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    Slc27a2 solute carrier family 27 member 2 [ Rattus norvegicus (Norway rat) ]

    Gene ID: 65192, updated on 2-Nov-2024

    Summary

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    Official Symbol
    Slc27a2provided by RGD
    Official Full Name
    solute carrier family 27 member 2provided by RGD
    Primary source
    RGD:71103
    See related
    EnsemblRapid:ENSRNOG00000010128 AllianceGenome:RGD:71103
    Gene type
    protein coding
    RefSeq status
    PROVISIONAL
    Organism
    Rattus norvegicus
    Lineage
    Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha; Muroidea; Muridae; Murinae; Rattus
    Summary
    Enables long-chain fatty acid-CoA ligase activity and very long-chain fatty acid-CoA ligase activity. Involved in long-chain fatty acid metabolic process. Located in endoplasmic reticulum and peroxisomal membrane. Orthologous to human SLC27A2 (solute carrier family 27 member 2). [provided by Alliance of Genome Resources, Nov 2024]
    Expression
    Biased expression in Liver (RPKM 1913.6) and Kidney (RPKM 1050.0) See more
    Orthologs
    human mouse all
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    Genomic context

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    See Slc27a2 in Genome Data Viewer
    Location:
    3q36
    Exon count:
    10
    Annotation release Status Assembly Chr Location
    RS_2024_02 current GRCr8 (GCF_036323735.1) 3 NC_086021.1 (134258101..134295581)
    RS_2023_06 previous assembly mRatBN7.2 (GCF_015227675.2) 3 NC_051338.1 (113804728..113842208)
    106 previous assembly Rnor_6.0 (GCF_000001895.5) 3 NC_005102.4 (119014620..119052531)

    Chromosome 3 - NC_086021.1Genomic Context describing neighboring genes Neighboring gene ATPase phospholipid transporting 8B4 (putative) Neighboring gene U6 spliceosomal RNA Neighboring gene histidine decarboxylase Neighboring gene small nucleolar RNA SNORA48 Neighboring gene GA binding protein transcription factor subunit beta 1

    Genomic regions, transcripts, and products

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    Go to nucleotide: Graphics FASTA GenBank

    Expression

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    • Project title: A rat RNA-Seq transcriptomic BodyMap across 11 organs and 4 developmental stages A rat RNA-Seq transcriptomic BodyMap across 11 organs and 4 developmental stages
    • Description: 320 RNA samples isolated from 11 organs (adrenal gland, brain, heart, kidney, liver, lung, muscle, spleen, thymus, and testes or uterus) from both sexes of Fischer 344 rats across four developmental stages (2-, 6-, 21-, and 104-weeks-old)
    • BioProject: PRJNA238328
    • Publication: PMID 24510058
    • Analysis date: Mon Jun 6 17:44:12 2016

    Bibliography

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    Related articles in PubMed

    1. Cellular cholesterol stimulates acute uptake of palmitate by redistribution of fatty acid translocase in type II pneumocytes. Kolleck I, et al. Biochemistry, 2002 May 21. PMID 12009898
    2. Slc27a2 expression in peripheral blood mononuclear cells as a molecular marker for overweight development. Caimari A, et al. Int J Obes (Lond), 2010 May. PMID 20142826
    3. Mouse very long-chain acyl-CoA synthetase in X-linked adrenoleukodystrophy. Heinzer AK, et al. J Biol Chem, 2002 Aug 9. PMID 12048192
    4. Human fatty acid transport protein 2a/very long chain acyl-CoA synthetase 1 (FATP2a/Acsvl1) has a preference in mediating the channeling of exogenous n-3 fatty acids into phosphatidylinositol. Melton EM, et al. J Biol Chem, 2011 Sep 2. PMID 21768100, Free PMC Article
    5. Molecular cloning of cDNA encoding rat very long-chain acyl-CoA synthetase. Uchiyama A, et al. J Biol Chem, 1996 Nov 29. PMID 8939997

    See all (25) citations in PubMed

    GeneRIFs: Gene References Into Functions

    What's a GeneRIF?
    1. We conclude that FATP2 is a major apical proximal tubule NEFA transporter that regulates lipoapoptosis and may be an amenable target for the prevention of CKD progression.
      Title: Kidney Proximal Tubule Lipoapoptosis Is Regulated by Fatty Acid Transporter-2 (FATP2).
    2. The progressive overexpression of slc27a2 in peripheral blood mononuclear cells of cafeteria-fed rats as the body weight increases suggests this gene as an early marker of overweight development related to the intake of a hyperlipidic diet.
      Title: Slc27a2 expression in peripheral blood mononuclear cells as a molecular marker for overweight development.
    3. In response to an increase of cellular cholesterol, fatty acid transporter is translocated from cytosol to membranes of type II pneumocytes.
      Title: Cellular cholesterol stimulates acute uptake of palmitate by redistribution of fatty acid translocase in type II pneumocytes.
    Submit: New GeneRIF Correction

