Gpr183 G protein-coupled receptor 183 [Rattus norvegicus (Norway rat)] - Gene

Summary

Official Symbol: Gpr183provided by RGD
Official Full Name: G protein-coupled receptor 183provided by RGD
Primary source: RGD:1598095
See related: EnsemblRapid:ENSRNOG00000025094 AllianceGenome:RGD:1598095
Gene type: protein coding
RefSeq status: PROVISIONAL
Organism: Rattus norvegicus
Lineage: Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha; Muroidea; Muridae; Murinae; Rattus
Also known as: Ebi2
Summary: Predicted to enable G protein-coupled receptor activity and oxysterol binding activity. Predicted to be involved in several processes, including dendritic cell homeostasis; leukocyte chemotaxis; and leukocyte differentiation. Predicted to be located in plasma membrane. Orthologous to human GPR183 (G protein-coupled receptor 183). [provided by Alliance of Genome Resources, Nov 2024]
Expression: Biased expression in Spleen (RPKM 29.5), Thymus (RPKM 19.8) and 9 other tissues See more
Orthologs: human mouse all
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Genomic context

Location:: 15q25

Exon count:: 3

Annotation release	Status	Assembly	Chr	Location
RS_2024_02	current	GRCr8 (GCF_036323735.1)	15	NC_086033.1 (105445129..105457192, complement)
RS_2023_06	previous assembly	mRatBN7.2 (GCF_015227675.2)	15	NC_051350.1 (99037764..99050550, complement)
106	previous assembly	Rnor_6.0 (GCF_000001895.5)	15	NC_005114.4 (108364701..108376221, complement)

Chromosome 15 - NC_086033.1 Genomic Context describing neighboring genes

Genomic regions, transcripts, and products

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Go to reference sequence details

Genomic Sequence:

Go to nucleotide: Graphics FASTA GenBank

Expression

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See details

Project title: A rat RNA-Seq transcriptomic BodyMap across 11 organs and 4 developmental stages A rat RNA-Seq transcriptomic BodyMap across 11 organs and 4 developmental stages
Description: 320 RNA samples isolated from 11 organs (adrenal gland, brain, heart, kidney, liver, lung, muscle, spleen, thymus, and testes or uterus) from both sexes of Fischer 344 rats across four developmental stages (2-, 6-, 21-, and 104-weeks-old)
BioProject: PRJNA238328
Publication: PMID 24510058
Analysis date: Mon Jun 6 17:44:12 2016

Bibliography

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GeneRIFs: Gene References Into Functions

What's a GeneRIF?

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General gene information

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Gene Ontology Provided by RGD

Function	Evidence Code	Pubs
enables G protein-coupled receptor activity	IBA Inferred from Biological aspect of Ancestor more info
enables G protein-coupled receptor activity	ISO Inferred from Sequence Orthology more info
enables G protein-coupled receptor activity	ISS Inferred from Sequence or Structural Similarity more info
enables oxysterol binding	ISO Inferred from Sequence Orthology more info
enables oxysterol binding	ISS Inferred from Sequence or Structural Similarity more info

