S100A10 S100 calcium binding protein A10 [Homo sapiens (human)] - Gene

Summary

Official Symbol: S100A10provided by HGNC
Official Full Name: S100 calcium binding protein A10provided by HGNC
Primary source: HGNC:HGNC:10487
See related: Ensembl:ENSG00000197747 MIM:114085; AllianceGenome:HGNC:10487
Gene type: protein coding
RefSeq status: REVIEWED
Organism: Homo sapiens
Lineage: Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Primates; Haplorrhini; Catarrhini; Hominidae; Homo
Also known as: 42C; P11; p10; GP11; ANX2L; CAL1L; CLP11; Ca[1]; ANX2LG
Summary: The protein encoded by this gene is a member of the S100 family of proteins containing 2 EF-hand calcium-binding motifs. S100 proteins are localized in the cytoplasm and/or nucleus of a wide range of cells, and involved in the regulation of a number of cellular processes such as cell cycle progression and differentiation. S100 genes include at least 13 members which are located as a cluster on chromosome 1q21. This protein may function in exocytosis and endocytosis. [provided by RefSeq, Jul 2008]
Expression: Broad expression in colon (RPKM 299.3), esophagus (RPKM 210.9) and 22 other tissues See more
Orthologs: mouse all
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Genomic context

Location:: 1q21.3

Exon count:: 3

Annotation release	Status	Assembly	Chr	Location
RS_2024_08	current	GRCh38.p14 (GCF_000001405.40)	1	NC_000001.11 (151982915..151993859, complement)
RS_2024_08	current	T2T-CHM13v2.0 (GCF_009914755.1)	1	NC_060925.1 (151106434..151117380, complement)
RS_2024_09	previous assembly	GRCh37.p13 (GCF_000001405.25)	1	NC_000001.10 (151955391..151966335, complement)

Chromosome 1 - NC_000001.11 Genomic Context describing neighboring genes

Genomic regions, transcripts, and products

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Go to reference sequence details

Genomic Sequence:

Go to nucleotide: Graphics FASTA GenBank

Expression

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See details

Project title: HPA RNA-seq normal tissues HPA RNA-seq normal tissues
Description: RNA-seq was performed of tissue samples from 95 human individuals representing 27 different tissues in order to determine tissue-specificity of all protein-coding genes
BioProject: PRJEB4337
Publication: PMID 24309898
Analysis date: Wed Apr 4 07:08:55 2018

Bibliography

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GeneRIFs: Gene References Into Functions

What's a GeneRIF?

S100A10 promotes cancer metastasis via recruitment of MDSCs within the lungs.
Title: S100A10 promotes cancer metastasis via recruitment of MDSCs within the lungs.
Accumulation of annexin A2 and S100A10 prevents apoptosis of apically delaminated, transformed epithelial cells.
Title: Accumulation of annexin A2 and S100A10 prevents apoptosis of apically delaminated, transformed epithelial cells.
[S100A10 promotes proliferation and invasion of lung adenocarcinoma cells by activating the Akt-mTOR signaling pathway].
Title: [S100A10 promotes proliferation and invasion of lung adenocarcinoma cells by activating the Akt-mTOR signaling pathway].
S100A10 promotes HCC development and progression via transfer in extracellular vesicles and regulating their protein cargos.
Title: S100A10 promotes HCC development and progression via transfer in extracellular vesicles and regulating their protein cargos.
S100 calcium-binding protein A10 contributes to malignant traits in osteosarcoma cells by regulating glycolytic metabolism via the AKT/mTOR pathway.
Title: S100 calcium-binding protein A10 contributes to malignant traits in osteosarcoma cells by regulating glycolytic metabolism via the AKT/mTOR pathway.
The prognostic value of S100A calcium binding protein family members in predicting severe forms of COVID-19.
Title: The prognostic value of S100A calcium binding protein family members in predicting severe forms of COVID-19.
The S100A10-AnxA2 complex is associated with the exocytosis of hepatitis B virus in intrauterine infection.
Title: The S100A10-AnxA2 complex is associated with the exocytosis of hepatitis B virus in intrauterine infection.
Mechanism of Zn(2+) and Ca(2+) Binding to Human S100A1.
Title: Mechanism of Zn(2+) and Ca(2+) Binding to Human S100A1.
The ANXA2/S100A10 Complex-Regulation of the Oncogenic Plasminogen Receptor.
Title: The ANXA2/S100A10 Complex-Regulation of the Oncogenic Plasminogen Receptor.
The Annexin A2/S100A10 Complex: The Mutualistic Symbiosis of Two Distinct Proteins.
Title: The Annexin A2/S100A10 Complex: The Mutualistic Symbiosis of Two Distinct Proteins.

