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    FANCL FA complementation group L [ Canis lupus familiaris (dog) ]

    Gene ID: 612161, updated on 17-Aug-2024

    Summary

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    Official Symbol
    FANCLprovided by VGNC
    Official Full Name
    FA complementation group Lprovided by VGNC
    Primary source
    VGNC:VGNC:40724
    See related
    Ensembl:ENSCAFG00845012667
    Gene type
    protein coding
    RefSeq status
    MODEL
    Organism
    Canis lupus familiaris (sub-species: familiaris)
    Lineage
    Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Laurasiatheria; Carnivora; Caniformia; Canidae; Canis
    Orthologs
    human mouse all
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    Genomic context

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    See FANCL in Genome Data Viewer
    Location:
    chromosome: 10
    Exon count:
    20
    Annotation release Status Assembly Chr Location
    106 current ROS_Cfam_1.0 (GCF_014441545.1) 10 NC_051814.1 (59525256..59641260, complement)
    106 current Dog10K_Boxer_Tasha (GCF_000002285.5) 10 NC_006592.4 (58474427..58590338, complement)
    106 current UU_Cfam_GSD_1.0 (GCF_011100685.1) 10 NC_049231.1 (59798922..59915100, complement)
    106 current UMICH_Zoey_3.1 (GCF_005444595.1) 10 NC_049270.1 (59221915..59337621, complement)
    106 current UNSW_CanFamBas_1.0 (GCF_013276365.1) 10 NC_049751.1 (59506524..59622215, complement)

    Chromosome 10 - NC_051814.1Genomic Context describing neighboring genes Neighboring gene uncharacterized LOC111097764 Neighboring gene cofilin-1-like Neighboring gene uncharacterized LOC119873685 Neighboring gene uncharacterized LOC119873686 Neighboring gene VRK serine/threonine kinase 2 Neighboring gene U6 spliceosomal RNA Neighboring gene uncharacterized LOC111097767 Neighboring gene uncharacterized LOC102154536 Neighboring gene uncharacterized LOC119873689

    Genomic regions, transcripts, and products

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    Go to nucleotide: Graphics FASTA GenBank

    Bibliography

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    Related articles in PubMed

    1. TreeGrafter: phylogenetic tree-based annotation of proteins with Gene Ontology terms and other annotations. Tang H, et al. Bioinformatics, 2019 Feb 1. PMID 30032202, Free PMC Article

    GeneRIFs: Gene References Into Functions

    General gene information

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    Markers

    Homology

    Gene Ontology Provided by RefSeq

    Function Evidence Code Pubs
    enables ubiquitin protein ligase activity IEA
    Inferred from Electronic Annotation
    more info
    		 PubMed 
    Process Evidence Code Pubs
    involved_in interstrand cross-link repair IEA
    Inferred from Electronic Annotation
    more info
    		 PubMed 
    involved_in protein monoubiquitination IEA
    Inferred from Electronic Annotation
    more info
    		 PubMed 
    Component Evidence Code Pubs
    part_of Fanconi anaemia nuclear complex IEA
    Inferred from Electronic Annotation
    more info
    		 PubMed 
    located_in nucleus IEA
    Inferred from Electronic Annotation
    more info
    		 PubMed 

    General protein information

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    Preferred Names
    E3 ubiquitin-protein ligase FANCL
    Names
    Fanconi anemia complementation group L
    XP_013973013.3
    XP_013973014.3
    XP_022280470.2
    XP_022280471.2
    XP_038345272.1
    XP_038345273.1
    XP_038345274.1
    XP_038345275.1
    XP_038345276.1
    XP_038345277.1
    XP_038407247.1
    XP_038407248.1
    XP_038407249.1
    XP_038407250.1
    XP_038407251.1
    XP_038407252.1
    XP_038471182.1
    XP_038471183.1
    XP_038471184.1
    XP_038471185.1
    XP_038471187.1
    XP_038471188.1
    XP_038504280.1
    XP_038504285.1
    XP_038536570.1
    XP_038536571.1
    XP_038536572.1
    XP_038536573.1
    XP_038536574.1
    XP_038536575.1

    NCBI Reference Sequences (RefSeq)

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    RefSeqs of Annotated Genomes: Canis lupus familiaris Annotation Release 106 details...Open this link in a new tab

    The following sections contain reference sequences that belong to a specific genome build. Explain

    Reference ROS_Cfam_1.0

    Genomic

    1. NC_051814.1 Reference ROS_Cfam_1.0

      Range
      59525256..59641260 complement
      Download
      GenBank, FASTA, Sequence Viewer (Graphics)

    mRNA and Protein(s)

