SLC22A2 solute carrier family 22 member 2 [Homo sapiens (human)] - Gene

Summary

Official Symbol: SLC22A2provided by HGNC
Official Full Name: solute carrier family 22 member 2provided by HGNC
Primary source: HGNC:HGNC:10966
See related: Ensembl:ENSG00000112499 MIM:602608; AllianceGenome:HGNC:10966
Gene type: protein coding
RefSeq status: REVIEWED
Organism: Homo sapiens
Lineage: Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Primates; Haplorrhini; Catarrhini; Hominidae; Homo
Also known as: OCT2
Summary: Polyspecific organic cation transporters in the liver, kidney, intestine, and other organs are critical for elimination of many endogenous small organic cations as well as a wide array of drugs and environmental toxins. This gene is one of three similar cation transporter genes located in a cluster on chromosome 6. The encoded protein contains twelve putative transmembrane domains and is a plasma integral membrane protein. It is found primarily in the kidney, where it may mediate the first step in cation reabsorption. [provided by RefSeq, Jul 2008]
Expression: Restricted expression toward kidney (RPKM 70.1) See more
Orthologs: mouse all
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Genomic context

Location:: 6q25.3

Exon count:: 11

Annotation release	Status	Assembly	Chr	Location
RS_2024_08	current	GRCh38.p14 (GCF_000001405.40)	6	NC_000006.12 (160216755..160258821, complement)
RS_2024_08	current	T2T-CHM13v2.0 (GCF_009914755.1)	6	NC_060930.1 (161462946..161508769, complement)
RS_2024_09	previous assembly	GRCh37.p13 (GCF_000001405.25)	6	NC_000006.11 (160637787..160679853, complement)

Chromosome 6 - NC_000006.12 Genomic Context describing neighboring genes

Genomic regions, transcripts, and products

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Go to reference sequence details

Genomic Sequence:

Go to nucleotide: Graphics FASTA GenBank

Expression

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See details

Project title: HPA RNA-seq normal tissues HPA RNA-seq normal tissues
Description: RNA-seq was performed of tissue samples from 95 human individuals representing 27 different tissues in order to determine tissue-specificity of all protein-coding genes
BioProject: PRJEB4337
Publication: PMID 24309898
Analysis date: Wed Apr 4 07:08:55 2018

Bibliography

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GeneRIFs: Gene References Into Functions

What's a GeneRIF?

The SLC22A2 gene is a determinant of hematological toxicity of oxaliplatin in patients with colorectal cancer.
Title: The SLC22A2 gene is a determinant of hematological toxicity of oxaliplatin in patients with colorectal cancer.
Promoter haplotype structure of solute carrier 22 member 2 (SLC22A2) in the Xhosa population of South Africa and their differential effect on gene expression.
Title: Promoter haplotype structure of solute carrier 22 member 2 (SLC22A2) in the Xhosa population of South Africa and their differential effect on gene expression.
Transport Turnover Rates for Human OCT2 and MATE1 Expressed in Chinese Hamster Ovary Cells.
Title: Transport Turnover Rates for Human OCT2 and MATE1 Expressed in Chinese Hamster Ovary Cells.
Role of Organic Cation Transporter 2 in Autophagy Induced by Platinum Derivatives.
Title: Role of Organic Cation Transporter 2 in Autophagy Induced by Platinum Derivatives.
Molecular basis for stereoselective transport of fenoterol by the organic cation transporters 1 and 2.
Title: Molecular basis for stereoselective transport of fenoterol by the organic cation transporters 1 and 2.
Substrate-Dependent Trans-Stimulation of Organic Cation Transporter 2 Activity.
Title: Substrate-Dependent Trans-Stimulation of Organic Cation Transporter 2 Activity.
Properties of Transport Mediated by the Human Organic Cation Transporter 2 Studied in a Polarized Three-Dimensional Epithelial Cell Culture Model.
Title: Properties of Transport Mediated by the Human Organic Cation Transporter 2 Studied in a Polarized Three-Dimensional Epithelial Cell Culture Model.
Effects of SLC22A2 808G>T polymorphism and bosutinib concentrations on serum creatinine in patients with chronic myeloid leukemia receiving bosutinib therapy.
Title: Effects of SLC22A2 808G>T polymorphism and bosutinib concentrations on serum creatinine in patients with chronic myeloid leukemia receiving bosutinib therapy.
Cetirizine Reduces Gabapentin Plasma Concentrations and Effect: Role of Renal Drug Transporters for Organic Cations.
Title: Cetirizine Reduces Gabapentin Plasma Concentrations and Effect: Role of Renal Drug Transporters for Organic Cations.
The failure of DAC to induce OCT2 expression and its remission by hemoglobin-based nanocarriers under hypoxia in renal cell carcinoma.
Title: The failure of DAC to induce OCT2 expression and its remission by hemoglobin-based nanocarriers under hypoxia in renal cell carcinoma.