Process	Evidence Code	Pubs
involved_in B cell activation involved in immune response	IBA Inferred from Biological aspect of Ancestor more info
involved_in G protein-coupled receptor signaling pathway	ISO Inferred from Sequence Orthology more info
involved_in G protein-coupled receptor signaling pathway	ISS Inferred from Sequence or Structural Similarity more info
involved_in T cell chemotaxis	ISO Inferred from Sequence Orthology more info
involved_in T cell chemotaxis	ISS Inferred from Sequence or Structural Similarity more info
involved_in T follicular helper cell differentiation	ISO Inferred from Sequence Orthology more info
involved_in T follicular helper cell differentiation	ISS Inferred from Sequence or Structural Similarity more info
involved_in adaptive immune response	ISO Inferred from Sequence Orthology more info
involved_in adaptive immune response	ISS Inferred from Sequence or Structural Similarity more info
involved_in biological_process	ND No biological Data available more info
involved_in cell chemotaxis	ISO Inferred from Sequence Orthology more info
involved_in dendritic cell chemotaxis	ISO Inferred from Sequence Orthology more info
involved_in dendritic cell chemotaxis	ISS Inferred from Sequence or Structural Similarity more info
involved_in dendritic cell homeostasis	ISO Inferred from Sequence Orthology more info
involved_in dendritic cell homeostasis	ISS Inferred from Sequence or Structural Similarity more info
involved_in humoral immune response	ISO Inferred from Sequence Orthology more info
acts_upstream_of_or_within leukocyte chemotaxis	ISO Inferred from Sequence Orthology more info
involved_in leukocyte chemotaxis	ISO Inferred from Sequence Orthology more info
involved_in leukocyte chemotaxis	ISS Inferred from Sequence or Structural Similarity more info
involved_in mature B cell differentiation involved in immune response	ISO Inferred from Sequence Orthology more info
involved_in osteoclast differentiation	ISO Inferred from Sequence Orthology more info
involved_in osteoclast differentiation	ISS Inferred from Sequence or Structural Similarity more info
involved_in positive regulation of B cell proliferation	ISO Inferred from Sequence Orthology more info
involved_in positive regulation of B cell proliferation	ISS Inferred from Sequence or Structural Similarity more info
involved_in positive regulation of ERK1 and ERK2 cascade	ISO Inferred from Sequence Orthology more info
involved_in positive regulation of ERK1 and ERK2 cascade	ISS Inferred from Sequence or Structural Similarity more info
involved_in regulation of astrocyte chemotaxis	ISO Inferred from Sequence Orthology more info
involved_in regulation of astrocyte chemotaxis	ISS Inferred from Sequence or Structural Similarity more info

Component	Evidence Code	Pubs
located_in plasma membrane	ISO Inferred from Sequence Orthology more info
located_in plasma membrane	ISS Inferred from Sequence or Structural Similarity more info

General protein information

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Preferred Names: G-protein coupled receptor 183

Names: EBV-induced G-protein coupled receptor 2; Epstein-Barr virus induced gene 2 (lymphocyte-specific G protein-coupled receptor); epstein-Barr virus-induced G-protein coupled receptor 2

NCBI Reference Sequences (RefSeq)

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RefSeqs maintained independently of Annotated Genomes

These reference sequences exist independently of genome builds. Explain

These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

mRNA and Protein(s)

NM_001109386.1 → NP_001102856.1 G-protein coupled receptor 183

See identical proteins and their annotated locations for NP_001102856.1

Status: PROVISIONAL

Source sequence(s)

CH473951

UniProtKB/Swiss-Prot

D4A7K7

Related

ENSRNOP00000110942.1, ENSRNOT00000153084.1

Conserved Domains (1) summary

cd15159
Location:28 → 315

7tmA_EBI2; Epstein-Barr virus (EBV)-induced gene 2, member of the class A family of seven-transmembrane G protein-coupled receptors

RefSeqs of Annotated Genomes: GCF_036323735.1-RS_2024_02

The following sections contain reference sequences that belong to a specific genome build. Explain

Reference GRCr8

Genomic

NC_086033.1 Reference GRCr8

Range

105445129..105457192 complement

Download

GenBank, FASTA, Sequence Viewer (Graphics)

mRNA and Protein(s)

XM_039093645.2 → XP_038949573.1 G-protein coupled receptor 183 isoform X1

UniProtKB/Swiss-Prot

D4A7K7

Related

ENSRNOP00000104804.1, ENSRNOT00000155187.1

Conserved Domains (1) summary

cd15159
Location:28 → 315

7tmA_EBI2; Epstein-Barr virus (EBV)-induced gene 2, member of the class A family of seven-transmembrane G protein-coupled receptors