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    PRKCE protein kinase C epsilon [ Canis lupus familiaris (dog) ]

    Gene ID: 609934, updated on 17-Aug-2024

    Summary

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    Official Symbol
    PRKCEprovided by VGNC
    Official Full Name
    protein kinase C epsilonprovided by VGNC
    Primary source
    VGNC:VGNC:44980
    See related
    Ensembl:ENSCAFG00845027571
    Gene type
    protein coding
    RefSeq status
    MODEL
    Organism
    Canis lupus familiaris (sub-species: familiaris)
    Lineage
    Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Laurasiatheria; Carnivora; Caniformia; Canidae; Canis
    Orthologs
    human mouse all
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    Genomic context

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    See PRKCE in Genome Data Viewer
    Location:
    chromosome: 10
    Exon count:
    17
    Annotation release Status Assembly Chr Location
    106 current ROS_Cfam_1.0 (GCF_014441545.1) 10 NC_051814.1 (48849986..49335766)
    106 current Dog10K_Boxer_Tasha (GCF_000002285.5) 10 NC_006592.4 (47832146..48319423)
    106 current UU_Cfam_GSD_1.0 (GCF_011100685.1) 10 NC_049231.1 (49029809..49517384)
    106 current UMICH_Zoey_3.1 (GCF_005444595.1) 10 NC_049270.1 (48557609..49044861)
    106 current UNSW_CanFamBas_1.0 (GCF_013276365.1) 10 NC_049751.1 (48849404..49334809)

    Chromosome 10 - NC_051814.1Genomic Context describing neighboring genes Neighboring gene S1 RNA binding domain 1 Neighboring gene uncharacterized LOC106559413 Neighboring gene DnaJ (Hsp40) homolog, subfamily A, member 1 pseudogene Neighboring gene uncharacterized LOC111097734 Neighboring gene uncharacterized LOC111097732 Neighboring gene uncharacterized LOC111097735 Neighboring gene uncharacterized LOC111097736

    Genomic regions, transcripts, and products

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    Go to nucleotide: Graphics FASTA GenBank

    Bibliography

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    Related articles in PubMed

    1. Protein kinase Cε regulates nuclear translocation of extracellular signal-regulated kinase, which contributes to bradykinin-induced cyclooxygenase-2 expression. Nakano R, et al. Sci Rep, 2018 Jun 4. PMID 29867151, Free PMC Article
    2. Phosphorylation of zona occludens-2 by protein kinase C epsilon regulates its nuclear exportation. Chamorro D, et al. Mol Biol Cell, 2009 Sep. PMID 19625451, Free PMC Article

    GeneRIFs: Gene References Into Functions

    What's a GeneRIF?
    1. bradykinin activates PKCepsilon via the PLD/PDK-1 pathway, which subsequently induces activation and translocation of ERK1 into the nucleus, and contributes to COX-2 expression for prostaglandin E2 synthesis in dermal fibroblasts.
      Title: Protein kinase Cε regulates nuclear translocation of extracellular signal-regulated kinase, which contributes to bradykinin-induced cyclooxygenase-2 expression.
    2. The departure of ZO-2 from the nucleus is regulated by phosphorylation at Ser369 by novel PKCepsilon.
      Title: Phosphorylation of zona occludens-2 by protein kinase C epsilon regulates its nuclear exportation.
    Submit: New GeneRIF Correction

    Pathways from PubChem

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    General gene information

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    Homology

    Gene Ontology Provided by RefSeq

    Function Evidence Code Pubs
    enables ATP binding IEA
    Inferred from Electronic Annotation
    more info
    		 PubMed 
    enables diacylglycerol-dependent, calcium-independent serine/threonine kinase activity IEA
    Inferred from Electronic Annotation
    more info
    		 PubMed 
    Process Evidence Code Pubs
    involved_in intracellular signal transduction IEA
    Inferred from Electronic Annotation
    more info
    		 PubMed 
    involved_in peptidyl-serine phosphorylation IEA
    Inferred from Electronic Annotation
    more info
    		 PubMed 

