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    Vps45 vacuolar protein sorting 45 homolog [ Rattus norvegicus (Norway rat) ]

    Gene ID: 64516, updated on 14-Nov-2024

    Summary

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    Official Symbol
    Vps45provided by RGD
    Official Full Name
    vacuolar protein sorting 45 homologprovided by RGD
    Primary source
    RGD:621267
    See related
    EnsemblRapid:ENSRNOG00000021173 AllianceGenome:RGD:621267
    Gene type
    protein coding
    RefSeq status
    PROVISIONAL
    Organism
    Rattus norvegicus
    Lineage
    Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha; Muroidea; Muridae; Murinae; Rattus
    Also known as
    Vsp45a
    Summary
    Predicted to be involved in intracellular protein transport and vesicle-mediated transport. Located in Golgi apparatus and membrane. Is active in synaptic vesicle. Human ortholog(s) of this gene implicated in severe congenital neutropenia 5. Orthologous to human VPS45 (vacuolar protein sorting 45 homolog). [provided by Alliance of Genome Resources, Nov 2024]
    Expression
    Biased expression in Brain (RPKM 100.7), Adrenal (RPKM 85.2) and 9 other tissues See more
    Orthologs
    human mouse all
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    Genomic context

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    See Vps45 in Genome Data Viewer
    Location:
    2q34
    Exon count:
    16
    Annotation release Status Assembly Chr Location
    RS_2024_02 current GRCr8 (GCF_036323735.1) 2 NC_086020.1 (186244839..186305177, complement)
    RS_2023_06 previous assembly mRatBN7.2 (GCF_015227675.2) 2 NC_051337.1 (183555919..183616312, complement)
    106 previous assembly Rnor_6.0 (GCF_000001895.5) 2 NC_005101.4 (198123747..198184739, complement)

    Chromosome 2 - NC_086020.1Genomic Context describing neighboring genes Neighboring gene ubiquitin A-52 residue ribosomal protein fusion product 1 like 1 Neighboring gene pleckstrin homology domain containing O1 Neighboring gene 60S ribosomal protein L15 pseudogene Neighboring gene large ribosomal subunit protein eL8-like

    Genomic regions, transcripts, and products

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    Go to nucleotide: Graphics FASTA GenBank

    Expression

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    • Project title: A rat RNA-Seq transcriptomic BodyMap across 11 organs and 4 developmental stages A rat RNA-Seq transcriptomic BodyMap across 11 organs and 4 developmental stages
    • Description: 320 RNA samples isolated from 11 organs (adrenal gland, brain, heart, kidney, liver, lung, muscle, spleen, thymus, and testes or uterus) from both sexes of Fischer 344 rats across four developmental stages (2-, 6-, 21-, and 104-weeks-old)
    • BioProject: PRJNA238328
    • Publication: PMID 24510058
    • Analysis date: Mon Jun 6 17:44:12 2016

    Bibliography

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    Related articles in PubMed

    1. Molecular cloning of a mammalian homologue of the yeast vesicular transport protein vps45. El-Husseini AE, et al. Biochim Biophys Acta, 1997 Apr 3. PMID 9106478
    2. Syntaxin 6 functions in trans-Golgi network vesicle trafficking. Bock JB, et al. Mol Biol Cell, 1997 Jul. PMID 9243506, Free PMC Article
    3. Identification of a mammalian Golgi Sec1p-like protein, mVps45. Tellam JT, et al. J Biol Chem, 1997 Mar 7. PMID 9045632
    4. Common and distinct roles for the binding partners Rabenosyn-5 and Vps45 in the regulation of endocytic trafficking in mammalian cells. Rahajeng J, et al. Exp Cell Res, 2010 Mar 10. PMID 19931244, Free PMC Article
    5. Munc18a controls SNARE assembly through its interaction with the syntaxin N-peptide. Burkhardt P, et al. EMBO J, 2008 Apr 9. PMID 18337752, Free PMC Article

    See all (11) citations in PubMed

    GeneRIFs: Gene References Into Functions

    Pathways from PubChem

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    Interactions

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    Products Interactant Other Gene Complex Source Pubs Description

    General gene information

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    Markers

    Homology

    Clone Names

    • MGC93104

    Gene Ontology Provided by RGD

    Function Evidence Code Pubs
    enables protein binding IPI
    Inferred from Physical Interaction
    more info
    		 PubMed 
    Process Evidence Code Pubs
    involved_in biological_process ND
    No biological Data available
    more info
    		  
    involved_in intracellular protein transport IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    involved_in protein transport IEA
    Inferred from Electronic Annotation
    more info
    		  
    involved_in vesicle-mediated transport IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    involved_in vesicle-mediated transport IEA
    Inferred from Electronic Annotation
    more info
    		  
    Component Evidence Code Pubs
    located_in Golgi apparatus IDA
    Inferred from Direct Assay
    more info
    		 PubMed 
    is_active_in Golgi membrane IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    located_in Golgi membrane ISO
    Inferred from Sequence Orthology
    more info
    		  
    located_in cytoplasm IEA
    Inferred from Electronic Annotation
    more info
    		  
    located_in endomembrane system IEA
    Inferred from Electronic Annotation
    more info
    		  
    located_in endosome membrane ISO
    Inferred from Sequence Orthology
    more info
    		  
    located_in intracellular membrane-bounded organelle IEA
    Inferred from Electronic Annotation
    more info
    		  
    located_in membrane IDA
    Inferred from Direct Assay
    more info
    		 PubMed 
    located_in membrane IEA
    Inferred from Electronic Annotation
    more info
    		  
    is_active_in synaptic vesicle IDA
    Inferred from Direct Assay
    more info
    		 PubMed 

    General protein information

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    Preferred Names
    vacuolar protein sorting-associated protein 45
    Names
    rvps45
    vesicular transport protein rvps45

    NCBI Reference Sequences (RefSeq)

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    RefSeqs maintained independently of Annotated Genomes

    These reference sequences exist independently of genome builds. Explain

    These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

    mRNA and Protein(s)

    1. NM_172072.2 → NP_742069.1  vacuolar protein sorting-associated protein 45

      See identical proteins and their annotated locations for NP_742069.1

      Status: PROVISIONAL

      Source sequence(s)
      BC081705
      UniProtKB/Swiss-Prot
      O08700
      UniProtKB/TrEMBL
      A0A8I5ZNB9, A6K348
      Related
      ENSRNOP00000028751.3, ENSRNOT00000028751.7
      Conserved Domains (1) summary
      pfam00995
      Location:23 → 539
      Sec1; Sec1 family

    RefSeqs of Annotated Genomes: GCF_036323735.1-RS_2024_02

    The following sections contain reference sequences that belong to a specific genome build. Explain

    Reference GRCr8

    Genomic

    1. NC_086020.1 Reference GRCr8

      Range
      186244839..186305177 complement
      Download
      GenBank, FASTA, Sequence Viewer (Graphics)

    mRNA and Protein(s)

    1. XM_039103068.2 → XP_038958996.1  vacuolar protein sorting-associated protein 45 isoform X1

      Conserved Domains (1) summary
      pfam00995
      Location:1 → 305
      Sec1; Sec1 family
    Nucleotide Protein Strain
    Heading Accession and Version
    Protein Accession Links
    GenPept Link UniProtKB Link
    O08700.1 GenPept UniProtKB/Swiss-Prot:O08700

    Gene LinkOut

    The following LinkOut resources are supplied by external providers. These providers are responsible for maintaining the links.

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