Golph3 golgi phosphoprotein 3 [Mus musculus (house mouse)] - Gene

Summary

Official Symbol: Golph3provided by MGI
Official Full Name: golgi phosphoprotein 3provided by MGI
Primary source: MGI:MGI:1913879
See related: Ensembl:ENSMUSG00000022200 AllianceGenome:MGI:1913879
Gene type: protein coding
RefSeq status: PROVISIONAL
Organism: Mus musculus
Lineage: Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha; Muroidea; Muridae; Murinae; Mus; Mus
Also known as: 4733401N08Rik; 5730410D03Rik
Summary: Predicted to enable cargo adaptor activity; enzyme binding activity; and phosphatidylinositol-4-phosphate binding activity. Predicted to be involved in several processes, including Golgi vesicle transport; cell adhesion molecule production; and protein localization to Golgi apparatus. Located in Golgi apparatus. Is expressed in several structures, including brain; limb; liver; and notochord. Orthologous to human GOLPH3 (golgi phosphoprotein 3). [provided by Alliance of Genome Resources, Nov 2024]
Expression: Ubiquitous expression in adrenal adult (RPKM 44.1), ovary adult (RPKM 42.3) and 28 other tissues See more
Orthologs: human all
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Genomic context

Location:: 15 A1; 15 5.9 cM

Exon count:: 4

Annotation release	Status	Assembly	Chr	Location
RS_2024_02	current	GRCm39 (GCF_000001635.27)	15	NC_000081.7 (12319617..12351687)
108.20200622	previous assembly	GRCm38.p6 (GCF_000001635.26)	15	NC_000081.6 (12320488..12351601)

Chromosome 15 - NC_000081.7 Genomic Context describing neighboring genes

Genomic regions, transcripts, and products

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Go to reference sequence details

Genomic Sequence:

Go to nucleotide: Graphics FASTA GenBank

Expression

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See details

Project title: Mouse ENCODE transcriptome data Mouse ENCODE transcriptome data
Description: RNA profiling data sets generated by the Mouse ENCODE project.
BioProject: PRJNA66167
Publication: PMID 25409824
Analysis date: n/a

Bibliography

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GeneRIFs: Gene References Into Functions

What's a GeneRIF?

Golph3 is a target gene of miR34a. miR34a/GOLPH3 axis abrogates cancer cell stemness involved in urothelial bladder cancer chemoresistance.
Title: miR34a/GOLPH3 Axis abrogates Urothelial Bladder Cancer Chemoresistance via Reduced Cancer Stemness.
The current study found that GOLPH3, an outer membrane protein of the Golgi complex, was significantly upregulated in N2A cells upon oxygen-glucose deprivation and reoxygenation.
Title: GOLPH3 Mediated Golgi Stress Response in Modulating N2A Cell Death upon Oxygen-Glucose Deprivation and Reoxygenation Injury.

Submit: New GeneRIF Correction

Variation

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Alleles

Alleles of this type are documented at Mouse Genome Informatics (MGI)

Endonuclease-mediated (5)

Interactions

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Products	Interactant	Other Gene	Complex	Source	Pubs	Description

General gene information

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Markers

Golph3 (e-PCR), detects polymorphism
- UniSTS:255282

08.MMHAP47FLC2.seq (e-PCR)
- UniSTS:122936

AW413496 (e-PCR)
- UniSTS:186020

NoName (e-PCR)
- UniSTS:237268

Gene Ontology Provided by MGI

Function	Evidence Code	Pubs
enables cargo adaptor activity	IEA Inferred from Electronic Annotation more info
enables cargo adaptor activity	ISO Inferred from Sequence Orthology more info
enables enzyme binding	IEA Inferred from Electronic Annotation more info
enables enzyme binding	ISO Inferred from Sequence Orthology more info
enables phosphatidylinositol-4-phosphate binding	IBA Inferred from Biological aspect of Ancestor more info
enables phosphatidylinositol-4-phosphate binding	ISO Inferred from Sequence Orthology more info
enables phosphatidylinositol-4-phosphate binding	ISS Inferred from Sequence or Structural Similarity more info

