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    PAK1 p21 (RAC1) activated kinase 1 [ Canis lupus familiaris (dog) ]

    Gene ID: 607885, updated on 17-Aug-2024

    Summary

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    Official Symbol
    PAK1provided by VGNC
    Official Full Name
    p21 (RAC1) activated kinase 1provided by VGNC
    Primary source
    VGNC:VGNC:52285
    See related
    Ensembl:ENSCAFG00845009162
    Gene type
    protein coding
    RefSeq status
    MODEL
    Organism
    Canis lupus familiaris (sub-species: familiaris)
    Lineage
    Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Laurasiatheria; Carnivora; Caniformia; Canidae; Canis
    Orthologs
    human mouse all
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    Genomic context

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    See PAK1 in Genome Data Viewer
    Location:
    chromosome: 21
    Exon count:
    17
    Annotation release Status Assembly Chr Location
    106 current ROS_Cfam_1.0 (GCF_014441545.1) 21 NC_051825.1 (21465428..21609203)
    106 current Dog10K_Boxer_Tasha (GCF_000002285.5) 21 NC_006603.4 (21157810..21301590)
    106 current UU_Cfam_GSD_1.0 (GCF_011100685.1) 21 NC_049242.1 (21380679..21525504)
    106 current UMICH_Zoey_3.1 (GCF_005444595.1) 21 NC_049281.1 (21241163..21385037)
    106 current UNSW_CanFamBas_1.0 (GCF_013276365.1) 21 NC_049762.1 (21457239..21600991)

    Chromosome 21 - NC_051825.1Genomic Context describing neighboring genes Neighboring gene chloride nucleotide-sensitive channel 1A Neighboring gene uncharacterized LOC111091522 Neighboring gene aquaporin 11 Neighboring gene 40S ribosomal protein S10-like Neighboring gene ribosomal protein L23a pseudogene Neighboring gene nucleophosmin-like Neighboring gene glycerophosphodiester phosphodiesterase domain containing 4 Neighboring gene myosin VIIA

    Genomic regions, transcripts, and products

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    Go to nucleotide: Graphics FASTA GenBank

    Bibliography

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    Related articles in PubMed

    1. Pak1 regulates the orientation of apical polarization and lumen formation by distinct pathways. deLeon O, et al. PLoS One, 2012. PMID 22815903, Free PMC Article
    2. Cadherins and Pak1 control contact inhibition of proliferation by Pak1-betaPIX-GIT complex-dependent regulation of cell-matrix signaling. Liu F, et al. Mol Cell Biol, 2010 Apr. PMID 20154149, Free PMC Article
    3. Silencing of p21-activated kinase attenuates vimentin phosphorylation on Ser-56 and reorientation of the vimentin network during stimulation of smooth muscle cells by 5-hydroxytryptamine. Tang DD, et al. Biochem J, 2005 Jun 15. PMID 15766329, Free PMC Article
    4. Cdk1 phosphorylates the Rac activator Tiam1 to activate centrosomal Pak and promote mitotic spindle formation. Whalley HJ, et al. Nat Commun, 2015 Jun 16. PMID 26078008, Free PMC Article
    5. Manual GO annotation of predictive protein signatures: the InterPro approach to GO curation. Burge S, et al. Database (Oxford), 2012. PMID 22301074, Free PMC Article

    See all (6) citations in PubMed

    GeneRIFs: Gene References Into Functions

    What's a GeneRIF?
    1. Pak1 and Pak2 counteract centrosome separation in a kinase-dependent manner.
      Title: Cdk1 phosphorylates the Rac activator Tiam1 to activate centrosomal Pak and promote mitotic spindle formation.
    2. Pak1 regulates the orientation of apical polarization and lumen formation by distinct pathways
      Title: Pak1 regulates the orientation of apical polarization and lumen formation by distinct pathways.
    3. Data suggest that cadherins are involved in regulation of contact inhibition by controlling the function of the Pak1-betaPIX-GIT complex at focal contacts.
      Title: Cadherins and Pak1 control contact inhibition of proliferation by Pak1-betaPIX-GIT complex-dependent regulation of cell-matrix signaling.
    4. results suggest that the PAK1-mediated site-specific phosphorylation of vimentin may play a role in regulating the reorganization of vimentin intermediate filaments during stimulation of smooth muscle cells with 5-HT
      Title: Silencing of p21-activated kinase attenuates vimentin phosphorylation on Ser-56 and reorientation of the vimentin network during stimulation of smooth muscle cells by 5-hydroxytryptamine.
    Submit: New GeneRIF Correction

    Pathways from PubChem

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    General gene information