Submit: New GeneRIF Correction See all GeneRIFs (98)

Phenotypes

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Find tests for this gene in the NIH Genetic Testing Registry (GTR)

Review eQTL and phenotype association data in this region using PheGenI

EBI GWAS Catalog

Description
An atlas of genetic influences on human blood metabolites. EBI GWAS Catalog EBI GWAS CatalogPubMed
Genetic loci influencing kidney function and chronic kidney disease. EBI GWAS Catalog EBI GWAS CatalogPubMed
New loci associated with kidney function and chronic kidney disease. EBI GWAS Catalog EBI GWAS CatalogPubMed

Variation

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See variants in ClinVar

See studies and variants in dbVar

See Variation Viewer (GRCh37.p13)

See Variation Viewer (GRCh38)

Interactions

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Products	Interactant	Other Gene	Complex	Source	Pubs	Description

General gene information

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Markers

SHGC-81309 (e-PCR)
- UniSTS:184470

SLC22A2_2598 (e-PCR)
- UniSTS:281010

Gene Ontology Provided by GOA

Function	Evidence Code	Pubs
enables L-amino acid transmembrane transporter activity	IMP Inferred from Mutant Phenotype more info	PubMed
enables L-arginine transmembrane transporter activity	IMP Inferred from Mutant Phenotype more info	PubMed
enables acetylcholine transmembrane transporter activity	IDA Inferred from Direct Assay more info	PubMed
enables amine transmembrane transporter activity	IDA Inferred from Direct Assay more info	PubMed
enables choline transmembrane transporter activity	IDA Inferred from Direct Assay more info	PubMed
enables efflux transmembrane transporter activity	IDA Inferred from Direct Assay more info	PubMed
enables monoamine transmembrane transporter activity	IDA Inferred from Direct Assay more info	PubMed
enables neurotransmitter transmembrane transporter activity	IDA Inferred from Direct Assay more info	PubMed
enables neurotransmitter transmembrane transporter activity	TAS Traceable Author Statement more info
enables organic anion transmembrane transporter activity	IDA Inferred from Direct Assay more info	PubMed
enables organic cation transmembrane transporter activity	EXP Inferred from Experiment more info	PubMed
enables organic cation transmembrane transporter activity	IBA Inferred from Biological aspect of Ancestor more info
enables organic cation transmembrane transporter activity	IDA Inferred from Direct Assay more info	PubMed
enables organic cation transmembrane transporter activity	IMP Inferred from Mutant Phenotype more info	PubMed
enables organic cation transmembrane transporter activity	TAS Traceable Author Statement more info
enables prostaglandin transmembrane transporter activity	IDA Inferred from Direct Assay more info	PubMed
enables putrescine transmembrane transporter activity	IDA Inferred from Direct Assay more info	PubMed
enables pyrimidine nucleoside transmembrane transporter activity	IMP Inferred from Mutant Phenotype more info	PubMed
enables quaternary ammonium group transmembrane transporter activity	IDA Inferred from Direct Assay more info	PubMed
enables spermidine transmembrane transporter activity	ISS Inferred from Sequence or Structural Similarity more info
enables thiamine transmembrane transporter activity	IDA Inferred from Direct Assay more info	PubMed
enables toxin transmembrane transporter activity	IDA Inferred from Direct Assay more info	PubMed
enables toxin transmembrane transporter activity	IMP Inferred from Mutant Phenotype more info	PubMed
enables xenobiotic transmembrane transporter activity	IDA Inferred from Direct Assay more info	PubMed
enables xenobiotic transmembrane transporter activity	IMP Inferred from Mutant Phenotype more info	PubMed