    General protein information

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    Preferred Names
    protein kinase C epsilon type
    XP_005626136.1
    XP_022280387.1
    XP_038345126.1
    XP_038345127.1
    XP_038345128.1
    XP_038407128.1
    XP_038407129.1
    XP_038407130.1
    XP_038471027.1
    XP_038471028.1
    XP_038471029.1
    XP_038536411.1
    XP_038536412.1
    XP_038536413.1
    XP_851861.1

    NCBI Reference Sequences (RefSeq)

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    RefSeqs of Annotated Genomes: Canis lupus familiaris Annotation Release 106 details...Open this link in a new tab

    The following sections contain reference sequences that belong to a specific genome build. Explain

    Reference ROS_Cfam_1.0

    Genomic

    1. NC_051814.1 Reference ROS_Cfam_1.0

      Range
      48849986..49335766
      Download
      GenBank, FASTA, Sequence Viewer (Graphics)

    mRNA and Protein(s)

    1. XM_038680483.1 → XP_038536411.1  protein kinase C epsilon type isoform X1

      UniProtKB/TrEMBL
      A0A8C0S1A2
      Conserved Domains (4) summary
      cd04014
      Location:3 → 135
      C2_PKC_epsilon; C2 domain in Protein Kinase C (PKC) epsilon
      cd20835
      Location:161 → 224
      C1_nPKC_epsilon-like_rpt1; first protein kinase C conserved region 1 (C1 domain) found in novel protein kinase C (nPKC) epsilon, eta, and similar proteins
      cd20838
      Location:241 → 295
      C1_nPKC_epsilon-like_rpt2; second protein kinase C conserved region 1 (C1 domain) found in novel protein kinase C (nPKC) epsilon, eta, and similar proteins
      cl21453
      Location:412 → 690
      PKc_like; Protein Kinases, catalytic domain

    2. XM_038680485.1 → XP_038536413.1  protein kinase C epsilon type isoform X3

      UniProtKB/TrEMBL
      A0A8C0S1A2, A0A8C0YQX9
      Conserved Domains (4) summary
      cd04014
      Location:3 → 135
      C2_PKC_epsilon; C2 domain in Protein Kinase C (PKC) epsilon
      cd20835
      Location:161 → 224
      C1_nPKC_epsilon-like_rpt1; first protein kinase C conserved region 1 (C1 domain) found in novel protein kinase C (nPKC) epsilon, eta, and similar proteins
      cd20838
      Location:241 → 295
      C1_nPKC_epsilon-like_rpt2; second protein kinase C conserved region 1 (C1 domain) found in novel protein kinase C (nPKC) epsilon, eta, and similar proteins
      cl21453
      Location:412 → 689
      PKc_like; Protein Kinases, catalytic domain

    3. XM_038680484.1 → XP_038536412.1  protein kinase C epsilon type isoform X2

      UniProtKB/TrEMBL
      A0A8C0MXM3, A0A8C0S1A2, A0A8I3Q258
      Related
      ENSCAFP00845038131.1, ENSCAFT00845048611.1
      Conserved Domains (4) summary
      cd04014
      Location:3 → 135
      C2_PKC_epsilon; C2 domain in Protein Kinase C (PKC) epsilon
      cd05591
      Location:412 → 732
      STKc_nPKC_epsilon; Catalytic domain of the Serine/Threonine Kinase, Novel Protein Kinase C epsilon
      cd20835
      Location:161 → 224
      C1_nPKC_epsilon-like_rpt1; first protein kinase C conserved region 1 (C1 domain) found in novel protein kinase C (nPKC) epsilon, eta, and similar proteins
      cd20838
      Location:241 → 295
      C1_nPKC_epsilon-like_rpt2; second protein kinase C conserved region 1 (C1 domain) found in novel protein kinase C (nPKC) epsilon, eta, and similar proteins