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    Markers

    Homology

    Gene Ontology Provided by RefSeq

    Function Evidence Code Pubs
    enables ATP binding IEA
    Inferred from Electronic Annotation
    more info
    		 PubMed 
    enables protein serine/threonine kinase activity IEA
    Inferred from Electronic Annotation
    more info
    		 PubMed 
    Process Evidence Code Pubs
    involved_in intracellular signal transduction IEA
    Inferred from Electronic Annotation
    more info
    		 PubMed 
    involved_in protein phosphorylation IEA
    Inferred from Electronic Annotation
    more info
    		 PubMed 
    involved_in regulation of MAPK cascade IEA
    Inferred from Electronic Annotation
    more info
    		 PubMed 
    involved_in regulation of actin cytoskeleton organization IEA
    Inferred from Electronic Annotation
    more info
    		 PubMed 
    involved_in regulation of axonogenesis IEA
    Inferred from Electronic Annotation
    more info
    		 PubMed 
    Component Evidence Code Pubs
    located_in cytoplasm IEA
    Inferred from Electronic Annotation
    more info
    		 PubMed 

    General protein information

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    Preferred Names
    serine/threonine-protein kinase PAK 1
    Names
    p21/Cdc42/Rac1-activated kinase 1 (STE20 homolog, yeast)
    XP_022263333.2
    XP_038285916.1
    XP_038285917.1
    XP_038285918.1
    XP_038312241.1
    XP_038312242.1
    XP_038361297.1
    XP_038361298.1
    XP_038361299.1
    XP_038424447.1
    XP_038424448.1
    XP_038424449.1
    XP_038488604.1
    XP_038488605.1
    XP_038488606.1

    NCBI Reference Sequences (RefSeq)

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    RefSeqs of Annotated Genomes: Canis lupus familiaris Annotation Release 106 details...Open this link in a new tab

    The following sections contain reference sequences that belong to a specific genome build. Explain

    Reference ROS_Cfam_1.0

    Genomic

    1. NC_051825.1 Reference ROS_Cfam_1.0

      Range
      21465428..21609203
      Download
      GenBank, FASTA, Sequence Viewer (Graphics)

    mRNA and Protein(s)

    1. XM_038429989.1 → XP_038285917.1  serine/threonine-protein kinase PAK 1

      UniProtKB/TrEMBL
      A0A8C0P0A4, A0A8C0QT67, A0A8I3NAT1, A0A8I3NB95, A0A8P0SAH4
      Related
      ENSCAFP00845012600.1, ENSCAFT00845016197.1
      Conserved Domains (2) summary
      cd06654
      Location:248 → 543
      STKc_PAK1; Catalytic domain of the Serine/Threonine Kinase, p21-activated kinase 1
      pfam00786
      Location:74 → 132
      PBD; P21-Rho-binding domain

    2. XM_038429990.1 → XP_038285918.1  serine/threonine-protein kinase PAK 1

      UniProtKB/TrEMBL
      A0A8C0P0A4, A0A8C0QT67, A0A8I3NAT1, A0A8I3NB95, A0A8P0SAH4
      Related
      ENSCAFP00845012560.1, ENSCAFT00845016147.1
      Conserved Domains (2) summary
      cd06654
      Location:248 → 543
      STKc_PAK1; Catalytic domain of the Serine/Threonine Kinase, p21-activated kinase 1
      pfam00786
      Location:74 → 132
      PBD; P21-Rho-binding domain

    3. XM_038429988.1 → XP_038285916.1  serine/threonine-protein kinase PAK 1

      UniProtKB/TrEMBL
      A0A8C0P0A4, A0A8C0QT67, A0A8I3NAT1, A0A8I3NB95, A0A8P0SAH4
      Related
      ENSCAFP00845012633.1, ENSCAFT00845016239.1
      Conserved Domains (2) summary
      cd06654
      Location:248 → 543
      STKc_PAK1; Catalytic domain of the Serine/Threonine Kinase, p21-activated kinase 1
      pfam00786
      Location:74 → 132
      PBD; P21-Rho-binding domain

    Alternate UMICH_Zoey_3.1

    Genomic

    1. NC_049281.1 Alternate UMICH_Zoey_3.1

      Range
      21241163..21385037
      Download
      GenBank, FASTA, Sequence Viewer (Graphics)

    mRNA and Protein(s)

    1. XM_038505370.1 → XP_038361298.1  serine/threonine-protein kinase PAK 1

      Conserved Domains (2) summary
      cd06654
      Location:248 → 543
      STKc_PAK1; Catalytic domain of the Serine/Threonine Kinase, p21-activated kinase 1
      pfam00786
      Location:74 → 132
      PBD; P21-Rho-binding domain

    2. XM_038505371.1 → XP_038361299.1  serine/threonine-protein kinase PAK 1

      Conserved Domains (2) summary
      cd06654
      Location:248 → 543
      STKc_PAK1; Catalytic domain of the Serine/Threonine Kinase, p21-activated kinase 1
      pfam00786
      Location:74 → 132
      PBD; P21-Rho-binding domain

    3. XM_038505369.1 → XP_038361297.1  serine/threonine-protein kinase PAK 1

      Conserved Domains (2) summary
      cd06654
      Location:248 → 543
      STKc_PAK1; Catalytic domain of the Serine/Threonine Kinase, p21-activated kinase 1
      pfam00786
      Location:74 → 132
      PBD; P21-Rho-binding domain

    Alternate UNSW_CanFamBas_1.0

    Genomic

    1. NC_049762.1 Alternate UNSW_CanFamBas_1.0

      Range
      21457239..21600991
      Download
      GenBank, FASTA, Sequence Viewer (Graphics)

    mRNA and Protein(s)