    1. XM_038680643.1 → XP_038536571.1  E3 ubiquitin-protein ligase FANCL isoform X2

      UniProtKB/TrEMBL
      A0A8I3NPL8, A0A8P0SXF2
      Related
      ENSCAFP00845017781.1, ENSCAFT00845022674.1
      Conserved Domains (4) summary
      cd16490
      Location:329 → 386
      RING-CH-C4HC3_FANCL; RING-CH finger, H2 subclass (C4HC3-type), found in Fanconi anemia group L protein (FANCL) and similar proteins
      pfam09765
      Location:7 → 116
      WD-3; WD-repeat region
      pfam18890
      Location:131 → 220
      FANCL_d2; FANCL UBC-like domain 2
      pfam18891
      Location:223 → 318
      FANCL_d3; FANCL UBC-like domain 3

    2. XM_038680645.1 → XP_038536573.1  E3 ubiquitin-protein ligase FANCL isoform X4

      UniProtKB/TrEMBL
      A0A8C0TUL1
      Conserved Domains (4) summary
      cd16490
      Location:259 → 316
      RING-CH-C4HC3_FANCL; RING-CH finger, H2 subclass (C4HC3-type), found in Fanconi anemia group L protein (FANCL) and similar proteins
      pfam09765
      Location:1 → 46
      WD-3; WD-repeat region
      pfam18890
      Location:61 → 150
      FANCL_d2; FANCL UBC-like domain 2
      pfam18891
      Location:153 → 248
      FANCL_d3; FANCL UBC-like domain 3

    3. XM_038680644.1 → XP_038536572.1  E3 ubiquitin-protein ligase FANCL isoform X3

      UniProtKB/TrEMBL
      A0A8C0TUL1
      Conserved Domains (4) summary
      cd16490
      Location:306 → 363
      RING-CH-C4HC3_FANCL; RING-CH finger, H2 subclass (C4HC3-type), found in Fanconi anemia group L protein (FANCL) and similar proteins
      pfam09765
      Location:7 → 93
      WD-3; WD-repeat region
      pfam18890
      Location:108 → 197
      FANCL_d2; FANCL UBC-like domain 2
      pfam18891
      Location:200 → 295
      FANCL_d3; FANCL UBC-like domain 3

    4. XM_038680642.1 → XP_038536570.1  E3 ubiquitin-protein ligase FANCL isoform X1

      UniProtKB/TrEMBL
      A0A8C0TUL1
      Conserved Domains (4) summary
      cd16490
      Location:329 → 386
      RING-CH-C4HC3_FANCL; RING-CH finger, H2 subclass (C4HC3-type), found in Fanconi anemia group L protein (FANCL) and similar proteins
      pfam09765
      Location:7 → 116
      WD-3; WD-repeat region
      pfam18890
      Location:131 → 220
      FANCL_d2; FANCL UBC-like domain 2
      pfam18891
      Location:223 → 318
      FANCL_d3; FANCL UBC-like domain 3

    5. XM_038680646.1 → XP_038536574.1  E3 ubiquitin-protein ligase FANCL isoform X5

      UniProtKB/TrEMBL
      A0A8P0NSC0
      Conserved Domains (4) summary
      pfam09765
      Location:7 → 116
      WD-3; WD-repeat region
      pfam11793
      Location:326 → 394
      FANCL_C; FANCL C-terminal domain
      pfam18890
      Location:131 → 220
      FANCL_d2; FANCL UBC-like domain 2
      pfam18891
      Location:223 → 318
      FANCL_d3; FANCL UBC-like domain 3

    6. XM_038680647.1 → XP_038536575.1  E3 ubiquitin-protein ligase FANCL isoform X6

      UniProtKB/TrEMBL
      A0A8P0NSC0
      Related
      ENSCAFP00845017876.1, ENSCAFT00845022805.1
      Conserved Domains (4) summary
      pfam09765
      Location:7 → 93
      WD-3; WD-repeat region
      pfam11793
      Location:303 → 371
      FANCL_C; FANCL C-terminal domain
      pfam18890
      Location:108 → 197
      FANCL_d2; FANCL UBC-like domain 2
      pfam18891
      Location:200 → 295
      FANCL_d3; FANCL UBC-like domain 3

    Alternate UMICH_Zoey_3.1

    Genomic

    1. NC_049270.1 Alternate UMICH_Zoey_3.1

      Range
      59221915..59337621 complement
      Download
      GenBank, FASTA, Sequence Viewer (Graphics)

    mRNA and Protein(s)