    Alternate UMICH_Zoey_3.1

    Genomic

    1. NC_049270.1 Alternate UMICH_Zoey_3.1

      Range
      48557609..49044861
      Download
      GenBank, FASTA, Sequence Viewer (Graphics)

    mRNA and Protein(s)

    1. XM_038489198.1 → XP_038345126.1  protein kinase C epsilon type isoform X1

      Conserved Domains (4) summary
      cd04014
      Location:3 → 135
      C2_PKC_epsilon; C2 domain in Protein Kinase C (PKC) epsilon
      cd20835
      Location:161 → 224
      C1_nPKC_epsilon-like_rpt1; first protein kinase C conserved region 1 (C1 domain) found in novel protein kinase C (nPKC) epsilon, eta, and similar proteins
      cd20838
      Location:241 → 295
      C1_nPKC_epsilon-like_rpt2; second protein kinase C conserved region 1 (C1 domain) found in novel protein kinase C (nPKC) epsilon, eta, and similar proteins
      cl21453
      Location:412 → 690
      PKc_like; Protein Kinases, catalytic domain

    2. XM_038489200.1 → XP_038345128.1  protein kinase C epsilon type isoform X3

      Conserved Domains (4) summary
      cd04014
      Location:3 → 135
      C2_PKC_epsilon; C2 domain in Protein Kinase C (PKC) epsilon
      cd20835
      Location:161 → 224
      C1_nPKC_epsilon-like_rpt1; first protein kinase C conserved region 1 (C1 domain) found in novel protein kinase C (nPKC) epsilon, eta, and similar proteins
      cd20838
      Location:241 → 295
      C1_nPKC_epsilon-like_rpt2; second protein kinase C conserved region 1 (C1 domain) found in novel protein kinase C (nPKC) epsilon, eta, and similar proteins
      cl21453
      Location:412 → 689
      PKc_like; Protein Kinases, catalytic domain

    3. XM_038489199.1 → XP_038345127.1  protein kinase C epsilon type isoform X2

      Conserved Domains (4) summary
      cd04014
      Location:3 → 135
      C2_PKC_epsilon; C2 domain in Protein Kinase C (PKC) epsilon
      cd05591
      Location:412 → 732
      STKc_nPKC_epsilon; Catalytic domain of the Serine/Threonine Kinase, Novel Protein Kinase C epsilon
      cd20835
      Location:161 → 224
      C1_nPKC_epsilon-like_rpt1; first protein kinase C conserved region 1 (C1 domain) found in novel protein kinase C (nPKC) epsilon, eta, and similar proteins
      cd20838
      Location:241 → 295
      C1_nPKC_epsilon-like_rpt2; second protein kinase C conserved region 1 (C1 domain) found in novel protein kinase C (nPKC) epsilon, eta, and similar proteins

    Alternate UNSW_CanFamBas_1.0

    Genomic

    1. NC_049751.1 Alternate UNSW_CanFamBas_1.0

      Range
      48849404..49334809
      Download
      GenBank, FASTA, Sequence Viewer (Graphics)

    mRNA and Protein(s)

    1. XM_038615099.1 → XP_038471027.1  protein kinase C epsilon type isoform X1

      Conserved Domains (4) summary
      cd04014
      Location:3 → 135
      C2_PKC_epsilon; C2 domain in Protein Kinase C (PKC) epsilon
      cd20835
      Location:161 → 224
      C1_nPKC_epsilon-like_rpt1; first protein kinase C conserved region 1 (C1 domain) found in novel protein kinase C (nPKC) epsilon, eta, and similar proteins
      cd20838
      Location:241 → 295
      C1_nPKC_epsilon-like_rpt2; second protein kinase C conserved region 1 (C1 domain) found in novel protein kinase C (nPKC) epsilon, eta, and similar proteins
      cl21453
      Location:412 → 690
      PKc_like; Protein Kinases, catalytic domain