    1. XM_038632677.1 → XP_038488605.1  serine/threonine-protein kinase PAK 1

      Conserved Domains (2) summary
      cd06654
      Location:248 → 543
      STKc_PAK1; Catalytic domain of the Serine/Threonine Kinase, p21-activated kinase 1
      pfam00786
      Location:74 → 132
      PBD; P21-Rho-binding domain

    2. XM_038632678.1 → XP_038488606.1  serine/threonine-protein kinase PAK 1

      Conserved Domains (2) summary
      cd06654
      Location:248 → 543
      STKc_PAK1; Catalytic domain of the Serine/Threonine Kinase, p21-activated kinase 1
      pfam00786
      Location:74 → 132
      PBD; P21-Rho-binding domain

    3. XM_038632676.1 → XP_038488604.1  serine/threonine-protein kinase PAK 1

      Conserved Domains (2) summary
      cd06654
      Location:248 → 543
      STKc_PAK1; Catalytic domain of the Serine/Threonine Kinase, p21-activated kinase 1
      pfam00786
      Location:74 → 132
      PBD; P21-Rho-binding domain

    Alternate UU_Cfam_GSD_1.0

    Genomic

    1. NC_049242.1 Alternate UU_Cfam_GSD_1.0

      Range
      21380679..21525504
      Download
      GenBank, FASTA, Sequence Viewer (Graphics)

    mRNA and Protein(s)

    1. XM_038568521.1 → XP_038424449.1  serine/threonine-protein kinase PAK 1

      UniProtKB/TrEMBL
      A0A8C0P0A4, A0A8C0QT67, A0A8I3NAT1, A0A8I3NB95, A0A8P0SAH4
      Conserved Domains (2) summary
      cd06654
      Location:248 → 543
      STKc_PAK1; Catalytic domain of the Serine/Threonine Kinase, p21-activated kinase 1
      pfam00786
      Location:74 → 132
      PBD; P21-Rho-binding domain

    2. XM_038568520.1 → XP_038424448.1  serine/threonine-protein kinase PAK 1

      UniProtKB/TrEMBL
      A0A8C0P0A4, A0A8C0QT67, A0A8I3NAT1, A0A8I3NB95, A0A8P0SAH4
      Conserved Domains (2) summary
      cd06654
      Location:248 → 543
      STKc_PAK1; Catalytic domain of the Serine/Threonine Kinase, p21-activated kinase 1
      pfam00786
      Location:74 → 132
      PBD; P21-Rho-binding domain

    3. XM_038568519.1 → XP_038424447.1  serine/threonine-protein kinase PAK 1

      UniProtKB/TrEMBL
      A0A8C0P0A4, A0A8C0QT67, A0A8I3NAT1, A0A8I3NB95, A0A8P0SAH4
      Conserved Domains (2) summary
      cd06654
      Location:248 → 543
      STKc_PAK1; Catalytic domain of the Serine/Threonine Kinase, p21-activated kinase 1
      pfam00786
      Location:74 → 132
      PBD; P21-Rho-binding domain

    Alternate Dog10K_Boxer_Tasha Primary Assembly

    Genomic

    1. NC_006603.4 Alternate Dog10K_Boxer_Tasha Primary Assembly

      Range
      21157810..21301590
      Download
      GenBank, FASTA, Sequence Viewer (Graphics)

    mRNA and Protein(s)

    1. XM_038456313.1 → XP_038312241.1  serine/threonine-protein kinase PAK 1

      UniProtKB/TrEMBL
      A0A8C0P0A4, A0A8C0QT67, A0A8I3NAT1, A0A8I3NB95, A0A8P0SAH4
      Conserved Domains (2) summary
      cd06654
      Location:248 → 543
      STKc_PAK1; Catalytic domain of the Serine/Threonine Kinase, p21-activated kinase 1
      pfam00786
      Location:74 → 132
      PBD; P21-Rho-binding domain

    2. XM_038456314.1 → XP_038312242.1  serine/threonine-protein kinase PAK 1

      UniProtKB/TrEMBL
      A0A8C0P0A4, A0A8C0QT67, A0A8I3NAT1, A0A8I3NB95, A0A8P0SAH4
      Conserved Domains (2) summary
      cd06654
      Location:248 → 543
      STKc_PAK1; Catalytic domain of the Serine/Threonine Kinase, p21-activated kinase 1
      pfam00786
      Location:74 → 132
      PBD; P21-Rho-binding domain

    3. XM_022407625.2 → XP_022263333.2  serine/threonine-protein kinase PAK 1

      UniProtKB/TrEMBL
      A0A8C0P0A4, A0A8C0QT67, A0A8I3NAT1, A0A8I3NB95, A0A8P0SAH4
      Conserved Domains (2) summary
      cd06654
      Location:248 → 543
      STKc_PAK1; Catalytic domain of the Serine/Threonine Kinase, p21-activated kinase 1
      pfam00786
      Location:74 → 132
      PBD; P21-Rho-binding domain
    Nucleotide Protein
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