Process	Evidence Code	Pubs
involved_in Golgi organization	IBA Inferred from Biological aspect of Ancestor more info
involved_in Golgi organization	ISO Inferred from Sequence Orthology more info
involved_in Golgi organization	ISS Inferred from Sequence or Structural Similarity more info
involved_in Golgi ribbon formation	ISO Inferred from Sequence Orthology more info
involved_in Golgi to plasma membrane protein transport	IBA Inferred from Biological aspect of Ancestor more info
involved_in Golgi to plasma membrane protein transport	ISO Inferred from Sequence Orthology more info
involved_in Golgi to plasma membrane protein transport	ISS Inferred from Sequence or Structural Similarity more info
involved_in Golgi vesicle budding	IBA Inferred from Biological aspect of Ancestor more info
involved_in Golgi vesicle budding	ISO Inferred from Sequence Orthology more info
involved_in Golgi vesicle budding	ISS Inferred from Sequence or Structural Similarity more info
involved_in asymmetric Golgi ribbon formation	IEA Inferred from Electronic Annotation more info
involved_in asymmetric Golgi ribbon formation	ISO Inferred from Sequence Orthology more info
involved_in cell adhesion molecule production	ISO Inferred from Sequence Orthology more info
involved_in cell adhesion molecule production	ISS Inferred from Sequence or Structural Similarity more info
involved_in cell migration	ISO Inferred from Sequence Orthology more info
involved_in cell migration	ISS Inferred from Sequence or Structural Similarity more info
involved_in cellular response to rapamycin	ISO Inferred from Sequence Orthology more info
involved_in cellular response to rapamycin	ISS Inferred from Sequence or Structural Similarity more info
involved_in gene expression	ISO Inferred from Sequence Orthology more info
involved_in gene expression	ISS Inferred from Sequence or Structural Similarity more info
involved_in glycoprotein biosynthetic process	ISO Inferred from Sequence Orthology more info
involved_in glycoprotein biosynthetic process	ISS Inferred from Sequence or Structural Similarity more info
involved_in lamellipodium assembly	ISO Inferred from Sequence Orthology more info
involved_in lamellipodium assembly	ISS Inferred from Sequence or Structural Similarity more info
involved_in leukocyte tethering or rolling	ISO Inferred from Sequence Orthology more info
involved_in leukocyte tethering or rolling	ISS Inferred from Sequence or Structural Similarity more info
involved_in negative regulation of apoptotic process	IEA Inferred from Electronic Annotation more info
involved_in negative regulation of apoptotic process	ISO Inferred from Sequence Orthology more info
involved_in positive regulation of TOR signaling	ISO Inferred from Sequence Orthology more info
involved_in positive regulation of TOR signaling	ISS Inferred from Sequence or Structural Similarity more info
involved_in positive regulation of protein secretion	ISO Inferred from Sequence Orthology more info
involved_in positive regulation of protein secretion	ISS Inferred from Sequence or Structural Similarity more info
involved_in protein retention in Golgi apparatus	ISO Inferred from Sequence Orthology more info
involved_in protein retention in Golgi apparatus	ISS Inferred from Sequence or Structural Similarity more info
involved_in protein secretion	ISO Inferred from Sequence Orthology more info
involved_in protein secretion	ISS Inferred from Sequence or Structural Similarity more info
involved_in protein targeting to Golgi apparatus	IEA Inferred from Electronic Annotation more info
involved_in protein targeting to Golgi apparatus	ISO Inferred from Sequence Orthology more info
involved_in regulation of mitochondrion organization	ISO Inferred from Sequence Orthology more info
involved_in regulation of mitochondrion organization	ISS Inferred from Sequence or Structural Similarity more info
involved_in retrograde vesicle-mediated transport, Golgi to endoplasmic reticulum	IBA Inferred from Biological aspect of Ancestor more info

Component	Evidence Code	Pubs
located_in Golgi apparatus	IDA Inferred from Direct Assay more info	PubMed
located_in Golgi apparatus	ISO Inferred from Sequence Orthology more info
is_active_in Golgi cisterna	IBA Inferred from Biological aspect of Ancestor more info
located_in Golgi cisterna	ISO Inferred from Sequence Orthology more info
located_in Golgi cisterna	ISS Inferred from Sequence or Structural Similarity more info
located_in Golgi cisterna membrane	IEA Inferred from Electronic Annotation more info
located_in Golgi membrane	IEA Inferred from Electronic Annotation more info
is_active_in cytosol	IBA Inferred from Biological aspect of Ancestor more info
located_in cytosol	ISO Inferred from Sequence Orthology more info
located_in cytosol	ISS Inferred from Sequence or Structural Similarity more info
located_in endosome	IEA Inferred from Electronic Annotation more info
located_in endosome	ISO Inferred from Sequence Orthology more info
located_in intracellular membrane-bounded organelle	ISO Inferred from Sequence Orthology more info
located_in mitochondrial intermembrane space	IEA Inferred from Electronic Annotation more info
located_in mitochondrion	ISO Inferred from Sequence Orthology more info
located_in mitochondrion	ISS Inferred from Sequence or Structural Similarity more info
located_in plasma membrane	IEA Inferred from Electronic Annotation more info
located_in plasma membrane	ISO Inferred from Sequence Orthology more info
is_active_in trans-Golgi network	IBA Inferred from Biological aspect of Ancestor more info
located_in trans-Golgi network	ISO Inferred from Sequence Orthology more info
located_in trans-Golgi network	ISS Inferred from Sequence or Structural Similarity more info

General protein information

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Preferred Names: Golgi phosphoprotein 3

Names: coat protein GPP34

NCBI Reference Sequences (RefSeq)

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RefSeqs maintained independently of Annotated Genomes

These reference sequences exist independently of genome builds. Explain

These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

mRNA and Protein(s)

NM_025673.2 → NP_079949.1 Golgi phosphoprotein 3

See identical proteins and their annotated locations for NP_079949.1

Status: PROVISIONAL

Source sequence(s)

BC051035

Consensus CDS

CCDS27389.1

UniProtKB/Swiss-Prot

A6BLP3, Q99KY1, Q9CRA5, Q9D636

Related

ENSMUSP00000057375.6, ENSMUST00000059680.7

Conserved Domains (1) summary

pfam05719
Location:62 → 271

GPP34; Golgi phosphoprotein 3 (GPP34)

RefSeqs of Annotated Genomes: GCF_000001635.27-RS_2024_02

The following sections contain reference sequences that belong to a specific genome build. Explain

Reference GRCm39 C57BL/6J

Genomic

NC_000081.7 Reference GRCm39 C57BL/6J

Range

12319617..12351687

Download

GenBank, FASTA, Sequence Viewer (Graphics)

mRNA and Protein(s)

XM_006520143.3 → XP_006520206.1 Golgi phosphoprotein 3 isoform X1

Conserved Domains (1) summary

pfam05719
Location:60 → 227

GPP34; Golgi phosphoprotein 3 (GPP34)