    2. XM_038615101.1 → XP_038471029.1  protein kinase C epsilon type isoform X3

      Conserved Domains (4) summary
      cd04014
      Location:3 → 135
      C2_PKC_epsilon; C2 domain in Protein Kinase C (PKC) epsilon
      cd20835
      Location:161 → 224
      C1_nPKC_epsilon-like_rpt1; first protein kinase C conserved region 1 (C1 domain) found in novel protein kinase C (nPKC) epsilon, eta, and similar proteins
      cd20838
      Location:241 → 295
      C1_nPKC_epsilon-like_rpt2; second protein kinase C conserved region 1 (C1 domain) found in novel protein kinase C (nPKC) epsilon, eta, and similar proteins
      cl21453
      Location:412 → 689
      PKc_like; Protein Kinases, catalytic domain

    3. XM_038615100.1 → XP_038471028.1  protein kinase C epsilon type isoform X2

      Conserved Domains (4) summary
      cd04014
      Location:3 → 135
      C2_PKC_epsilon; C2 domain in Protein Kinase C (PKC) epsilon
      cd05591
      Location:412 → 732
      STKc_nPKC_epsilon; Catalytic domain of the Serine/Threonine Kinase, Novel Protein Kinase C epsilon
      cd20835
      Location:161 → 224
      C1_nPKC_epsilon-like_rpt1; first protein kinase C conserved region 1 (C1 domain) found in novel protein kinase C (nPKC) epsilon, eta, and similar proteins
      cd20838
      Location:241 → 295
      C1_nPKC_epsilon-like_rpt2; second protein kinase C conserved region 1 (C1 domain) found in novel protein kinase C (nPKC) epsilon, eta, and similar proteins

    Alternate UU_Cfam_GSD_1.0

    Genomic

    1. NC_049231.1 Alternate UU_Cfam_GSD_1.0

      Range
      49029809..49517384
      Download
      GenBank, FASTA, Sequence Viewer (Graphics)

    mRNA and Protein(s)

    1. XM_038551200.1 → XP_038407128.1  protein kinase C epsilon type isoform X1

      UniProtKB/TrEMBL
      A0A8C0S1A2
      Conserved Domains (4) summary
      cd04014
      Location:3 → 135
      C2_PKC_epsilon; C2 domain in Protein Kinase C (PKC) epsilon
      cd20835
      Location:161 → 224
      C1_nPKC_epsilon-like_rpt1; first protein kinase C conserved region 1 (C1 domain) found in novel protein kinase C (nPKC) epsilon, eta, and similar proteins
      cd20838
      Location:241 → 295
      C1_nPKC_epsilon-like_rpt2; second protein kinase C conserved region 1 (C1 domain) found in novel protein kinase C (nPKC) epsilon, eta, and similar proteins
      cl21453
      Location:412 → 690
      PKc_like; Protein Kinases, catalytic domain

    2. XM_038551202.1 → XP_038407130.1  protein kinase C epsilon type isoform X3

      UniProtKB/TrEMBL
      A0A8C0S1A2, A0A8C0YQX9
      Conserved Domains (4) summary
      cd04014
      Location:3 → 135
      C2_PKC_epsilon; C2 domain in Protein Kinase C (PKC) epsilon
      cd20835
      Location:161 → 224
      C1_nPKC_epsilon-like_rpt1; first protein kinase C conserved region 1 (C1 domain) found in novel protein kinase C (nPKC) epsilon, eta, and similar proteins
      cd20838
      Location:241 → 295
      C1_nPKC_epsilon-like_rpt2; second protein kinase C conserved region 1 (C1 domain) found in novel protein kinase C (nPKC) epsilon, eta, and similar proteins
      cl21453
      Location:412 → 689
      PKc_like; Protein Kinases, catalytic domain

