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    ERN1 endoplasmic reticulum to nucleus signaling 1 [ Canis lupus familiaris (dog) ]

    Gene ID: 610766, updated on 17-Aug-2024

    Summary

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    Official Symbol
    ERN1provided by VGNC
    Official Full Name
    endoplasmic reticulum to nucleus signaling 1provided by VGNC
    Primary source
    VGNC:VGNC:40464
    See related
    Ensembl:ENSCAFG00845022274
    Gene type
    protein coding
    RefSeq status
    MODEL
    Organism
    Canis lupus familiaris (sub-species: familiaris)
    Lineage
    Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Laurasiatheria; Carnivora; Caniformia; Canidae; Canis
    Orthologs
    human mouse all
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    Genomic context

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    See ERN1 in Genome Data Viewer
    Location:
    chromosome: 9
    Exon count:
    26
    Annotation release Status Assembly Chr Location
    106 current ROS_Cfam_1.0 (GCF_014441545.1) 9 NC_051813.1 (13591579..13669839, complement)
    106 current Dog10K_Boxer_Tasha (GCF_000002285.5) 9 NC_006591.4 (12825652..12903073, complement)
    106 current UU_Cfam_GSD_1.0 (GCF_011100685.1) 9 NC_049230.1 (14918080..14996082)
    106 current UMICH_Zoey_3.1 (GCF_005444595.1) 9 NC_049269.1 (12538344..12616358, complement)
    106 current UNSW_CanFamBas_1.0 (GCF_013276365.1) 9 NC_049750.1 (14915804..14993944)

    Chromosome 9 - NC_051813.1Genomic Context describing neighboring genes Neighboring gene proline rich 29 Neighboring gene intercellular adhesion molecule 2 Neighboring gene uncharacterized LOC119873254 Neighboring gene U6 spliceosomal RNA Neighboring gene small nucleolar RNA SNORD104 Neighboring gene small nucleolar RNA SNORA76

    Genomic regions, transcripts, and products

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    Go to nucleotide: Graphics FASTA GenBank

    Bibliography

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    GeneRIFs: Gene References Into Functions

    General gene information

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    Homology

    Gene Ontology Provided by RefSeq

    Function Evidence Code Pubs
    enables ATP binding IEA
    Inferred from Electronic Annotation
    more info
    		 PubMed 
    enables RNA endonuclease activity IEA
    Inferred from Electronic Annotation
    more info
    		 PubMed 
    enables protein serine/threonine kinase activity IEA
    Inferred from Electronic Annotation
    more info
    		 PubMed 
    enables unfolded protein binding IEA
    Inferred from Electronic Annotation
    more info
    		 PubMed 
    Process Evidence Code Pubs
    involved_in IRE1-mediated unfolded protein response IEA
    Inferred from Electronic Annotation
    more info
    		 PubMed 
    involved_in intrinsic apoptotic signaling pathway in response to endoplasmic reticulum stress IEA
    Inferred from Electronic Annotation
    more info
    		 PubMed 
    involved_in mRNA processing IEA
    Inferred from Electronic Annotation
    more info
    		 PubMed 
    involved_in protein phosphorylation IEA
    Inferred from Electronic Annotation
    more info
    		 PubMed 
    Component Evidence Code Pubs
    part_of IRE1-TRAF2-ASK1 complex IEA
    Inferred from Electronic Annotation
    more info
    		 PubMed 

    General protein information

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    Preferred Names
    serine/threonine-protein kinase/endoribonuclease IRE1; LOW QUALITY PROTEIN: serine/threonine-protein kinase/endoribonuclease IRE1
    Names
    endoplasmic reticulum to nucleus signalling 1
    XP_005624312.1
    XP_022278543.1
    XP_022278544.1
    XP_022278545.1
    XP_022278546.1
    XP_022278547.1
    XP_038341094.1
    XP_038341095.1
    XP_038341096.1
    XP_038341097.1
    XP_038341098.1
    XP_038341099.1
    XP_038341100.1
    XP_038402792.1
    XP_038402793.1
    XP_038402795.1
    XP_038402796.1
    XP_038402797.1
    XP_038402798.1
    XP_038402799.1
    XP_038466769.1
    XP_038531941.1
    XP_038531942.1
    XP_038531943.1
    XP_038531944.1
    XP_038531945.1
    XP_038531946.1
    XP_038531947.1
    XP_853409.3

