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    Rps12 ribosomal protein S12 [ Rattus norvegicus (Norway rat) ]

    Gene ID: 65139, updated on 17-Aug-2024

    Summary

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    Official Symbol
    Rps12provided by RGD
    Official Full Name
    ribosomal protein S12provided by RGD
    Primary source
    RGD:62024
    See related
    EnsemblRapid:ENSRNOG00000016411 AllianceGenome:RGD:62024
    Gene type
    protein coding
    RefSeq status
    VALIDATED
    Organism
    Rattus norvegicus
    Lineage
    Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha; Muroidea; Muridae; Murinae; Rattus
    Summary
    Predicted to be a structural constituent of ribosome. Involved in response to organonitrogen compound. Part of cytosolic large ribosomal subunit and cytosolic small ribosomal subunit. Orthologous to human RPS12 (ribosomal protein S12). [provided by Alliance of Genome Resources, Apr 2022]
    Expression
    Biased expression in Spleen (RPKM 7768.2), Thymus (RPKM 5951.0) and 9 other tissues See more
    Orthologs
    human mouse all
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    Genomic context

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    Location:
    1p12
    Exon count:
    6
    Annotation release Status Assembly Chr Location
    RS_2024_02 current GRCr8 (GCF_036323735.1) 1 NC_086019.1 (23499943..23502234)
    RS_2023_06 previous assembly mRatBN7.2 (GCF_015227675.2) 1 NC_051336.1 (21680854..21683010)
    106 previous assembly Rnor_6.0 (GCF_000001895.5) 1 NC_005100.4 (22758214..22760370)

    Chromosome 1 - NC_086019.1Genomic Context describing neighboring genes Neighboring gene solute carrier family 18 member B1 Neighboring gene uncharacterized LOC100910237 Neighboring gene small nucleolar RNA SNORA33 Neighboring gene small nucleolar RNA, C/D box 101 Neighboring gene small nucleolar RNA, C/D box 100 Neighboring gene uncharacterized LOC103690933 Neighboring gene uncharacterized LOC134484970

    Genomic regions, transcripts, and products

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    Go to nucleotide: Graphics FASTA GenBank

    Expression

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    • Project title: A rat RNA-Seq transcriptomic BodyMap across 11 organs and 4 developmental stages A rat RNA-Seq transcriptomic BodyMap across 11 organs and 4 developmental stages
    • Description: 320 RNA samples isolated from 11 organs (adrenal gland, brain, heart, kidney, liver, lung, muscle, spleen, thymus, and testes or uterus) from both sexes of Fischer 344 rats across four developmental stages (2-, 6-, 21-, and 104-weeks-old)
    • BioProject: PRJNA238328
    • Publication: PMID 24510058
    • Analysis date: Mon Jun 6 17:44:12 2016

    Bibliography

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    Related articles in PubMed

    1. 3-morpholinosydnonimine participates in the attenuation of neointima formation via inhibition of annexin A2-mediated vascular smooth muscle cell migration. Won KJ, et al. Proteomics, 2011 Jan. PMID 21204247
    2. Topography and stoichiometry of acidic phosphoproteins in rat liver 60 S ribosomal subunit. Lavergne JP, et al. FEBS Lett, 1988 May 9. PMID 3366245
    3. The primary structure of rat ribosomal protein S12. The relationship of rat S12 to other ribosomal proteins and a correlation of the amino acid sequences of rat and yeast ribosomal proteins. Lin A, et al. J Biol Chem, 1987 Oct 15. PMID 3308890
    4. Identification of differentially expressed genes related to metabolic syndrome induced with high-fat diet in E3 rats. Lan X, et al. Exp Biol Med (Maywood), 2015 Feb. PMID 25294893, Free PMC Article
    5. The primary structure of rat ribosomal proteins: the amino acid sequences of L27a and L28 and corrections in the sequences of S4 and S12. Wool IG, et al. Biochim Biophys Acta, 1990 Aug 27. PMID 2207170

    See all (15) citations in PubMed

    GeneRIFs: Gene References Into Functions

    Pathways from PubChem

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    Interactions

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    Products Interactant Other Gene Complex Source Pubs Description

    General gene information

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    Homology

    Gene Ontology Provided by RGD

    Function Evidence Code Pubs
    enables structural constituent of ribosome IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    enables structural constituent of ribosome IEA
    Inferred from Electronic Annotation
    more info
    		  
    enables structural constituent of ribosome ISO
    Inferred from Sequence Orthology
    more info
    		  
