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    PPP4R3A protein phosphatase 4 regulatory subunit 3A [ Canis lupus familiaris (dog) ]

    Gene ID: 612974, updated on 17-Aug-2024

    Summary

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    Official Symbol
    PPP4R3Aprovided by VGNC
    Official Full Name
    protein phosphatase 4 regulatory subunit 3Aprovided by VGNC
    Primary source
    VGNC:VGNC:44923
    See related
    Ensembl:ENSCAFG00845013787
    Gene type
    protein coding
    RefSeq status
    MODEL
    Organism
    Canis lupus familiaris (sub-species: familiaris)
    Lineage
    Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Laurasiatheria; Carnivora; Caniformia; Canidae; Canis
    Also known as
    SMEK1
    Orthologs
    human mouse all
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    Genomic context

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    See PPP4R3A in Genome Data Viewer
    Location:
    chromosome: 8
    Exon count:
    15
    Annotation release Status Assembly Chr Location
    106 current ROS_Cfam_1.0 (GCF_014441545.1) 8 NC_051812.1 (62575974..62615348, complement)
    106 current Dog10K_Boxer_Tasha (GCF_000002285.5) 8 NC_006590.4 (61882231..61921384, complement)
    106 current UU_Cfam_GSD_1.0 (GCF_011100685.1) 8 NC_049229.1 (62635753..62675109, complement)
    106 current UMICH_Zoey_3.1 (GCF_005444595.1) 8 NC_049268.1 (62255227..62294359, complement)
    106 current UNSW_CanFamBas_1.0 (GCF_013276365.1) 8 NC_049749.1 (62306118..62345243, complement)

    Chromosome 8 - NC_051812.1Genomic Context describing neighboring genes Neighboring gene G protein-coupled receptor 68 Neighboring gene coiled-coil domain containing 88C Neighboring gene U6 spliceosomal RNA Neighboring gene modulator of apoptosis 1

    Genomic regions, transcripts, and products

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    Go to nucleotide: Graphics FASTA GenBank

    Bibliography

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    Related articles in PubMed

    1. TreeGrafter: phylogenetic tree-based annotation of proteins with Gene Ontology terms and other annotations. Tang H, et al. Bioinformatics, 2019 Feb 1. PMID 30032202, Free PMC Article

    GeneRIFs: Gene References Into Functions

    General gene information

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    Markers

    Homology

    Gene Ontology Provided by RefSeq

    Function Evidence Code Pubs
    enables protein phosphatase activator activity IEA
    Inferred from Electronic Annotation
    more info
    		 PubMed 
    Process Evidence Code Pubs
    involved_in DNA damage response IEA
    Inferred from Electronic Annotation
    more info
    		 PubMed 
    involved_in protein dephosphorylation IEA
    Inferred from Electronic Annotation
    more info
    		 PubMed 
    Component Evidence Code Pubs
    located_in nucleoplasm IEA
    Inferred from Electronic Annotation
    more info
    		 PubMed 
    part_of protein phosphatase 4 complex IEA
    Inferred from Electronic Annotation
    more info
    		 PubMed 

    General protein information

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    Preferred Names
    serine/threonine-protein phosphatase 4 regulatory subunit 3A
    Names
    SMEK homolog 1, suppressor of mek1

    NCBI Reference Sequences (RefSeq)

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    RefSeqs of Annotated Genomes: Canis lupus familiaris Annotation Release 106 details...Open this link in a new tab

    The following sections contain reference sequences that belong to a specific genome build. Explain

    Reference ROS_Cfam_1.0

    Genomic

    1. NC_051812.1 Reference ROS_Cfam_1.0

      Range
      62575974..62615348 complement
      Download
      GenBank, FASTA, Sequence Viewer (Graphics)

    mRNA and Protein(s)

    1. XM_038674481.1 → XP_038530409.1  serine/threonine-protein phosphatase 4 regulatory subunit 3A isoform X2

      Conserved Domains (3) summary
      pfam04802
      Location:166 → 357
      SMK-1; Component of IIS longevity pathway SMK-1
      cl17171
      Location:7 → 65
      PH-like; Pleckstrin homology-like domain
      cl26969
      Location:325 → 402
      Vitellogenin_N; Lipoprotein amino terminal region

    2. XM_038674480.1 → XP_038530408.1  serine/threonine-protein phosphatase 4 regulatory subunit 3A isoform X1

      UniProtKB/TrEMBL
      A0A8C0PWT9, A0A8I3NRE9
      Related
      ENSCAFP00845019384.1, ENSCAFT00845024640.1
      Conserved Domains (3) summary
      pfam04802
      Location:166 → 357
      SMK-1; Component of IIS longevity pathway SMK-1
      cl17171
      Location:7 → 65
      PH-like; Pleckstrin homology-like domain
      cl26969
      Location:325 → 402
      Vitellogenin_N; Lipoprotein amino terminal region

    Alternate UMICH_Zoey_3.1

    Genomic

    1. NC_049268.1 Alternate UMICH_Zoey_3.1

      Range
      62255227..62294359 complement
      Download
      GenBank, FASTA, Sequence Viewer (Graphics)

    mRNA and Protein(s)