    1. XM_038489346.1 → XP_038345274.1  E3 ubiquitin-protein ligase FANCL isoform X7

    2. XM_038489347.1 → XP_038345275.1  E3 ubiquitin-protein ligase FANCL isoform X4

      Conserved Domains (4) summary
      cd16490
      Location:259 → 316
      RING-CH-C4HC3_FANCL; RING-CH finger, H2 subclass (C4HC3-type), found in Fanconi anemia group L protein (FANCL) and similar proteins
      pfam09765
      Location:1 → 46
      WD-3; WD-repeat region
      pfam18890
      Location:61 → 150
      FANCL_d2; FANCL UBC-like domain 2
      pfam18891
      Location:153 → 248
      FANCL_d3; FANCL UBC-like domain 3

    3. XM_038489345.1 → XP_038345273.1  E3 ubiquitin-protein ligase FANCL isoform X3

      Conserved Domains (4) summary
      cd16490
      Location:306 → 363
      RING-CH-C4HC3_FANCL; RING-CH finger, H2 subclass (C4HC3-type), found in Fanconi anemia group L protein (FANCL) and similar proteins
      pfam09765
      Location:7 → 93
      WD-3; WD-repeat region
      pfam18890
      Location:108 → 197
      FANCL_d2; FANCL UBC-like domain 2
      pfam18891
      Location:200 → 295
      FANCL_d3; FANCL UBC-like domain 3

    4. XM_038489344.1 → XP_038345272.1  E3 ubiquitin-protein ligase FANCL isoform X1

      Conserved Domains (4) summary
      cd16490
      Location:329 → 386
      RING-CH-C4HC3_FANCL; RING-CH finger, H2 subclass (C4HC3-type), found in Fanconi anemia group L protein (FANCL) and similar proteins
      pfam09765
      Location:7 → 116
      WD-3; WD-repeat region
      pfam18890
      Location:131 → 220
      FANCL_d2; FANCL UBC-like domain 2
      pfam18891
      Location:223 → 318
      FANCL_d3; FANCL UBC-like domain 3

    5. XM_038489348.1 → XP_038345276.1  E3 ubiquitin-protein ligase FANCL isoform X5

      Conserved Domains (4) summary
      pfam09765
      Location:7 → 116
      WD-3; WD-repeat region
      pfam11793
      Location:326 → 394
      FANCL_C; FANCL C-terminal domain
      pfam18890
      Location:131 → 220
      FANCL_d2; FANCL UBC-like domain 2
      pfam18891
      Location:223 → 318
      FANCL_d3; FANCL UBC-like domain 3

    6. XM_038489349.1 → XP_038345277.1  E3 ubiquitin-protein ligase FANCL isoform X6

      Conserved Domains (4) summary
      pfam09765
      Location:7 → 93
      WD-3; WD-repeat region
      pfam11793
      Location:303 → 371
      FANCL_C; FANCL C-terminal domain
      pfam18890
      Location:108 → 197
      FANCL_d2; FANCL UBC-like domain 2
      pfam18891
      Location:200 → 295
      FANCL_d3; FANCL UBC-like domain 3

    Alternate UNSW_CanFamBas_1.0

    Genomic

    1. NC_049751.1 Alternate UNSW_CanFamBas_1.0

      Range
      59506524..59622215 complement
      Download
      GenBank, FASTA, Sequence Viewer (Graphics)

    mRNA and Protein(s)

    1. XM_038615255.1 → XP_038471183.1  E3 ubiquitin-protein ligase FANCL isoform X2

      Conserved Domains (4) summary
      cd16490
      Location:329 → 386
      RING-CH-C4HC3_FANCL; RING-CH finger, H2 subclass (C4HC3-type), found in Fanconi anemia group L protein (FANCL) and similar proteins
      pfam09765
      Location:7 → 116
      WD-3; WD-repeat region
      pfam18890
      Location:131 → 220
      FANCL_d2; FANCL UBC-like domain 2
      pfam18891
      Location:223 → 318
      FANCL_d3; FANCL UBC-like domain 3

    2. XM_038615257.1 → XP_038471185.1  E3 ubiquitin-protein ligase FANCL isoform X4

      Conserved Domains (4) summary
      cd16490
      Location:259 → 316
      RING-CH-C4HC3_FANCL; RING-CH finger, H2 subclass (C4HC3-type), found in Fanconi anemia group L protein (FANCL) and similar proteins
      pfam09765
      Location:1 → 46
      WD-3; WD-repeat region
      pfam18890
      Location:61 → 150
      FANCL_d2; FANCL UBC-like domain 2
      pfam18891
      Location:153 → 248
      FANCL_d3; FANCL UBC-like domain 3