    3. XM_038551201.1 → XP_038407129.1  protein kinase C epsilon type isoform X2

      UniProtKB/TrEMBL
      A0A8C0MXM3, A0A8C0S1A2, A0A8I3Q258
      Conserved Domains (4) summary
      cd04014
      Location:3 → 135
      C2_PKC_epsilon; C2 domain in Protein Kinase C (PKC) epsilon
      cd05591
      Location:412 → 732
      STKc_nPKC_epsilon; Catalytic domain of the Serine/Threonine Kinase, Novel Protein Kinase C epsilon
      cd20835
      Location:161 → 224
      C1_nPKC_epsilon-like_rpt1; first protein kinase C conserved region 1 (C1 domain) found in novel protein kinase C (nPKC) epsilon, eta, and similar proteins
      cd20838
      Location:241 → 295
      C1_nPKC_epsilon-like_rpt2; second protein kinase C conserved region 1 (C1 domain) found in novel protein kinase C (nPKC) epsilon, eta, and similar proteins

    Alternate Dog10K_Boxer_Tasha Primary Assembly

    Genomic

    1. NC_006592.4 Alternate Dog10K_Boxer_Tasha Primary Assembly

      Range
      47832146..48319423
      Download
      GenBank, FASTA, Sequence Viewer (Graphics)

    mRNA and Protein(s)

    1. XM_022424679.2 → XP_022280387.1  protein kinase C epsilon type isoform X1

      UniProtKB/TrEMBL
      A0A8C0S1A2
      Conserved Domains (4) summary
      cd04014
      Location:3 → 135
      C2_PKC_epsilon; C2 domain in Protein Kinase C (PKC) epsilon
      cd20835
      Location:161 → 224
      C1_nPKC_epsilon-like_rpt1; first protein kinase C conserved region 1 (C1 domain) found in novel protein kinase C (nPKC) epsilon, eta, and similar proteins
      cd20838
      Location:241 → 295
      C1_nPKC_epsilon-like_rpt2; second protein kinase C conserved region 1 (C1 domain) found in novel protein kinase C (nPKC) epsilon, eta, and similar proteins
      cl21453
      Location:412 → 690
      PKc_like; Protein Kinases, catalytic domain

    2. XM_005626079.4 → XP_005626136.1  protein kinase C epsilon type isoform X3

      UniProtKB/TrEMBL
      A0A8C0S1A2, A0A8C0YQX9
      Conserved Domains (4) summary
      cd04014
      Location:3 → 135
      C2_PKC_epsilon; C2 domain in Protein Kinase C (PKC) epsilon
      cd20835
      Location:161 → 224
      C1_nPKC_epsilon-like_rpt1; first protein kinase C conserved region 1 (C1 domain) found in novel protein kinase C (nPKC) epsilon, eta, and similar proteins
      cd20838
      Location:241 → 295
      C1_nPKC_epsilon-like_rpt2; second protein kinase C conserved region 1 (C1 domain) found in novel protein kinase C (nPKC) epsilon, eta, and similar proteins
      cl21453
      Location:412 → 689
      PKc_like; Protein Kinases, catalytic domain

    3. XM_846768.6 → XP_851861.1  protein kinase C epsilon type isoform X2

      UniProtKB/TrEMBL
      A0A8C0MXM3, A0A8C0S1A2, A0A8I3Q258
      Conserved Domains (4) summary
      cd04014
      Location:3 → 135
      C2_PKC_epsilon; C2 domain in Protein Kinase C (PKC) epsilon
      cd05591
      Location:412 → 732
      STKc_nPKC_epsilon; Catalytic domain of the Serine/Threonine Kinase, Novel Protein Kinase C epsilon
      cd20835
      Location:161 → 224
      C1_nPKC_epsilon-like_rpt1; first protein kinase C conserved region 1 (C1 domain) found in novel protein kinase C (nPKC) epsilon, eta, and similar proteins
      cd20838
      Location:241 → 295
      C1_nPKC_epsilon-like_rpt2; second protein kinase C conserved region 1 (C1 domain) found in novel protein kinase C (nPKC) epsilon, eta, and similar proteins
    Nucleotide Protein
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