    NCBI Reference Sequences (RefSeq)

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    RefSeqs of Annotated Genomes: Canis lupus familiaris Annotation Release 106 details...Open this link in a new tab

    The following sections contain reference sequences that belong to a specific genome build. Explain

    Reference ROS_Cfam_1.0

    Genomic

    1. NC_051813.1 Reference ROS_Cfam_1.0

      Range
      13591579..13669839 complement
      Download
      GenBank, FASTA, Sequence Viewer (Graphics)

    mRNA and Protein(s)

    1. XM_038676013.1 → XP_038531941.1  serine/threonine-protein kinase/endoribonuclease IRE1 isoform X4

      UniProtKB/TrEMBL
      A0A8C0NGF4, A0A8C0SZA9, A0A8I3PJV6
      Related
      ENSCAFP00845030974.1, ENSCAFT00845039523.1
      Conserved Domains (3) summary
      cd09769
      Location:30 → 298
      Luminal_IRE1; The Luminal domain, a dimerization domain, of the Serine/Threonine protein kinase, Inositol-requiring protein 1
      cd10422
      Location:834 → 959
      RNase_Ire1; RNase domain (also known as the kinase extension nuclease domain) of Ire1
      cd13982
      Location:566 → 831
      STKc_IRE1; Catalytic domain of the Serine/Threonine kinase, Inositol-requiring protein 1

    2. XM_038676019.1 → XP_038531947.1  serine/threonine-protein kinase/endoribonuclease IRE1 isoform X3

      UniProtKB/TrEMBL
      A0A8I3PJE1
      Conserved Domains (3) summary
      cd10422
      Location:670 → 795
      RNase_Ire1; RNase domain (also known as the kinase extension nuclease domain) of Ire1
      cd13982
      Location:402 → 667
      STKc_IRE1; Catalytic domain of the Serine/Threonine kinase, Inositol-requiring protein 1
      cl14874
      Location:1 → 134
      Luminal_IRE1_like; The Luminal domain, a dimerization domain, of Inositol-requiring protein 1-like proteins

    3. XM_038676017.1 → XP_038531945.1  serine/threonine-protein kinase/endoribonuclease IRE1 isoform X2

      UniProtKB/TrEMBL
      A0A8I3PJE1
      Conserved Domains (3) summary
      cd10422
      Location:717 → 842
      RNase_Ire1; RNase domain (also known as the kinase extension nuclease domain) of Ire1
      cd13982
      Location:449 → 714
      STKc_IRE1; Catalytic domain of the Serine/Threonine kinase, Inositol-requiring protein 1
      cl14874
      Location:1 → 181
      Luminal_IRE1_like; The Luminal domain, a dimerization domain, of Inositol-requiring protein 1-like proteins

    4. XM_038676018.1 → XP_038531946.1  serine/threonine-protein kinase/endoribonuclease IRE1 isoform X3

      UniProtKB/TrEMBL
      A0A8I3PJE1
      Conserved Domains (3) summary
      cd10422
      Location:670 → 795
      RNase_Ire1; RNase domain (also known as the kinase extension nuclease domain) of Ire1
      cd13982
      Location:402 → 667
      STKc_IRE1; Catalytic domain of the Serine/Threonine kinase, Inositol-requiring protein 1
      cl14874
      Location:1 → 134
      Luminal_IRE1_like; The Luminal domain, a dimerization domain, of Inositol-requiring protein 1-like proteins

    5. XM_038676015.1 → XP_038531943.1  serine/threonine-protein kinase/endoribonuclease IRE1 isoform X2

      UniProtKB/TrEMBL
      A0A8I3PJE1
      Conserved Domains (3) summary
      cd10422
      Location:717 → 842
      RNase_Ire1; RNase domain (also known as the kinase extension nuclease domain) of Ire1
      cd13982
      Location:449 → 714
      STKc_IRE1; Catalytic domain of the Serine/Threonine kinase, Inositol-requiring protein 1
      cl14874
      Location:1 → 181
      Luminal_IRE1_like; The Luminal domain, a dimerization domain, of Inositol-requiring protein 1-like proteins

