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    Aup1 AUP1, lipid droplet regulating VLDL assembly factor [ Rattus norvegicus (Norway rat) ]

    Gene ID: 680423, updated on 2-Nov-2024

    Summary

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    Official Symbol
    Aup1provided by RGD
    Official Full Name
    AUP1, lipid droplet regulating VLDL assembly factorprovided by RGD
    Primary source
    RGD:1591777
    See related
    EnsemblRapid:ENSRNOG00000007842 AllianceGenome:RGD:1591777
    Gene type
    protein coding
    RefSeq status
    PROVISIONAL
    Organism
    Rattus norvegicus
    Lineage
    Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha; Muroidea; Muridae; Murinae; Rattus
    Summary
    Predicted to enable ubiquitin conjugating enzyme binding activity and ubiquitin protein ligase binding activity. Predicted to be involved in several processes, including lipid droplet formation; lipophagy; and protein localization to lipid droplet. Predicted to be located in autophagosome; endoplasmic reticulum; and lipid droplet. Predicted to be active in endoplasmic reticulum membrane. Orthologous to human AUP1 (AUP1 lipid droplet regulating VLDL assembly factor). [provided by Alliance of Genome Resources, Nov 2024]
    Expression
    Biased expression in Liver (RPKM 260.8), Kidney (RPKM 258.6) and 9 other tissues See more
    Orthologs
    human mouse all
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    Genomic context

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    See Aup1 in Genome Data Viewer
    Location:
    4q34
    Exon count:
    11
    Annotation release Status Assembly Chr Location
    RS_2024_02 current GRCr8 (GCF_036323735.1) 4 NC_086022.1 (117118035..117121063)
    RS_2023_06 previous assembly mRatBN7.2 (GCF_015227675.2) 4 NC_051339.1 (115560274..115563346)
    106 previous assembly Rnor_6.0 (GCF_000001895.5) 4 NC_005103.4 (113887030..113890103)

    Chromosome 4 - NC_086022.1Genomic Context describing neighboring genes Neighboring gene docking protein 1 Neighboring gene lysyl oxidase-like 3 Neighboring gene HtrA serine peptidase 2 Neighboring gene DEAQ box RNA-dependent ATPase 1 Neighboring gene T-cell leukemia homeobox 2

    Genomic regions, transcripts, and products

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    Go to nucleotide: Graphics FASTA GenBank

    Expression

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    • Project title: A rat RNA-Seq transcriptomic BodyMap across 11 organs and 4 developmental stages A rat RNA-Seq transcriptomic BodyMap across 11 organs and 4 developmental stages
    • Description: 320 RNA samples isolated from 11 organs (adrenal gland, brain, heart, kidney, liver, lung, muscle, spleen, thymus, and testes or uterus) from both sexes of Fischer 344 rats across four developmental stages (2-, 6-, 21-, and 104-weeks-old)
    • BioProject: PRJNA238328
    • Publication: PMID 24510058
    • Analysis date: Mon Jun 6 17:44:12 2016

    Bibliography

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    Related articles in PubMed

    1. NUMBL interacts with TAB2 and inhibits TNFalpha and IL-1beta-induced NF-kappaB activation. Ma Q, et al. Cell Signal, 2008 Jun. PMID 18299187
    2. Identification of ERAD components essential for dislocation of the null Hong Kong variant of α-1-antitrypsin (NHK). Zhong Y, et al. Biochem Biophys Res Commun, 2015 Mar 6. PMID 25660456
    3. Proteomic analysis of exosomes from human neural stem cells by flow field-flow fractionation and nanoflow liquid chromatography-tandem mass spectrometry. Kang D, et al. J Proteome Res, 2008 Aug. PMID 18570454
    4. Synaptic protein ubiquitination in rat brain revealed by antibody-based ubiquitome analysis. Na CH, et al. J Proteome Res, 2012 Sep 7. PMID 22871113, Free PMC Article
    5. Defining the membrane proteome of NK cells. Ghosh D, et al. J Mass Spectrom, 2010 Jan. PMID 19946888

    See all (8) citations in PubMed

    GeneRIFs: Gene References Into Functions

    Pathways from PubChem

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    Interactions

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    Products Interactant Other Gene Complex Source Pubs Description

    General gene information

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    Markers

    Homology

    Gene Ontology Provided by RGD

    Function Evidence Code Pubs
    enables ubiquitin binding IEA
    Inferred from Electronic Annotation
    more info
    		  
    enables ubiquitin conjugating enzyme binding IEA
    Inferred from Electronic Annotation
    more info
    		  
    enables ubiquitin conjugating enzyme binding ISO
    Inferred from Sequence Orthology
    more info
    		  
    enables ubiquitin conjugating enzyme binding ISS
    Inferred from Sequence or Structural Similarity
    more info
    		  
    enables ubiquitin protein ligase binding IEA
    Inferred from Electronic Annotation
    more info
    		  
    enables ubiquitin protein ligase binding ISO
    Inferred from Sequence Orthology
    more info
    		  
    enables ubiquitin protein ligase binding ISS
    Inferred from Sequence or Structural Similarity
    more info
    		  