    1. XM_038484067.1 → XP_038339995.1  serine/threonine-protein phosphatase 4 regulatory subunit 3A isoform X2

      Conserved Domains (3) summary
      pfam04802
      Location:166 → 357
      SMK-1; Component of IIS longevity pathway SMK-1
      cl17171
      Location:7 → 65
      PH-like; Pleckstrin homology-like domain
      cl26969
      Location:325 → 402
      Vitellogenin_N; Lipoprotein amino terminal region

    2. XM_038484066.1 → XP_038339994.1  serine/threonine-protein phosphatase 4 regulatory subunit 3A isoform X1

      Conserved Domains (3) summary
      pfam04802
      Location:166 → 357
      SMK-1; Component of IIS longevity pathway SMK-1
      cl17171
      Location:7 → 65
      PH-like; Pleckstrin homology-like domain
      cl26969
      Location:325 → 402
      Vitellogenin_N; Lipoprotein amino terminal region

    Alternate UNSW_CanFamBas_1.0

    Genomic

    1. NC_049749.1 Alternate UNSW_CanFamBas_1.0

      Range
      62306118..62345243 complement
      Download
      GenBank, FASTA, Sequence Viewer (Graphics)

    mRNA and Protein(s)

    1. XM_038609671.1 → XP_038465599.1  serine/threonine-protein phosphatase 4 regulatory subunit 3A isoform X2

      Conserved Domains (3) summary
      pfam04802
      Location:166 → 357
      SMK-1; Component of IIS longevity pathway SMK-1
      cl17171
      Location:7 → 65
      PH-like; Pleckstrin homology-like domain
      cl26969
      Location:325 → 402
      Vitellogenin_N; Lipoprotein amino terminal region

    2. XM_038609670.1 → XP_038465598.1  serine/threonine-protein phosphatase 4 regulatory subunit 3A isoform X1

      Conserved Domains (3) summary
      pfam04802
      Location:166 → 357
      SMK-1; Component of IIS longevity pathway SMK-1
      cl17171
      Location:7 → 65
      PH-like; Pleckstrin homology-like domain
      cl26969
      Location:325 → 402
      Vitellogenin_N; Lipoprotein amino terminal region

    Alternate UU_Cfam_GSD_1.0

    Genomic

    1. NC_049229.1 Alternate UU_Cfam_GSD_1.0

      Range
      62635753..62675109 complement
      Download
      GenBank, FASTA, Sequence Viewer (Graphics)

    mRNA and Protein(s)

    1. XM_038545576.1 → XP_038401504.1  serine/threonine-protein phosphatase 4 regulatory subunit 3A isoform X2

      Conserved Domains (3) summary
      pfam04802
      Location:166 → 357
      SMK-1; Component of IIS longevity pathway SMK-1
      cl17171
      Location:7 → 65
      PH-like; Pleckstrin homology-like domain
      cl26969
      Location:325 → 402
      Vitellogenin_N; Lipoprotein amino terminal region

    2. XM_038545575.1 → XP_038401503.1  serine/threonine-protein phosphatase 4 regulatory subunit 3A isoform X1

      UniProtKB/TrEMBL
      A0A8C0PWT9, A0A8I3NRE9
      Conserved Domains (3) summary
      pfam04802
      Location:166 → 357
      SMK-1; Component of IIS longevity pathway SMK-1
      cl17171
      Location:7 → 65
      PH-like; Pleckstrin homology-like domain
      cl26969
      Location:325 → 402
      Vitellogenin_N; Lipoprotein amino terminal region

    Alternate Dog10K_Boxer_Tasha Primary Assembly

    Genomic

    1. NC_006590.4 Alternate Dog10K_Boxer_Tasha Primary Assembly

      Range
      61882231..61921384 complement
      Download
      GenBank, FASTA, Sequence Viewer (Graphics)

    mRNA and Protein(s)

    1. XM_849330.5 → XP_854423.1  serine/threonine-protein phosphatase 4 regulatory subunit 3A isoform X2

      Conserved Domains (3) summary
      pfam04802
      Location:166 → 357
      SMK-1; Component of IIS longevity pathway SMK-1
      cl17171
      Location:7 → 65
      PH-like; Pleckstrin homology-like domain
      cl26969
      Location:325 → 402
      Vitellogenin_N; Lipoprotein amino terminal region

    2. XM_005623747.3 → XP_005623804.1  serine/threonine-protein phosphatase 4 regulatory subunit 3A isoform X1

      UniProtKB/TrEMBL
      A0A8C0PWT9, A0A8I3NRE9
      Conserved Domains (3) summary
      pfam04802
      Location:166 → 357
      SMK-1; Component of IIS longevity pathway SMK-1
      cl17171
      Location:7 → 65
      PH-like; Pleckstrin homology-like domain
      cl26969
      Location:325 → 402
      Vitellogenin_N; Lipoprotein amino terminal region
    Nucleotide Protein
    Heading Accession and Version

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