    6. XM_038676016.1 → XP_038531944.1  serine/threonine-protein kinase/endoribonuclease IRE1 isoform X2

      UniProtKB/TrEMBL
      A0A8I3PJE1
      Conserved Domains (3) summary
      cd10422
      Location:717 → 842
      RNase_Ire1; RNase domain (also known as the kinase extension nuclease domain) of Ire1
      cd13982
      Location:449 → 714
      STKc_IRE1; Catalytic domain of the Serine/Threonine kinase, Inositol-requiring protein 1
      cl14874
      Location:1 → 181
      Luminal_IRE1_like; The Luminal domain, a dimerization domain, of Inositol-requiring protein 1-like proteins

    7. XM_038676014.1 → XP_038531942.1  serine/threonine-protein kinase/endoribonuclease IRE1 isoform X1

      UniProtKB/TrEMBL
      A0A8C0NK15
      Conserved Domains (3) summary
      cd09769
      Location:16 → 284
      Luminal_IRE1; The Luminal domain, a dimerization domain, of the Serine/Threonine protein kinase, Inositol-requiring protein 1
      cd10422
      Location:820 → 945
      RNase_Ire1; RNase domain (also known as the kinase extension nuclease domain) of Ire1
      cd13982
      Location:552 → 817
      STKc_IRE1; Catalytic domain of the Serine/Threonine kinase, Inositol-requiring protein 1

    Alternate UMICH_Zoey_3.1

    Genomic

    1. NC_049269.1 Alternate UMICH_Zoey_3.1

      Range
      12538344..12616358 complement
      Download
      GenBank, FASTA, Sequence Viewer (Graphics)

    mRNA and Protein(s)

    1. XM_038485166.1 → XP_038341094.1  serine/threonine-protein kinase/endoribonuclease IRE1 isoform X4

      Conserved Domains (3) summary
      cd09769
      Location:30 → 298
      Luminal_IRE1; The Luminal domain, a dimerization domain, of the Serine/Threonine protein kinase, Inositol-requiring protein 1
      cd10422
      Location:834 → 959
      RNase_Ire1; RNase domain (also known as the kinase extension nuclease domain) of Ire1
      cd13982
      Location:566 → 831
      STKc_IRE1; Catalytic domain of the Serine/Threonine kinase, Inositol-requiring protein 1

    2. XM_038485172.1 → XP_038341100.1  serine/threonine-protein kinase/endoribonuclease IRE1 isoform X3

      Conserved Domains (3) summary
      cd10422
      Location:670 → 795
      RNase_Ire1; RNase domain (also known as the kinase extension nuclease domain) of Ire1
      cd13982
      Location:402 → 667
      STKc_IRE1; Catalytic domain of the Serine/Threonine kinase, Inositol-requiring protein 1
      cl14874
      Location:1 → 134
      Luminal_IRE1_like; The Luminal domain, a dimerization domain, of Inositol-requiring protein 1-like proteins

    3. XM_038485170.1 → XP_038341098.1  serine/threonine-protein kinase/endoribonuclease IRE1 isoform X2

      Conserved Domains (3) summary
      cd10422
      Location:717 → 842
      RNase_Ire1; RNase domain (also known as the kinase extension nuclease domain) of Ire1
      cd13982
      Location:449 → 714
      STKc_IRE1; Catalytic domain of the Serine/Threonine kinase, Inositol-requiring protein 1
      cl14874
      Location:1 → 181
      Luminal_IRE1_like; The Luminal domain, a dimerization domain, of Inositol-requiring protein 1-like proteins

