Slc15a3 solute carrier family 15, member 3 [Mus musculus (house mouse)] - Gene

Summary

Official Symbol: Slc15a3provided by MGI
Official Full Name: solute carrier family 15, member 3provided by MGI
Primary source: MGI:MGI:1929691
See related: Ensembl:ENSMUSG00000024737 AllianceGenome:MGI:1929691
Gene type: protein coding
RefSeq status: VALIDATED
Organism: Mus musculus
Lineage: Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha; Muroidea; Muridae; Murinae; Mus; Mus
Also known as: Ci1; cI-1
Summary: Enables peptidoglycan transmembrane transporter activity. Involved in peptidoglycan transport and positive regulation of nucleotide-binding activity oligomerization domain containing 2 signaling pathway. Located in endosome membrane and lysosomal membrane. Is expressed in several structures, including brain; gut; hemolymphoid system; liver lobe; and testis. Orthologous to human SLC15A3 (solute carrier family 15 member 3). [provided by Alliance of Genome Resources, Nov 2024]
Expression: Broad expression in spleen adult (RPKM 18.7), lung adult (RPKM 15.6) and 17 other tissues See more
Orthologs: human all
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Genomic context

Location:: 19 A; 19 7.23 cM

Exon count:: 8

Annotation release	Status	Assembly	Chr	Location
RS_2024_02	current	GRCm39 (GCF_000001635.27)	19	NC_000085.7 (10819908..10835279)
108.20200622	previous assembly	GRCm38.p6 (GCF_000001635.26)	19	NC_000085.6 (10842544..10857915)

Chromosome 19 - NC_000085.7 Genomic Context describing neighboring genes

Genomic regions, transcripts, and products

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Genomic Sequence:

Go to nucleotide: Graphics FASTA GenBank

Expression

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See details

Project title: Mouse ENCODE transcriptome data Mouse ENCODE transcriptome data
Description: RNA profiling data sets generated by the Mouse ENCODE project.
BioProject: PRJNA66167
Publication: PMID 25409824
Analysis date: n/a

Bibliography

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GeneRIFs: Gene References Into Functions

What's a GeneRIF?

SLC15A3 plays a crucial role in pulmonary fibrosis by regulating macrophage oxidative stress.
Title: SLC15A3 plays a crucial role in pulmonary fibrosis by regulating macrophage oxidative stress.

Submit: New GeneRIF Correction

Variation

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Alleles

Alleles of this type are documented at Mouse Genome Informatics (MGI)

Chemically induced (ENU) (1) 1 citation
Endonuclease-mediated (6)
Targeted (3)

Interactions

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Products	Interactant	Other Gene	Complex	Source	Pubs	Description

General gene information

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Markers

01.MMHAP6FRA7.seq (e-PCR)
- UniSTS:122670

R74613 (e-PCR)
- UniSTS:125506

RH125077 (e-PCR)
- UniSTS:161899

RH141151 (e-PCR)
- UniSTS:223147

Slc15a3 (e-PCR), detects polymorphism
- UniSTS:547313

Gene Ontology Provided by MGI

Function	Evidence Code	Pubs
enables dipeptide transmembrane transporter activity	IBA Inferred from Biological aspect of Ancestor more info
enables dipeptide transmembrane transporter activity	ISO Inferred from Sequence Orthology more info
enables dipeptide transmembrane transporter activity	ISS Inferred from Sequence or Structural Similarity more info
enables peptidoglycan transmembrane transporter activity	IDA Inferred from Direct Assay more info	PubMed
enables symporter activity	IEA Inferred from Electronic Annotation more info

Process	Evidence Code	Pubs
involved_in dipeptide import across plasma membrane	IBA Inferred from Biological aspect of Ancestor more info
involved_in dipeptide import across plasma membrane	ISO Inferred from Sequence Orthology more info
involved_in dipeptide import across plasma membrane	ISS Inferred from Sequence or Structural Similarity more info
involved_in innate immune response	IEA Inferred from Electronic Annotation more info
involved_in peptidoglycan transport	IDA Inferred from Direct Assay more info	PubMed
involved_in positive regulation of nucleotide-binding oligomerization domain containing 2 signaling pathway	IDA Inferred from Direct Assay more info	PubMed
involved_in protein transport	IEA Inferred from Electronic Annotation more info

Component	Evidence Code	Pubs
located_in endosome membrane	IDA Inferred from Direct Assay more info	PubMed
located_in intracellular membrane-bounded organelle	ISO Inferred from Sequence Orthology more info
is_active_in lysosomal membrane	IBA Inferred from Biological aspect of Ancestor more info
located_in lysosomal membrane	IDA Inferred from Direct Assay more info	PubMed
located_in lysosomal membrane	ISO Inferred from Sequence Orthology more info

General protein information

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Preferred Names: solute carrier family 15 member 3

Names: cAMP inducible gene 1; cAMP-inducible gene 1 protein; peptide transporter 3; peptide/histidine transporter 2

NCBI Reference Sequences (RefSeq)

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RefSeqs maintained independently of Annotated Genomes

These reference sequences exist independently of genome builds. Explain

These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

mRNA and Protein(s)

NM_023044.2 → NP_075531.2 solute carrier family 15 member 3

See identical proteins and their annotated locations for NP_075531.2

Status: VALIDATED

Source sequence(s)

AC132402

Consensus CDS

CCDS29588.1

UniProtKB/Swiss-Prot

Q8BPX9, Q9WU80

Related

ENSMUSP00000025646.3, ENSMUST00000025646.3

Conserved Domains (2) summary

COG3104
Location:41 → 567

PTR2; Dipeptide/tripeptide permease [Amino acid transport and metabolism]

cl21472
Location:179 → 515

MFS; The Major Facilitator Superfamily (MFS) is a large and diverse group of secondary transporters that includes uniporters, symporters, and antiporters. MFS proteins facilitate the transport across cytoplasmic or internal membranes of a variety of ...