Submit: New GeneRIF Correction See all GeneRIFs (91)

Phenotypes

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Review eQTL and phenotype association data in this region using PheGenI

Variation

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See variants in ClinVar

See studies and variants in dbVar

See Variation Viewer (GRCh37.p13)

See Variation Viewer (GRCh38)

Interactions

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Products	Interactant	Other Gene	Complex	Source	Pubs	Description

General gene information

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Markers

G34842 (e-PCR)
- UniSTS:49881

RH17741 (e-PCR)
- UniSTS:11763

D1S3250 (e-PCR)
- UniSTS:13045

Gene Ontology Provided by GOA

Function	Evidence Code	Pubs
enables calcium ion binding	IBA Inferred from Biological aspect of Ancestor more info
enables calcium-dependent protein binding	IBA Inferred from Biological aspect of Ancestor more info
NOT enables lipid binding	IDA Inferred from Direct Assay more info	PubMed
enables protein binding	IPI Inferred from Physical Interaction more info	PubMed
enables protein homodimerization activity	IDA Inferred from Direct Assay more info	PubMed
enables transmembrane transporter binding	IBA Inferred from Biological aspect of Ancestor more info
enables transmembrane transporter binding	IPI Inferred from Physical Interaction more info	PubMed

Process	Evidence Code	Pubs
involved_in mRNA transcription by RNA polymerase II	ISO Inferred from Sequence Orthology more info
involved_in membrane raft assembly	IDA Inferred from Direct Assay more info	PubMed
involved_in positive regulation of GTPase activity	IMP Inferred from Mutant Phenotype more info	PubMed
involved_in positive regulation of exocytosis	NAS Non-traceable Author Statement more info	PubMed
involved_in positive regulation of focal adhesion assembly	IMP Inferred from Mutant Phenotype more info	PubMed
involved_in positive regulation of plasma membrane repair	NAS Non-traceable Author Statement more info	PubMed
involved_in positive regulation of plasminogen activation	IDA Inferred from Direct Assay more info	PubMed
involved_in positive regulation of stress fiber assembly	IMP Inferred from Mutant Phenotype more info	PubMed
involved_in positive regulation of substrate adhesion-dependent cell spreading	IMP Inferred from Mutant Phenotype more info	PubMed
involved_in positive regulation of transcription by RNA polymerase II	ISO Inferred from Sequence Orthology more info
involved_in protein localization to plasma membrane	IDA Inferred from Direct Assay more info	PubMed
involved_in regulation of neurogenesis	ISO Inferred from Sequence Orthology more info
involved_in vesicle budding from membrane	IDA Inferred from Direct Assay more info	PubMed

Component	Evidence Code	Pubs
part_of AnxA2-p11 complex	IDA Inferred from Direct Assay more info	PubMed
part_of RNA polymerase II transcription regulator complex	EXP Inferred from Experiment more info	PubMed
located_in cell surface	IEA Inferred from Electronic Annotation more info
located_in collagen-containing extracellular matrix	HDA more info	PubMed
is_active_in cytoplasm	IBA Inferred from Biological aspect of Ancestor more info
located_in extracellular exosome	HDA more info	PubMed
located_in extracellular region	HDA more info	PubMed
colocalizes_with membrane raft	IDA Inferred from Direct Assay more info	PubMed
located_in nuclear matrix	NAS Non-traceable Author Statement more info	PubMed
located_in plasma membrane	IDA Inferred from Direct Assay more info	PubMed
located_in plasma membrane	NAS Non-traceable Author Statement more info	PubMed
part_of plasma membrane protein complex	IPI Inferred from Physical Interaction more info	PubMed

General protein information

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Preferred Names: protein S100-A10

Names: S100 calcium binding protein A10 (annexin II ligand, calpactin I, light polypeptide (p11)); annexin II ligand, calpactin I, light polypeptide; annexin II tetramer (AIIt) p11 subunit; calpactin I light chain; calpactin-1 light chain; cellular ligand of annexin II

NCBI Reference Sequences (RefSeq)

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RefSeqs maintained independently of Annotated Genomes

These reference sequences exist independently of genome builds. Explain

These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

mRNA and Protein(s)

NM_002966.3 → NP_002957.1 protein S100-A10

See identical proteins and their annotated locations for NP_002957.1

Status: REVIEWED

Source sequence(s)

BE378444, BQ050753

Consensus CDS

CCDS1008.1

UniProtKB/Swiss-Prot

A8K4V8, P08206, P60903, Q5T1C5

UniProtKB/TrEMBL

Q6FGE5

Related

ENSP00000357801.3, ENST00000368811.8

Conserved Domains (1) summary

cd05024
Location:3 → 93

S-100A10; A subgroup of the S-100A10 domain found in proteins similar to S100A10. S100A10 is a member of the S100 family of EF-hand superfamily of calcium-binding proteins. Note that the S-100 hierarchy, to which this S-100A10 group belongs, contains only S-100 ...