    Process Evidence Code Pubs
    involved_in ERAD pathway IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    involved_in ERAD pathway IEA
    Inferred from Electronic Annotation
    more info
    		  
    involved_in ERAD pathway ISO
    Inferred from Sequence Orthology
    more info
    		  
    involved_in ERAD pathway ISS
    Inferred from Sequence or Structural Similarity
    more info
    		  
    involved_in lipid droplet formation IEA
    Inferred from Electronic Annotation
    more info
    		  
    involved_in lipid droplet formation ISO
    Inferred from Sequence Orthology
    more info
    		  
    involved_in lipid droplet formation ISS
    Inferred from Sequence or Structural Similarity
    more info
    		  
    involved_in lipid droplet organization ISO
    Inferred from Sequence Orthology
    more info
    		  
    involved_in lipid droplet organization ISS
    Inferred from Sequence or Structural Similarity
    more info
    		  
    involved_in lipophagy IEA
    Inferred from Electronic Annotation
    more info
    		  
    involved_in lipophagy ISO
    Inferred from Sequence Orthology
    more info
    		  
    involved_in protein localization to lipid droplet IEA
    Inferred from Electronic Annotation
    more info
    		  
    involved_in protein localization to lipid droplet ISO
    Inferred from Sequence Orthology
    more info
    		  
    involved_in protein localization to lipid droplet ISS
    Inferred from Sequence or Structural Similarity
    more info
    		  
    involved_in response to virus IEA
    Inferred from Electronic Annotation
    more info
    		  
    involved_in response to virus ISO
    Inferred from Sequence Orthology
    more info
    		  
    involved_in retrograde protein transport, ER to cytosol IEA
    Inferred from Electronic Annotation
    more info
    		  
    involved_in retrograde protein transport, ER to cytosol ISO
    Inferred from Sequence Orthology
    more info
    		  
    Component Evidence Code Pubs
    located_in autophagosome IEA
    Inferred from Electronic Annotation
    more info
    		  
    located_in autophagosome ISO
    Inferred from Sequence Orthology
    more info
    		  
    located_in endoplasmic reticulum ISO
    Inferred from Sequence Orthology
    more info
    		  
    is_active_in endoplasmic reticulum membrane IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    located_in endoplasmic reticulum membrane IEA
    Inferred from Electronic Annotation
    more info
    		  
    located_in endoplasmic reticulum membrane ISO
    Inferred from Sequence Orthology
    more info
    		  
    located_in endoplasmic reticulum membrane ISS
    Inferred from Sequence or Structural Similarity
    more info
    		  
    located_in lipid droplet IEA
    Inferred from Electronic Annotation
    more info
    		  
    located_in lipid droplet ISO
    Inferred from Sequence Orthology
    more info
    		  
    located_in lipid droplet ISS
    Inferred from Sequence or Structural Similarity
    more info
    		  

    General protein information

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    Preferred Names
    lipid droplet-regulating VLDL assembly factor AUP1
    Names
    ancient ubiquitous protein 1

    NCBI Reference Sequences (RefSeq)

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    RefSeqs maintained independently of Annotated Genomes

    These reference sequences exist independently of genome builds. Explain

    These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

    mRNA and Protein(s)

    1. NM_001079899.1 → NP_001073368.1  lipid droplet-regulating VLDL assembly factor AUP1

      See identical proteins and their annotated locations for NP_001073368.1

      Status: PROVISIONAL

      Source sequence(s)
      BC127544
      UniProtKB/Swiss-Prot
      A1L134
      UniProtKB/TrEMBL
      A0A8L2Q4W6
      Related
      ENSRNOP00000077286.2, ENSRNOT00000104950.2
      Conserved Domains (2) summary
      cd14420
      Location:300 → 340
      CUE_AUP1; CUE domain found in ancient ubiquitous protein 1 (AUP1) and similar proteins
      cl17185
      Location:66 → 264
      LPLAT; Lysophospholipid acyltransferases (LPLATs) of glycerophospholipid biosynthesis

    RefSeqs of Annotated Genomes: GCF_036323735.1-RS_2024_02

    The following sections contain reference sequences that belong to a specific genome build. Explain

    Reference GRCr8

    Genomic

    1. NC_086022.1 Reference GRCr8

      Range
      117118035..117121063
      Download
      GenBank, FASTA, Sequence Viewer (Graphics)

    mRNA and Protein(s)

    1. XM_063286675.1 → XP_063142745.1  lipid droplet-regulating VLDL assembly factor AUP1 isoform X1

      Related
      ENSRNOP00000010602.7, ENSRNOT00000010602.9

    2. XM_008763029.3 → XP_008761251.1  lipid droplet-regulating VLDL assembly factor AUP1 isoform X2

      UniProtKB/TrEMBL
      A0A8I5YCA8
      Conserved Domains (2) summary
      cd14420
      Location:300 → 340
      CUE_AUP1; CUE domain found in ancient ubiquitous protein 1 (AUP1) and similar proteins
      cl17185
      Location:66 → 264
      LPLAT; Lysophospholipid acyltransferases (LPLATs) of glycerophospholipid biosynthesis
    Nucleotide Protein Strain
    Heading Accession and Version
    Protein Accession Links
    GenPept Link UniProtKB Link
    A1L134.1 GenPept UniProtKB/Swiss-Prot:A1L134

    Gene LinkOut

    The following LinkOut resources are supplied by external providers. These providers are responsible for maintaining the links.

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