    Pathways from PubChem

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    Interactions

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    Products Interactant Other Gene Complex Source Pubs Description

    General gene information

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    Markers

    Homology

    Clone Names

    • MGC93337

    Gene Ontology Provided by RGD

    Function Evidence Code Pubs
    enables ATP binding IEA
    Inferred from Electronic Annotation
    more info
    		  
    enables arachidonate-CoA ligase activity IEA
    Inferred from Electronic Annotation
    more info
    		  
    enables cholate-CoA ligase activity IEA
    Inferred from Electronic Annotation
    more info
    		  
    enables enzyme binding IEA
    Inferred from Electronic Annotation
    more info
    		  
    enables enzyme binding ISO
    Inferred from Sequence Orthology
    more info
    		  
    enables fatty acid transmembrane transporter activity ISO
    Inferred from Sequence Orthology
    more info
    		  
    enables long-chain fatty acid transmembrane transporter activity IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    enables long-chain fatty acid transmembrane transporter activity IEA
    Inferred from Electronic Annotation
    more info
    		  
    enables long-chain fatty acid transmembrane transporter activity ISO
    Inferred from Sequence Orthology
    more info
    		  
    enables long-chain fatty acid-CoA ligase activity IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    enables long-chain fatty acid-CoA ligase activity IDA
    Inferred from Direct Assay
    more info
    		 PubMed 
    enables long-chain fatty acid-CoA ligase activity IEA
    Inferred from Electronic Annotation
    more info
    		  
    enables long-chain fatty acid-CoA ligase activity IMP
    Inferred from Mutant Phenotype
    more info
    		 PubMed 
    enables long-chain fatty acid-CoA ligase activity ISO
    Inferred from Sequence Orthology
    more info
    		  
    enables nucleotide binding IEA
    Inferred from Electronic Annotation
    more info
    		  
    enables oleate transmembrane transporter activity IEA
    Inferred from Electronic Annotation
    more info
    		  
    enables phytanate-CoA ligase activity IEA
    Inferred from Electronic Annotation
    more info
    		  
    enables phytanate-CoA ligase activity ISO
    Inferred from Sequence Orthology
    more info
    		  
    enables pristanate-CoA ligase activity IEA
    Inferred from Electronic Annotation
    more info
    		  
    enables pristanate-CoA ligase activity ISO
    Inferred from Sequence Orthology
    more info
    		  
    enables protein binding IPI
    Inferred from Physical Interaction
    more info
    		 PubMed 
    enables very long-chain fatty acid-CoA ligase activity IEA
    Inferred from Electronic Annotation
    more info
    		  
    enables very long-chain fatty acid-CoA ligase activity IMP
    Inferred from Mutant Phenotype
    more info
    		 PubMed 
    enables very long-chain fatty acid-CoA ligase activity ISO
    Inferred from Sequence Orthology
    more info
    		  
    enables very long-chain fatty acid-CoA ligase activity ISS
    Inferred from Sequence or Structural Similarity
    more info
    		 PubMed 
    Process Evidence Code Pubs
    involved_in bile acid biosynthetic process IEA
    Inferred from Electronic Annotation
    more info
    		  
    involved_in bile acid biosynthetic process ISO
    Inferred from Sequence Orthology
    more info
    		  
    involved_in bile acid metabolic process IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    involved_in fatty acid alpha-oxidation IEA
    Inferred from Electronic Annotation
    more info
    		  
    involved_in fatty acid alpha-oxidation ISO
    Inferred from Sequence Orthology
    more info
    		  
    involved_in fatty acid beta-oxidation IEA
    Inferred from Electronic Annotation
    more info
    		  
    involved_in fatty acid beta-oxidation ISO
    Inferred from Sequence Orthology
    more info
    		  
    acts_upstream_of_or_within fatty acid transport ISO
    Inferred from Sequence Orthology
    more info
    		  
    involved_in long-chain fatty acid import into cell IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    involved_in long-chain fatty acid import into cell IEA
    Inferred from Electronic Annotation
    more info
    		  
    acts_upstream_of long-chain fatty acid import into cell ISO
    Inferred from Sequence Orthology
    more info
    		  
    involved_in long-chain fatty acid metabolic process IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    involved_in long-chain fatty acid metabolic process IEA
    Inferred from Electronic Annotation
    more info
    		  
    involved_in long-chain fatty acid metabolic process IMP
    Inferred from Mutant Phenotype
    more info
    		 PubMed 
    acts_upstream_of_or_within long-chain fatty acid metabolic process ISO
    Inferred from Sequence Orthology
    more info
    		  