    3. XM_038615256.1 → XP_038471184.1  E3 ubiquitin-protein ligase FANCL isoform X3

      Conserved Domains (4) summary
      cd16490
      Location:306 → 363
      RING-CH-C4HC3_FANCL; RING-CH finger, H2 subclass (C4HC3-type), found in Fanconi anemia group L protein (FANCL) and similar proteins
      pfam09765
      Location:7 → 93
      WD-3; WD-repeat region
      pfam18890
      Location:108 → 197
      FANCL_d2; FANCL UBC-like domain 2
      pfam18891
      Location:200 → 295
      FANCL_d3; FANCL UBC-like domain 3

    4. XM_038615254.1 → XP_038471182.1  E3 ubiquitin-protein ligase FANCL isoform X1

      Conserved Domains (4) summary
      cd16490
      Location:329 → 386
      RING-CH-C4HC3_FANCL; RING-CH finger, H2 subclass (C4HC3-type), found in Fanconi anemia group L protein (FANCL) and similar proteins
      pfam09765
      Location:7 → 116
      WD-3; WD-repeat region
      pfam18890
      Location:131 → 220
      FANCL_d2; FANCL UBC-like domain 2
      pfam18891
      Location:223 → 318
      FANCL_d3; FANCL UBC-like domain 3

    5. XM_038615259.1 → XP_038471187.1  E3 ubiquitin-protein ligase FANCL isoform X5

      Conserved Domains (4) summary
      pfam09765
      Location:7 → 116
      WD-3; WD-repeat region
      pfam11793
      Location:326 → 394
      FANCL_C; FANCL C-terminal domain
      pfam18890
      Location:131 → 220
      FANCL_d2; FANCL UBC-like domain 2
      pfam18891
      Location:223 → 318
      FANCL_d3; FANCL UBC-like domain 3

    6. XM_038615260.1 → XP_038471188.1  E3 ubiquitin-protein ligase FANCL isoform X6

      Conserved Domains (4) summary
      pfam09765
      Location:7 → 93
      WD-3; WD-repeat region
      pfam11793
      Location:303 → 371
      FANCL_C; FANCL C-terminal domain
      pfam18890
      Location:108 → 197
      FANCL_d2; FANCL UBC-like domain 2
      pfam18891
      Location:200 → 295
      FANCL_d3; FANCL UBC-like domain 3

    Alternate UU_Cfam_GSD_1.0

    Genomic

    1. NC_049231.1 Alternate UU_Cfam_GSD_1.0

      Range
      59798922..59915100 complement
      Download
      GenBank, FASTA, Sequence Viewer (Graphics)

    mRNA and Protein(s)

    1. XM_038551321.1 → XP_038407249.1  E3 ubiquitin-protein ligase FANCL isoform X8

      UniProtKB/TrEMBL
      A0A8C0Z668

    2. XM_038551322.1 → XP_038407250.1  E3 ubiquitin-protein ligase FANCL isoform X4

      UniProtKB/TrEMBL
      A0A8C0TUL1

    3. XM_038551320.1 → XP_038407248.1  E3 ubiquitin-protein ligase FANCL isoform X3

      UniProtKB/TrEMBL
      A0A8C0TUL1

    4. XM_038551319.1 → XP_038407247.1  E3 ubiquitin-protein ligase FANCL isoform X1

      UniProtKB/TrEMBL
      A0A8C0TUL1

    5. XM_038551323.1 → XP_038407251.1  E3 ubiquitin-protein ligase FANCL isoform X5

      UniProtKB/TrEMBL
      A0A8P0NSC0
      Conserved Domains (4) summary
      pfam09765
      Location:7 → 116
      WD-3; WD-repeat region
      pfam11793
      Location:326 → 394
      FANCL_C; FANCL C-terminal domain
      pfam18890
      Location:131 → 220
      FANCL_d2; FANCL UBC-like domain 2
      pfam18891
      Location:223 → 318
      FANCL_d3; FANCL UBC-like domain 3

    6. XM_038551324.1 → XP_038407252.1  E3 ubiquitin-protein ligase FANCL isoform X6

      UniProtKB/TrEMBL
      A0A8P0NSC0
      Conserved Domains (4) summary
      pfam09765
      Location:7 → 93
      WD-3; WD-repeat region
      pfam11793
      Location:303 → 371
      FANCL_C; FANCL C-terminal domain
      pfam18890
      Location:108 → 197
      FANCL_d2; FANCL UBC-like domain 2
      pfam18891
      Location:200 → 295
      FANCL_d3; FANCL UBC-like domain 3

