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    Med24 mediator complex subunit 24 [ Rattus norvegicus (Norway rat) ]

    Gene ID: 619436, updated on 2-Nov-2024

    Summary

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    Official Symbol
    Med24provided by RGD
    Official Full Name
    mediator complex subunit 24provided by RGD
    Primary source
    RGD:1564565
    See related
    EnsemblRapid:ENSRNOG00000008711 AllianceGenome:RGD:1564565
    Gene type
    protein coding
    RefSeq status
    VALIDATED
    Organism
    Rattus norvegicus
    Lineage
    Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha; Muroidea; Muridae; Murinae; Rattus
    Also known as
    Thrap4
    Summary
    Enables histone acetyltransferase activity and transcription coactivator activity. Contributes to ubiquitin protein ligase activity. Involved in protein ubiquitination. Part of ubiquitin ligase complex. Orthologous to human MED24 (mediator complex subunit 24). [provided by Alliance of Genome Resources, Nov 2024]
    Expression
    Biased expression in Thymus (RPKM 124.1), Brain (RPKM 98.4) and 9 other tissues See more
    Orthologs
    human mouse all
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    Genomic context

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    See Med24 in Genome Data Viewer
    Location:
    10q31
    Exon count:
    28
    Annotation release Status Assembly Chr Location
    RS_2024_02 current GRCr8 (GCF_036323735.1) 10 NC_086028.1 (84160866..84198607, complement)
    RS_2023_06 previous assembly mRatBN7.2 (GCF_015227675.2) 10 NC_051345.1 (83664609..83702315, complement)
    106 previous assembly Rnor_6.0 (GCF_000001895.5) 10 NC_005109.4 (86620166..86658014, complement)

    Chromosome 10 - NC_086028.1Genomic Context describing neighboring genes Neighboring gene proteasome 26S subunit, non-ATPase 3 Neighboring gene colony stimulating factor 3 Neighboring gene small nucleolar RNA, C/D box 124 Neighboring gene thyroid hormone receptor alpha Neighboring gene uncharacterized LOC108352130 Neighboring gene nuclear receptor subfamily 1, group D, member 1

    Genomic regions, transcripts, and products

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    Go to nucleotide: Graphics FASTA GenBank

    Expression

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    • Project title: A rat RNA-Seq transcriptomic BodyMap across 11 organs and 4 developmental stages A rat RNA-Seq transcriptomic BodyMap across 11 organs and 4 developmental stages
    • Description: 320 RNA samples isolated from 11 organs (adrenal gland, brain, heart, kidney, liver, lung, muscle, spleen, thymus, and testes or uterus) from both sexes of Fischer 344 rats across four developmental stages (2-, 6-, 21-, and 104-weeks-old)
    • BioProject: PRJNA238328
    • Publication: PMID 24510058
    • Analysis date: Mon Jun 6 17:44:12 2016

    Bibliography

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    Related articles in PubMed

    1. The TRAP100 component of the TRAP/Mediator complex is essential in broad transcriptional events and development. Ito M, et al. EMBO J, 2002 Jul 1. PMID 12093747, Free PMC Article
    2. A coregulatory role for the TRAP-mediator complex in androgen receptor-mediated gene expression. Wang Q, et al. J Biol Chem, 2002 Nov 8. PMID 12218053
    3. Identification of a transcriptionally active peroxisome proliferator-activated receptor alpha -interacting cofactor complex in rat liver and characterization of PRIC285 as a coactivator. Surapureddi S, et al. Proc Natl Acad Sci U S A, 2002 Sep 3. PMID 12189208, Free PMC Article
    4. Mammalian mediator subunit mMED8 is an Elongin BC-interacting protein that can assemble with Cul2 and Rbx1 to reconstitute a ubiquitin ligase. Brower CS, et al. Proc Natl Acad Sci U S A, 2002 Aug 6. PMID 12149480, Free PMC Article
    5. Identity between TRAP and SMCC complexes indicates novel pathways for the function of nuclear receptors and diverse mammalian activators. Ito M, et al. Mol Cell, 1999 Mar. PMID 10198638

    See all (13) citations in PubMed

    GeneRIFs: Gene References Into Functions

    General gene information

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    Markers

    Homology

    Gene Ontology Provided by RGD

    Function Evidence Code Pubs
    enables histone acetyltransferase activity IDA
    Inferred from Direct Assay
    more info
    		 PubMed 
    enables nuclear thyroid hormone receptor binding IEA
    Inferred from Electronic Annotation
    more info
    		  
    enables nuclear thyroid hormone receptor binding ISO
    Inferred from Sequence Orthology
    more info
    		  
    enables protein-containing complex binding IDA
    Inferred from Direct Assay
    more info
    		 PubMed 
    enables transcription coactivator activity IDA
    Inferred from Direct Assay
    more info
    		 PubMed 
    enables transcription coactivator activity IEA
    Inferred from Electronic Annotation
    more info
    		  
    enables transcription coactivator activity ISO
    Inferred from Sequence Orthology
    more info
    		  
    enables transcription coregulator activity IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    enables transcription coregulator activity ISO
    Inferred from Sequence Orthology
    more info
    		  
    contributes_to ubiquitin protein ligase activity IDA
    Inferred from Direct Assay
    more info
    		 PubMed 
    Process Evidence Code Pubs
    involved_in chromatin remodeling IEA
    Inferred from Electronic Annotation
    more info
    		  
    involved_in positive regulation of DNA-templated transcription ISO
    Inferred from Sequence Orthology
    more info
    		  
    involved_in positive regulation of transcription initiation by RNA polymerase II IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    involved_in positive regulation of transcription initiation by RNA polymerase II IEA
    Inferred from Electronic Annotation
    more info
    		  
    involved_in positive regulation of transcription initiation by RNA polymerase II ISO
    Inferred from Sequence Orthology
    more info
    		  
    involved_in protein ubiquitination IDA
    Inferred from Direct Assay
    more info
    		 PubMed 
    acts_upstream_of_or_within somatic stem cell population maintenance ISO
    Inferred from Sequence Orthology
    more info
    		  
    acts_upstream_of_or_within transcription by RNA polymerase II ISO
    Inferred from Sequence Orthology
    more info
    		  
