Acap2 ArfGAP with coiled-coil, ankyrin repeat and PH domains 2 [Rattus norvegicus (Norway rat)] - Gene

Summary

Official Symbol: Acap2provided by RGD
Official Full Name: ArfGAP with coiled-coil, ankyrin repeat and PH domains 2provided by RGD
Primary source: RGD:1562939
See related: EnsemblRapid:ENSRNOG00000001730 AllianceGenome:RGD:1562939
Gene type: protein coding
RefSeq status: VALIDATED
Organism: Rattus norvegicus
Lineage: Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha; Muroidea; Muridae; Murinae; Rattus
Also known as: Centb2; cnt-b2
Summary: Predicted to enable GTPase activator activity; phosphatidylinositol-3,5-bisphosphate binding activity; and small GTPase binding activity. Involved in cellular response to nerve growth factor stimulus and endocytic recycling. Located in endosome membrane. Orthologous to human ACAP2 (ArfGAP with coiled-coil, ankyrin repeat and PH domains 2). [provided by Alliance of Genome Resources, Apr 2022]
Expression: Biased expression in Adrenal (RPKM 208.9), Lung (RPKM 189.3) and 9 other tissues See more
Orthologs: human mouse all
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Genomic context

Location:: 11q22

Exon count:: 25

Annotation release	Status	Assembly	Chr	Location
RS_2024_02	current	GRCr8 (GCF_036323735.1)	11	NC_086029.1 (83043442..83159105)
RS_2023_06	previous assembly	mRatBN7.2 (GCF_015227675.2)	11	NC_051346.1 (69538487..69654156)
106	previous assembly	Rnor_6.0 (GCF_000001895.5)	11	NC_005110.4 (73078966..73193496)

Chromosome 11 - NC_086029.1 Genomic Context describing neighboring genes

Genomic regions, transcripts, and products

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Genomic Sequence:

Go to nucleotide: Graphics FASTA GenBank

Expression

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See details

Project title: A rat RNA-Seq transcriptomic BodyMap across 11 organs and 4 developmental stages
Description: 320 RNA samples isolated from 11 organs (adrenal gland, brain, heart, kidney, liver, lung, muscle, spleen, thymus, and testes or uterus) from both sexes of Fischer 344 rats across four developmental stages (2-, 6-, 21-, and 104-weeks-old)
BioProject: PRJNA238328
Publication: PMID 24510058
Analysis date: Mon Jun 6 17:44:12 2016

Bibliography

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GeneRIFs: Gene References Into Functions

What's a GeneRIF?

showed by knockdown-rescue approaches that neither a centaurin-beta2 binding-deficient Rab35(T76S/T81A) mutant nor a Rab35 binding-deficient centaurin-beta2(N610A/N691A) mutant supported neurite outgrowth of PC12 cells
Title: Structure-function analyses of the small GTPase Rab35 and its effector protein centaurin-β2/ACAP2 during neurite outgrowth of PC12 cells.
Rab35/ACAP2 and cytohesin-2 antagonistically control oligodendrocyte differentiation and myelination through Arf6 regulation.
Title: Rab35, acting through ACAP2 switching off Arf6, negatively regulates oligodendrocyte differentiation and myelination.
Rab35 regulates Arf6 activity through centaurin-beta2 (ACAP2) during neurite outgrowth.
Title: Rab35 regulates Arf6 activity through centaurin-β2 (ACAP2) during neurite outgrowth.

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General gene information

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Markers

BI296803 (e-PCR)
- UniSTS:247616

RH132336 (e-PCR)
- UniSTS:215619

AU047727 (e-PCR)
- UniSTS:110223

Gene Ontology Provided by RGD

Function	Evidence Code	Pubs
enables GTPase activator activity	IEA Inferred from Electronic Annotation more info
enables GTPase activator activity	ISO Inferred from Sequence Orthology more info
enables metal ion binding	IEA Inferred from Electronic Annotation more info
enables phosphatidylinositol-3,5-bisphosphate binding	ISO Inferred from Sequence Orthology more info
enables small GTPase binding	ISO Inferred from Sequence Orthology more info

Process	Evidence Code	Pubs
involved_in actin filament-based process	IEA Inferred from Electronic Annotation more info
acts_upstream_of_or_within actin filament-based process	ISO Inferred from Sequence Orthology more info
involved_in cellular response to nerve growth factor stimulus	IDA Inferred from Direct Assay more info	PubMed
involved_in endocytic recycling	IMP Inferred from Mutant Phenotype more info	PubMed

Component	Evidence Code	Pubs
is_active_in endosome membrane	IBA Inferred from Biological aspect of Ancestor more info
located_in endosome membrane	IDA Inferred from Direct Assay more info	PubMed
located_in endosome membrane	IEA Inferred from Electronic Annotation more info
located_in ruffle	IEA Inferred from Electronic Annotation more info
located_in ruffle	ISO Inferred from Sequence Orthology more info

General protein information

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Preferred Names: arf-GAP with coiled-coil, ANK repeat and PH domain-containing protein 2

Names: centaurin-beta-2

NCBI Reference Sequences (RefSeq)

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RefSeqs maintained independently of Annotated Genomes

These reference sequences exist independently of genome builds. Explain

These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

mRNA and Protein(s)

NM_001034006.2 → NP_001029178.1 arf-GAP with coiled-coil, ANK repeat and PH domain-containing protein 2