Process	Evidence Code	Pubs
involved_in L-alpha-amino acid transmembrane transport	IMP Inferred from Mutant Phenotype more info	PubMed
involved_in L-arginine import across plasma membrane	IMP Inferred from Mutant Phenotype more info	PubMed
involved_in L-arginine transmembrane transport	IEA Inferred from Electronic Annotation more info
involved_in acetylcholine transport	IDA Inferred from Direct Assay more info	PubMed
acts_upstream_of activation of cysteine-type endopeptidase activity involved in apoptotic process	ISS Inferred from Sequence or Structural Similarity more info
involved_in amine transport	IDA Inferred from Direct Assay more info	PubMed
involved_in amino acid import across plasma membrane	IMP Inferred from Mutant Phenotype more info	PubMed
involved_in body fluid secretion	TAS Traceable Author Statement more info	PubMed
involved_in cellular detoxification	IDA Inferred from Direct Assay more info	PubMed
involved_in cellular detoxification	IMP Inferred from Mutant Phenotype more info	PubMed
involved_in choline transport	IDA Inferred from Direct Assay more info	PubMed
involved_in dopamine transport	IDA Inferred from Direct Assay more info	PubMed
involved_in dopamine transport	ISS Inferred from Sequence or Structural Similarity more info
involved_in dopamine uptake	IDA Inferred from Direct Assay more info	PubMed
involved_in epinephrine transport	IDA Inferred from Direct Assay more info	PubMed
involved_in epinephrine transport	ISS Inferred from Sequence or Structural Similarity more info
involved_in export across plasma membrane	IDA Inferred from Direct Assay more info	PubMed
involved_in histamine transport	IDA Inferred from Direct Assay more info	PubMed
involved_in histamine uptake	IDA Inferred from Direct Assay more info	PubMed
involved_in monoatomic cation transport	IEA Inferred from Electronic Annotation more info
involved_in neurotransmitter transport	IDA Inferred from Direct Assay more info	PubMed
involved_in neurotransmitter transport	TAS Traceable Author Statement more info
involved_in norepinephrine transport	IDA Inferred from Direct Assay more info	PubMed
involved_in norepinephrine uptake	IDA Inferred from Direct Assay more info	PubMed
involved_in norepinephrine uptake	TAS Traceable Author Statement more info
involved_in organic cation transport	IBA Inferred from Biological aspect of Ancestor more info
acts_upstream_of_or_within organic cation transport	IDA Inferred from Direct Assay more info	PubMed
involved_in organic cation transport	IDA Inferred from Direct Assay more info	PubMed
involved_in organic cation transport	IMP Inferred from Mutant Phenotype more info	PubMed
acts_upstream_of_or_within positive regulation of gene expression	ISS Inferred from Sequence or Structural Similarity more info
involved_in prostaglandin transport	IDA Inferred from Direct Assay more info	PubMed
involved_in purine-containing compound transmembrane transport	TAS Traceable Author Statement more info
involved_in putrescine transport	IDA Inferred from Direct Assay more info	PubMed
involved_in quaternary ammonium group transport	IEA Inferred from Electronic Annotation more info
involved_in serotonin transport	IDA Inferred from Direct Assay more info	PubMed
involved_in serotonin uptake	IDA Inferred from Direct Assay more info	PubMed
involved_in spermidine transmembrane transport	IEA Inferred from Electronic Annotation more info
involved_in spermidine transport	ISS Inferred from Sequence or Structural Similarity more info
involved_in thiamine transmembrane transport	IDA Inferred from Direct Assay more info	PubMed
involved_in transport across blood-brain barrier	NAS Non-traceable Author Statement more info	PubMed
involved_in xenobiotic transport	IDA Inferred from Direct Assay more info	PubMed
involved_in xenobiotic transport	IMP Inferred from Mutant Phenotype more info	PubMed
involved_in xenobiotic transport across blood-brain barrier	NAS Non-traceable Author Statement more info	PubMed

Component	Evidence Code	Pubs
located_in apical plasma membrane	IDA Inferred from Direct Assay more info	PubMed
located_in basal plasma membrane	IDA Inferred from Direct Assay more info	PubMed
located_in basolateral plasma membrane	ISS Inferred from Sequence or Structural Similarity more info
located_in extracellular exosome	HDA more info	PubMed
located_in membrane	TAS Traceable Author Statement more info	PubMed
located_in plasma membrane	IDA Inferred from Direct Assay more info	PubMed
located_in plasma membrane	TAS Traceable Author Statement more info
located_in presynapse	IEA Inferred from Electronic Annotation more info

General protein information

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Preferred Names: solute carrier family 22 member 2

Names: organic cation transporter 2; solute carrier family 22 (organic cation transporter), member 2

NCBI Reference Sequences (RefSeq)

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RefSeqs maintained independently of Annotated Genomes

These reference sequences exist independently of genome builds. Explain

These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

mRNA and Protein(s)

NM_003058.4 → NP_003049.2 solute carrier family 22 member 2

See identical proteins and their annotated locations for NP_003049.2

Status: REVIEWED

Source sequence(s)

AL162582

Consensus CDS

CCDS5276.1

UniProtKB/Swiss-Prot

O15244, Q5T7Q6, Q6PIQ8, Q8NG62, Q9NQB9

Related

ENSP00000355920.3, ENST00000366953.8

Conserved Domains (2) summary

cd06174
Location:124 → 492

MFS; The Major Facilitator Superfamily (MFS) is a large and diverse group of secondary transporters that includes uniporters, symporters, and antiporters. MFS proteins facilitate the transport across cytoplasmic or internal membranes of a variety of ...

TIGR00898
Location:13 → 525

2A0119; cation transport protein

RefSeqs of Annotated Genomes: GCF_000001405.40-RS_2024_08

The following sections contain reference sequences that belong to a specific genome build. Explain

Reference GRCh38.p14 Primary Assembly

Genomic

NC_000006.12 Reference GRCh38.p14 Primary Assembly

Range

160216755..160258821 complement

Download

GenBank, FASTA, Sequence Viewer (Graphics)

Alternate T2T-CHM13v2.0

Genomic

NC_060930.1 Alternate T2T-CHM13v2.0

Range

161462946..161508769 complement

Download

GenBank, FASTA, Sequence Viewer (Graphics)

Suppressed Reference Sequence(s)

The following Reference Sequences have been suppressed. Explain

NM_153191.1: Suppressed sequence

Description

NM_153191.1: This RefSeq was permanently suppressed because it is a nonsense-mediated mRNA decay (NMD) candidate.