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    Yeats4 YEATS domain containing 4 [ Mus musculus (house mouse) ]

    Gene ID: 64050, updated on 2-Nov-2024

    Summary

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    Official Symbol
    Yeats4provided by MGI
    Official Full Name
    YEATS domain containing 4provided by MGI
    Primary source
    MGI:MGI:1927224
    See related
    Ensembl:ENSMUSG00000020171 AllianceGenome:MGI:1927224
    Gene type
    protein coding
    RefSeq status
    VALIDATED
    Organism
    Mus musculus
    Lineage
    Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha; Muroidea; Muridae; Murinae; Mus; Mus
    Also known as
    GAS41; NuBI-1; 4930573H17Rik; B230215M10Rik
    Summary
    Predicted to enable lysine-acetylated histone binding activity. Predicted to be involved in chromatin remodeling; regulation of cell cycle; and regulation of nucleobase-containing compound metabolic process. Located in nucleoplasm. Is expressed in genitourinary system; sensory organ; tooth; and trunk somite. Orthologous to human YEATS4 (YEATS domain containing 4). [provided by Alliance of Genome Resources, Nov 2024]
    Expression
    Ubiquitous expression in CNS E11.5 (RPKM 52.0), whole brain E14.5 (RPKM 41.1) and 28 other tissues See more
    Orthologs
    human all
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    Genomic context

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    See Yeats4 in Genome Data Viewer
    Location:
    10 D2; 10 65.26 cM
    Exon count:
    7
    Annotation release Status Assembly Chr Location
    RS_2024_02 current GRCm39 (GCF_000001635.27) 10 NC_000076.7 (117051046..117060412, complement)
    108.20200622 previous assembly GRCm38.p6 (GCF_000001635.26) 10 NC_000076.6 (117215141..117224507, complement)

    Chromosome 10 - NC_000076.7Genomic Context describing neighboring genes Neighboring gene predicted gene, 53635 Neighboring gene RIKEN cDNA 4930423D24 gene Neighboring gene predicted gene, 40769 Neighboring gene STARR-positive B cell enhancer ABC_E3918 Neighboring gene STARR-positive B cell enhancer ABC_E8367 Neighboring gene STARR-positive B cell enhancer ABC_E9353 Neighboring gene lysozyme 3 Neighboring gene lysozyme 2

    Genomic regions, transcripts, and products

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    Go to nucleotide: Graphics FASTA GenBank

    Expression

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    • Project title: Mouse ENCODE transcriptome data Mouse ENCODE transcriptome data
    • Description: RNA profiling data sets generated by the Mouse ENCODE project.
    • BioProject: PRJNA66167
    • Publication: PMID 25409824
    • Analysis date: n/a

    Bibliography

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    Related articles in PubMed

    1. Yeats4 drives ILC lineage commitment via activation of Lmo4 transcription. Liu B, et al. J Exp Med, 2019 Nov 4. PMID 31434684, Free PMC Article
    2. Anomalous incisor morphology indicates tissue-specific roles for Tfap2a and Tfap2b in tooth development. Woodruff ED, et al. Dev Biol, 2021 Apr. PMID 33460639, Free PMC Article
    3. Expression, cellular distribution and protein binding of the glioma amplified sequence (GAS41), a highly conserved putative transcription factor. Munnia A, et al. Oncogene, 2001 Aug 9. PMID 11521196
    4. GAS41, a highly conserved protein in eukaryotic nuclei, binds to NuMA. Harborth J, et al. J Biol Chem, 2000 Oct 13. PMID 10913114
    5. Purification of a human SRCAP complex that remodels chromatin by incorporating the histone variant H2A.Z into nucleosomes. Ruhl DD, et al. Biochemistry, 2006 May 2. PMID 16634648

    See all (30) citations in PubMed

    GeneRIFs: Gene References Into Functions

    Variation

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    Alleles

    Alleles of this type are documented at Mouse Genome Informatics  (MGI)

    Pathways from PubChem

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    Interactions

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    Products Interactant Other Gene Complex Source Pubs Description

