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    Bcl2l2 Bcl2-like 2 [ Rattus norvegicus (Norway rat) ]

    Gene ID: 60434, updated on 2-Nov-2024

    Summary

    Official Symbol
    Bcl2l2provided by RGD
    Official Full Name
    Bcl2-like 2provided by RGD
    Primary source
    RGD:620717
    See related
    EnsemblRapid:ENSRNOG00000015732 AllianceGenome:RGD:620717
    Gene type
    protein coding
    RefSeq status
    PROVISIONAL
    Organism
    Rattus norvegicus
    Lineage
    Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha; Muroidea; Muridae; Murinae; Rattus
    Also known as
    Bclw; BCL-W; BCL-WS; BCL-WEL
    Summary
    Enables BH domain binding activity. Involved in several processes, including cellular response to amyloid-beta; cellular response to estradiol stimulus; and cellular response to glycine. Located in mitochondrial membrane. Biomarker of Alzheimer's disease; epilepsy; pterygium; and transient cerebral ischemia. Human ortholog(s) of this gene implicated in transient cerebral ischemia. Orthologous to several human genes including BCL2L2 (BCL2 like 2). [provided by Alliance of Genome Resources, Nov 2024]
    Expression
    Biased expression in Brain (RPKM 171.4), Kidney (RPKM 125.3) and 9 other tissues See more
    Orthologs
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    Genomic context

    See Bcl2l2 in Genome Data Viewer
    Location:
    15p13
    Exon count:
    5
    Annotation release Status Assembly Chr Location
    RS_2024_02 current GRCr8 (GCF_036323735.1) 15 NC_086033.1 (32326686..32337834)
    RS_2023_06 previous assembly mRatBN7.2 (GCF_015227675.2) 15 NC_051350.1 (28346449..28361627)
    106 previous assembly Rnor_6.0 (GCF_000001895.5) 15 NC_005114.4 (33543774..33549165)

    Chromosome 15 - NC_086033.1Genomic Context describing neighboring genes Neighboring gene homeobox and leucine zipper encoding Neighboring gene protein phosphatase 1, regulatory subunit 3E Neighboring gene poly(A) binding protein, nuclear 1 Neighboring gene solute carrier family 22, member 17

    Genomic regions, transcripts, and products

    Expression

    • Project title: A rat RNA-Seq transcriptomic BodyMap across 11 organs and 4 developmental stages A rat RNA-Seq transcriptomic BodyMap across 11 organs and 4 developmental stages
    • Description: 320 RNA samples isolated from 11 organs (adrenal gland, brain, heart, kidney, liver, lung, muscle, spleen, thymus, and testes or uterus) from both sexes of Fischer 344 rats across four developmental stages (2-, 6-, 21-, and 104-weeks-old)
    • BioProject: PRJNA238328
    • Publication: PMID 24510058
    • Analysis date: Mon Jun 6 17:44:12 2016

    Bibliography

    GeneRIFs: Gene References Into Functions

    What's a GeneRIF?

    Pathways from PubChem

    Interactions

    Products Interactant Other Gene Complex Source Pubs Description

    General gene information

    Markers

    Clone Names

    • MGC91704

    Gene Ontology Provided by RGD

    Function Evidence Code Pubs
    enables BH domain binding IPI
    Inferred from Physical Interaction
    more info
    PubMed 
    enables channel activity IBA
    Inferred from Biological aspect of Ancestor
    more info
     
    enables disordered domain specific binding ISO
    Inferred from Sequence Orthology
    more info
     
    enables identical protein binding ISO
    Inferred from Sequence Orthology
    more info
     
    enables protein binding IPI
    Inferred from Physical Interaction
    more info
    PubMed 
    enables protein-containing complex binding IPI
    Inferred from Physical Interaction
    more info
    PubMed 
    Process Evidence Code Pubs
    acts_upstream_of_or_within Sertoli cell proliferation ISO
    Inferred from Sequence Orthology
    more info
     