    Alternate Dog10K_Boxer_Tasha Primary Assembly

    Genomic

    1. NC_006592.4 Alternate Dog10K_Boxer_Tasha Primary Assembly

      Range
      58474427..58590338 complement
      Download
      GenBank, FASTA, Sequence Viewer (Graphics)

    mRNA and Protein(s)

    1. XM_022424762.2 → XP_022280470.2  E3 ubiquitin-protein ligase FANCL isoform X2

      UniProtKB/TrEMBL
      A0A8I3NPL8, A0A8P0SXF2
      Conserved Domains (4) summary
      cd16490
      Location:329 → 386
      RING-CH-C4HC3_FANCL; RING-CH finger, H2 subclass (C4HC3-type), found in Fanconi anemia group L protein (FANCL) and similar proteins
      pfam09765
      Location:7 → 116
      WD-3; WD-repeat region
      pfam18890
      Location:131 → 220
      FANCL_d2; FANCL UBC-like domain 2
      pfam18891
      Location:223 → 318
      FANCL_d3; FANCL UBC-like domain 3

    2. XM_038648357.1 → XP_038504285.1  E3 ubiquitin-protein ligase FANCL isoform X4

      UniProtKB/TrEMBL
      A0A8C0TUL1
      Conserved Domains (4) summary
      cd16490
      Location:259 → 316
      RING-CH-C4HC3_FANCL; RING-CH finger, H2 subclass (C4HC3-type), found in Fanconi anemia group L protein (FANCL) and similar proteins
      pfam09765
      Location:1 → 46
      WD-3; WD-repeat region
      pfam18890
      Location:61 → 150
      FANCL_d2; FANCL UBC-like domain 2
      pfam18891
      Location:153 → 248
      FANCL_d3; FANCL UBC-like domain 3

    3. XM_038648352.1 → XP_038504280.1  E3 ubiquitin-protein ligase FANCL isoform X3

      UniProtKB/TrEMBL
      A0A8C0TUL1
      Conserved Domains (4) summary
      cd16490
      Location:306 → 363
      RING-CH-C4HC3_FANCL; RING-CH finger, H2 subclass (C4HC3-type), found in Fanconi anemia group L protein (FANCL) and similar proteins
      pfam09765
      Location:7 → 93
      WD-3; WD-repeat region
      pfam18890
      Location:108 → 197
      FANCL_d2; FANCL UBC-like domain 2
      pfam18891
      Location:200 → 295
      FANCL_d3; FANCL UBC-like domain 3

    4. XM_022424763.2 → XP_022280471.2  E3 ubiquitin-protein ligase FANCL isoform X1

      UniProtKB/TrEMBL
      A0A8C0TUL1
      Conserved Domains (4) summary
      cd16490
      Location:329 → 386
      RING-CH-C4HC3_FANCL; RING-CH finger, H2 subclass (C4HC3-type), found in Fanconi anemia group L protein (FANCL) and similar proteins
      pfam09765
      Location:7 → 116
      WD-3; WD-repeat region
      pfam18890
      Location:131 → 220
      FANCL_d2; FANCL UBC-like domain 2
      pfam18891
      Location:223 → 318
      FANCL_d3; FANCL UBC-like domain 3

    5. XM_014117538.3 → XP_013973013.3  E3 ubiquitin-protein ligase FANCL isoform X5

      UniProtKB/TrEMBL
      A0A8P0NSC0
      Conserved Domains (4) summary
      pfam09765
      Location:7 → 116
      WD-3; WD-repeat region
      pfam11793
      Location:326 → 394
      FANCL_C; FANCL C-terminal domain
      pfam18890
      Location:131 → 220
      FANCL_d2; FANCL UBC-like domain 2
      pfam18891
      Location:223 → 318
      FANCL_d3; FANCL UBC-like domain 3

    6. XM_014117539.3 → XP_013973014.3  E3 ubiquitin-protein ligase FANCL isoform X6

      UniProtKB/TrEMBL
      A0A8P0NSC0
      Conserved Domains (4) summary
      pfam09765
      Location:7 → 93
      WD-3; WD-repeat region
      pfam11793
      Location:303 → 371
      FANCL_C; FANCL C-terminal domain
      pfam18890
      Location:108 → 197
      FANCL_d2; FANCL UBC-like domain 2
      pfam18891
      Location:200 → 295
      FANCL_d3; FANCL UBC-like domain 3
    Nucleotide Protein
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