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    HSD17B8 hydroxysteroid 17-beta dehydrogenase 8 [ Canis lupus familiaris (dog) ]

    Gene ID: 607895, updated on 19-Jun-2024

    Summary

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    Official Symbol
    HSD17B8provided by VGNC
    Official Full Name
    hydroxysteroid 17-beta dehydrogenase 8provided by VGNC
    Primary source
    VGNC:VGNC:41810
    See related
    Ensembl:ENSCAFG00845020603
    Gene type
    protein coding
    RefSeq status
    MODEL
    Organism
    Canis lupus familiaris (sub-species: familiaris)
    Lineage
    Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Laurasiatheria; Carnivora; Caniformia; Canidae; Canis
    Orthologs
    human mouse all
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    Genomic context

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    See HSD17B8 in Genome Data Viewer
    Location:
    chromosome: 12
    Exon count:
    9
    Annotation release Status Assembly Chr Location
    106 current ROS_Cfam_1.0 (GCF_014441545.1) 12 NC_051816.1 (2998414..3000653)
    106 current Dog10K_Boxer_Tasha (GCF_000002285.5) 12 NC_006594.4 (2748819..2751058)
    106 current UU_Cfam_GSD_1.0 (GCF_011100685.1) 12 NC_049233.1 (2822541..2824780)
    106 current UMICH_Zoey_3.1 (GCF_005444595.1) 12 NC_049272.1 (2666602..2668840)
    106 current UNSW_CanFamBas_1.0 (GCF_013276365.1) 12 NC_049753.1 (2747969..2750208)

    Chromosome 12 - NC_051816.1Genomic Context describing neighboring genes Neighboring gene collagen type XI alpha 2 chain Neighboring gene retinoid X receptor beta Neighboring gene solute carrier family 39 member 7 Neighboring gene microRNA mir-219-1 Neighboring gene ring finger protein 1

    Genomic regions, transcripts, and products

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    Go to nucleotide: Graphics FASTA GenBank

    Bibliography

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    GeneRIFs: Gene References Into Functions

    General gene information

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    Markers

    Homology

    Gene Ontology Provided by RefSeq

    Function Evidence Code Pubs
    enables estradiol 17-beta-dehydrogenase [NAD(P)+] activity IEA
    Inferred from Electronic Annotation
    more info
    		 PubMed 
    Process Evidence Code Pubs
    involved_in estrogen biosynthetic process IEA
    Inferred from Electronic Annotation
    more info
    		 PubMed 

    General protein information

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    Preferred Names
    (3R)-3-hydroxyacyl-CoA dehydrogenase; estradiol 17-beta-dehydrogenase 8
    Names
    17-beta-HSD 8
    17-beta-hydroxysteroid dehydrogenase 8
    3-ketoacyl-[acyl-carrier-protein] reductase alpha subunit
    3-oxoacyl-[acyl-carrier-protein] reductase
    Estradiol 17-beta-dehydrogenase 8
    KAR alpha subunit
    Testosterone 17-beta-dehydrogenase 8
    XP_005627255.2
    XP_013973838.1
    XP_013973839.1
    XP_038347413.1
    XP_038347414.1
    XP_038347415.1
    XP_038347416.1
    XP_038409636.1
    XP_038409637.1
    XP_038409638.1
    XP_038409639.1
    XP_038473499.1
    XP_038473500.1
    XP_038473501.1
    XP_038473502.1
    XP_038539107.1
    XP_038539108.1
    XP_038539109.1
    XP_038539110.1
    XP_851004.3

    NCBI Reference Sequences (RefSeq)

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    RefSeqs of Annotated Genomes: Canis lupus familiaris Annotation Release 106 details...Open this link in a new tab

    The following sections contain reference sequences that belong to a specific genome build. Explain

    Reference ROS_Cfam_1.0

    Genomic

    1. NC_051816.1 Reference ROS_Cfam_1.0

      Range
      2998414..3000653
      Download
      GenBank, FASTA, Sequence Viewer (Graphics)

    mRNA and Protein(s)

    1. XM_038683179.1 → XP_038539107.1  estradiol 17-beta-dehydrogenase 8 isoform X1

      Conserved Domains (1) summary
      cl21454
      Location:11 → 226
      NADB_Rossmann; Rossmann-fold NAD(P)(+)-binding proteins

    2. XM_038683182.1 → XP_038539110.1  estradiol 17-beta-dehydrogenase 8 isoform X4

      UniProtKB/Swiss-Prot
      Q5TJF5
      UniProtKB/TrEMBL
      A0A8C0JNZ3, A0A8C0QUD7
      Related
      ENSCAFP00845028421.1, ENSCAFT00845036315.1
      Conserved Domains (1) summary
      cd05333
      Location:11 → 258
      BKR_SDR_c; beta-Keto acyl carrier protein reductase (BKR), involved in Type II FAS, classical (c) SDRs

    3. XM_038683180.1 → XP_038539108.1  estradiol 17-beta-dehydrogenase 8 isoform X2

      Conserved Domains (1) summary
      cl21454
      Location:11 → 219
      NADB_Rossmann; Rossmann-fold NAD(P)(+)-binding proteins

    4. XM_038683181.1 → XP_038539109.1  estradiol 17-beta-dehydrogenase 8 isoform X3

      UniProtKB/TrEMBL
      A0A8C0JNZ3
      Conserved Domains (1) summary
      cd05333
      Location:11 → 265
      BKR_SDR_c; beta-Keto acyl carrier protein reductase (BKR), involved in Type II FAS, classical (c) SDRs

    Alternate UMICH_Zoey_3.1

    Genomic

    1. NC_049272.1 Alternate UMICH_Zoey_3.1

      Range
      2666602..2668840
      Download
      GenBank, FASTA, Sequence Viewer (Graphics)

    mRNA and Protein(s)

