Gpc1 glypican 1 [Rattus norvegicus (Norway rat)] - Gene

Summary

Official Symbol: Gpc1provided by RGD
Official Full Name: glypican 1provided by RGD
Primary source: RGD:61853
See related: Ensembl:ENSRNOG00000049437 AllianceGenome:RGD:61853
Gene type: protein coding
RefSeq status: PROVISIONAL
Organism: Rattus norvegicus
Lineage: Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha; Muroidea; Muridae; Murinae; Rattus
Also known as: HSPGM12; HSPG M12
Summary: Enables collagen V binding activity. Involved in Schwann cell differentiation and myelin assembly. Located in neuronal cell body. Orthologous to human GPC1 (glypican 1). [provided by Alliance of Genome Resources, Apr 2022]
Expression: Biased expression in Heart (RPKM 904.5), Muscle (RPKM 537.7) and 6 other tissues See more
Orthologs: human mouse all
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Genomic context

Location:: 9q36

Exon count:: 9

Annotation release	Status	Assembly	Chr	Location
RS_2024_02	current	GRCr8 (GCF_036323735.1)	9	NC_086027.1 (100843645..100871458)
RS_2023_06	previous assembly	mRatBN7.2 (GCF_015227675.2)	9	NC_051344.1 (93396234..93424047)
106	previous assembly	Rnor_6.0 (GCF_000001895.5)	9	NC_005108.4 (99998275..100026818)

Chromosome 9 - NC_086027.1 Genomic Context describing neighboring genes

Genomic regions, transcripts, and products

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Go to reference sequence details

Genomic Sequence:

Go to nucleotide: Graphics FASTA GenBank

Expression

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See details

Project title: A rat RNA-Seq transcriptomic BodyMap across 11 organs and 4 developmental stages
Description: 320 RNA samples isolated from 11 organs (adrenal gland, brain, heart, kidney, liver, lung, muscle, spleen, thymus, and testes or uterus) from both sexes of Fischer 344 rats across four developmental stages (2-, 6-, 21-, and 104-weeks-old)
BioProject: PRJNA238328
Publication: PMID 24510058
Analysis date: Mon Jun 6 17:44:12 2016

Bibliography

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GeneRIFs: Gene References Into Functions

What's a GeneRIF?

The glycocalyx core protein Glypican 1 protects vessel wall endothelial cells from stiffness-mediated dysfunction and disease.
Title: The glycocalyx core protein Glypican 1 protects vessel wall endothelial cells from stiffness-mediated dysfunction and disease.
These data suggest that fluid shear stress induced the cell junctional clustering of lipid rafts with their anchored glypican-1 and associated HS.
Title: Fluid shear stress induces the clustering of heparan sulfate via mobility of glypican-1 in lipid rafts.
Glypican increased fibroblast growth factor-2 expression and neurite extension in cortical neuron cultures.
Title: Intracerebral chondroitinase ABC and heparan sulfate proteoglycan glypican improve outcome from chronic stroke in rats.
Suggest that membrane proteoglycans glypican-1/syndecan-4 participate in the sequence of events triggered by diabetes and inflicted on cardiac and skeletal muscles.
Title: Changes in cardiac heparan sulfate proteoglycan expression and streptozotocin-induced diastolic dysfunction in rats.
conclusion, gpc-1 expression in odontoblast-like cells is associated with the early differentiation but not with the formation of reparative dentine.
Title: Effect of glypican-1 gene on the pulp cells during the reparative dentine process.
Data suggest that glypican-1 acts as a positive regulator of muscle differentiation by sequestering FGF-2 in lipid rafts and preventing its binding and dependent signaling.
Title: A novel mechanism of sequestering fibroblast growth factor 2 by glypican in lipid rafts, allowing skeletal muscle differentiation.
Glypican-1 was coexpressed with slit2 mRNA in reactive astrocytes, suggesting that glypican-1 might also prevent regenerating axons from entering into brain lesions.
Title: Slit and glypican-1 mRNAs are coexpressed in the reactive astrocytes of the injured adult brain.
altered HSPGs contribute to enhanced signaling of FGF-2 via FGFR1c in gliomas with glypican-1 playing a significant role in this mitogenic pathway
Title: Glypican-1 is frequently overexpressed in human gliomas and enhances FGF-2 signaling in glioma cells.
Glypican-1 has an important role in peripheral nerve terminal differentiation.
Title: Glypican-1 and alpha4(V) collagen are required for Schwann cell myelination.
glypican-1 is involved in the neuronal-like differentiation of PC12 cells and could play an important role on the regeneration responses of peripheral nerves
Title: Role of glypican-1 in the trophic activity on PC12 cells induced by cultured sciatic nerve conditioned medium: identification of a glypican-1-neuregulin complex.