    4. XM_038485171.1 → XP_038341099.1  serine/threonine-protein kinase/endoribonuclease IRE1 isoform X3

      Conserved Domains (3) summary
      cd10422
      Location:670 → 795
      RNase_Ire1; RNase domain (also known as the kinase extension nuclease domain) of Ire1
      cd13982
      Location:402 → 667
      STKc_IRE1; Catalytic domain of the Serine/Threonine kinase, Inositol-requiring protein 1
      cl14874
      Location:1 → 134
      Luminal_IRE1_like; The Luminal domain, a dimerization domain, of Inositol-requiring protein 1-like proteins

    5. XM_038485168.1 → XP_038341096.1  serine/threonine-protein kinase/endoribonuclease IRE1 isoform X2

      Conserved Domains (3) summary
      cd10422
      Location:717 → 842
      RNase_Ire1; RNase domain (also known as the kinase extension nuclease domain) of Ire1
      cd13982
      Location:449 → 714
      STKc_IRE1; Catalytic domain of the Serine/Threonine kinase, Inositol-requiring protein 1
      cl14874
      Location:1 → 181
      Luminal_IRE1_like; The Luminal domain, a dimerization domain, of Inositol-requiring protein 1-like proteins

    6. XM_038485169.1 → XP_038341097.1  serine/threonine-protein kinase/endoribonuclease IRE1 isoform X2

      Conserved Domains (3) summary
      cd10422
      Location:717 → 842
      RNase_Ire1; RNase domain (also known as the kinase extension nuclease domain) of Ire1
      cd13982
      Location:449 → 714
      STKc_IRE1; Catalytic domain of the Serine/Threonine kinase, Inositol-requiring protein 1
      cl14874
      Location:1 → 181
      Luminal_IRE1_like; The Luminal domain, a dimerization domain, of Inositol-requiring protein 1-like proteins

    7. XM_038485167.1 → XP_038341095.1  serine/threonine-protein kinase/endoribonuclease IRE1 isoform X1

      Conserved Domains (3) summary
      cd09769
      Location:16 → 284
      Luminal_IRE1; The Luminal domain, a dimerization domain, of the Serine/Threonine protein kinase, Inositol-requiring protein 1
      cd10422
      Location:820 → 945
      RNase_Ire1; RNase domain (also known as the kinase extension nuclease domain) of Ire1
      cd13982
      Location:552 → 817
      STKc_IRE1; Catalytic domain of the Serine/Threonine kinase, Inositol-requiring protein 1

    Alternate UNSW_CanFamBas_1.0

    Genomic

    1. NC_049750.1 Alternate UNSW_CanFamBas_1.0

      Range
      14915804..14993944
      Download
      GenBank, FASTA, Sequence Viewer (Graphics)

    mRNA and Protein(s)

    1. XM_038610841.1 → XP_038466769.1  LOW QUALITY PROTEIN: serine/threonine-protein kinase/endoribonuclease IRE1 isoform X4

    Alternate UU_Cfam_GSD_1.0

    Genomic

    1. NC_049230.1 Alternate UU_Cfam_GSD_1.0

      Range
      14918080..14996082
      Download
      GenBank, FASTA, Sequence Viewer (Graphics)

    mRNA and Protein(s)

    1. XM_038546864.1 → XP_038402792.1  serine/threonine-protein kinase/endoribonuclease IRE1 isoform X4

      UniProtKB/TrEMBL
      A0A8C0NGF4, A0A8P0NDV4

    2. XM_038546867.1 → XP_038402795.1  serine/threonine-protein kinase/endoribonuclease IRE1 isoform X2

      UniProtKB/TrEMBL
      A0A8I3PJE1
      Conserved Domains (3) summary
      cd10422
      Location:717 → 842
      RNase_Ire1; RNase domain (also known as the kinase extension nuclease domain) of Ire1
      cd13982
      Location:449 → 714
      STKc_IRE1; Catalytic domain of the Serine/Threonine kinase, Inositol-requiring protein 1
      cl14874
      Location:1 → 181
      Luminal_IRE1_like; The Luminal domain, a dimerization domain, of Inositol-requiring protein 1-like proteins