    Component Evidence Code Pubs
    part_of core mediator complex IEA
    Inferred from Electronic Annotation
    more info
    		  
    part_of core mediator complex ISO
    Inferred from Sequence Orthology
    more info
    		  
    part_of mediator complex IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    part_of mediator complex IEA
    Inferred from Electronic Annotation
    more info
    		  
    part_of mediator complex ISO
    Inferred from Sequence Orthology
    more info
    		  
    located_in nucleus ISO
    Inferred from Sequence Orthology
    more info
    		  
    part_of ubiquitin ligase complex IDA
    Inferred from Direct Assay
    more info
    		 PubMed 

    General protein information

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    Preferred Names
    mediator of RNA polymerase II transcription subunit 24
    Names
    thyroid hormone receptor-associated protein 4

    NCBI Reference Sequences (RefSeq)

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    RefSeqs maintained independently of Annotated Genomes

    These reference sequences exist independently of genome builds. Explain

    These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

    mRNA and Protein(s)

    1. NM_001034079.1 → NP_001029251.1  mediator of RNA polymerase II transcription subunit 24

      See identical proteins and their annotated locations for NP_001029251.1

      Status: VALIDATED

      Source sequence(s)
      BC097461
      UniProtKB/Swiss-Prot
      Q4V8B3
      UniProtKB/TrEMBL
      A0A8I6AA67
      Related
      ENSRNOP00000106783.1, ENSRNOT00000165183.1
      Conserved Domains (1) summary
      pfam11277
      Location:1 → 985
      Med24_N; Mediator complex subunit 24 N-terminal

    RefSeqs of Annotated Genomes: GCF_036323735.1-RS_2024_02

    The following sections contain reference sequences that belong to a specific genome build. Explain

    Reference GRCr8

    Genomic

    1. NC_086028.1 Reference GRCr8

      Range
      84160866..84198607 complement
      Download
      GenBank, FASTA, Sequence Viewer (Graphics)

    mRNA and Protein(s)

    1. XM_063269788.1 → XP_063125858.1  mediator of RNA polymerase II transcription subunit 24 isoform X2

      UniProtKB/Swiss-Prot
      Q4V8B3

    2. XM_017597516.3 → XP_017453005.1  mediator of RNA polymerase II transcription subunit 24 isoform X1

      UniProtKB/TrEMBL
      A0A8I6AA67, A0A8L2Q599, A6HIT9
      Conserved Domains (1) summary
      pfam11277
      Location:1 → 1004
      Med24_N; Mediator complex subunit 24 N-terminal

    3. XM_039086760.1 → XP_038942688.1  mediator of RNA polymerase II transcription subunit 24 isoform X4

      UniProtKB/TrEMBL
      A0A8I6AA67
      Conserved Domains (1) summary
      pfam11277
      Location:1 → 944
      Med24_N; Mediator complex subunit 24 N-terminal

    4. XM_039086759.1 → XP_038942687.1  mediator of RNA polymerase II transcription subunit 24 isoform X3

      UniProtKB/TrEMBL
      A0A8I6AA67
      Conserved Domains (1) summary
      pfam11277
      Location:1 → 963
      Med24_N; Mediator complex subunit 24 N-terminal

    5. XM_006247415.4 → XP_006247477.1  mediator of RNA polymerase II transcription subunit 24 isoform X1

      See identical proteins and their annotated locations for XP_006247477.1

      UniProtKB/TrEMBL
      A0A8I6AA67, A0A8L2Q599, A6HIT9
      Related
      ENSRNOP00000011947.4, ENSRNOT00000011947.6
      Conserved Domains (1) summary
      pfam11277
      Location:1 → 1004
      Med24_N; Mediator complex subunit 24 N-terminal

    6. XM_063269789.1 → XP_063125859.1  mediator of RNA polymerase II transcription subunit 24 isoform X4

    7. XM_063269787.1 → XP_063125857.1  mediator of RNA polymerase II transcription subunit 24 isoform X2

      UniProtKB/Swiss-Prot
      Q4V8B3

    8. XM_006247416.4 → XP_006247478.1  mediator of RNA polymerase II transcription subunit 24 isoform X1

      See identical proteins and their annotated locations for XP_006247478.1

      UniProtKB/TrEMBL
      A0A8I6AA67, A0A8L2Q599, A6HIT9
      Conserved Domains (1) summary
      pfam11277
      Location:1 → 1004
      Med24_N; Mediator complex subunit 24 N-terminal

    9. XM_063269791.1 → XP_063125861.1  mediator of RNA polymerase II transcription subunit 24 isoform X6

    10. XM_039086761.1 → XP_038942689.1  mediator of RNA polymerase II transcription subunit 24 isoform X5

      Conserved Domains (1) summary
      pfam11277
      Location:1 → 589
      Med24_N; Mediator complex subunit 24 N-terminal
    Nucleotide Protein Strain
    Heading Accession and Version
    Protein Accession Links
    GenPept Link UniProtKB Link
    Q4V8B3.1 GenPept UniProtKB/Swiss-Prot:Q4V8B3

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