    involved_in cellular response to amino acid stimulus IEP
    Inferred from Expression Pattern
    more info
    PubMed 
    involved_in cellular response to amyloid-beta IEP
    Inferred from Expression Pattern
    more info
    PubMed 
    involved_in cellular response to estradiol stimulus IEP
    Inferred from Expression Pattern
    more info
    PubMed 
    involved_in cellular response to glycine IEP
    Inferred from Expression Pattern
    more info
    PubMed 
    involved_in extrinsic apoptotic signaling pathway in absence of ligand IBA
    Inferred from Biological aspect of Ancestor
    more info
     
    acts_upstream_of_or_within extrinsic apoptotic signaling pathway in absence of ligand ISO
    Inferred from Sequence Orthology
    more info
     
    involved_in intrinsic apoptotic signaling pathway in response to DNA damage IBA
    Inferred from Biological aspect of Ancestor
    more info
     
    involved_in negative regulation of apoptotic process ISO
    Inferred from Sequence Orthology
    more info
     
    involved_in negative regulation of mitochondrial membrane permeability IDA
    Inferred from Direct Assay
    more info
    PubMed 
    involved_in negative regulation of release of cytochrome c from mitochondria IDA
    Inferred from Direct Assay
    more info
    PubMed 
    involved_in positive regulation of apoptotic process IBA
    Inferred from Biological aspect of Ancestor
    more info
     
    involved_in regulation of apoptotic process ISO
    Inferred from Sequence Orthology
    more info
     
    involved_in release of cytochrome c from mitochondria IBA
    Inferred from Biological aspect of Ancestor
    more info
     
    involved_in response to ischemia IEP
    Inferred from Expression Pattern
    more info
    PubMed 
    Component Evidence Code Pubs
    part_of Bcl-2 family protein complex ISO
    Inferred from Sequence Orthology
    more info
     
    located_in cytosol ISO
    Inferred from Sequence Orthology
    more info
     
    located_in mitochondrial membrane IDA
    Inferred from Direct Assay
    more info
    PubMed 
    located_in mitochondrial membrane ISO
    Inferred from Sequence Orthology
    more info
     
    is_active_in mitochondrial outer membrane IBA
    Inferred from Biological aspect of Ancestor
    more info
     
    located_in mitochondrion ISO
    Inferred from Sequence Orthology
    more info
    PubMed 

    NCBI Reference Sequences (RefSeq)

    NEW Try the new Transcript table

    RefSeqs maintained independently of Annotated Genomes

    These reference sequences exist independently of genome builds. Explain

    These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

    mRNA and Protein(s)

    1. NM_021850.2NP_068622.1  bcl-2-like protein 2

      See identical proteins and their annotated locations for NP_068622.1

      Status: PROVISIONAL

      Source sequence(s)
      BC074021
      UniProtKB/TrEMBL
      F7ELB1, O88996
      Related
      ENSRNOP00000020409.3, ENSRNOT00000020409.6
      Conserved Domains (1) summary
      TIGR00865
      Location:11193
      bcl-2; apoptosis regulator

    RefSeqs of Annotated Genomes: GCF_036323735.1-RS_2024_02

    The following sections contain reference sequences that belong to a specific genome build. Explain

    Reference GRCr8

    Genomic

    1. NC_086033.1 Reference GRCr8

      Range
      32326686..32337834
      Download
      GenBank, FASTA, Sequence Viewer (Graphics)

    mRNA and Protein(s)

    1. XM_063274606.1XP_063130676.1  bcl-2-like protein 2 isoform X2

      Related
      ENSRNOP00000106792.1, ENSRNOT00000132509.1
    2. XM_063274607.1XP_063130677.1  bcl-2-like protein 2 isoform X3

    3. XM_017599793.3XP_017455282.1  bcl-2-like protein 2 isoform X1

      UniProtKB/TrEMBL
      Q7TS60
      Related
      ENSRNOP00000108168.1, ENSRNOT00000121884.1
      Conserved Domains (3) summary
      cd06845
      Location:35173
      Bcl-2_like; Apoptosis regulator proteins of the Bcl-2 family, named after B-cell lymphoma 2. This alignment model spans what have been described as Bcl-2 homology regions BH1, BH2, BH3, and BH4. Many members of this family have an additional C-terminal transmembrane ...
      TIGR00865
      Location:37219
      bcl-2; apoptosis regulator
      pfam07336
      Location:146205
      ABATE; Putative stress-induced transcription regulator