Submit: New GeneRIF Correction See all GeneRIFs (13)

Interactions

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Products	Interactant	Other Gene	Complex	Source	Pubs	Description

General gene information

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Markers

BE095670 (e-PCR)
- UniSTS:243494

D9Got115 (e-PCR)
- UniSTS:111925

RH133623 (e-PCR)
- UniSTS:216906

Tbxas1 (e-PCR), detects polymorphism
- UniSTS:265585

BF390538 (e-PCR)
- UniSTS:249494

UniSTS:498343 (e-PCR)
- UniSTS:498343

Gpc1 (e-PCR), detects polymorphism
- UniSTS:498343

UniSTS:498431 (e-PCR)
- UniSTS:498431

Gpc1 (e-PCR), detects polymorphism
- UniSTS:498431

Gene Ontology Provided by RGD

Function	Evidence Code	Pubs
enables collagen V binding	IPI Inferred from Physical Interaction more info	PubMed
enables copper ion binding	IEA Inferred from Electronic Annotation more info
enables copper ion binding	ISO Inferred from Sequence Orthology more info
enables copper ion binding	ISS Inferred from Sequence or Structural Similarity more info
enables fibroblast growth factor binding	IBA Inferred from Biological aspect of Ancestor more info
enables fibroblast growth factor binding	IEA Inferred from Electronic Annotation more info
enables fibroblast growth factor binding	ISO Inferred from Sequence Orthology more info
enables fibroblast growth factor binding	ISS Inferred from Sequence or Structural Similarity more info
enables laminin binding	IEA Inferred from Electronic Annotation more info
enables laminin binding	ISO Inferred from Sequence Orthology more info
enables laminin binding	ISS Inferred from Sequence or Structural Similarity more info
enables protein binding	IPI Inferred from Physical Interaction more info	PubMed

Process	Evidence Code	Pubs
involved_in Schwann cell differentiation	IDA Inferred from Direct Assay more info	PubMed
involved_in biological_process	ND No biological Data available more info
involved_in cell migration	IBA Inferred from Biological aspect of Ancestor more info
involved_in heparan sulfate proteoglycan catabolic process	IEA Inferred from Electronic Annotation more info
involved_in heparan sulfate proteoglycan catabolic process	ISO Inferred from Sequence Orthology more info
involved_in heparan sulfate proteoglycan catabolic process	ISS Inferred from Sequence or Structural Similarity more info
involved_in myelin assembly	IDA Inferred from Direct Assay more info	PubMed
involved_in negative regulation of fibroblast growth factor receptor signaling pathway	IBA Inferred from Biological aspect of Ancestor more info
involved_in negative regulation of fibroblast growth factor receptor signaling pathway	IEA Inferred from Electronic Annotation more info
involved_in negative regulation of fibroblast growth factor receptor signaling pathway	ISO Inferred from Sequence Orthology more info
involved_in negative regulation of fibroblast growth factor receptor signaling pathway	ISS Inferred from Sequence or Structural Similarity more info
involved_in positive regulation of skeletal muscle cell differentiation	IEA Inferred from Electronic Annotation more info
involved_in positive regulation of skeletal muscle cell differentiation	ISO Inferred from Sequence Orthology more info
involved_in positive regulation of skeletal muscle cell differentiation	ISS Inferred from Sequence or Structural Similarity more info
involved_in regulation of protein localization to membrane	IBA Inferred from Biological aspect of Ancestor more info

Component	Evidence Code	Pubs
is_active_in cell surface	IBA Inferred from Biological aspect of Ancestor more info
located_in collagen-containing extracellular matrix	IEA Inferred from Electronic Annotation more info
located_in cytosol	IEA Inferred from Electronic Annotation more info
located_in cytosol	ISO Inferred from Sequence Orthology more info
located_in endosome	IEA Inferred from Electronic Annotation more info
located_in extracellular matrix	ISO Inferred from Sequence Orthology more info
located_in extracellular matrix	ISS Inferred from Sequence or Structural Similarity more info
located_in extracellular region	IEA Inferred from Electronic Annotation more info
located_in membrane raft	IEA Inferred from Electronic Annotation more info
located_in membrane raft	ISO Inferred from Sequence Orthology more info
located_in membrane raft	ISS Inferred from Sequence or Structural Similarity more info
located_in neuronal cell body	IDA Inferred from Direct Assay more info	PubMed
located_in nucleoplasm	IEA Inferred from Electronic Annotation more info
located_in nucleoplasm	ISO Inferred from Sequence Orthology more info
located_in plasma membrane	IEA Inferred from Electronic Annotation more info
located_in plasma membrane	ISO Inferred from Sequence Orthology more info
located_in side of membrane	IEA Inferred from Electronic Annotation more info
is_active_in synapse	IBA Inferred from Biological aspect of Ancestor more info
located_in synapse	IEA Inferred from Electronic Annotation more info
is_active_in synapse	ISO Inferred from Sequence Orthology more info

General protein information

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Preferred Names: glypican-1

Names: GPI-anchored cell surface heparan sulfate proteoglycan

NCBI Reference Sequences (RefSeq)

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RefSeqs maintained independently of Annotated Genomes

These reference sequences exist independently of genome builds. Explain

These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

mRNA and Protein(s)

NM_030828.2 → NP_110455.2 glypican-1 precursor

Status: PROVISIONAL

Source sequence(s)

JAXUCZ010000009

UniProtKB/Swiss-Prot

P35053

UniProtKB/TrEMBL

Q6P7Q2

Related

ENSRNOP00000066597.1, ENSRNOT00000074395.2

Conserved Domains (1) summary

pfam01153
Location:22 → 539

Glypican