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    SHH sonic hedgehog signaling molecule [ Canis lupus familiaris (dog) ]

    Gene ID: 608860, updated on 17-Aug-2024

    Summary

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    Official Symbol
    SHHprovided by VGNC
    Official Full Name
    sonic hedgehog signaling moleculeprovided by VGNC
    Primary source
    VGNC:VGNC:46147
    See related
    Ensembl:ENSCAFG00845013237
    Gene type
    protein coding
    RefSeq status
    MODEL
    Organism
    Canis lupus familiaris (sub-species: familiaris)
    Lineage
    Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Laurasiatheria; Carnivora; Caniformia; Canidae; Canis
    Orthologs
    human mouse all
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    Genomic context

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    See SHH in Genome Data Viewer
    Location:
    chromosome: 16
    Exon count:
    3
    Annotation release Status Assembly Chr Location
    106 current ROS_Cfam_1.0 (GCF_014441545.1) 16 NC_051820.1 (20382879..20392367, complement)
    106 current Dog10K_Boxer_Tasha (GCF_000002285.5) 16 NC_006598.4 (19286449..19295913, complement)
    106 current UU_Cfam_GSD_1.0 (GCF_011100685.1) 16 NC_049237.1 (19386812..19396258, complement)
    106 current UMICH_Zoey_3.1 (GCF_005444595.1) 16 NC_049276.1 (18753210..18762671, complement)
    106 current UNSW_CanFamBas_1.0 (GCF_013276365.1) 16 NC_049757.1 (19333131..19342583, complement)

    Chromosome 16 - NC_051820.1Genomic Context describing neighboring genes Neighboring gene canopy FGF signaling regulator 1 Neighboring gene RNA binding motif protein 33 Neighboring gene developmental pluripotency-associated protein 2-like Neighboring gene uncharacterized LOC119869608 Neighboring gene uncharacterized LOC102155425 Neighboring gene uncharacterized LOC119869530

    Genomic regions, transcripts, and products

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    Go to nucleotide: Graphics FASTA GenBank

    Bibliography

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    Related articles in PubMed

    1. Sonic Hedgehog, a key development gene, experienced intensified molecular evolution in primates. Dorus S, et al. Hum Mol Genet, 2006 Jul 1. PMID 16687440
    2. Quantitative analysis of mRNA transcripts of Hox, SHH, PTCH, Wnt, and Fzd genes in canine hematopoietic progenitor cells and various in vitro colonies differentiated from the cells. Ide K, et al. J Vet Med Sci, 2009 Jan. PMID 19194078

    GeneRIFs: Gene References Into Functions

    Pathways from PubChem

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    General gene information

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    Markers

    Homology

    Gene Ontology Provided by RefSeq

    Function Evidence Code Pubs
    enables calcium ion binding IEA
    Inferred from Electronic Annotation
    more info
    		 PubMed 
    enables patched binding IEA
    Inferred from Electronic Annotation
    more info
    		 PubMed 
    Process Evidence Code Pubs
    involved_in cell fate specification IEA
    Inferred from Electronic Annotation
    more info
    		 PubMed 
    involved_in cell-cell signaling IEA
    Inferred from Electronic Annotation
    more info
    		 PubMed 
    involved_in intein-mediated protein splicing IEA
    Inferred from Electronic Annotation
    more info
    		 PubMed 
    involved_in multicellular organism development IEA
    Inferred from Electronic Annotation
    more info
    		 PubMed 
    involved_in oligodendrocyte differentiation IEA
    Inferred from Electronic Annotation
    more info
    		 PubMed 
    involved_in protein autoprocessing IEA
    Inferred from Electronic Annotation
    more info
    		 PubMed 
    involved_in regulation of gene expression IEA
    Inferred from Electronic Annotation
    more info
    		 PubMed 
    involved_in smoothened signaling pathway IEA
    Inferred from Electronic Annotation
    more info
    		 PubMed 
    Component Evidence Code Pubs
    located_in extracellular space IEA
    Inferred from Electronic Annotation
    more info
    		 PubMed 