    3. XM_038546870.1 → XP_038402798.1  serine/threonine-protein kinase/endoribonuclease IRE1 isoform X3

      UniProtKB/TrEMBL
      A0A8I3PJE1
      Conserved Domains (3) summary
      cd10422
      Location:670 → 795
      RNase_Ire1; RNase domain (also known as the kinase extension nuclease domain) of Ire1
      cd13982
      Location:402 → 667
      STKc_IRE1; Catalytic domain of the Serine/Threonine kinase, Inositol-requiring protein 1
      cl14874
      Location:1 → 134
      Luminal_IRE1_like; The Luminal domain, a dimerization domain, of Inositol-requiring protein 1-like proteins

    4. XM_038546869.1 → XP_038402797.1  serine/threonine-protein kinase/endoribonuclease IRE1 isoform X2

      UniProtKB/TrEMBL
      A0A8I3PJE1
      Conserved Domains (3) summary
      cd10422
      Location:717 → 842
      RNase_Ire1; RNase domain (also known as the kinase extension nuclease domain) of Ire1
      cd13982
      Location:449 → 714
      STKc_IRE1; Catalytic domain of the Serine/Threonine kinase, Inositol-requiring protein 1
      cl14874
      Location:1 → 181
      Luminal_IRE1_like; The Luminal domain, a dimerization domain, of Inositol-requiring protein 1-like proteins

    5. XM_038546871.1 → XP_038402799.1  serine/threonine-protein kinase/endoribonuclease IRE1 isoform X3

      UniProtKB/TrEMBL
      A0A8I3PJE1
      Conserved Domains (3) summary
      cd10422
      Location:670 → 795
      RNase_Ire1; RNase domain (also known as the kinase extension nuclease domain) of Ire1
      cd13982
      Location:402 → 667
      STKc_IRE1; Catalytic domain of the Serine/Threonine kinase, Inositol-requiring protein 1
      cl14874
      Location:1 → 134
      Luminal_IRE1_like; The Luminal domain, a dimerization domain, of Inositol-requiring protein 1-like proteins

    6. XM_038546868.1 → XP_038402796.1  serine/threonine-protein kinase/endoribonuclease IRE1 isoform X2

      UniProtKB/TrEMBL
      A0A8I3PJE1
      Conserved Domains (3) summary
      cd10422
      Location:717 → 842
      RNase_Ire1; RNase domain (also known as the kinase extension nuclease domain) of Ire1
      cd13982
      Location:449 → 714
      STKc_IRE1; Catalytic domain of the Serine/Threonine kinase, Inositol-requiring protein 1
      cl14874
      Location:1 → 181
      Luminal_IRE1_like; The Luminal domain, a dimerization domain, of Inositol-requiring protein 1-like proteins

    7. XM_038546865.1 → XP_038402793.1  serine/threonine-protein kinase/endoribonuclease IRE1 isoform X5

      UniProtKB/TrEMBL
      A0A8C0NK15

    Alternate Dog10K_Boxer_Tasha Primary Assembly

    Genomic

    1. NC_006591.4 Alternate Dog10K_Boxer_Tasha Primary Assembly

      Range
      12825652..12903073 complement
      Download
      GenBank, FASTA, Sequence Viewer (Graphics)

    mRNA and Protein(s)

    1. XM_848316.5 → XP_853409.3  serine/threonine-protein kinase/endoribonuclease IRE1 isoform X4

      UniProtKB/TrEMBL
      A0A8C0NGF4, A0A8P0NDV4
      Conserved Domains (4) summary
      cd09769
      Location:30 → 298
      Luminal_IRE1; The Luminal domain, a dimerization domain, of the Serine/Threonine protein kinase, Inositol-requiring protein 1
      cd10422
      Location:834 → 959
      RNase_Ire1; RNase domain (also known as the kinase extension nuclease domain) of Ire1
      smart00220
      Location:569 → 830
      S_TKc; Serine/Threonine protein kinases, catalytic domain
      cd13982
      Location:566 → 831
      STKc_IRE1; Catalytic domain of the Serine/Threonine kinase, Inositol-requiring protein 1

