULT1A3/4 re-expression could serve as a biomarker for hepatocellular carcinoma prognosis.
      Title: Dopamine-induced SULT1A3/4 promotes EMT and cancer stemness in hepatocellular carcinoma.
    9. The present study revealed SULT1A3 as the major human SULT enzyme capable of sulfating dextrorphan
      Title: Human Cytosolic Sulfotransferase SULT1A3 Mediates the Sulfation of Dextrorphan.
    10. Sulfate metabolites R-6-S and R-4'-S were generated from raloxifene in SULT293 expression HEK293 cells. Cellular excretion of the raloxifene sulfates was mainly mediated by BCRP and MRP4.
      Title: Sulfonation of raloxifene in HEK293 cells overexpressing SULT1A3: Involvement of breast cancer resistance protein (BCRP/ABCG2) and multidrug resistance-associated protein 4 (MRP4/ABCC4) in excretion of sulfate metabolites.
    Submit: New GeneRIF Correction See all GeneRIFs (29)

    Phenotypes

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    Review eQTL and phenotype association data in this region using PheGenI

    Variation

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    See variants in ClinVar

    See studies and variants in dbVar

    See Variation Viewer (GRCh37.p13)

    See Variation Viewer (GRCh38)

    Pathways from PubChem

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    Interactions

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    Products Interactant Other Gene Complex Source Pubs Description

    General gene information

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    Markers

    Readthrough SLX1A-SULT1A3

    Readthrough gene: SLX1A-SULT1A3, Included gene: SLX1A

    Homology

    Clone Names

    • MGC117469

    Gene Ontology Provided by GOA

    Function Evidence Code Pubs
    enables amine sulfotransferase activity IDA
    Inferred from Direct Assay
    more info
    		 PubMed 
    enables aryl sulfotransferase activity IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    enables aryl sulfotransferase activity IMP
    Inferred from Mutant Phenotype
    more info
    		 PubMed 
    enables protein binding IPI
    Inferred from Physical Interaction
    more info
    		 PubMed 
    enables sulfate binding IDA
    Inferred from Direct Assay
    more info
    		 PubMed 
    enables sulfotransferase activity IDA
    Inferred from Direct Assay
    more info
    		 PubMed 
    Process Evidence Code Pubs
    involved_in 3'-phosphoadenosine 5'-phosphosulfate metabolic process IDA
    Inferred from Direct Assay
    more info
    		 PubMed 
    involved_in cellular response to dopamine IMP
    Inferred from Mutant Phenotype
    more info
    		 PubMed 
    involved_in dopamine catabolic process IDA
    Inferred from Direct Assay
    more info
    		 PubMed 
    involved_in dopamine metabolic process IMP
    Inferred from Mutant Phenotype
    more info
    		 PubMed 
    involved_in ethanol catabolic process IDA
    Inferred from Direct Assay
    more info
    		 PubMed 
    involved_in flavonoid metabolic process IDA
    Inferred from Direct Assay
    more info
    		 PubMed 
    involved_in steroid metabolic process IEA
    Inferred from Electronic Annotation
    more info
    		  
    involved_in sulfation IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    involved_in sulfation IDA
    Inferred from Direct Assay
    more info
    		 PubMed 
    involved_in xenobiotic metabolic process IDA
    Inferred from Direct Assay
    more info
    		 PubMed 
    Component Evidence Code Pubs
    is_active_in cytoplasm IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    located_in cytosol TAS
    Traceable Author Statement
    more info
    		  

    General protein information

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    Preferred Names
    sulfotransferase 1A3
    Names
    Sulfotransferase 1A4
    aryl sulfotransferase 1A3/1A4
    catecholamine-sulfating phenol sulfotransferase
    dopamine-specific sulfotransferase
    monoamine-sulfating phenosulfotransferase
    phenol sulfotransferase 1A5
    placental estrogen sulfotransferase
    sulfokinase
    sulfotransferase family, cytosolic, 1A, phenol-preferring, member 3
    thermolabile (monoamine, M form) phenol sulfotransferase
    NP_808220.1

    NCBI Reference Sequences (RefSeq)

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    RefSeqs maintained independently of Annotated Genomes

    These reference sequences exist independently of genome builds. Explain

    These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

    mRNA and Protein(s)

    1. NM_177552.4 → NP_808220.1  sulfotransferase 1A3

      See identical proteins and their annotated locations for NP_808220.1

      Status: REVIEWED

      Source sequence(s)
      BC078144, BC144355
      Consensus CDS
      CCDS10674.1
      UniProtKB/Swiss-Prot
      B4DNV0, O95603, P0DMM9, P0DMN0, P50224, Q1ET66, Q6ZWJ5
      UniProtKB/TrEMBL
      B3KT14, Q1ET61, Q1ET62, Q1ET63, Q2TAB3
      Related
      ENSP00000343645.6, ENST00000338971.10
      Conserved Domains (1) summary
      pfam00685
      Location:38 → 287
      Sulfotransfer_1; Sulfotransferase domain

    RefSeqs of Annotated Genomes: GCF_000001405.40-RS_2024_08

    The following sections contain reference sequences that belong to a specific genome build. Explain

    Reference GRCh38.p14 Primary Assembly

    Genomic

    1. NC_000016.10 Reference GRCh38.p14 Primary Assembly

      Range
      30199255..30204310
      Download
      GenBank, FASTA, Sequence Viewer (Graphics)

    Alternate T2T-CHM13v2.0

    Genomic

    1. NC_060940.1 Alternate T2T-CHM13v2.0

      Range
      30483809..30488863
      Download
      GenBank, FASTA, Sequence Viewer (Graphics)

    Suppressed Reference Sequence(s)

    The following Reference Sequences have been suppressed. Explain

    1. NM_001017387.1: Suppressed sequence

      Description
      NM_001017387.1: This RefSeq was permanently suppressed because currently there is not sufficient data to support this transcript.

    2. NM_003166.3: Suppressed sequence

      Description
      NM_003166.3: This RefSeq was permanently suppressed because it is a nonsense-mediated mRNA decay (NMD) candidate.
    Nucleotide Protein
    Heading Accession and Version
    Protein Accession Links
    GenPept Link UniProtKB Link
    P0DMM9.1 GenPept UniProtKB/Swiss-Prot:P0DMM9

    Gene LinkOut

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