    General gene information

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    Markers

    Homology

    Gene Ontology Provided by MGI

    Function Evidence Code Pubs
    enables histone binding IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    enables lysine-acetylated histone binding ISO
    Inferred from Sequence Orthology
    more info
    		  
    enables lysine-acetylated histone binding ISS
    Inferred from Sequence or Structural Similarity
    more info
    		  
    enables modification-dependent protein binding ISO
    Inferred from Sequence Orthology
    more info
    		  
    enables modification-dependent protein binding ISS
    Inferred from Sequence or Structural Similarity
    more info
    		  
    enables protein binding IPI
    Inferred from Physical Interaction
    more info
    		 PubMed 
    Process Evidence Code Pubs
    involved_in chromatin organization IEA
    Inferred from Electronic Annotation
    more info
    		  
    involved_in chromatin remodeling IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    involved_in positive regulation of DNA-templated transcription NAS
    Non-traceable Author Statement
    more info
    		 PubMed 
    involved_in positive regulation of double-strand break repair via homologous recombination ISO
    Inferred from Sequence Orthology
    more info
    		  
    involved_in regulation of DNA-templated transcription NAS
    Non-traceable Author Statement
    more info
    		 PubMed 
    involved_in regulation of apoptotic process NAS
    Non-traceable Author Statement
    more info
    		 PubMed 
    involved_in regulation of cell cycle ISO
    Inferred from Sequence Orthology
    more info
    		  
    involved_in regulation of double-strand break repair NAS
    Non-traceable Author Statement
    more info
    		 PubMed 
    involved_in regulation of transcription by RNA polymerase II IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    Component Evidence Code Pubs
    part_of NuA4 histone acetyltransferase complex IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    part_of NuA4 histone acetyltransferase complex ISO
    Inferred from Sequence Orthology
    more info
    		  
    part_of NuA4 histone acetyltransferase complex ISS
    Inferred from Sequence or Structural Similarity
    more info
    		  
    located_in nuclear membrane IEA
    Inferred from Electronic Annotation
    more info
    		  
    located_in nuclear membrane ISO
    Inferred from Sequence Orthology
    more info
    		  
    located_in nucleoplasm IDA
    Inferred from Direct Assay
    more info
    		 PubMed 
    located_in nucleoplasm ISO
    Inferred from Sequence Orthology
    more info
    		  
    part_of nucleosome ISO
    Inferred from Sequence Orthology
    more info
    		  
    part_of nucleosome NAS
    Non-traceable Author Statement
    more info
    		 PubMed 
    is_active_in nucleus IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    located_in nucleus ISO
    Inferred from Sequence Orthology
    more info
    		  

    General protein information

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    Preferred Names
    YEATS domain-containing protein 4
    Names
    glioma-amplified sequence 41 homolog
    glioma-amplified sequence-41

    NCBI Reference Sequences (RefSeq)

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    RefSeqs maintained independently of Annotated Genomes

    These reference sequences exist independently of genome builds. Explain

    These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

    mRNA and Protein(s)

    1. NM_026570.4 → NP_080846.1  YEATS domain-containing protein 4

      See identical proteins and their annotated locations for NP_080846.1

      Status: VALIDATED

      Source sequence(s)
      AK010522, CJ213771
      Consensus CDS
      CCDS24191.1
      UniProtKB/Swiss-Prot
      Q9CR11, Q9CW86
      Related
      ENSMUSP00000020382.7, ENSMUST00000020382.8
      Conserved Domains (1) summary
      cd16909
      Location:19 → 155
      YEATS_GAS41_like; YEATS domain found in YEATS domain-containing protein 4 and similar proteins

    RefSeqs of Annotated Genomes: GCF_000001635.27-RS_2024_02

    The following sections contain reference sequences that belong to a specific genome build. Explain

    Reference GRCm39 C57BL/6J

    Genomic

    1. NC_000076.7 Reference GRCm39 C57BL/6J

      Range
      117051046..117060412 complement
      Download
      GenBank, FASTA, Sequence Viewer (Graphics)
    Nucleotide Protein Strain
    Heading Accession and Version
    Protein Accession Links
    GenPept Link UniProtKB Link
    Q9CR11.1 GenPept UniProtKB/Swiss-Prot:Q9CR11

    Gene LinkOut

    The following LinkOut resources are supplied by external providers. These providers are responsible for maintaining the links.

    Other Literature Sources
    Chemical Information
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