    involved_in long-chain fatty acid metabolic process ISO
    Inferred from Sequence Orthology
    more info
    		  
    involved_in methyl-branched fatty acid metabolic process IEA
    Inferred from Electronic Annotation
    more info
    		  
    involved_in methyl-branched fatty acid metabolic process ISO
    Inferred from Sequence Orthology
    more info
    		  
    involved_in very long-chain fatty acid catabolic process IEA
    Inferred from Electronic Annotation
    more info
    		  
    acts_upstream_of_or_within very long-chain fatty acid catabolic process ISO
    Inferred from Sequence Orthology
    more info
    		  
    acts_upstream_of_or_within very long-chain fatty acid metabolic process ISO
    Inferred from Sequence Orthology
    more info
    		  
    Component Evidence Code Pubs
    located_in endoplasmic reticulum IDA
    Inferred from Direct Assay
    more info
    		 PubMed 
    located_in endoplasmic reticulum ISO
    Inferred from Sequence Orthology
    more info
    		  
    located_in endoplasmic reticulum lumen IEA
    Inferred from Electronic Annotation
    more info
    		  
    located_in endoplasmic reticulum lumen ISO
    Inferred from Sequence Orthology
    more info
    		  
    located_in endoplasmic reticulum lumen ISS
    Inferred from Sequence or Structural Similarity
    more info
    		 PubMed 
    is_active_in endoplasmic reticulum membrane IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    located_in endoplasmic reticulum membrane IEA
    Inferred from Electronic Annotation
    more info
    		  
    located_in endoplasmic reticulum membrane ISO
    Inferred from Sequence Orthology
    more info
    		  
    is_active_in peroxisomal membrane IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    located_in peroxisomal membrane IDA
    Inferred from Direct Assay
    more info
    		 PubMed 
    located_in peroxisomal membrane IEA
    Inferred from Electronic Annotation
    more info
    		  
    located_in peroxisomal membrane ISO
    Inferred from Sequence Orthology
    more info
    		  
    located_in peroxisomal membrane ISS
    Inferred from Sequence or Structural Similarity
    more info
    		 PubMed 
    located_in peroxisome IDA
    Inferred from Direct Assay
    more info
    		 PubMed 
    located_in peroxisome ISO
    Inferred from Sequence Orthology
    more info
    		  
    is_active_in plasma membrane IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    located_in plasma membrane IEA
    Inferred from Electronic Annotation
    more info
    		  
    located_in plasma membrane ISO
    Inferred from Sequence Orthology
    more info
    		  

    General protein information

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    Preferred Names
    long-chain fatty acid transport protein 2
    Names
    FATP-2
    THCA-CoA ligase
    VLACS
    VLCS
    arachidonate--CoA ligase
    fatty acid transport protein 2
    fatty-acid-coenzyme A ligase, very long-chain 1
    long-chain-fatty-acid--CoA ligase
    phytanate--CoA ligase
    solute carrier family 27 (fatty acid transporter), member 2
    solute carrier family 27 (fatty acid transporter), member 32
    very long-chain acyl-CoA synthetase
    very long-chain-fatty-acid-CoA ligase
    NP_113924.2

    NCBI Reference Sequences (RefSeq)

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    RefSeqs maintained independently of Annotated Genomes

    These reference sequences exist independently of genome builds. Explain

    These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

    mRNA and Protein(s)

    1. NM_031736.2 → NP_113924.2  long-chain fatty acid transport protein 2

      Status: PROVISIONAL

      Source sequence(s)
      JAXUCZ010000003
      UniProtKB/Swiss-Prot
      P97524
      UniProtKB/TrEMBL
      D3ZSL9, Q66HN6
      Related
      ENSRNOP00000059771.4, ENSRNOT00000067700.5
      Conserved Domains (1) summary
      cd05938
      Location:74 → 610
      hsFATP2a_ACSVL_like; Fatty acid transport proteins (FATP) including hsFATP2, hsFATP5, and hsFATP6, and similar proteins

    RefSeqs of Annotated Genomes: GCF_036323735.1-RS_2024_02

    The following sections contain reference sequences that belong to a specific genome build. Explain

    Reference GRCr8

    Genomic

    1. NC_086021.1 Reference GRCr8

      Range
      134258101..134295581
      Download
      GenBank, FASTA, Sequence Viewer (Graphics)
    Nucleotide Protein Strain
    Heading Accession and Version
    Protein Accession Links
    GenPept Link UniProtKB Link
    P97524.1 GenPept UniProtKB/Swiss-Prot:P97524

    Gene LinkOut

    The following LinkOut resources are supplied by external providers. These providers are responsible for maintaining the links.

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