    General protein information

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    Preferred Names
    sonic hedgehog protein
    Names
    sonic hedgehog homolog

    NCBI Reference Sequences (RefSeq)

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    RefSeqs of Annotated Genomes: Canis lupus familiaris Annotation Release 106 details...Open this link in a new tab

    The following sections contain reference sequences that belong to a specific genome build. Explain

    Reference ROS_Cfam_1.0

    Genomic

    1. NC_051820.1 Reference ROS_Cfam_1.0

      Range
      20382879..20392367 complement
      Download
      GenBank, FASTA, Sequence Viewer (Graphics)

    mRNA and Protein(s)

    1. XM_038689583.1 → XP_038545511.1  sonic hedgehog protein

      UniProtKB/TrEMBL
      A0A8C0JX79, A0A8C0JXL5, A0A8C0NU16, A0A8I3NQ51
      Related
      ENSCAFP00845018508.1, ENSCAFT00845023574.1
      Conserved Domains (2) summary
      pfam01079
      Location:187 → 447
      Hint; Hint module
      pfam01085
      Location:39 → 184
      HH_signal; Hedgehog amino-terminal signalling domain

    Alternate UMICH_Zoey_3.1

    Genomic

    1. NC_049276.1 Alternate UMICH_Zoey_3.1

      Range
      18753210..18762671 complement
      Download
      GenBank, FASTA, Sequence Viewer (Graphics)

    mRNA and Protein(s)

    1. XM_038497393.1 → XP_038353321.1  sonic hedgehog protein

      Conserved Domains (2) summary
      pfam01079
      Location:187 → 447
      Hint; Hint module
      pfam01085
      Location:39 → 184
      HH_signal; Hedgehog amino-terminal signalling domain

    Alternate UNSW_CanFamBas_1.0

    Genomic

    1. NC_049757.1 Alternate UNSW_CanFamBas_1.0

      Range
      19333131..19342583 complement
      Download
      GenBank, FASTA, Sequence Viewer (Graphics)

    mRNA and Protein(s)

    1. XM_038623817.1 → XP_038479745.1  sonic hedgehog protein

      Conserved Domains (2) summary
      pfam01079
      Location:187 → 447
      Hint; Hint module
      pfam01085
      Location:39 → 184
      HH_signal; Hedgehog amino-terminal signalling domain

    Alternate UU_Cfam_GSD_1.0

    Genomic

    1. NC_049237.1 Alternate UU_Cfam_GSD_1.0

      Range
      19386812..19396258 complement
      Download
      GenBank, FASTA, Sequence Viewer (Graphics)

    mRNA and Protein(s)

    1. XM_038559814.1 → XP_038415742.1  sonic hedgehog protein

      UniProtKB/TrEMBL
      A0A8C0JX79, A0A8C0JXL5, A0A8C0NU16, A0A8I3NQ51
      Conserved Domains (2) summary
      pfam01079
      Location:187 → 447
      Hint; Hint module
      pfam01085
      Location:39 → 184
      HH_signal; Hedgehog amino-terminal signalling domain

    Alternate Dog10K_Boxer_Tasha Primary Assembly

    Genomic

    1. NC_006598.4 Alternate Dog10K_Boxer_Tasha Primary Assembly

      Range
      19286449..19295913 complement
      Download
      GenBank, FASTA, Sequence Viewer (Graphics)

    mRNA and Protein(s)

    1. XM_845357.5 → XP_850450.1  sonic hedgehog protein

      UniProtKB/TrEMBL
      A0A8C0JX79, A0A8C0JXL5, A0A8C0NU16, A0A8I3NQ51
      Conserved Domains (2) summary
      pfam01079
      Location:187 → 447
      Hint; Hint module
      pfam01085
      Location:39 → 184
      HH_signal; Hedgehog amino-terminal signalling domain
    Nucleotide Protein Strain
    Heading Accession and Version

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    Molecular Biology Databases
    Research Materials