    1. XM_038491485.1 → XP_038347413.1  estradiol 17-beta-dehydrogenase 8 isoform X1

      Conserved Domains (1) summary
      cl21454
      Location:11 → 226
      NADB_Rossmann; Rossmann-fold NAD(P)(+)-binding proteins

    2. XM_038491488.1 → XP_038347416.1  estradiol 17-beta-dehydrogenase 8 isoform X4

      Conserved Domains (1) summary
      cd05333
      Location:11 → 258
      BKR_SDR_c; beta-Keto acyl carrier protein reductase (BKR), involved in Type II FAS, classical (c) SDRs

    3. XM_038491486.1 → XP_038347414.1  estradiol 17-beta-dehydrogenase 8 isoform X2

      Conserved Domains (1) summary
      cl21454
      Location:11 → 219
      NADB_Rossmann; Rossmann-fold NAD(P)(+)-binding proteins

    4. XM_038491487.1 → XP_038347415.1  estradiol 17-beta-dehydrogenase 8 isoform X3

      Conserved Domains (1) summary
      cd05333
      Location:11 → 265
      BKR_SDR_c; beta-Keto acyl carrier protein reductase (BKR), involved in Type II FAS, classical (c) SDRs

    Alternate UNSW_CanFamBas_1.0

    Genomic

    1. NC_049753.1 Alternate UNSW_CanFamBas_1.0

      Range
      2747969..2750208
      Download
      GenBank, FASTA, Sequence Viewer (Graphics)

    mRNA and Protein(s)

    1. XM_038617571.1 → XP_038473499.1  estradiol 17-beta-dehydrogenase 8 isoform X1

      Conserved Domains (1) summary
      cl21454
      Location:11 → 226
      NADB_Rossmann; Rossmann-fold NAD(P)(+)-binding proteins

    2. XM_038617574.1 → XP_038473502.1  estradiol 17-beta-dehydrogenase 8 isoform X4

      Conserved Domains (1) summary
      cd05333
      Location:11 → 258
      BKR_SDR_c; beta-Keto acyl carrier protein reductase (BKR), involved in Type II FAS, classical (c) SDRs

    3. XM_038617572.1 → XP_038473500.1  estradiol 17-beta-dehydrogenase 8 isoform X2

      Conserved Domains (1) summary
      cl21454
      Location:11 → 219
      NADB_Rossmann; Rossmann-fold NAD(P)(+)-binding proteins

    4. XM_038617573.1 → XP_038473501.1  estradiol 17-beta-dehydrogenase 8 isoform X3

      Conserved Domains (1) summary
      cd05333
      Location:11 → 265
      BKR_SDR_c; beta-Keto acyl carrier protein reductase (BKR), involved in Type II FAS, classical (c) SDRs

    Alternate UU_Cfam_GSD_1.0

    Genomic

    1. NC_049233.1 Alternate UU_Cfam_GSD_1.0

      Range
      2822541..2824780
      Download
      GenBank, FASTA, Sequence Viewer (Graphics)

    mRNA and Protein(s)

    1. XM_038553708.1 → XP_038409636.1  estradiol 17-beta-dehydrogenase 8 isoform X1

    2. XM_038553711.1 → XP_038409639.1  estradiol 17-beta-dehydrogenase 8 isoform X4

      UniProtKB/TrEMBL
      A0A8C0JNZ3

    3. XM_038553709.1 → XP_038409637.1  estradiol 17-beta-dehydrogenase 8 isoform X2

    4. XM_038553710.1 → XP_038409638.1  estradiol 17-beta-dehydrogenase 8 isoform X3

      UniProtKB/TrEMBL
      A0A8C0JNZ3

    Alternate Dog10K_Boxer_Tasha Primary Assembly

    Genomic

    1. NC_006594.4 Alternate Dog10K_Boxer_Tasha Primary Assembly

      Range
      2748819..2751058
      Download
      GenBank, FASTA, Sequence Viewer (Graphics)

    mRNA and Protein(s)

    1. XM_014118363.3 → XP_013973838.1  estradiol 17-beta-dehydrogenase 8 isoform X1

      Conserved Domains (1) summary
      cl21454
      Location:11 → 226
      NADB_Rossmann; Rossmann-fold NAD(P)(+)-binding proteins

    2. XM_845911.6 → XP_851004.3  estradiol 17-beta-dehydrogenase 8 isoform X4

      UniProtKB/TrEMBL
      A0A8C0JNZ3, A0A8C0TC64, A0A8P0S6V8
      Conserved Domains (1) summary
      cd05333
      Location:11 → 258
      BKR_SDR_c; beta-Keto acyl carrier protein reductase (BKR), involved in Type II FAS, classical (c) SDRs

    3. XM_014118364.3 → XP_013973839.1  estradiol 17-beta-dehydrogenase 8 isoform X2

      Conserved Domains (1) summary
      cl21454
      Location:11 → 219
      NADB_Rossmann; Rossmann-fold NAD(P)(+)-binding proteins

    4. XM_005627198.4 → XP_005627255.2  estradiol 17-beta-dehydrogenase 8 isoform X3

      UniProtKB/TrEMBL
      A0A8C0JNZ3
      Conserved Domains (1) summary
      cd05333
      Location:11 → 265
      BKR_SDR_c; beta-Keto acyl carrier protein reductase (BKR), involved in Type II FAS, classical (c) SDRs
    Nucleotide Protein
    Heading Accession and Version
    Protein Accession Links
    GenPept Link UniProtKB Link
    Q5TJF5.1 GenPept UniProtKB/Swiss-Prot:Q5TJF5

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