    2. XM_022422839.2 → XP_022278547.1  serine/threonine-protein kinase/endoribonuclease IRE1 isoform X3

      UniProtKB/TrEMBL
      A0A8I3PJE1
      Conserved Domains (3) summary
      cd10422
      Location:670 → 795
      RNase_Ire1; RNase domain (also known as the kinase extension nuclease domain) of Ire1
      cd13982
      Location:402 → 667
      STKc_IRE1; Catalytic domain of the Serine/Threonine kinase, Inositol-requiring protein 1
      cl14874
      Location:1 → 134
      Luminal_IRE1_like; The Luminal domain, a dimerization domain, of Inositol-requiring protein 1-like proteins

    3. XM_022422837.2 → XP_022278545.1  serine/threonine-protein kinase/endoribonuclease IRE1 isoform X2

      UniProtKB/TrEMBL
      A0A8I3PJE1
      Conserved Domains (3) summary
      cd10422
      Location:717 → 842
      RNase_Ire1; RNase domain (also known as the kinase extension nuclease domain) of Ire1
      cd13982
      Location:449 → 714
      STKc_IRE1; Catalytic domain of the Serine/Threonine kinase, Inositol-requiring protein 1
      cl14874
      Location:1 → 181
      Luminal_IRE1_like; The Luminal domain, a dimerization domain, of Inositol-requiring protein 1-like proteins

    4. XM_022422838.2 → XP_022278546.1  serine/threonine-protein kinase/endoribonuclease IRE1 isoform X3

      UniProtKB/TrEMBL
      A0A8I3PJE1
      Conserved Domains (3) summary
      cd10422
      Location:670 → 795
      RNase_Ire1; RNase domain (also known as the kinase extension nuclease domain) of Ire1
      cd13982
      Location:402 → 667
      STKc_IRE1; Catalytic domain of the Serine/Threonine kinase, Inositol-requiring protein 1
      cl14874
      Location:1 → 134
      Luminal_IRE1_like; The Luminal domain, a dimerization domain, of Inositol-requiring protein 1-like proteins

    5. XM_022422835.2 → XP_022278543.1  serine/threonine-protein kinase/endoribonuclease IRE1 isoform X2

      UniProtKB/TrEMBL
      A0A8I3PJE1
      Conserved Domains (3) summary
      cd10422
      Location:717 → 842
      RNase_Ire1; RNase domain (also known as the kinase extension nuclease domain) of Ire1
      cd13982
      Location:449 → 714
      STKc_IRE1; Catalytic domain of the Serine/Threonine kinase, Inositol-requiring protein 1
      cl14874
      Location:1 → 181
      Luminal_IRE1_like; The Luminal domain, a dimerization domain, of Inositol-requiring protein 1-like proteins

    6. XM_022422836.2 → XP_022278544.1  serine/threonine-protein kinase/endoribonuclease IRE1 isoform X2

      UniProtKB/TrEMBL
      A0A8I3PJE1
      Conserved Domains (3) summary
      cd10422
      Location:717 → 842
      RNase_Ire1; RNase domain (also known as the kinase extension nuclease domain) of Ire1
      cd13982
      Location:449 → 714
      STKc_IRE1; Catalytic domain of the Serine/Threonine kinase, Inositol-requiring protein 1
      cl14874
      Location:1 → 181
      Luminal_IRE1_like; The Luminal domain, a dimerization domain, of Inositol-requiring protein 1-like proteins

    7. XM_005624255.3 → XP_005624312.1  serine/threonine-protein kinase/endoribonuclease IRE1 isoform X6

      See identical proteins and their annotated locations for XP_005624312.1

      UniProtKB/TrEMBL
      A0A8C0NK15
      Conserved Domains (4) summary
      cd09769
      Location:17 → 285
      Luminal_IRE1; The Luminal domain, a dimerization domain, of the Serine/Threonine protein kinase, Inositol-requiring protein 1
      cd10422
      Location:821 → 946
      RNase_Ire1; RNase domain (also known as the kinase extension nuclease domain) of Ire1
      smart00220
      Location:556 → 817
      S_TKc; Serine/Threonine protein kinases, catalytic domain
      cd13982
      Location:553 → 818
      STKc_IRE1; Catalytic domain of the Serine/Threonine kinase, Inositol-requiring protein 1
    Nucleotide Protein
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