    Process Evidence Code Pubs
    involved_in maintenance of translational fidelity IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    acts_upstream_of positive regulation of canonical Wnt signaling pathway ISO
    Inferred from Sequence Orthology
    more info
    		  
    involved_in ribosomal small subunit biogenesis IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    involved_in ribosomal small subunit biogenesis ISO
    Inferred from Sequence Orthology
    more info
    		  
    involved_in ribosomal small subunit biogenesis ISS
    Inferred from Sequence or Structural Similarity
    more info
    		  
    involved_in translation IEA
    Inferred from Electronic Annotation
    more info
    		  
    Component Evidence Code Pubs
    located_in Golgi apparatus ISO
    Inferred from Sequence Orthology
    more info
    		  
    located_in cytosol ISO
    Inferred from Sequence Orthology
    more info
    		  
    part_of cytosolic large ribosomal subunit IDA
    Inferred from Direct Assay
    more info
    		 PubMed 
    located_in cytosolic ribosome ISO
    Inferred from Sequence Orthology
    more info
    		  
    part_of cytosolic small ribosomal subunit IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    part_of cytosolic small ribosomal subunit IDA
    Inferred from Direct Assay
    more info
    		 PubMed 
    part_of cytosolic small ribosomal subunit ISO
    Inferred from Sequence Orthology
    more info
    		  
    located_in intracellular membrane-bounded organelle ISO
    Inferred from Sequence Orthology
    more info
    		  
    located_in nucleolus IEA
    Inferred from Electronic Annotation
    more info
    		  
    part_of ribonucleoprotein complex IEA
    Inferred from Electronic Annotation
    more info
    		  
    located_in ribosome IEA
    Inferred from Electronic Annotation
    more info
    		  
    part_of small-subunit processome ISO
    Inferred from Sequence Orthology
    more info
    		  
    part_of small-subunit processome ISS
    Inferred from Sequence or Structural Similarity
    more info
    		  
    is_active_in synapse ISO
    Inferred from Sequence Orthology
    more info
    		  

    General protein information

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    Preferred Names
    small ribosomal subunit protein eS12
    Names
    40S ribosomal protein S12

    NCBI Reference Sequences (RefSeq)

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    RefSeqs maintained independently of Annotated Genomes

    These reference sequences exist independently of genome builds. Explain

    These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

    mRNA and Protein(s)

    1. NM_031709.3 → NP_113897.2  small ribosomal subunit protein eS12

      See identical proteins and their annotated locations for NP_113897.2

      Status: VALIDATED

      Source sequence(s)
      BC058460
      UniProtKB/Swiss-Prot
      P63324
      UniProtKB/TrEMBL
      Q6PDW1
      Related
      ENSRNOP00000022184.5, ENSRNOT00000022184.6
      Conserved Domains (1) summary
      pfam01248
      Location:16 → 111
      Ribosomal_L7Ae; Ribosomal protein L7Ae/L30e/S12e/Gadd45 family

    RefSeqs of Annotated Genomes: GCF_036323735.1-RS_2024_02

    The following sections contain reference sequences that belong to a specific genome build. Explain

    Reference GRCr8

    Genomic

    1. NC_086019.1 Reference GRCr8

      Range
      23499943..23502234
      Download
      GenBank, FASTA, Sequence Viewer (Graphics)

    mRNA and Protein(s)

    1. XM_063272910.1 → XP_063128980.1  small ribosomal subunit protein eS12 isoform X1

    2. XM_063272913.1 → XP_063128983.1  small ribosomal subunit protein eS12 isoform X2

      UniProtKB/Swiss-Prot
      P63324
      UniProtKB/TrEMBL
      Q6PDW1

    3. XM_063272917.1 → XP_063128987.1  small ribosomal subunit protein eS12 isoform X2

      UniProtKB/Swiss-Prot
      P63324
      UniProtKB/TrEMBL
      Q6PDW1
    Nucleotide Protein Strain
    Heading Accession and Version
    Protein Accession Links
    GenPept Link UniProtKB Link
    P63324.2 GenPept UniProtKB/Swiss-Prot:P63324

    Gene LinkOut

    The following LinkOut resources are supplied by external providers. These providers are responsible for maintaining the links.

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