See identical proteins and their annotated locations for NP_001029178.1

Status: VALIDATED

Source sequence(s)

JAXUCZ010000011

UniProtKB/Swiss-Prot

Q5FVC7

UniProtKB/TrEMBL

A0A8L2QG26

Conserved Domains (6) summary

PTZ00322
Location:634 → 718

PTZ00322; 6-phosphofructo-2-kinase/fructose-2,6-biphosphatase; Provisional

cd07638
Location:18 → 217

BAR_ACAP2; The Bin/Amphiphysin/Rvs (BAR) domain of ArfGAP with Coiled-coil, ANK repeat and PH domain containing protein 2

cd13250
Location:269 → 365

PH_ACAP; ArfGAP with coiled-coil, ankyrin repeat and PH domains Pleckstrin homology (PH) domain

sd00045
Location:630 → 663

ANK; ANK repeat [structural motif]

cd08851
Location:399 → 513

ArfGap_ACAP2; ArfGAP domain of ACAP2 (ArfGAP with Coiled-coil, ANK repeat and PH domains 2)

pfam13637
Location:602 → 653

Ank_4; Ankyrin repeats (many copies)

RefSeqs of Annotated Genomes: GCF_036323735.1-RS_2024_02

The following sections contain reference sequences that belong to a specific genome build. Explain

Reference GRCr8

Genomic

NC_086029.1 Reference GRCr8

Range

83043442..83159105

Download

GenBank, FASTA, Sequence Viewer (Graphics)

mRNA and Protein(s)

XM_006248489.5 → XP_006248551.1 arf-GAP with coiled-coil, ANK repeat and PH domain-containing protein 2 isoform X2

UniProtKB/TrEMBL

A0A8L2QG26

Conserved Domains (7) summary

cd07638
Location:18 → 217

BAR_ACAP2; The Bin/Amphiphysin/Rvs (BAR) domain of ArfGAP with Coiled-coil, ANK repeat and PH domain containing protein 2

smart00105
Location:402 → 517

ArfGap; Putative GTP-ase activating proteins for the small GTPase, ARF

cd00204
Location:637 → 753

ANK; ankyrin repeats; ankyrin repeats mediate protein-protein interactions in very diverse families of proteins. The number of ANK repeats in a protein can range from 2 to over 20 (ankyrins, for example). ANK repeats may occur in combinations with other ...

cd13250
Location:269 → 365

PH_ACAP; ArfGAP with coiled-coil, ankyrin repeat and PH domains Pleckstrin homology (PH) domain

pfam00169
Location:267 → 361

PH; PH domain

pfam12796
Location:637 → 731

Ank_2; Ankyrin repeats (3 copies)

sd00045
Location:665 → 698

ANK; ANK repeat [structural motif]
XM_006248487.4 → XP_006248549.1 arf-GAP with coiled-coil, ANK repeat and PH domain-containing protein 2 isoform X1

UniProtKB/TrEMBL

A0A8L2QG26

Related

ENSRNOP00000082482.2, ENSRNOT00000094946.2

Conserved Domains (7) summary

cd07638
Location:18 → 217

BAR_ACAP2; The Bin/Amphiphysin/Rvs (BAR) domain of ArfGAP with Coiled-coil, ANK repeat and PH domain containing protein 2

smart00105
Location:409 → 524

ArfGap; Putative GTP-ase activating proteins for the small GTPase, ARF

cd00204
Location:644 → 760

ANK; ankyrin repeats; ankyrin repeats mediate protein-protein interactions in very diverse families of proteins. The number of ANK repeats in a protein can range from 2 to over 20 (ankyrins, for example). ANK repeats may occur in combinations with other ...

cd13250
Location:269 → 372

PH_ACAP; ArfGAP with coiled-coil, ankyrin repeat and PH domains Pleckstrin homology (PH) domain

pfam00169
Location:267 → 368

PH; PH domain

pfam12796
Location:644 → 738

Ank_2; Ankyrin repeats (3 copies)

sd00045
Location:672 → 705

ANK; ANK repeat [structural motif]
XM_006248491.5 → XP_006248553.1 arf-GAP with coiled-coil, ANK repeat and PH domain-containing protein 2 isoform X3

UniProtKB/TrEMBL

A0A8L2QG26

Related

ENSRNOP00000073162.3, ENSRNOT00000080834.3

Conserved Domains (7) summary

cd07638
Location:18 → 217

BAR_ACAP2; The Bin/Amphiphysin/Rvs (BAR) domain of ArfGAP with Coiled-coil, ANK repeat and PH domain containing protein 2

smart00105
Location:409 → 524

ArfGap; Putative GTP-ase activating proteins for the small GTPase, ARF

cd00204
Location:609 → 725

ANK; ankyrin repeats; ankyrin repeats mediate protein-protein interactions in very diverse families of proteins. The number of ANK repeats in a protein can range from 2 to over 20 (ankyrins, for example). ANK repeats may occur in combinations with other ...

cd13250
Location:269 → 372

PH_ACAP; ArfGAP with coiled-coil, ankyrin repeat and PH domains Pleckstrin homology (PH) domain

pfam00169
Location:267 → 368

PH; PH domain

pfam12796
Location:609 → 703

Ank_2; Ankyrin repeats (3 copies)

sd00045
Location:637 → 670

ANK; ANK repeat [structural motif]